LT3827B - Chimopapaine, pharmaceutical compositions containing thereof, process for purification of chimopapaine, inhibiting peptides and chromatographic carriers - Google Patents

Chimopapaine, pharmaceutical compositions containing thereof, process for purification of chimopapaine, inhibiting peptides and chromatographic carriers Download PDF

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Publication number
LT3827B
LT3827B LTIP1645A LTIP1645A LT3827B LT 3827 B LT3827 B LT 3827B LT IP1645 A LTIP1645 A LT IP1645A LT IP1645 A LTIP1645 A LT IP1645A LT 3827 B LT3827 B LT 3827B
Authority
LT
Lithuania
Prior art keywords
solution
chymopalans
phe
chymopamine
added
Prior art date
Application number
LTIP1645A
Other languages
English (en)
Lithuanian (lt)
Inventor
Alan John Barrett
David John Buttle
Daniel Hulbert Rich
Original Assignee
Boots Co Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boots Co Plc filed Critical Boots Co Plc
Publication of LTIP1645A publication Critical patent/LTIP1645A/xx
Publication of LT3827B publication Critical patent/LT3827B/lt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Steroid Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Detergent Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
LTIP1645A 1989-04-28 1993-12-21 Chimopapaine, pharmaceutical compositions containing thereof, process for purification of chimopapaine, inhibiting peptides and chromatographic carriers LT3827B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB898909836A GB8909836D0 (en) 1989-04-28 1989-04-28 Therapeutic agent

Publications (2)

Publication Number Publication Date
LTIP1645A LTIP1645A (en) 1995-07-25
LT3827B true LT3827B (en) 1996-03-25

Family

ID=10655944

Family Applications (1)

Application Number Title Priority Date Filing Date
LTIP1645A LT3827B (en) 1989-04-28 1993-12-21 Chimopapaine, pharmaceutical compositions containing thereof, process for purification of chimopapaine, inhibiting peptides and chromatographic carriers

Country Status (34)

