LT3869B - Tertiary hydroxyalkylxantines, process for the preparation thereof and pharmaceutical composition containing them - Google Patents

Tertiary hydroxyalkylxantines, process for the preparation thereof and pharmaceutical composition containing them Download PDF

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Publication number
LT3869B
LT3869B LTIP1467A LTIP1467A LT3869B LT 3869 B LT3869 B LT 3869B LT IP1467 A LTIP1467 A LT IP1467A LT IP1467 A LTIP1467 A LT IP1467A LT 3869 B LT3869 B LT 3869B
Authority
LT
Lithuania
Prior art keywords
formula
compounds
tertiary
group
residue
Prior art date
Application number
LTIP1467A
Other languages
English (en)
Lithuanian (lt)
Inventor
Ulrich Gebert
Ismahan Okyayuz-Baklouti
Werner Thorwart
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of LTIP1467A publication Critical patent/LTIP1467A/xx
Publication of LT3869B publication Critical patent/LT3869B/lt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • C07D473/08—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1 and 3, e.g. theophylline

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
LTIP1467A 1985-07-19 1993-11-12 Tertiary hydroxyalkylxantines, process for the preparation thereof and pharmaceutical composition containing them LT3869B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19853525801 DE3525801A1 (de) 1985-07-19 1985-07-19 Tertiaere hydroxyalkylxanthine, verfahren zu ihrer herstellung, die sie enthaltenden arzneimittel und ihre verwendung

Publications (2)

Publication Number Publication Date
LTIP1467A LTIP1467A (en) 1995-05-25
LT3869B true LT3869B (en) 1996-04-25

Family

ID=6276182

Family Applications (1)

Application Number Title Priority Date Filing Date
LTIP1467A LT3869B (en) 1985-07-19 1993-11-12 Tertiary hydroxyalkylxantines, process for the preparation thereof and pharmaceutical composition containing them

Country Status (33)

Country Link
US (1) US4833146A (fr)
EP (1) EP0268585B1 (fr)
JP (1) JPH0788382B2 (fr)
KR (1) KR950001019B1 (fr)
CN (1) CN1026112C (fr)
AR (1) AR244689A1 (fr)
AT (1) ATE53211T1 (fr)
AU (1) AU588350B2 (fr)
BG (1) BG60767B2 (fr)
CA (1) CA1262248A (fr)
CS (1) CS272766B2 (fr)
DD (1) DD261156A5 (fr)
DE (2) DE3525801A1 (fr)
DK (1) DK157867C (fr)
ES (1) ES2001019A6 (fr)
FI (1) FI89921C (fr)
GR (1) GR861866B (fr)
HU (1) HU198486B (fr)
IE (1) IE59025B1 (fr)
IL (1) IL79457A0 (fr)
LT (1) LT3869B (fr)
LV (1) LV5703A3 (fr)
MA (1) MA20739A1 (fr)
MX (1) MX9254A (fr)
NO (1) NO165803C (fr)
NZ (1) NZ216888A (fr)
OA (1) OA08707A (fr)
PH (1) PH26262A (fr)
PT (1) PT83013B (fr)
RU (1) RU2051918C1 (fr)
TN (1) TNSN86111A1 (fr)
WO (1) WO1987000523A2 (fr)
ZA (1) ZA865374B (fr)

