LT5138B - Epotilono analogo polimorfinės formos - Google Patents
Epotilono analogo polimorfinės formos Download PDFInfo
- Publication number
- LT5138B LT5138B LT2003017A LT2003017A LT5138B LT 5138 B LT5138 B LT 5138B LT 2003017 A LT2003017 A LT 2003017A LT 2003017 A LT2003017 A LT 2003017A LT 5138 B LT5138 B LT 5138B
- Authority
- LT
- Lithuania
- Prior art keywords
- crystalline
- hours
- mixture
- formula
- analogue
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Plural Heterocyclic Compounds (AREA)
- Steroid Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US22559000P | 2000-08-16 | 2000-08-16 |
Publications (2)
Publication Number | Publication Date |
---|---|
LT2003017A LT2003017A (en) | 2004-03-25 |
LT5138B true LT5138B (lt) | 2004-06-25 |
Family
ID=22845469
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
LT2003017A LT5138B (lt) | 2000-08-16 | 2003-02-25 | Epotilono analogo polimorfinės formos |
Country Status (42)
Country | Link |
---|---|
US (4) | US6689802B2 (xx) |
EP (1) | EP1309597B1 (xx) |
JP (1) | JP5046467B2 (xx) |
KR (1) | KR100810342B1 (xx) |
CN (1) | CN1269821C (xx) |
AR (1) | AR034259A1 (xx) |
AT (1) | ATE366735T1 (xx) |
AU (2) | AU2001281082B2 (xx) |
BG (1) | BG66132B1 (xx) |
BR (1) | BR0113234A (xx) |
CA (1) | CA2418109C (xx) |
CY (1) | CY1107758T1 (xx) |
CZ (1) | CZ305523B6 (xx) |
DE (1) | DE60129334T2 (xx) |
DK (1) | DK1309597T3 (xx) |
EE (1) | EE05273B1 (xx) |
ES (1) | ES2288518T3 (xx) |
GE (1) | GEP20053495B (xx) |
HK (1) | HK1052010A1 (xx) |
HR (1) | HRP20030190B1 (xx) |
HU (1) | HU229314B1 (xx) |
IL (2) | IL153993A0 (xx) |
IS (1) | IS2845B (xx) |
LT (1) | LT5138B (xx) |
LV (1) | LV13032B (xx) |
MX (1) | MXPA03001431A (xx) |
MY (1) | MY134129A (xx) |
NO (1) | NO328500B1 (xx) |
NZ (1) | NZ523722A (xx) |
PE (1) | PE20020290A1 (xx) |
PL (1) | PL205628B1 (xx) |
PT (1) | PT1309597E (xx) |
RO (1) | RO123296B1 (xx) |
RU (1) | RU2272039C2 (xx) |
SI (1) | SI21100B (xx) |
SK (1) | SK287876B6 (xx) |
TW (1) | TWI320040B (xx) |
UA (1) | UA75365C2 (xx) |
UY (1) | UY26886A1 (xx) |
WO (1) | WO2002014323A2 (xx) |
YU (1) | YU12103A (xx) |
ZA (1) | ZA200300522B (xx) |
Families Citing this family (56)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69734362T2 (de) | 1996-12-03 | 2006-07-20 | Sloan-Kettering Institute For Cancer Research | Synthese von epothilonen, zwischenprodukte dazu, analoga und verwendungen davon |
US20050043376A1 (en) * | 1996-12-03 | 2005-02-24 | Danishefsky Samuel J. | Synthesis of epothilones, intermediates thereto, analogues and uses thereof |
US6605599B1 (en) | 1997-07-08 | 2003-08-12 | Bristol-Myers Squibb Company | Epothilone derivatives |
US6194181B1 (en) * | 1998-02-19 | 2001-02-27 | Novartis Ag | Fermentative preparation process for and crystal forms of cytostatics |
US20020058286A1 (en) * | 1999-02-24 | 2002-05-16 | Danishefsky Samuel J. | Synthesis of epothilones, intermediates thereto and analogues thereof |
US6518421B1 (en) * | 2000-03-20 | 2003-02-11 | Bristol-Myers Squibb Company | Process for the preparation of epothilone analogs |