Country Link
US (2) US5380656A (de)
EP (1) EP0470136B1 (de)
JP (1) JPH04506003A (de)
KR (1) KR920701241A (de)
CN (1) CN1047340A (de)
AT (1) ATE107660T1 (de)
AU (1) AU631641B2 (de)
BG (1) BG60916B1 (de)
CA (1) CA2056402C (de)
DD (1) DD296960A5 (de)
DE (1) DE69010199T2 (de)
DK (1) DK0470136T3 (de)
EG (1) EG19583A (de)
ES (1) ES2055427T3 (de)
FI (1) FI914995A0 (de)
GB (1) GB8909836D0 (de)
GR (1) GR1001011B (de)
HR (1) HRP930700A2 (de)
HU (2) HUT58345A (de)
IE (1) IE64351B1 (de)
IL (1) IL94227A (de)
IN (2) IN170683B (de)
LT (1) LT3827B (de)
LV (1) LV10200B (de)
MX (1) MX20503A (de)
NO (1) NO914206L (de)
NZ (1) NZ233475A (de)
PL (1) PL166810B1 (de)
PT (1) PT93921B (de)
RO (1) RO112032B1 (de)
RU (1) RU2074891C1 (de)
WO (1) WO1990013561A1 (de)
YU (1) YU87090A (de)
ZA (1) ZA903228B (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8909836D0 (en) * 1989-04-28 1989-06-14 Boots Co Plc Therapeutic agent
EP0572547A1 (de) * 1991-02-22 1993-12-08 The Du Pont Merck Pharmaceutical Company Substituierte alpha-amino aldehyde und derivate
CA2061861A1 (en) * 1991-03-04 1992-09-05 Jonathan Duvick Plant polypeptides with inhibitory activity towards pathogenic microorganisms
CN1060519C (zh) * 1991-05-09 2001-01-10 广西亚热带作物研究所 桄榔植物蛋白酶的提取方法
ES2112333T3 (es) * 1991-10-14 1998-04-01 Cash Eng Res Combinacion de control de admision para un sistema compresor.
US6753006B1 (en) 1993-02-22 2004-06-22 American Bioscience, Inc. Paclitaxel-containing formulations
WO1994028012A1 (en) * 1993-05-28 1994-12-08 Warner-Lambert Company Hydroxamate inhibitors of endothelin converting enzyme
JP2002538151A (ja) 1999-03-02 2002-11-12 ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド カテプシンの可逆的インヒビターとして有用な化合物
KR100688740B1 (ko) * 1999-03-15 2007-02-28 액시스 파마슈티컬스 인코포레이티드 프로테아제 억제제로서의 ｎ-시아노메틸 아미드
US6420364B1 (en) 1999-09-13 2002-07-16 Boehringer Ingelheim Pharmaceuticals, Inc. Compound useful as reversible inhibitors of cysteine proteases
US6703040B2 (en) 2000-01-11 2004-03-09 Intralytix, Inc. Polymer blends as biodegradable matrices for preparing biocomposites
AU2003292755A1 (en) 2002-12-25 2004-07-22 Hirotaka Haro Remedy for degenerative intervertebral discs
US7169405B2 (en) * 2003-08-06 2007-01-30 Warsaw Orthopedic, Inc. Methods and devices for the treatment of intervertebral discs
US20080069907A1 (en) * 2004-07-06 2008-03-20 Chikao Morimoto Compositions for Cancer Prevention, Treatment, or Amelioration Comprising Papaya Extract
CN1320111C (zh) * 2004-08-09 2007-06-06 王美岭 一种制备木瓜凝乳酶的方法
US20060241566A1 (en) * 2005-04-11 2006-10-26 Orthox, Llc Nucleus Extraction from Spine Intervertebral Disc
US7879027B2 (en) * 2006-04-24 2011-02-01 Warsaw Orthopedic, Inc. Controlled release devices for fusion of osteal structures
US7771414B2 (en) * 2006-04-24 2010-08-10 Warsaw Orthopedic, Inc. Controlled release devices for therapeutic treatments of spinal discs
US8642059B2 (en) 2006-04-24 2014-02-04 Warsaw Orthopedic, Inc. Controlled release systems and methods for intervertebral discs
US8642060B2 (en) * 2006-04-24 2014-02-04 Warsaw Orthopedic, Inc. Controlled release systems and methods for osteal growth
US20070265633A1 (en) * 2006-05-11 2007-11-15 Moon Jon K Implement and method to extract nucleus from spine intervertebral disc
US8257938B2 (en) * 2009-02-27 2012-09-04 Medical Diagnostic Laboratories, Llc Hemolysin and its protein fragments in sero-detection of Anaplasma phagocytophilum
WO2013038936A1 (ja) * 2011-09-13 2013-03-21 タカラバイオ株式会社 ペルオキシダーゼ反応の停止方法及び反応停止剤
WO2014004512A1 (en) 2012-06-25 2014-01-03 Surmodics, Inc. Bioerodable poly(etheresteramides) and medical article uses

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2098897A (en) 1981-04-13 1982-12-01 Sintokogio Ltd A core making method and apparatus
WO1984000365A1 (en) 1982-07-19 1984-02-02 Nat Res Dev Synthetic peptides and their preparation

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE270723C (de) *
US2313875A (en) * 1940-12-17 1943-03-16 Eugene F Jansen Proteolytic enzyme process
US3320131A (en) * 1964-10-23 1967-05-16 Baxter Laboratories Inc Method for the treatment of herniation of intervertebral discs
US3558433A (en) * 1967-11-07 1971-01-26 Baxter Laboratories Inc Process for purification of chymopapain
YU40433B (en) * 1975-02-20 1986-02-28 Lek Tovarna Farmacevtskih Process for obtaining pure, proteolytically active anzymes
EP0065395B1 (de) * 1981-05-13 1988-08-24 BOOTS-FLINT, INC. (a Delaware corp.) Chymopapain und Verfahren zu seiner Herstellung und Verwendung
US4439423A (en) * 1981-05-13 1984-03-27 Smith Laboratories, Inc. Chymopapain and method for its use
US4374926A (en) * 1981-05-13 1983-02-22 Smith Laboratories, Inc. Method for the production of improved chymopapain
US4719108A (en) * 1981-05-13 1988-01-12 Smith Laboratories, Inc. Chymopapain composition and method for its use
GB2156821A (en) * 1984-04-03 1985-10-16 Simmons James W Process for purifying chymopapain
HU196624B (en) * 1986-12-08 1988-12-28 Chinoin Gyogyszer Es Vegyeszet Process for producing chymopapain with high specific activity
GB8909836D0 (en) * 1989-04-28 1989-06-14 Boots Co Plc Therapeutic agent