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GB8826595D0 (en) * 1988-11-14 1988-12-21 Beecham Wuelfing Gmbh & Co Kg Active compounds
DD298051A5 (de) * 1989-08-16 1992-02-06 ��@���������@�������k�� Verfahren zur herstellung eines therapeutischen agens zur behandlung von verdauungskrankheiten
GB8924392D0 (en) * 1989-10-30 1989-12-20 Bayer Ag Substituted cycloalkano/b/dihydroindole-and-indolesulphonamides
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DE3942872A1 (de) * 1989-12-23 1991-06-27 Hoechst Ag Verfahren zur enantioselektiven darstellung von ((omega)-1)-hydroxyalkylxanthinen
IT1240843B (it) * 1990-05-24 1993-12-17 Malesci Istituto Farmacobiologico Derivati xantinici 1-7 sostituiti ad attivita' antiasmatica, loro sali fisiologicamente accettabili, loro composizioni farmaceutiche e procedimento per la loro preparazione.
DE4019892A1 (de) * 1990-06-22 1992-01-02 Boehringer Ingelheim Kg Neue xanthinderivate
US5039666A (en) * 1990-10-30 1991-08-13 Hoechst-Roussel Pharmaceuticals Inc. Aminoglycoside composition having substantially reduced nephrotoxicity induced by the aminoglycoside
ATE138266T1 (de) * 1990-11-07 1996-06-15 Hoechst Roussel Pharma Verwendung von xanthinen zur herstellung von arzneimitteln zur hemmung der vermehrung menschlicher retroviren
US6420374B1 (en) 1990-11-30 2002-07-16 Fred Hutchinson Cancer Research Center Use of xanthines as immunosuppressants and to inhibit allograft reactions
MX9203323A (es) * 1991-07-11 1994-07-29 Hoechst Ag El empleo de derivados de xantina para el tratamiento de lesiones secundarias de las celulas nerviosas y trastornos funcionales despues de traumas craneo-cerebrales.
TW209834B (fr) * 1991-12-11 1993-07-21 Hoechst Ag
EP0557876B1 (fr) * 1992-02-22 1996-12-11 Hoechst Aktiengesellschaft Utilisation de dérivées de la xanthine pour le traitement des dommages musculaires après l'interruption complète de la circulation sanguine
CA2112239C (fr) * 1992-03-04 2000-05-09 James A. Bianco Xanthines enantiomeres hydroxylees
EP0570831A2 (fr) * 1992-05-20 1993-11-24 Hoechst Aktiengesellschaft Utilisation de dérivés de Xanthine pour le traitement de dommages cérébraux après interruption de la circulation sanguine
US5288721A (en) * 1992-09-22 1994-02-22 Cell Therapeutics, Inc. Substituted epoxyalkyl xanthines
US5817662A (en) * 1992-11-09 1998-10-06 Cell Therapeutics, Inc. Substituted amino alkyl compounds
US5804584A (en) * 1992-11-16 1998-09-08 Cell Therapeutics, Inc. Therapeutic compounds containing a monocyclic five- to six- membered ring structure having one to two nitrogen atoms
US5473070A (en) * 1992-11-16 1995-12-05 Cell Therapeutics, Inc. Substituted long chain alcohol xanthine compounds
US6693105B1 (en) 1992-11-16 2004-02-17 Cell Therapeutics, Inc. Hydroxyl-containing compounds
US5866576A (en) * 1992-12-16 1999-02-02 Cell Therapeutics, Inc. Epoxide-containing compounds
AU6087894A (en) * 1993-01-14 1994-08-15 Cell Therapeutics, Inc. Acetal or ketal substituted therapeutic compounds
AU6092794A (en) * 1993-01-19 1994-08-15 Cell Therapeutics, Inc. Oxime-substituted therapeutic compounds
US5837703A (en) * 1993-03-31 1998-11-17 Cell Therapeutics, Inc. Amino-alcohol substituted cyclic compounds
US5641783A (en) * 1993-11-12 1997-06-24 Cell Therapeutics, Inc. Substituted amino alcohol compounds
US6020337A (en) * 1993-04-05 2000-02-01 Cell Therapeutics, Inc. Electronegative-substituted long chain xanthine compounds
EP0739203A4 (fr) * 1994-01-14 2000-12-20 Cell Therapeutics Inc Methode de traitement d'affections dues a la proliferation cellulaire en reponse aux pdgf, egf, fgf et vegf
US6103730A (en) * 1994-03-24 2000-08-15 Cell Therapeutics, Inc. Amine substituted compounds
JPH09511496A (ja) * 1994-02-18 1997-11-18 セル・セラピューティックス・インコーポレーテッド 細胞内メッセンジャー
US5801182A (en) * 1994-03-24 1998-09-01 Cell Therapeutics, Inc. Amine substituted compounds
US5807861A (en) * 1994-03-24 1998-09-15 Cell Therapeutics, Inc. Amine substituted xanthinyl compounds
DE19540798A1 (de) * 1995-11-02 1997-05-07 Hoechst Ag Alkylxanthinphosphonate und Alkylxanthinphosphinoxide und deren Verwendung als Arzneimittel
US5965555A (en) * 1996-06-07 1999-10-12 Hoechst Aktiengesellschaft Xanthine compounds having terminally animated alkynol side chains
US5856330A (en) * 1996-07-31 1999-01-05 Hoechst Aktiengesellschaft Use of xanthine derivatives for the inhibition of dephosphorylation of cofilin
US5981536A (en) * 1996-07-31 1999-11-09 Hoechst Aktiengesellschaft Use of xanthine derivatives for the modulation of apoptosis
DE19707655A1 (de) * 1997-02-26 1998-08-27 Hoechst Ag Kombinationspräparat zur Anwendung bei Demenz
US5985592A (en) * 1997-06-05 1999-11-16 Dalhousie University Uses for pentoxifylline or functional derivatives/metabolites thereof
US6294350B1 (en) 1997-06-05 2001-09-25 Dalhousie University Methods for treating fibroproliferative diseases
US6075029A (en) * 1998-01-02 2000-06-13 Cell Therapeutics, Inc. Xanthine modulators of metabolism of cellular P-450
US20030207901A1 (en) * 1999-07-27 2003-11-06 Cell Therapeutics, Inc. Hydroxyl-containing compounds
DE10042152A1 (de) * 2000-08-26 2002-03-28 Basf Coatings Ag Mit aktinischer Strahlung aktivierbares Thixotropierungsmittel, Verfahren zu seiner Herstellung und seine Verwendung
DE10122390A1 (de) * 2001-05-09 2002-11-28 Basf Coatings Ag Carbamat-und/oder Allophanatgruppen enthaltende, thermisch härtbare, thixotrope Gemische
DE10139262C1 (de) * 2001-08-09 2003-01-02 Basf Coatings Ag Rheologiehilfsmittel, Verfahren zu seiner Herstellung und seine Verwendung
EP1497387A1 (fr) * 2002-04-24 2005-01-19 BASF Coatings Aktiengesellschaft Melanges thixotropes thermodurcissables contenant des groupes carbamate et/ou allophanate
KR100872788B1 (ko) * 2002-05-28 2008-12-09 엘지전자 주식회사 드럼세탁기
US8686090B2 (en) * 2003-12-10 2014-04-01 Basf Coatings Gmbh Use of urea crystals for non-polymeric coatings
US20080081816A1 (en) * 2006-10-03 2008-04-03 Kaohsiung Medical University Anti-inflammation activity of newly synthesized xanthine derivatives kmup-1 and kmup-3
MX2010009300A (es) * 2008-02-29 2010-11-05 Concert Pharmaceuticals Inc Derivados de xantina substituidos.
JP2011516464A (ja) * 2008-03-31 2011-05-26 サン・ファーマシューティカル・インダストリーズ・リミテッド モルフィナン類似体の改良された調製方法
US8263601B2 (en) 2009-02-27 2012-09-11 Concert Pharmaceuticals, Inc. Deuterium substituted xanthine derivatives
EP2473052A4 (fr) 2009-09-02 2013-03-20 Concert Pharmaceuticals Inc Dérivés de xanthine substitués
WO2011028820A1 (fr) 2009-09-02 2011-03-10 Concert Pharmaceuticals, Inc. Dérivés substitués de composés [4.3.0] hétéroaryle bicycliques
US9074233B2 (en) 2010-09-01 2015-07-07 Concert Pharmaceuticals, Inc. Process for preparing an enantiomerically enriched, deuterated secondary alcohol from a corresponding ketone without reducing deuterium incorporation
US9085788B2 (en) 2010-09-01 2015-07-21 Concert Pharmaceuticals, Inc. Process for preparing an enantiomerically enriched, deuterated secondary alcohol from a corresponding ketone without reducing deuterium incorporation
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Also Published As

