LT3869B - Tertiary hydroxyalkylxantines, process for the preparation thereof and pharmaceutical composition containing them - Google Patents

Tertiary hydroxyalkylxantines, process for the preparation thereof and pharmaceutical composition containing them Download PDF

Info

Publication number
LT3869B
LT3869B LTIP1467A LTIP1467A LT3869B LT 3869 B LT3869 B LT 3869B LT IP1467 A LTIP1467 A LT IP1467A LT IP1467 A LTIP1467 A LT IP1467A LT 3869 B LT3869 B LT 3869B
Authority
LT
Lithuania
Prior art keywords
formula
compounds
tertiary
group
residue
Prior art date
Application number
LTIP1467A
Other languages
English (en)
Lithuanian (lt)
Inventor
Ulrich Gebert
Ismahan Okyayuz-Baklouti
Werner Thorwart
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of LTIP1467A publication Critical patent/LTIP1467A/xx
Publication of LT3869B publication Critical patent/LT3869B/lt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D473/00Heterocyclic compounds containing purine ring systems
    • C07D473/02Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D473/00Heterocyclic compounds containing purine ring systems
    • C07D473/02Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/08Vasodilators for multiple indications
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D473/00Heterocyclic compounds containing purine ring systems
    • C07D473/02Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • C07D473/08Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1 and 3, e.g. theophylline

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
LTIP1467A 1985-07-19 1993-11-12 Tertiary hydroxyalkylxantines, process for the preparation thereof and pharmaceutical composition containing them LT3869B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19853525801 DE3525801A1 (de) 1985-07-19 1985-07-19 Tertiaere hydroxyalkylxanthine, verfahren zu ihrer herstellung, die sie enthaltenden arzneimittel und ihre verwendung

Publications (2)

Publication Number Publication Date
LTIP1467A LTIP1467A (en) 1995-05-25
LT3869B true LT3869B (en) 1996-04-25

Family

ID=6276182

Family Applications (1)

Application Number Title Priority Date Filing Date
LTIP1467A LT3869B (en) 1985-07-19 1993-11-12 Tertiary hydroxyalkylxantines, process for the preparation thereof and pharmaceutical composition containing them

Country Status (33)

