LU86074A1 - Composes antibiotiques et leur preparation - Google Patents

Composes antibiotiques et leur preparation Download PDF

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Publication number
LU86074A1
LU86074A1 LU86074A LU86074A LU86074A1 LU 86074 A1 LU86074 A1 LU 86074A1 LU 86074 A LU86074 A LU 86074A LU 86074 A LU86074 A LU 86074A LU 86074 A1 LU86074 A1 LU 86074A1
Authority
LU
Luxembourg
Prior art keywords
compounds
compound according
ncib
compound
factor
Prior art date
Application number
LU86074A
Other languages
English (en)
French (fr)
Inventor
Hazel Mary Noble
David Noble
John Barrie Dr Ward
Neil Dr Porter
Richard Alan Dr Fletton
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB848423278A external-priority patent/GB8423278D0/en
Priority claimed from GB848432519A external-priority patent/GB8432519D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of LU86074A1 publication Critical patent/LU86074A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/181—Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465—Streptomyces
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/886—Streptomyces

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
LU86074A 1984-09-14 1985-09-13 Composes antibiotiques et leur preparation LU86074A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB8423278 1984-09-14
GB848423278A GB8423278D0 (en) 1984-09-14 1984-09-14 Antibiotic compounds
GB848432519A GB8432519D0 (en) 1984-12-21 1984-12-21 Antibiotic compounds
GB8432519 1984-12-21

Publications (1)

Publication Number Publication Date
LU86074A1 true LU86074A1 (fr) 1986-04-03

Family

ID=26288220

Family Applications (1)

Application Number Title Priority Date Filing Date
LU86074A LU86074A1 (fr) 1984-09-14 1985-09-13 Composes antibiotiques et leur preparation

Country Status (33)

Country Link
US (2) US4898821A (ja)
JP (2) JPH07116199B2 (ja)
KR (1) KR940004098B1 (ja)
AT (1) AT396250B (ja)
AU (1) AU596565B2 (ja)
BE (1) BE903232A (ja)
BG (1) BG44205A3 (ja)
BR (1) BR8504457A (ja)
CA (1) CA1313155C (ja)
CH (1) CH666690A5 (ja)
CS (1) CS268803B2 (ja)
DE (1) DE3532794A1 (ja)
DK (1) DK162099C (ja)
ES (2) ES8704545A1 (ja)
FI (1) FI87366C (ja)
FR (1) FR2570390B1 (ja)
GB (1) GB2166436B (ja)
GR (1) GR852232B (ja)
HU (1) HU197046B (ja)
IE (1) IE59394B1 (ja)
IL (1) IL76385A (ja)
IT (1) IT1182857B (ja)
LU (1) LU86074A1 (ja)
NL (1) NL8502511A (ja)
NZ (1) NZ213463A (ja)
PH (2) PH21995A (ja)
PL (1) PL152148B1 (ja)
PT (1) PT81125B (ja)
RO (1) RO92478A (ja)
SE (2) SE502748C2 (ja)
SU (1) SU1738090A3 (ja)
UA (1) UA19162A (ja)
ZW (1) ZW15585A1 (ja)

Families Citing this family (69)

