KR910007882B1 - 1-벤질-아미노알킬-피롤리디논의 제조방법 - Google Patents

1-벤질-아미노알킬-피롤리디논의 제조방법 Download PDF

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Publication number
KR910007882B1
KR910007882B1 KR1019840006136A KR840006136A KR910007882B1 KR 910007882 B1 KR910007882 B1 KR 910007882B1 KR 1019840006136 A KR1019840006136 A KR 1019840006136A KR 840006136 A KR840006136 A KR 840006136A KR 910007882 B1 KR910007882 B1 KR 910007882B1
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KR
South Korea
Prior art keywords
pyrrolidin
formula
compound
benzyl
aminomethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
KR1019840006136A
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English (en)
Korean (ko)
Other versions
KR850003393A (ko
Inventor
하인쯔 베버 칼
발터 게르하르트
슈나이더 클라우스
힌젠 디터
조세프 쿤 프란즈
레어 에리히
Original Assignee
베링거 인겔하임 케이지
디터 라우디엔, 루돌프 호프만
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Publication of KR850003393A publication Critical patent/KR850003393A/ko
Application granted granted Critical
Publication of KR910007882B1 publication Critical patent/KR910007882B1/ko
Expired legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
KR1019840006136A 1983-10-04 1984-10-04 1-벤질-아미노알킬-피롤리디논의 제조방법 Expired KR910007882B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19833336024 DE3336024A1 (de) 1983-10-04 1983-10-04 4-amino-l-benzyl-pyrrolidinone und ihre saeureadditionssalze, verfahren zu ihrer herstellung und arzneimittel
DEP3336024.3 1983-10-04

Publications (2)

Publication Number Publication Date
KR850003393A KR850003393A (ko) 1985-06-17
KR910007882B1 true KR910007882B1 (ko) 1991-10-04

Family

ID=6210932

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019840006136A Expired KR910007882B1 (ko) 1983-10-04 1984-10-04 1-벤질-아미노알킬-피롤리디논의 제조방법

Country Status (27)