Country Link
US (1) US4833146A (fr)
EP (1) EP0268585B1 (fr)
JP (1) JPH0788382B2 (fr)
KR (1) KR950001019B1 (fr)
CN (1) CN1026112C (fr)
AR (1) AR244689A1 (fr)
AT (1) ATE53211T1 (fr)
AU (1) AU588350B2 (fr)
BG (1) BG60767B2 (fr)
CA (1) CA1262248A (fr)
CS (1) CS272766B2 (fr)
DD (1) DD261156A5 (fr)
DE (2) DE3525801A1 (fr)
DK (1) DK157867C (fr)
ES (1) ES2001019A6 (fr)
FI (1) FI89921C (fr)
GR (1) GR861866B (fr)
HU (1) HU198486B (fr)
IE (1) IE59025B1 (fr)
IL (1) IL79457A0 (fr)
LT (1) LT3869B (fr)
LV (1) LV5703A3 (fr)
MA (1) MA20739A1 (fr)
MX (1) MX9254A (fr)
NO (1) NO165803C (fr)
NZ (1) NZ216888A (fr)
OA (1) OA08707A (fr)
PH (1) PH26262A (fr)
PT (1) PT83013B (fr)
RU (1) RU2051918C1 (fr)
TN (1) TNSN86111A1 (fr)
WO (1) WO1987000523A2 (fr)
ZA (1) ZA865374B (fr)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8621870D0 (en) * 1986-09-11 1986-10-15 Beecham Group Plc Active compounds
US5338741A (en) * 1986-10-27 1994-08-16 Nestec S.A. 1-hydroxyalkylxanthines and medicaments containing them
JP2661666B2 (ja) * 1988-02-19 1997-10-08 ヘキスト薬品工業株式会社 抗消化性潰瘍剤
GB8826595D0 (en) * 1988-11-14 1988-12-21 Beecham Wuelfing Gmbh & Co Kg Active compounds
DD298051A5 (de) * 1989-08-16 1992-02-06 ��@���������@�������k�� Verfahren zur herstellung eines therapeutischen agens zur behandlung von verdauungskrankheiten
GB8924392D0 (en) * 1989-10-30 1989-12-20 Bayer Ag Substituted cycloalkano/b/dihydroindole-and-indolesulphonamides
EP0430300A3 (en) * 1989-12-01 1992-03-25 Takeda Chemical Industries, Ltd. Xanthine derivatives, their production and use
DE3942872A1 (de) * 1989-12-23 1991-06-27 Hoechst Ag Verfahren zur enantioselektiven darstellung von ((omega)-1)-hydroxyalkylxanthinen
IT1240843B (it) * 1990-05-24 1993-12-17 Malesci Istituto Farmacobiologico Derivati xantinici 1-7 sostituiti ad attivita' antiasmatica, loro sali fisiologicamente accettabili, loro composizioni farmaceutiche e procedimento per la loro preparazione.
DE4019892A1 (de) * 1990-06-22 1992-01-02 Boehringer Ingelheim Kg Neue xanthinderivate
US5039666A (en) * 1990-10-30 1991-08-13 Hoechst-Roussel Pharmaceuticals Inc. Aminoglycoside composition having substantially reduced nephrotoxicity induced by the aminoglycoside
ATE138266T1 (de) * 1990-11-07 1996-06-15 Hoechst Roussel Pharma Verwendung von xanthinen zur herstellung von arzneimitteln zur hemmung der vermehrung menschlicher retroviren
US6420374B1 (en) 1990-11-30 2002-07-16 Fred Hutchinson Cancer Research Center Use of xanthines as immunosuppressants and to inhibit allograft reactions
MX9203323A (es) * 1991-07-11 1994-07-29 Hoechst Ag El empleo de derivados de xantina para el tratamiento de lesiones secundarias de las celulas nerviosas y trastornos funcionales despues de traumas craneo-cerebrales.
TW209834B (fr) * 1991-12-11 1993-07-21 Hoechst Ag
EP0557876B1 (fr) * 1992-02-22 1996-12-11 Hoechst Aktiengesellschaft Utilisation de dérivées de la xanthine pour le traitement des dommages musculaires après l'interruption complète de la circulation sanguine
CA2112239C (fr) * 1992-03-04 2000-05-09 James A. Bianco Xanthines enantiomeres hydroxylees
EP0570831A2 (fr) * 1992-05-20 1993-11-24 Hoechst Aktiengesellschaft Utilisation de dérivés de Xanthine pour le traitement de dommages cérébraux après interruption de la circulation sanguine
US5288721A (en) * 1992-09-22 1994-02-22 Cell Therapeutics, Inc. Substituted epoxyalkyl xanthines
US5817662A (en) * 1992-11-09 1998-10-06 Cell Therapeutics, Inc. Substituted amino alkyl compounds
US5804584A (en) * 1992-11-16 1998-09-08 Cell Therapeutics, Inc. Therapeutic compounds containing a monocyclic five- to six- membered ring structure having one to two nitrogen atoms
US5473070A (en) * 1992-11-16 1995-12-05 Cell Therapeutics, Inc. Substituted long chain alcohol xanthine compounds
US6693105B1 (en) 1992-11-16 2004-02-17 Cell Therapeutics, Inc. Hydroxyl-containing compounds
US5866576A (en) * 1992-12-16 1999-02-02 Cell Therapeutics, Inc. Epoxide-containing compounds
AU6087894A (en) * 1993-01-14 1994-08-15 Cell Therapeutics, Inc. Acetal or ketal substituted therapeutic compounds