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LV5536A3 (lv) * 1984-09-14 1994-03-10 American Cyanamid Co Panemiens antibiotikas s-541 iegusanai streptomicetu celmi-antibiotikas s-541 producenti
US4696922A (en) * 1984-11-26 1987-09-29 Ciba-Geigy Corporation 5-azolylacetoxymilbemycins as ecto- and endoparasites
AU596586B2 (en) * 1985-04-30 1990-05-10 American Cyanamid Company Chemical derivatives of antibiotics S541
AT399441B (de) * 1985-04-30 1995-05-26 American Cyanamid Co Schädlingsbekämpfungsmittel und verfahren zur bekämpfung von schädlingen
ES8800986A1 (es) * 1985-07-27 1987-12-01 Pfizer Un procedimiento para la produccion de un nuevo derivado de avermectina
IE67373B1 (en) * 1985-09-13 1996-03-20 American Cyanamid Co Macrolide antibiotics and their preparation
GB8606120D0 (en) * 1986-03-12 1986-04-16 Glaxo Group Ltd Process
AT398312B (de) * 1986-03-12 1994-11-25 American Cyanamid Co Verfahren zur herstellung einer neuen makroliden verbindung
GB8606116D0 (en) * 1986-03-12 1986-04-16 Glaxo Group Ltd Process
BR8701118A (pt) * 1986-03-12 1988-01-05 Glaxo Group Ltd Processo para a preparacao de um composto quimico,processo para combater pestes em agricultura,horicultura ou silvicultura,ou em lojas,predios e outros locais publicos e composicao de controle de pestes
ES2059366T3 (es) * 1986-03-12 1994-11-16 American Cyanamid Co Compuestos macrolidos.
GB8606105D0 (en) * 1986-03-12 1986-04-16 Glaxo Group Ltd Chemical compounds
CA1296329C (en) * 1986-06-06 1992-02-25 Derek R. Sutherland Macrolide compounds
GB8613790D0 (en) * 1986-06-06 1986-07-09 Glaxo Group Ltd Chemical compounds
US5840704A (en) * 1986-07-16 1998-11-24 Pfizer Inc. Antiparasitic agents and process for their preparation
EP0253378A3 (de) * 1986-07-18 1988-03-23 Ciba-Geigy Ag 13Beta-Alkyl-derivate von S541-Antibiotika zur Bekämpfung von Parasiten an Nutztieren und Pflanzen
DE3750495T2 (de) * 1986-07-24 1995-02-23 Beecham Group Plc Milbemycin-Derivate mit parasitenabtötender Aktivität, ein Verfahren zu ihrer Herstellung und die sie enthaltenden Zusammensetzungen.
US5149832A (en) * 1986-09-12 1992-09-22 American Cyanamid Company Mono and diacyl derivatives of ll-f28249 compounds
US4886828A (en) * 1986-09-12 1989-12-12 American Cyanamid Company Δ22 -derivatives of LL-F28249 compounds
ES2055695T3 (es) * 1986-09-12 1994-09-01 American Cyanamid Co Derivados 23-desoxi de compuestos ll-f28249.
EP0259779B1 (en) * 1986-09-12 1994-08-10 American Cyanamid Company 23-Oxo (Keto) and 23-imino Derivatives of LL-F28249 Compounds
US4916154A (en) * 1986-09-12 1990-04-10 American Cyanamid Company 23-Imino derivatives of LL-F28249 compounds
US5019589A (en) * 1986-09-12 1991-05-28 American Cyanamid Company Δ23 -LL-F28249 compounds
US5525506A (en) * 1987-01-23 1996-06-11 Pfizer Inc. Process for production of avermectins and cultures therefor
US5238848A (en) * 1987-01-23 1993-08-24 Pfizer Inc Cultures for production of avermectins
US5234831A (en) * 1987-01-23 1993-08-10 Pfizer Inc Cultures for production of B avermectins
US5183749A (en) * 1987-02-04 1993-02-02 Sankyo Company, Ltd. Microbial process for the preparation of milbemycin derivatives
US4897416A (en) * 1987-02-18 1990-01-30 Ciba-Geigy Corporation Insecticides and parasiticides
US4886829A (en) * 1987-03-06 1989-12-12 American Cyanamid Company 23-Oxo (keto) and 23-imino derivatives of mono- and diepoxy LL-F28249 compounds
US4886830A (en) * 1987-03-06 1989-12-12 American Cyanamid Company Mono- and diepoxide derivatives of 23-deoxyl-LL-F28249 compounds
US4956479A (en) * 1987-03-06 1990-09-11 American Cyanamid Company 23-deoxy-27-chloro derivatives of LL-F28249 compounds
US4851428A (en) * 1987-03-06 1989-07-25 American Cyanamid Company Mono- and diepoxide derivatives of Δ22-LL-F28249 compounds
US4855317A (en) * 1987-03-06 1989-08-08 Ciba-Geigy Corporation Insecticides and parasiticides
US4876272A (en) * 1987-03-06 1989-10-24 American Cyanamid Company Mono- and diepoxide derivatives of LL-F28249 compounds
US4806527A (en) * 1987-03-16 1989-02-21 Merck & Co., Inc. Avermectin derivatives
US4871719A (en) * 1987-03-24 1989-10-03 Ciba-Geigy Corporation Composition for controlling parasites in productive livestock
EP0285561A3 (de) * 1987-03-27 1989-10-25 Ciba-Geigy Ag Parasitizide und insektizide Milbemycin-Derivate
GB8721378D0 (en) * 1987-09-11 1987-10-21 Glaxo Group Ltd Chemical process
GB8721375D0 (en) * 1987-09-11 1987-10-21 Glaxo Group Ltd Chemical process
GB8721377D0 (en) * 1987-09-11 1987-10-21 Glaxo Group Ltd Chemical compounds
GB8721647D0 (en) * 1987-09-15 1987-10-21 Pfizer Ltd Antiparasitic agents
US5240850A (en) * 1987-10-23 1993-08-31 Pfizer Inc. Cultures for production of avermectin aglycones
ES2045146T3 (es) * 1987-11-09 1994-01-16 Pfizer Avermectinas etiladas.
GB8726730D0 (en) * 1987-11-14 1987-12-16 Pfizer Ltd Antiparasitic agents
GB8803836D0 (en) * 1988-02-18 1988-03-16 Glaxo Group Ltd Compositions
GB8804440D0 (en) * 1988-02-25 1988-03-23 Pfizer Ltd Antiparasitic agents
GB8805978D0 (en) * 1988-03-14 1988-04-13 Glaxo Group Ltd Process
GB8813760D0 (en) * 1988-06-10 1988-07-13 American Cyanamid Co Chemical process
NZ232422A (en) * 1989-02-16 1992-11-25 Merck & Co Inc 13-ketal milbemycin derivatives and parasiticides
US5322692A (en) * 1989-02-28 1994-06-21 American Cyanamid Company Sustained release bolus effective for the prolonged prevention, treatment or control of nematode, acarid and endo- and ectoparasitic infestations of ruminants
DK0393890T3 (da) * 1989-04-11 1992-09-28 Pfizer Injicerbart præparat indeholdende 25-cyclohexyl-avermectin B1
US6001822A (en) * 1989-04-11 1999-12-14 Pfizer Inc. Antiparasitic formulations
DK0426948T3 (da) 1989-08-11 1996-05-28 American Cyanamid Co Arylpyrroler som insekticide, acaricide og nematodicide midler samt fremgangsmåder til deres fremstilling
NZ234802A (en) * 1989-08-14 1992-11-25 Merck & Co Inc Long acting injectable formulations comprising an avermectin compound and triacetin. treatment for internal and external parasites of animals
US5830875A (en) * 1989-10-30 1998-11-03 Merck & Co., Inc. 24-and 25-substituted avermectin and milbemycin derivatives
US5055454A (en) * 1989-10-30 1991-10-08 Merck & Co., Inc. 13-epi-avermectin derivatives useful as antiparasitic agents
US5208222A (en) * 1991-03-28 1993-05-04 Merck & Co., Inc. 4"-and 4'-alkylthio avermectin derivatives
US5262400A (en) * 1991-06-20 1993-11-16 Merck & Co., Inc. 4α-substituted avermectin derivatives
MD24C2 (ro) * 1991-07-09 1994-05-31 Fabrica De Parfumerii Si Cosmetica "Viorica" Compoziţie de substanţe odorante
GB9205007D0 (en) * 1992-03-07 1992-04-22 Pfizer Ltd Antiparasitic agents
US5229415A (en) * 1992-03-24 1993-07-20 Merck & Co., Inc. Alkylthio alkyl avermectins are active antiparasitic agents
US6103504A (en) * 1992-03-25 2000-08-15 Pfizer Inc. Process for production of avermectins and cultures therefor
US6486195B1 (en) * 1993-08-19 2002-11-26 Merck & Co., Inc. Thermodynamically stable crystal form of 4″-deoxy-4″-epi-methylamino avermectin B1a/B1b benzoic acid salt and processes for its preparation
JP2855181B2 (ja) 1993-12-10 1999-02-10 敏雄 鈴木 松類の枯損防止用組成物及び防止方法
US6495591B1 (en) 1997-10-02 2002-12-17 Essential Therapeutics, Inc. Fungal efflux pump inhibitors
PT1197215E (pt) 2000-10-10 2006-07-31 Wyeth Corp Composicoes antelminticas
GB0205253D0 (en) * 2002-03-06 2002-04-17 Univ Gent Immediate release pharmaceutical granule compositions and a continuous process for making them
JP2008531553A (ja) * 2005-02-25 2008-08-14 メディジーンズ カンパニー リミテッド 血漿または血清を含むアベリノ角膜ジストロフィー治療用の医薬組成物
CN100394983C (zh) * 2006-01-09 2008-06-18 浙江海正药业股份有限公司 含有大豆油的多拉菌素注射液