AU2002245296B2 (en) * | 2001-01-25 | 2006-12-21 | Bristol-Myers Squibb Company | Methods of administering epothilone analogs for the treatment of cancer |
IL156580A0 (en) * | 2001-01-25 | 2004-01-04 | Bristol Myers Squibb Co | A method for formulating an epothilone analog for parenteral use and pharmaceutical preparations including an epothilone analog |
CN1774253A (zh) | 2001-02-20 | 2006-05-17 | 布里斯托尔-迈尔斯斯奎布公司 | 用环氧丙酯酮衍生物治疗顽固性肿瘤 |
ES2384789T3 (es) * | 2001-03-14 | 2012-07-12 | Bristol-Myers Squibb Company | Combinación de un análogo de epotilona y agentes quimioterapéuticos para el tratamiento de enfermedades proliferativas |
DE60316775T2 (de) * | 2002-03-08 | 2008-04-30 | Novartis Ag | Kombinationspräparat aus epothilone derivate und imidazotetrazinone |
US7649006B2 (en) * | 2002-08-23 | 2010-01-19 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
DK1767535T3 (da) * | 2002-08-23 | 2010-04-12 | Sloan Kettering Inst Cancer | Syntese af epothiloner, mellemprodukter deraf, analoge og deres anvendelse |
US6921769B2 (en) | 2002-08-23 | 2005-07-26 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
US20050171167A1 (en) * | 2003-11-04 | 2005-08-04 | Haby Thomas A. | Process and formulation containing epothilones and analogs thereof |
ITMI20032144A1 (it) * | 2003-11-07 | 2005-05-08 | Alfa Wassermann Spa | Forme polimorfe di rifaximina, processi per ottenerle e |
US20090004277A1 (en) * | 2004-05-18 | 2009-01-01 | Franchini Miriam K | Nanoparticle dispersion containing lactam compound |
EP1640004A1 (en) * | 2004-09-24 | 2006-03-29 | Schering Aktiengesellschaft | Use of epothilones in the treatment of bone metastases and bone tumors or cancers |
MX2007005763A (es) | 2004-11-18 | 2007-07-20 | Squibb Bristol Myers Co | Perla recubierta enterica que comprende ixabepilona, y preparacion y administracion de la misma. |
US20060134214A1 (en) * | 2004-11-18 | 2006-06-22 | Ismat Ullah | Enteric coated bead comprising epothilone or epothilone analog, and preparation and administration thereof |
US20060121511A1 (en) | 2004-11-30 | 2006-06-08 | Hyerim Lee | Biomarkers and methods for determining sensitivity to microtubule-stabilizing agents |
EP1674098A1 (en) | 2004-12-23 | 2006-06-28 | Schering Aktiengesellschaft | Stable and tolerable parental formulations of highly reactive organic drug substances with low or no solubility in water |
EP2634252B1 (en) | 2005-02-11 | 2018-12-19 | University of Southern California | Method of expressing proteins with disulfide bridges |
ES2522895T3 (es) * | 2005-03-03 | 2014-11-19 | Alfa Wassermann S.P.A. | Nuevas formas polimorfas de rifaximina, procedimientos para su producción y uso de las mismas en preparados medicinales |
US7772177B2 (en) | 2005-05-18 | 2010-08-10 | Aegera Therapeutics, Inc. | BIR domain binding compounds |
US7693596B2 (en) | 2005-12-14 | 2010-04-06 | Dell Products L.P. | System and method for configuring information handling system integrated circuits |
US20080286325A1 (en) * | 2006-01-05 | 2008-11-20 | Med Institute, Inc. | Cyclodextrin elution media for medical device coatings comprising a taxane therapeutic agent |