AU6092794A (en) * 1993-01-19 1994-08-15 Cell Therapeutics, Inc. Oxime-substituted therapeutic compounds
US5837703A (en) * 1993-03-31 1998-11-17 Cell Therapeutics, Inc. Amino-alcohol substituted cyclic compounds
US5641783A (en) * 1993-11-12 1997-06-24 Cell Therapeutics, Inc. Substituted amino alcohol compounds
US6020337A (en) * 1993-04-05 2000-02-01 Cell Therapeutics, Inc. Electronegative-substituted long chain xanthine compounds
EP0739203A4 (fr) * 1994-01-14 2000-12-20 Cell Therapeutics Inc Methode de traitement d'affections dues a la proliferation cellulaire en reponse aux pdgf, egf, fgf et vegf
US6103730A (en) * 1994-03-24 2000-08-15 Cell Therapeutics, Inc. Amine substituted compounds
JPH09511496A (ja) * 1994-02-18 1997-11-18 セル・セラピューティックス・インコーポレーテッド 細胞内メッセンジャー
US5801182A (en) * 1994-03-24 1998-09-01 Cell Therapeutics, Inc. Amine substituted compounds
US5807861A (en) * 1994-03-24 1998-09-15 Cell Therapeutics, Inc. Amine substituted xanthinyl compounds
DE19540798A1 (de) * 1995-11-02 1997-05-07 Hoechst Ag Alkylxanthinphosphonate und Alkylxanthinphosphinoxide und deren Verwendung als Arzneimittel
US5965555A (en) * 1996-06-07 1999-10-12 Hoechst Aktiengesellschaft Xanthine compounds having terminally animated alkynol side chains
US5856330A (en) * 1996-07-31 1999-01-05 Hoechst Aktiengesellschaft Use of xanthine derivatives for the inhibition of dephosphorylation of cofilin
US5981536A (en) * 1996-07-31 1999-11-09 Hoechst Aktiengesellschaft Use of xanthine derivatives for the modulation of apoptosis
DE19707655A1 (de) * 1997-02-26 1998-08-27 Hoechst Ag Kombinationspräparat zur Anwendung bei Demenz
US5985592A (en) * 1997-06-05 1999-11-16 Dalhousie University Uses for pentoxifylline or functional derivatives/metabolites thereof
US6294350B1 (en) 1997-06-05 2001-09-25 Dalhousie University Methods for treating fibroproliferative diseases
US6075029A (en) * 1998-01-02 2000-06-13 Cell Therapeutics, Inc. Xanthine modulators of metabolism of cellular P-450
US20030207901A1 (en) * 1999-07-27 2003-11-06 Cell Therapeutics, Inc. Hydroxyl-containing compounds
DE10042152A1 (de) * 2000-08-26 2002-03-28 Basf Coatings Ag Mit aktinischer Strahlung aktivierbares Thixotropierungsmittel, Verfahren zu seiner Herstellung und seine Verwendung
DE10122390A1 (de) * 2001-05-09 2002-11-28 Basf Coatings Ag Carbamat-und/oder Allophanatgruppen enthaltende, thermisch härtbare, thixotrope Gemische
DE10139262C1 (de) * 2001-08-09 2003-01-02 Basf Coatings Ag Rheologiehilfsmittel, Verfahren zu seiner Herstellung und seine Verwendung
EP1497387A1 (fr) * 2002-04-24 2005-01-19 BASF Coatings Aktiengesellschaft Melanges thixotropes thermodurcissables contenant des groupes carbamate et/ou allophanate
KR100872788B1 (ko) * 2002-05-28 2008-12-09 엘지전자 주식회사 드럼세탁기
US8686090B2 (en) * 2003-12-10 2014-04-01 Basf Coatings Gmbh Use of urea crystals for non-polymeric coatings
US20080081816A1 (en) * 2006-10-03 2008-04-03 Kaohsiung Medical University Anti-inflammation activity of newly synthesized xanthine derivatives kmup-1 and kmup-3
MX2010009300A (es) * 2008-02-29 2010-11-05 Concert Pharmaceuticals Inc Derivados de xantina substituidos.
JP2011516464A (ja) * 2008-03-31 2011-05-26 サン・ファーマシューティカル・インダストリーズ・リミテッド モルフィナン類似体の改良された調製方法
US8263601B2 (en) 2009-02-27 2012-09-11 Concert Pharmaceuticals, Inc. Deuterium substituted xanthine derivatives
EP2473052A4 (fr) 2009-09-02 2013-03-20 Concert Pharmaceuticals Inc Dérivés de xanthine substitués
WO2011028820A1 (fr) 2009-09-02 2011-03-10 Concert Pharmaceuticals, Inc. Dérivés substitués de composés [4.3.0] hétéroaryle bicycliques
US9074233B2 (en) 2010-09-01 2015-07-07 Concert Pharmaceuticals, Inc. Process for preparing an enantiomerically enriched, deuterated secondary alcohol from a corresponding ketone without reducing deuterium incorporation
US9085788B2 (en) 2010-09-01 2015-07-21 Concert Pharmaceuticals, Inc. Process for preparing an enantiomerically enriched, deuterated secondary alcohol from a corresponding ketone without reducing deuterium incorporation
MX2014012384A (es) 2012-04-13 2014-11-26 Concert Pharmaceuticals Inc Derivados sustituidos de xantina.