Country Link
US (4) US4767759A (enExample)
EP (1) EP0136658B1 (enExample)
JP (2) JPS6094959A (enExample)
KR (1) KR910007882B1 (enExample)
AR (1) AR243503A1 (enExample)
AU (1) AU565839B2 (enExample)
CA (1) CA1242193A (enExample)
CS (2) CS244148B2 (enExample)
DD (1) DD227963A5 (enExample)
DE (2) DE3336024A1 (enExample)
DK (1) DK164049C (enExample)
ES (3) ES8505652A1 (enExample)
FI (1) FI78464C (enExample)
GR (1) GR80546B (enExample)
HK (1) HK75892A (enExample)
HU (1) HU193229B (enExample)
IE (1) IE58155B1 (enExample)
IL (1) IL73125A (enExample)
NO (1) NO165239C (enExample)
NZ (1) NZ209759A (enExample)
PH (1) PH23764A (enExample)
PL (2) PL145630B1 (enExample)
PT (1) PT79306B (enExample)
SG (1) SG44192G (enExample)
SU (2) SU1373318A3 (enExample)
YU (2) YU43858B (enExample)
ZA (1) ZA847755B (enExample)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3326724A1 (de) * 1983-07-25 1985-02-07 Boehringer Ingelheim KG, 6507 Ingelheim In 1-stellung substituierte 4-hydroxymethyl-pyrrolidinone, verfahren zu ihrer herstellung, pharmazeutische zusammensetzungen und zwischenprodukte
DE3336024A1 (de) * 1983-10-04 1985-04-18 Boehringer Ingelheim KG, 6507 Ingelheim 4-amino-l-benzyl-pyrrolidinone und ihre saeureadditionssalze, verfahren zu ihrer herstellung und arzneimittel
DE3420193A1 (de) * 1984-05-30 1985-12-05 Boehringer Ingelheim KG, 6507 Ingelheim Neue substituierte pyrrolidinone, verfahren zu ihrer herstellung und arzneimittel
DE3634220A1 (de) * 1986-10-08 1988-04-14 Boehringer Ingelheim Kg Verwendung von 1-benzyl-aminoalkyl-pyrrolidinonen als antidepressiva
DE3706399A1 (de) * 1987-02-27 1988-09-08 Boehringer Ingelheim Kg Mittel mit antidepressiver wirkung
WO1988009330A1 (en) * 1987-05-20 1988-12-01 Zambon Group S.P.A. Isoxazoles with nootropic activity
US4772601A (en) * 1988-01-25 1988-09-20 Hoechst-Roussel Pharmaceuticals, Inc. 5-Substituted 1-(4-(1-pyrrolidinyl)-2-butynyl)-2-pyrrolidinones, pharmaceutical compositions and use
IE61631B1 (en) * 1988-05-20 1994-11-16 Zambon Spa Compounds with central analgesic activity, process for their preparation and pharmaceutical compositions containing them
CA2007732A1 (en) * 1989-01-17 1990-07-17 Gary L. Olson Cyclohexaneacetamide derivatives
IT1231477B (it) * 1989-07-12 1991-12-07 Sigma Tau Ind Farmaceuti (pirrolidin-2-one-1-il) acetammidi quali attivatori dei processi di apprendimento e della memoria e composizioni farmaceutiche comprendenti tali composti
US5066663A (en) * 1990-05-21 1991-11-19 Warner-Lambert Company Substituted-hetero-cyclopentanones and cyclopentenones and derivatives thereof acting at muscarinic receptors
JPH083023Y2 (ja) * 1991-05-21 1996-01-29 株式会社四国総合研究所 太陽電池モジュール用架台
US5538985A (en) * 1994-01-27 1996-07-23 Mitsui Toatsu Chemicals, Inc. Pyrrolidinone derivatives
US6001835A (en) * 1996-04-03 1999-12-14 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
CA2250353A1 (en) * 1996-04-03 1997-10-09 Christopher J. Dinsmore Inhibitors of farnesyl-protein transferase
BR9709857A (pt) * 1996-06-21 2002-05-21 Syntroleum Corp processo e sistema de produção de gás de sìntese
MY118075A (en) 1996-07-09 2004-08-30 Syntroleum Corp Process for converting gas to liquids
US5969138A (en) * 1996-11-01 1999-10-19 Mitsui Chemicals, Inc. Pyrrolidinone derivatives
US5950732A (en) * 1997-04-02 1999-09-14 Syntroleum Corporation System and method for hydrate recovery
WO1999019277A1 (en) 1997-10-10 1999-04-22 Syntroleum Corporation System and method for converting light hydrocarbons to heavier hydrocarbons with separation of water into oxygen and hydrogen
AU3386400A (en) * 1999-03-02 2000-09-21 Merck & Co., Inc. 3-alkyl substituted pyrrolidine modulators of chemokine receptor activity
US6372764B1 (en) 1999-03-02 2002-04-16 Merck & Co., Inc. Pyrrolidine modulators of chemokine receptor activity
AU3386500A (en) 1999-03-02 2000-09-21 Merck & Co., Inc. 3-cyclopropyl and 3-cyclobutyl pyrrolidine modulators of chemokine receptor activity
RU2195447C1 (ru) * 2001-07-31 2002-12-27 Кубанский государственный технологический университет 1-(4-нитрофенил)-4-n-x-аминопирролидоны-2, проявляющие рострегулирующую и антистрессовую активность, и способ их получения
US6794417B2 (en) 2002-06-19 2004-09-21 Syntroleum Corporation System and method for treatment of water and disposal of contaminants produced by converting lighter hydrocarbons into heavier hydrocarbon
GEP20084527B (en) * 2003-09-03 2008-11-10 Pfizer Benzimidazolone compounds having 5-ht4 receptor agonistic activity
CA2569654C (en) 2004-06-15 2010-12-21 Pfizer Inc. Benzimidazolone carboxylic acid derivatives
GR1004905B (el) * 2004-07-14 2005-05-27 Ε.Ι.Ε. (Εθνικο Ιδρυμα Ερευνων) Καινοτομα αντιυπερτασικα προιοντα
RU2330660C2 (ru) * 2005-12-01 2008-08-10 ГОУ ВПО Военно-медицинская академия им. С.М. Кирова ПРИМЕНЕНИЕ ИМИДАЗО[4,5-b]ИНДОЛ-2-ТИОНА ДЛЯ ЗАЩИТЫ ОТ ВОЗДЕЙСТВИЯ ГЕМИЧЕСКОЙ ГИПОКСИИ
RU2327458C1 (ru) * 2007-02-19 2008-06-27 Открытое акционерное общество "Щелковский витаминный завод" Новая препаративная форма вещества, обладающего ноотропной и нейромодуляторной активностью, и способ ее получения
FR2940609B1 (fr) * 2008-12-30 2011-05-06 Oreal Association de monosaccharides et d'agents desquamants et son utilisation en cosmetique