US7919108B2 (en) * | 2006-03-10 | 2011-04-05 | Cook Incorporated | Taxane coatings for implantable medical devices |
US7875284B2 (en) * | 2006-03-10 | 2011-01-25 | Cook Incorporated | Methods of manufacturing and modifying taxane coatings for implantable medical devices |
US20110104664A1 (en) | 2006-03-31 | 2011-05-05 | Bristol-Myers Squibb Company | Biomarkers and methods for determining sensitivity to micortubule-stabilizing agents |
WO2007130501A2 (en) * | 2006-05-01 | 2007-11-15 | University Of Southern California | Combination therapy for treatment of cancer |
NZ572836A (en) | 2006-05-16 | 2011-12-22 | Pharmascience Inc | Iap bir domain binding compounds |
CA2658475A1 (en) * | 2006-08-16 | 2008-02-21 | Novartis Ag | Organic compounds |
US8463852B2 (en) * | 2006-10-06 | 2013-06-11 | Oracle International Corporation | Groupware portlets for integrating a portal with groupware systems |
WO2008103916A2 (en) * | 2007-02-23 | 2008-08-28 | The Trustees Of Columbia Univeristy In The City Of New York | Compositions and methods for treating cancer or a neurotrophic disorder |
EP2065054A1 (en) | 2007-11-29 | 2009-06-03 | Bayer Schering Pharma Aktiengesellschaft | Combinations comprising a prostaglandin and uses thereof |
EP2070521A1 (en) | 2007-12-10 | 2009-06-17 | Bayer Schering Pharma Aktiengesellschaft | Surface-modified nanoparticles |
DE102007059752A1 (de) | 2007-12-10 | 2009-06-18 | Bayer Schering Pharma Aktiengesellschaft | Funktionalisierte, feste Polymernanopartikel enthaltend Epothilone |
US8802394B2 (en) | 2008-11-13 | 2014-08-12 | Radu O. Minea | Method of expressing proteins with disulfide bridges with enhanced yields and activity |
EP2210584A1 (en) | 2009-01-27 | 2010-07-28 | Bayer Schering Pharma Aktiengesellschaft | Stable polymeric composition comprising an epothilone and an amphiphilic block copolymer |
SG182724A1 (en) | 2010-02-12 | 2012-08-30 | Pharmascience Inc | Iap bir domain binding compounds |
IT1398550B1 (it) | 2010-03-05 | 2013-03-01 | Alfa Wassermann Spa | Formulazioni comprendenti rifaximina utili per ottenere un effetto prolungato nel tempo |
JP2013527239A (ja) * | 2010-06-01 | 2013-06-27 | プラス・ケミカルス・エスアー | イクサベピロンの固体形 |
EP2793947B1 (en) | 2011-12-23 | 2021-02-03 | Innate Pharma | Enzymatic conjugation of polypeptides |
ITBO20120368A1 (it) | 2012-07-06 | 2014-01-07 | Alfa Wassermann Spa | Composizioni comprendenti rifaximina e amminoacidi, cristalli di rifaximina derivanti da tali composizioni e loro uso. |
WO2014009426A2 (en) | 2012-07-13 | 2014-01-16 | Innate Pharma | Screening of conjugated antibodies |
EP2916872B1 (en) | 2012-11-09 | 2019-02-27 | Innate Pharma | Recognition tags for tgase-mediated conjugation |
CN103183681B (zh) * | 2013-03-06 | 2016-01-13 | 浙江海正药业股份有限公司 | 伊沙匹隆的新晶型及其制备方法 |
EP2968582B1 (en) | 2013-03-15 | 2020-07-01 | Innate Pharma | Solid phase tgase-mediated conjugation of antibodies |
US10071169B2 (en) | 2013-06-20 | 2018-09-11 | Innate Pharma | Enzymatic conjugation of polypeptides |
WO2014202775A1 (en) | 2013-06-21 | 2014-12-24 | Innate Pharma | Enzymatic conjugation of polypeptides |