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1245969B (de) * 1967-08-03 VEB Arzneimittelwerk Dresden, Radebeul Verfahren zur Herstellung von Xanthinderivaten
US2517410A (en) * 1947-08-15 1950-08-01 Searle & Co Hydroxy alkyl xanthines and the production thereof
FR1211333A (fr) * 1955-10-19 1960-03-15 Boehringer Sohn Ingelheim Perfectionnements apportés aux procédés pour fabriquer des oxyalcoylxanthines
US4576947A (en) * 1967-12-16 1986-03-18 Hoechst Aktiengesellschaft Pharmaceutical compositions
DE2335170C2 (de) * 1973-07-11 1989-07-20 Hoechst Ag, 6230 Frankfurt 1,3-Dialkyl-7-(hydroxyalkyl)-xanthine, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
BE795345A (fr) * 1972-02-19 1973-08-13 Albert Ag Chem Werke MEDICAMENT UTILE NOTAMMENT POUR L'IRRIGATION CEREBRALE, PROCEDE DE PREPARATION DE SES MATIERES ACTIVES ET CES MATIERES ElLES-MEMES
CH622519A5 (en) * 1974-07-05 1981-04-15 Hoechst Ag Process for the preparation of hydroxyalkylxanthines
DE2432702C2 (de) * 1974-07-08 1983-01-20 Hoechst Ag, 6000 Frankfurt Verfahren zur Herstellung von Hydroxyalkylxanthinen
CA1075690A (fr) * 1974-12-13 1980-04-15 Hoechst Aktiengesellschaft Derives de la xanthine
DE3062499D1 (en) * 1979-04-05 1983-05-05 Beecham Wuelfing Gmbh & Co Kg Dialkoxy- and dioxacycloalkyl-alkyltheobromines, pharmaceutical compositions containing them and their preparation
JPS5838284A (ja) * 1981-09-01 1983-03-05 Teikoku Chem Ind Corp Ltd 1−(5′−オキソヘキシル)−3,7−ジメチルキサンチンの製造方法
DE3138397A1 (de) * 1981-09-26 1983-04-07 Hoechst Ag, 6230 Frankfurt "arzneimittel, darin enthaltene vicinale dihydroxyalkylxanthine und herstellungsverfahren fuer diese xanthinverbindungen"
US4575795A (en) * 1983-04-01 1986-03-11 Honeywell Information Systems Inc. Apparatus for detecting a predetermined character of a data string