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JPS4914624A (ja) * 1972-06-08 1974-02-08
SE434277B (sv) * 1976-04-19 1984-07-16 Merck & Co Inc Sett att framstella nya antihelmintiskt verkande foreningar genom odling av streptomyces avermitilis
PH16612A (en) * 1977-12-19 1983-11-28 Merck & Co Inc 13-halo and 13-deoxy derivatives of c-076 compounds
US4173571A (en) * 1977-12-19 1979-11-06 Merck & Co., Inc. 13-Halo and 13-deoxy derivatives of C-076 compounds
US4171314A (en) * 1977-12-19 1979-10-16 Merck & Co., Inc. 13-Halo and 13-deoxy C-076 compounds
US4200581A (en) * 1978-08-04 1980-04-29 Merck & Co., Inc. Alkyl derivatives of C-076 compounds
NZ201681A (en) * 1981-09-03 1985-11-08 Merck & Co Inc Avermectin derivatives and parasiticidal compositions
PT80577B (pt) * 1984-06-05 1987-09-18 American Cyanamid Co Processo para a producao de novos agentes macrolidos ll-f28249 uteis no tratamento de infeccoes helminticas por ectoparasitas artropodes e por acarideos
AU596586B2 (en) * 1985-04-30 1990-05-10 American Cyanamid Company Chemical derivatives of antibiotics S541
ES8800986A1 (es) * 1985-07-27 1987-12-01 Pfizer Un procedimiento para la produccion de un nuevo derivado de avermectina

