FR2598433B1 - Procede de production d'interleukine-2 humaine, interleukine-2 ainsi obtenue, son utilisation a titre de medicament et composition pharmaceutique la contenant - Google Patents

Procede de production d'interleukine-2 humaine, interleukine-2 ainsi obtenue, son utilisation a titre de medicament et composition pharmaceutique la contenant

Info

Publication number
FR2598433B1
FR2598433B1 FR8706563A FR8706563A FR2598433B1 FR 2598433 B1 FR2598433 B1 FR 2598433B1 FR 8706563 A FR8706563 A FR 8706563A FR 8706563 A FR8706563 A FR 8706563A FR 2598433 B1 FR2598433 B1 FR 2598433B1
Authority
FR
France
Prior art keywords
interleukin
medicament
pharmaceutical composition
composition containing
same
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR8706563A
Other languages
English (en)
Other versions
FR2598433A1 (fr
Inventor
Bryan Richard Cullen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of FR2598433A1 publication Critical patent/FR2598433A1/fr
Application granted granted Critical
Publication of FR2598433B1 publication Critical patent/FR2598433B1/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/55—IL-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/10—Plasmid DNA
    • C12N2800/108—Plasmid DNA episomal vectors

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
FR8706563A 1986-05-12 1987-05-11 Procede de production d'interleukine-2 humaine, interleukine-2 ainsi obtenue, son utilisation a titre de medicament et composition pharmaceutique la contenant Expired - Fee Related FR2598433B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/862,082 US4992367A (en) 1986-05-12 1986-05-12 Enhanced expression of human interleukin-2 in mammalian cells

Publications (2)

Publication Number Publication Date
FR2598433A1 FR2598433A1 (fr) 1987-11-13
FR2598433B1 true FR2598433B1 (fr) 1990-09-21

Family

ID=25337602

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8706563A Expired - Fee Related FR2598433B1 (fr) 1986-05-12 1987-05-11 Procede de production d'interleukine-2 humaine, interleukine-2 ainsi obtenue, son utilisation a titre de medicament et composition pharmaceutique la contenant

Country Status (25)

Country Link
US (1) US4992367A (fr)
JP (1) JPS62278994A (fr)
AR (1) AR241794A1 (fr)
AT (1) AT389892B (fr)
AU (1) AU603576B2 (fr)
BE (1) BE1000717A5 (fr)
CH (1) CH675731A5 (fr)
DE (1) DE3715808A1 (fr)
DK (1) DK234087A (fr)
ES (2) ES2006476A6 (fr)
FI (1) FI872096A (fr)
FR (1) FR2598433B1 (fr)
GB (1) GB2190382B (fr)
GR (1) GR870727B (fr)
HU (1) HU205384B (fr)
IL (1) IL82475A0 (fr)
IT (1) IT1215478B (fr)
LU (1) LU86874A1 (fr)
MC (1) MC1821A1 (fr)
NL (1) NL8701132A (fr)
NO (1) NO871939L (fr)
NZ (1) NZ220246A (fr)
PT (1) PT84849B (fr)
SE (1) SE8701934L (fr)
ZA (1) ZA872768B (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3855747T2 (de) * 1987-08-26 1997-06-12 Biogen Inc Biologische materialien, deren herstellung und verwendung in der therapie
FR2619719B1 (fr) * 1987-09-01 1991-05-10 Sanofi Sa Procede d'obtention d'interleukine-2 a partir de cellules eucaryotes, vecteurs necessaires a sa mise en oeuvre et lignees cellulaires hautement productrices
FR2636231A1 (fr) * 1988-09-09 1990-03-16 Sanofi Sa Cellules eucaryotes recombinees productrices d'interleukine-1 (beta) mature n-glycosylee, procede et vecteurs necessaires pour leur obtention et procede d'obtention d'interleukine-1 (beta) mature n-glycosylee
WO1990010069A1 (fr) * 1989-02-28 1990-09-07 Institut Organicheskogo Sinteza Akademii Nauk Latviiskoi Ssr ADN pAA 1213-23 ET pAC 262-33 DE PLASMIDE DE RECOMBINAISON CODANT POUR LA SYNTHESE D'INTERLEUKINE-2 HUMAINE, LEUR PROCEDE DE CONSTRUCTION ET SOUCHE DE BACTERIES ESCHERICHIA COLI RRI/pAC 262-33 EN TANT QUE PRODUCTEUR D'INTERLEUKINE-2 HUMAINE
CA2022983A1 (fr) * 1989-08-11 1991-02-12 Mei-Huei Lai Expression d'un gene fonctionnel de la toxine specifique d'un insecte dans des cellules de mammiferes
GB9106185D0 (en) * 1991-03-22 1991-05-08 Wellcome Found Biological control agents
US5856178A (en) * 1993-08-30 1999-01-05 Utah State University DNA cassettes for expression of lytic peptides in mammalian cells and transgenic organisms containing same
US5548075A (en) * 1993-08-30 1996-08-20 Utah State University DNA cassette and transgenic organisms carrying lytic peptide-encoding genes
US5641665A (en) * 1994-11-28 1997-06-24 Vical Incorporated Plasmids suitable for IL-2 expression
US5686246A (en) * 1995-08-03 1997-11-11 Kornman; Kenneth S. Detecting genetic predisposition to periodontal disease
WO1997014433A1 (fr) 1995-10-17 1997-04-24 Wayne State University Interleukine-15 du poulet et ses utilisations
US6001613A (en) * 1996-05-24 1999-12-14 Board Of Regents Of University Of Nebraska Plasmid bearing a cDNA copy of the genome of bovine viral diarrhea virus, chimeric derivatives thereof, and method of producing an infectious bovine viral diarrhea virus using said plasmid
AUPP655698A0 (en) 1998-10-16 1998-11-05 Commonwealth Scientific And Industrial Research Organisation Delivery system for porcine somatotropin
US20070025958A1 (en) 2000-10-27 2007-02-01 Hadden John W Vaccine immunotherapy
KR20020043448A (ko) * 2000-12-04 2002-06-10 리송알렉스인근 인터루킨-2 재조합 단백질 및 그의 제조방법
DE60226853D1 (de) * 2001-02-20 2008-07-10 Ortho Mcneil Pharm Inc Zelltherapieverfahren für die behandlung von tumoren
US20040071671A1 (en) * 2001-02-20 2004-04-15 Leturcq Didier J. Cell therapy method for the treatment of tumors