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
MICHAEL H. KARGER, YEHUDA MAZUR: "Methoxymethyl methanesulfonate. Active oxyalkylating agent", J. AM. CHEM. SOC, 1969, pages 5663 - 5665
MÜLLER EUGEN, BAYER OTTO, CRIEGEE RUDOLF: "Methoden der organischen Chemie (Houben-Weyl) ; Bd. 6, 1a", pages: 928 - 940
YEHUDA MAZUR, MICHAEL H. KARGER: "Mixed sulfonic-carboxylic anhydrides. I. Synthesis and thermal stability. New syntheses of sulfonic anhydrides", J. ORG. CHEM., 1971, pages 528 - 531, XP002480436, DOI: doi:10.1021/jo00803a009

Also Published As

Publication number Publication date
PT83013A (de) 1986-08-01
MA20739A1 (fr) 1987-04-01
TNSN86111A1 (fr) 1990-01-01
KR870700623A (ko) 1987-12-30
MX9254A (es) 1993-06-01
BG60767B2 (bg) 1996-02-29
DD261156A5 (de) 1988-10-19
FI89921C (fi) 1993-12-10
IE861917L (en) 1987-01-19
PT83013B (pt) 1989-01-30
NO871111L (no) 1987-03-18
US4833146A (en) 1989-05-23
DK139287A (da) 1987-03-18
JPS63501149A (ja) 1988-04-28
CS545386A2 (en) 1990-04-11
OA08707A (en) 1989-03-31
HU198486B (en) 1989-10-30
CS272766B2 (en) 1991-02-12
DE3671627D1 (de) 1990-07-05
DE3525801A1 (de) 1987-01-22
ZA865374B (en) 1987-02-25
AR244689A1 (es) 1993-11-30
NZ216888A (en) 1989-05-29
AU6143986A (en) 1987-02-10
AU588350B2 (en) 1989-09-14
WO1987000523A2 (fr) 1987-01-29
HUT47274A (en) 1989-02-28
IL79457A0 (en) 1986-10-31
ATE53211T1 (de) 1990-06-15
NO165803C (no) 1991-04-10
GR861866B (en) 1986-11-17
CN86105835A (zh) 1987-01-14
DK157867B (da) 1990-02-26
DK157867C (da) 1990-07-30
LTIP1467A (en) 1995-05-25
KR950001019B1 (ko) 1995-02-07
FI880174A (fi) 1988-01-15
PH26262A (en) 1992-04-01
WO1987000523A3 (fr) 1987-02-26
RU2051918C1 (ru) 1996-01-10
IE59025B1 (en) 1993-12-15
CN1026112C (zh) 1994-10-05
NO871111D0 (no) 1987-03-18
JPH0788382B2 (ja) 1995-09-27
EP0268585A1 (fr) 1988-06-01
FI89921B (fi) 1993-08-31
DK139287D0 (da) 1987-03-18
CA1262248A (fr) 1989-10-10
LV5703A3 (lv) 1995-02-20
NO165803B (no) 1991-01-02
FI880174A0 (fi) 1988-01-15
EP0268585B1 (fr) 1990-05-30
ES2001019A6 (es) 1988-04-16

Similar Documents

Publication Publication Date Title
LT3869B (en) Tertiary hydroxyalkylxantines, process for the preparation thereof and pharmaceutical composition containing them
KR100937620B1 (ko) A2b 아데노신 수용체 길항제
ES2232871T3 (es) Nuevos derivados de purina.
JPH0130834B2 (fr)
JP2001525412A (ja) Pdeiv阻害活性を有するプリン化合物および合成方法
JP2002540207A (ja) ピリミド[6,1−a]イソキノリン−4−オン誘導体
US20120035192A1 (en) Selective antagonists of a2a adenosine receptors
US20080188495A1 (en) A2a adenosine receptor antagonists
JPS5948483A (ja) 置換9−(1−o−もしくは3−o−モノ置換又は1,3−ジ−o−置換プロポキシメチル)プリン類、これらの製造方法、これらを含む医薬組成物及びウイルス感染の治療方法
US10045972B2 (en) Hydroxypyridone derivatives, pharmaceutical compositions thereof, and their therapeutic use for treating inflammatory, neurodegenerative, or immune-mediated diseases
JPS6363547B2 (fr)
CZ174397A3 (en) Use of xanthine derivatives for preparing a medicament for treating and prophylaxis of shock diseases, novel xanthine derivatives and process of their preparation
CN118217290B (zh) 可溶性鸟苷酸环化酶刺激剂在防治高原肺水肿中的用途
JPS63246378A (ja) 8−アザキサンチン類、その製法及び医薬組成物
CS272800B2 (en) Method of tertiary hydroxyalkylxantine production
CN118217290A (zh) 可溶性鸟苷酸环化酶刺激剂在防治高原肺水肿中的用途
ES2368998T3 (es) Antagonistas del receptor de adenosina a2b.
CN113493459A (zh) Pde5抑制剂化合物及其制备方法和应用
JPS62289580A (ja) テオフイリンおよびテオブロミンのピペラジン誘導体
JPS603391B2 (ja) 新規ピリミジン化合物の製法
JPH04128285A (ja) キサンチン誘導体

Legal Events

Date Code Title Description
MM9A Lapsed patents

Effective date: 19961112