Also Published As

Publication number Publication date
BR8504457A (pt) 1986-07-15
AU596565B2 (en) 1990-05-10
ES557237A0 (es) 1988-08-01
IL76385A (en) 1990-09-17
FR2570390A1 (fr) 1986-03-21
JPS61118387A (ja) 1986-06-05
CS268803B2 (en) 1990-04-11
PL255360A1 (en) 1988-02-18
SE8504254L (sv) 1986-03-15
PT81125A (en) 1985-10-01
IT8548551A0 (it) 1985-09-13
GB2166436B (en) 1989-05-24
IE852263L (en) 1986-03-14
IE59394B1 (en) 1994-02-23
SE469173B (sv) 1993-05-24
SE8802985D0 (sv) 1988-08-25
JPH07116199B2 (ja) 1995-12-13
ATA268485A (de) 1992-11-15
US4898821A (en) 1990-02-06
NL8502511A (nl) 1986-04-01
US4935531A (en) 1990-06-19
FI87366B (fi) 1992-09-15
IL76385A0 (en) 1986-01-31
FR2570390B1 (fr) 1987-11-27
CH666690A5 (de) 1988-08-15
DK162099B (da) 1991-09-16
ZW15585A1 (en) 1986-04-23
SE8504254D0 (sv) 1985-09-13
AT396250B (de) 1993-07-26
FI853520A0 (fi) 1985-09-13
AU4742685A (en) 1986-03-20
JPH07213278A (ja) 1995-08-15
DK418085D0 (da) 1985-09-13
GR852232B (ja) 1986-01-14
IT1182857B (it) 1987-10-05
RO92478A (ro) 1987-09-30
FI87366C (fi) 1992-12-28
ES8704545A1 (es) 1987-04-01
JP2566385B2 (ja) 1996-12-25
BG44205A3 (en) 1988-10-14
PL152148B1 (en) 1990-11-30
ES8802555A1 (es) 1988-08-01
GB8522699D0 (en) 1985-10-16
DK418085A (da) 1986-03-15
CA1313155C (en) 1993-01-26
CS654685A2 (en) 1989-08-14
DK162099C (da) 1992-02-24
HU197046B (en) 1989-02-28
SE502748C2 (sv) 1995-12-18
PH24247A (en) 1990-05-04
KR940004098B1 (ko) 1994-05-13
NZ213463A (en) 1993-04-28
DE3532794A1 (de) 1986-04-17
SE8802985L (sv) 1988-08-25
PT81125B (pt) 1987-10-20
FI853520L (fi) 1986-03-15
HUT39779A (en) 1986-10-29
SU1738090A3 (ru) 1992-05-30
PH21995A (en) 1988-05-02
ES546962A0 (es) 1987-04-01
GB2166436A (en) 1986-05-08
KR860002576A (ko) 1986-04-26
BE903232A (fr) 1986-03-13
UA19162A (uk) 1997-12-25

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