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2814039C3 (de) * 1978-03-31 1981-02-19 Gesellschaft Fuer Biotechnologische Forschung Mbh (Gbf), 3300 Braunschweig Verfahren zur Herstellung von Hybrid-Bakterien
US4405712A (en) * 1981-07-01 1983-09-20 The United States Of America As Represented By The Department Of Health And Human Services LTR-Vectors
EP0091539B2 (fr) * 1982-03-31 1996-11-27 Ajinomoto Co., Inc. Gène codant pour interleukin-2 polypeptide, ADN recombinant portant ledit gène, lignées cellulaires possédant le recombinant ADN et procédé pour la préparation d'interleukin-2 utilisant lesdites cellules
AU556353B2 (en) * 1982-12-15 1986-10-30 Ajinomoto Co., Inc. Interleukin-2 polypeptide
AU579089B2 (en) * 1983-02-08 1988-11-17 Biogen, Inc. Human interleukin-2-like polypeptides
EP0119621A1 (fr) * 1983-03-21 1984-09-26 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Interleukin-2
WO1985000817A1 (fr) * 1983-08-10 1985-02-28 Amgen Expression microbienne de l'interleukine ii
GB8327880D0 (en) * 1983-10-18 1983-11-16 Ajinomoto Kk Saccharomyces cerevisiae
WO1985002200A1 (fr) * 1983-11-14 1985-05-23 Chiron Corporation Production d'interleukine-2 en utilisant des genes clones pou r l'interleukine-2 et le facteur alpha de levure
FR2559782B1 (fr) * 1984-02-16 1986-07-18 Transgene Sa Vecteur d'expression dans les levures de l'interleukine-2, levures transformees et procede de preparation de l'interleukine-2
ATE48641T1 (de) * 1984-05-08 1989-12-15 Genetics Inst Ein menschlicher t-zellwachstumsfaktor.
DE3419995A1 (de) * 1984-05-29 1985-12-05 Hoechst Ag, 6230 Frankfurt Gentechnologisches verfahren zur herstellung von human-interleukin-2 und mittel zur durchfuehrung dieses verfahrens
EP0172619A1 (fr) * 1984-06-20 1986-02-26 Takeda Chemical Industries, Ltd. Transformateur et son utilisation
CA1275954C (fr) * 1984-08-31 1990-11-06 Hing Cheug Wong Fragments augmentant l'expression en 3' et methode
FR2583770B1 (fr) * 1985-06-21 1988-08-19 Transgene Sa Expression de l'il-2 humaine dans les cellules de mammiferes par un poxvirus recombine
FR2619719B1 (fr) * 1987-09-01 1991-05-10 Sanofi Sa Procede d'obtention d'interleukine-2 a partir de cellules eucaryotes, vecteurs necessaires a sa mise en oeuvre et lignees cellulaires hautement productrices