Publication number Publication date
PT83013A (de) 1986-08-01
MA20739A1 (fr) 1987-04-01
TNSN86111A1 (fr) 1990-01-01
KR870700623A (ko) 1987-12-30
MX9254A (es) 1993-06-01
BG60767B2 (bg) 1996-02-29
DD261156A5 (de) 1988-10-19
FI89921C (fi) 1993-12-10
IE861917L (en) 1987-01-19
PT83013B (pt) 1989-01-30
NO871111L (no) 1987-03-18
US4833146A (en) 1989-05-23
DK139287A (da) 1987-03-18
JPS63501149A (ja) 1988-04-28
CS545386A2 (en) 1990-04-11
OA08707A (en) 1989-03-31
HU198486B (en) 1989-10-30
CS272766B2 (en) 1991-02-12
DE3671627D1 (de) 1990-07-05
DE3525801A1 (de) 1987-01-22
ZA865374B (en) 1987-02-25
AR244689A1 (es) 1993-11-30
NZ216888A (en) 1989-05-29
AU6143986A (en) 1987-02-10
AU588350B2 (en) 1989-09-14
WO1987000523A2 (fr) 1987-01-29
HUT47274A (en) 1989-02-28
IL79457A0 (en) 1986-10-31
ATE53211T1 (de) 1990-06-15
NO165803C (no) 1991-04-10
GR861866B (en) 1986-11-17
CN86105835A (zh) 1987-01-14
DK157867B (da) 1990-02-26
DK157867C (da) 1990-07-30
LTIP1467A (en) 1995-05-25
KR950001019B1 (ko) 1995-02-07
FI880174A (fi) 1988-01-15
PH26262A (en) 1992-04-01
WO1987000523A3 (fr) 1987-02-26
RU2051918C1 (ru) 1996-01-10
IE59025B1 (en) 1993-12-15
CN1026112C (zh) 1994-10-05
NO871111D0 (no) 1987-03-18
JPH0788382B2 (ja) 1995-09-27
EP0268585A1 (fr) 1988-06-01
FI89921B (fi) 1993-08-31
DK139287D0 (da) 1987-03-18
CA1262248A (fr) 1989-10-10
LV5703A3 (lv) 1995-02-20
NO165803B (no) 1991-01-02
FI880174A0 (fi) 1988-01-15
EP0268585B1 (fr) 1990-05-30
ES2001019A6 (es) 1988-04-16

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Effective date: 19961112