WO2019092148A1 (en) | 2017-11-10 | 2019-05-16 | Innate Pharma | Antibodies with functionalized glutamine residues |
CA3168446A1 (en) | 2020-01-31 | 2021-08-05 | Allarity Therapeutics Europe ApS | Methods for predicting ixabepilone responsiveness in cancer patients |
CN112375085A (zh) * | 2020-11-30 | 2021-02-19 | 湖北宏中药业股份有限公司 | 一种伊沙匹隆反应液的高收率高纯度处理方法 |
CN112457320A (zh) * | 2020-11-30 | 2021-03-09 | 湖北宏中药业股份有限公司 | 一种提高伊沙匹隆合成反应速率的方法 |
CN112409366A (zh) * | 2020-11-30 | 2021-02-26 | 湖北宏中药业股份有限公司 | 一种伊沙匹隆二聚体的高收率制备方法 |
Citations (3)
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WO1997019086A1 (de) | 1995-11-17 | 1997-05-29 | GESELLSCHAFT FüR BIOTECHNOLOGISCHE FORSCHUNG MBH (GBF) | Epothilonderivate, herstellung und verwendung |
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EP1353668B1 (en) | 2001-01-25 | 2008-03-19 | Bristol-Myers Squibb Company | Processes for the preparation of pharmaceutical preparations containing epothilone analogues for the treatment of cancer |
-
2001
- 2001-01-08 UA UA2003032259A patent/UA75365C2/uk unknown
- 2001-07-26 MY MYPI20013545 patent/MY134129A/en unknown
- 2001-08-01 SI SI200120055A patent/SI21100B/sl not_active IP Right Cessation
- 2001-08-01 BR BR0113234-2A patent/BR0113234A/pt active Search and Examination
- 2001-08-01 CZ CZ2003-418A patent/CZ305523B6/cs not_active IP Right Cessation
- 2001-08-01 SK SK134-2003A patent/SK287876B6/sk not_active IP Right Cessation
- 2001-08-01 ES ES01959536T patent/ES2288518T3/es not_active Expired - Lifetime
- 2001-08-01 RO ROA200300114A patent/RO123296B1/ro unknown
- 2001-08-01 JP JP2002519462A patent/JP5046467B2/ja not_active Expired - Fee Related
- 2001-08-01 YU YU12103A patent/YU12103A/sh unknown
- 2001-08-01 IL IL15399301A patent/IL153993A0/xx unknown
- 2001-08-01 AT AT01959536T patent/ATE366735T1/de active
- 2001-08-01 GE GE5091A patent/GEP20053495B/en unknown
- 2001-08-01 MX MXPA03001431A patent/MXPA03001431A/es active IP Right Grant
- 2001-08-01 PL PL365610A patent/PL205628B1/pl unknown
- 2001-08-01 CN CNB018170641A patent/CN1269821C/zh not_active Expired - Lifetime
- 2001-08-01 HU HU0300826A patent/HU229314B1/hu not_active IP Right Cessation
- 2001-08-01 PT PT01959536T patent/PT1309597E/pt unknown
- 2001-08-01 DE DE60129334T patent/DE60129334T2/de not_active Expired - Lifetime
- 2001-08-01 EE EEP200300063A patent/EE05273B1/xx not_active IP Right Cessation
- 2001-08-01 AU AU2001281082A patent/AU2001281082B2/en not_active Ceased
- 2001-08-01 NZ NZ523722A patent/NZ523722A/en not_active IP Right Cessation
- 2001-08-01 RU RU2003106431/04A patent/RU2272039C2/ru active
- 2001-08-01 CA CA2418109A patent/CA2418109C/en not_active Expired - Lifetime
- 2001-08-01 WO PCT/US2001/024540 patent/WO2002014323A2/en active IP Right Grant
- 2001-08-01 DK DK01959536T patent/DK1309597T3/da active
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WO1997019086A1 (de) | 1995-11-17 | 1997-05-29 | GESELLSCHAFT FüR BIOTECHNOLOGISCHE FORSCHUNG MBH (GBF) | Epothilonderivate, herstellung und verwendung |
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