Also Published As

Publication number Publication date
AU7270387A (en) 1987-11-19
GB8711072D0 (en) 1987-06-17
AU603576B2 (en) 1990-11-22
SE8701934L (sv) 1987-11-13
ATA263787A (de) 1989-07-15
AR241794A1 (es) 1992-12-30
GB2190382B (en) 1990-08-15
FR2598433A1 (fr) 1987-11-13
HUT45558A (en) 1988-07-28
NZ220246A (en) 1990-07-26
HU205384B (en) 1992-04-28
BE1000717A5 (fr) 1989-03-21
GB2190382A (en) 1987-11-18
PT84849B (pt) 1990-02-08
AT389892B (de) 1990-02-12
FI872096A (fi) 1987-11-13
ES2012940A6 (es) 1990-04-16
MC1821A1 (fr) 1988-03-18
DK234087A (da) 1987-11-13
SE8701934D0 (sv) 1987-05-11
DE3715808A1 (de) 1987-12-10
ZA872768B (en) 1988-04-27
NL8701132A (nl) 1987-12-01
FI872096A0 (fi) 1987-05-12
ES2006476A6 (es) 1989-05-01
PT84849A (pt) 1987-06-01
IL82475A0 (en) 1987-11-30
IT1215478B (it) 1990-02-14
NO871939L (no) 1987-11-13
IT8720479A0 (it) 1987-05-12
GR870727B (en) 1987-09-21
CH675731A5 (fr) 1990-10-31
NO871939D0 (no) 1987-05-11
DK234087D0 (da) 1987-05-08
US4992367A (en) 1991-02-12
LU86874A1 (fr) 1988-06-13
JPS62278994A (ja) 1987-12-03

Similar Documents

Publication Publication Date Title
FR2598433B1 (fr) Procede de production d'interleukine-2 humaine, interleukine-2 ainsi obtenue, son utilisation a titre de medicament et composition pharmaceutique la contenant
FR2526443B1 (fr) Activateur de plasminogene de tissu humain, son procede de production et composition pharmaceutique le contenant
ATE103914T1 (de) Neue thienylcarbonsaeureester von aminoalkoholen, ihre quaternierungsprodukte sowie die herstellung und verwendung dieser verbindungen.
FR2564097B1 (fr) Polypeptide physiologiquement actif humain, acide desoxyribonucleique comprenant une sequence de base codant ce polypeptide, procede de production de ce polypeptide, et composition pharmaceutique le contenant
FR2617488B1 (fr) Procede de fabrication de structures organisees de collagene, notamment d'origine humaine, et structures organisees de collagene correspondantes
FR2633181B1 (fr) Composition pharmaceutique a base de ranitidine et son procede de preparation
EP0279149A3 (en) Benzimidazole derivatives, process for their production and a pharmaceutical composition containing the same
HUT40804A (en) Process for production of medical preparatives containing n-acetyl neuramin acid
FR2573426B1 (fr) Procede de preparation de silibinine depourvue d'isosilybine et medicaments renfermant de la silibinine
ATE27914T1 (de) Verwendung von n-acetyl(alpha, beta) aspartylglutaminsaeure zur herstellung eines arzneimittels mit anti-allergischer wirkung zur lokalen verabreichung.
FR2608921B1 (fr) Composition pharmaceutique contenant de la ranitidine
FR2331343A1 (fr) Nouvelle spiro(1,3-dioxolane-4,3')quinuclidine, son procede de preparation et medicament la contenant
BE895961A (fr) Procede de preparation d'un clone bacterien produisant de 1'alpha 1-antitrypsine humaine
MX163341A (es) N procedimiento para la preparacion de nuevas 1,4 dihidropiridinas,utiles como medicamentos antibioticos
FR2610932B1 (fr) Nouvel acide piperazinecarboxylique, sa preparation et son utilisation comme medicament
MA19731A1 (fr) Isomere levogyre de la mequitazine , son procede de praparation et medicaments le contenant .
FR2510571B1 (fr) Spirothiazolidinedione, son procede de production et preparation pharmaceutique la contenant
HUT40066A (en) Process for production of poliphrens
HUT44786A (en) Process for production of quinazolin-dions, piridopirimidin-dions and medical preparatives containing them as active substance
FR2550802B1 (fr) Procede de production d'interleukine 1 humaine et medicaments correspondants
FR2541576B1 (fr) Medicament contenant de la muzolimine et son procede de preparation
BE894597A (fr) Nouvelles xanthines a activite pharmacologique, leur procede d'obtention, les compositions pharmaceutiques les contenant et leur utilisation en medecine humaine
ZA875344B (en) Platinum(ii)complexes of 2,3-dimercapto-2-butene-dinitrilate(2-)-s,s'process for their production and pharmaceutical compositions containing them
FR2652086B1 (fr) Compose nouveau d'origine vegetale, derive de l'acide cafeique, l'oraposide; composition a usage therapeutique et composition dermato-cosmetique le contenant.
DE3777709D1 (de) Verwendung von 3'azido-3'deoxythymidin zur herstellung eines arzneimittels zur behandlung von gardiasis.

Legal Events

Date Code Title Description
TP Transmission of property
ST Notification of lapse