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2098897A (en) 1981-04-13 1982-12-01 Sintokogio Ltd A core making method and apparatus
WO1984000365A1 (en) 1982-07-19 1984-02-02 Nat Res Dev Synthetic peptides and their preparation

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
A L LUACES, A J BARRETT: "Affinity purification and biochemical characterization of histolysin, the major cysteine proteinase of Entamoeba histolytica", BIOCHEMICAL JOURNAL, 1988, pages 903 - 909
D J BUTTLE ET AL.: "Affinity purification of the novel cysteine proteinase papaya proteinase IV, and papain from papaya latex", BIOCHEMICAL JOURNAL, 1989, pages 469 - 476, XP000913659
DUBOIS T. ET AL.: "The thiol proteinases from the latex of Carica papaya L. I. Fractionation, purification and preliminary characterization.", BIOL CHEM HOPPE SEYLER, 1988, pages 733 - 740
LYMAN SMITH, MD: "Enzyme Dissolution of the Nucleus Pulposus in Humans", JAMA, 1964, pages 137 - 140
POLGAR, L.: "Isolation of highly active papaya peptidases A and B from commercial chymopapain", BIOCHIM. BIOPHYS. ACTA, 1981, pages 262 - 269, XP023514995, DOI: doi:10.1016/0005-2744(81)90296-5
RICH, D.H. ET AL.: "Purification of cathepsin B by a new form of affinity chromatography", BIOCHEMICAL JOURNAL, 1986, pages 731 - 734
ZUCKER, S. ET AL.: "Proteolytic activities of papain, chymopapain and papaya proteinase III.", BIOCHIM. BIOPHYS. ACTA, 1985, pages 196 - 204, XP025441048, DOI: doi:10.1016/0167-4838(85)90057-3

Also Published As

Publication number Publication date
GB8909836D0 (en) 1989-06-14
HU903342D0 (en) 1992-01-28
IN173230B (de) 1994-03-12
ZA903228B (en) 1990-12-28
IL94227A0 (en) 1991-01-31
RO112032B1 (ro) 1997-04-30
US5468480A (en) 1995-11-21
CA2056402A1 (en) 1990-10-29
NO914206L (no) 1991-12-17
ATE107660T1 (de) 1994-07-15
DE69010199D1 (de) 1994-07-28
HU211746A9 (en) 1995-12-28
EP0470136B1 (de) 1994-06-22
DD296960A5 (de) 1991-12-19
US5380656A (en) 1995-01-10
IE64351B1 (en) 1995-07-26
MX20503A (es) 1993-12-01
CA2056402C (en) 1999-11-16
PT93921A (pt) 1990-11-20
HUT58345A (en) 1992-02-28
GR1001011B (el) 1993-03-31
DE69010199T2 (de) 1994-10-13
NZ233475A (en) 1991-10-25
KR920701241A (ko) 1992-08-11
PT93921B (pt) 1996-10-31
ES2055427T3 (es) 1994-08-16
EG19583A (en) 1995-09-30
LV10200A (lv) 1994-10-20
HRP930700A2 (en) 1995-06-30
GR900100315A (en) 1991-09-27
RU2074891C1 (ru) 1997-03-10
JPH04506003A (ja) 1992-10-22
EP0470136A1 (de) 1992-02-12
IN170683B (de) 1992-05-02
NO914206D0 (no) 1991-10-25
AU5547290A (en) 1990-11-29
IE901538L (en) 1990-10-28
AU631641B2 (en) 1992-12-03
FI914995A0 (fi) 1991-10-23
LV10200B (en) 1995-04-20
PL166810B1 (pl) 1995-06-30
CN1047340A (zh) 1990-11-28
IL94227A (en) 1994-12-29
LTIP1645A (en) 1995-07-25
BG60916B1 (bg) 1996-06-28
YU87090A (sh) 1992-09-07
WO1990013561A1 (en) 1990-11-15
DK0470136T3 (da) 1994-08-01

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