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3133082A (en) * 1960-06-09 1964-05-12 Mead Johnson & Co 1-substituted-3-pyrrolidylmethylamines
NL295221A (enExample) * 1962-07-13
GB1039113A (en) * 1964-08-06 1966-08-17 Ucb Sa New n-substituted lactams
BE791606A (fr) * 1972-07-10 1973-03-16 Pilot Pen Co Ltd Procede et appareil pour aspirer et soulever la feuille la plussuperieure d'une pile de feuilles de ce type
JPS5346966A (en) * 1976-10-06 1978-04-27 Teijin Ltd Lactamamines and their preparation
JPS5344559A (en) * 1976-10-06 1978-04-21 Teijin Ltd New urethanes and their preparation
FR2387218A1 (fr) * 1977-04-15 1978-11-10 Ile De France Nouveaux n-(1'-ethyl 2'-oxo 5'-pyrrolidinyl methyl) benzamides, leurs procedes de preparation et leur application comme modificateurs du comportement
AU518986B2 (en) * 1977-10-11 1981-10-29 Takeda Chemical Industries Ltd. Lactams
CA1115212A (en) * 1978-02-10 1981-12-29 Emilio Kyburz Pyrrolidine derivatives
CU21107A3 (es) * 1978-02-10 1988-02-01 Hoffmann La Roche Pyrrolidines derivatives
DE2923975A1 (de) * 1979-06-13 1980-12-18 Nattermann A & Cie Pyrrolidinone, verfahren zu deren herstellung und diese enthaltende arzneimittel
DE2924011C2 (de) * 1979-06-13 1982-04-08 A. Nattermann & Cie GmbH, 5000 Köln Pyrrolidin-(2)-on-(1)-ylessigsäure-2,6,-dimethylanilid, Verfahren zur Herstellung und Arzneimittel, welche diese Verbindung enthalten
CH657527A5 (de) * 1980-02-13 1986-09-15 Ciba Geigy Ag Verwendung von zentralnervoes-wirksamen verbindungen in einem mittel, welches zur verhinderung oder linderung von nebenwirkungen bestimmt ist.
CH646149A5 (de) * 1981-02-05 1984-11-15 Hoffmann La Roche Pyrrolidin-derivat.
DE3361609D1 (en) * 1982-03-24 1986-02-06 Prodes Sa New n-((2-oxo-1-pyrrolidinyl)acetyl)piperazines, the methods of producing such new compounds and their salts as well as pharmaceutical preparations for therapeutic use containing these compounds or salts
FR2549053B1 (fr) * 1983-07-12 1985-12-27 Sanofi Sa Nouveaux derives de la pyrrolidine actifs sur le systeme nerveux central, leur procede de preparation, les medicaments en contenant
DE3326724A1 (de) * 1983-07-25 1985-02-07 Boehringer Ingelheim KG, 6507 Ingelheim In 1-stellung substituierte 4-hydroxymethyl-pyrrolidinone, verfahren zu ihrer herstellung, pharmazeutische zusammensetzungen und zwischenprodukte
DE3336024A1 (de) * 1983-10-04 1985-04-18 Boehringer Ingelheim KG, 6507 Ingelheim 4-amino-l-benzyl-pyrrolidinone und ihre saeureadditionssalze, verfahren zu ihrer herstellung und arzneimittel
DE3420193A1 (de) * 1984-05-30 1985-12-05 Boehringer Ingelheim KG, 6507 Ingelheim Neue substituierte pyrrolidinone, verfahren zu ihrer herstellung und arzneimittel

Also Published As

Publication number Publication date
PL253280A1 (en) 1986-02-11
SU1306472A3 (ru) 1987-04-23
PL249852A1 (en) 1985-09-10
AR243503A1 (es) 1993-08-31
HUT35641A (en) 1985-07-29
JPH04261152A (ja) 1992-09-17
PL145637B1 (en) 1988-10-31
ZA847755B (en) 1986-06-25
GR80546B (en) 1985-02-05
ES539884A0 (es) 1985-11-16
NZ209759A (en) 1989-04-26
ES536469A0 (es) 1985-06-01
ES539883A0 (es) 1985-11-16
IL73125A (en) 1988-10-31
AU3383484A (en) 1985-04-18
US4996224A (en) 1991-02-26
DE3477922D1 (en) 1989-06-01
CS410891A3 (en) 1992-08-12
HU193229B (en) 1987-08-28
JPH046684B2 (enExample) 1992-02-06
DK164049C (da) 1992-09-28
AU565839B2 (en) 1987-10-01
CS244148B2 (en) 1986-07-17
DE3336024A1 (de) 1985-04-18
EP0136658B1 (de) 1989-04-26
FI78464C (fi) 1989-08-10
ES8601877A1 (es) 1985-11-16
NO843979L (no) 1985-04-09
FI78464B (fi) 1989-04-28
US4767759A (en) 1988-08-30
YU43901B (en) 1989-12-31
IE58155B1 (en) 1993-07-14
FI843856A0 (fi) 1984-10-02
PH23764A (en) 1989-11-03
ES8505652A1 (es) 1985-06-01
CS153784A2 (en) 1985-08-15
PT79306B (de) 1986-11-13
YU169684A (en) 1987-10-31
IE842519L (en) 1985-04-04
DD227963A5 (de) 1985-10-02
YU43858B (en) 1989-12-31
HK75892A (en) 1992-10-09
JPH0739387B2 (ja) 1995-05-01
ES8601878A1 (es) 1985-11-16
US4833140A (en) 1989-05-23
NO165239B (no) 1990-10-08
EP0136658A2 (de) 1985-04-10
EP0136658A3 (enExample) 1985-06-05
KR850003393A (ko) 1985-06-17
SG44192G (en) 1992-09-04
US5073671A (en) 1991-12-17
DK474684A (da) 1985-04-05
PT79306A (de) 1984-11-01
DK164049B (da) 1992-05-04
YU199086A (en) 1987-10-31
IL73125A0 (en) 1984-12-31
DK474684D0 (da) 1984-10-03
NO165239C (no) 1991-01-16
CA1242193A (en) 1988-09-20
SU1373318A3 (ru) 1988-02-07
JPS6094959A (ja) 1985-05-28
FI843856L (fi) 1985-04-05
PL145630B1 (en) 1988-10-31

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