KR910002826A - 푸란 유도체 - Google Patents

푸란 유도체 Download PDF

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Publication number
KR910002826A
KR910002826A KR1019890010213A KR890010213A KR910002826A KR 910002826 A KR910002826 A KR 910002826A KR 1019890010213 A KR1019890010213 A KR 1019890010213A KR 890010213 A KR890010213 A KR 890010213A KR 910002826 A KR910002826 A KR 910002826A
Authority
KR
South Korea
Prior art keywords
methyl
salt
bismuth
complex
pharmaceutical composition
Prior art date
Application number
KR1019890010213A
Other languages
English (en)
Other versions
KR0122598B1 (ko
Inventor
왓슨 클리써로우 존
Original Assignee
베리 안토니 뉴샘
글락소 그룹 리미티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB888817098A external-priority patent/GB8817098D0/en
Priority claimed from GB898904686A external-priority patent/GB8904686D0/en
Application filed by 베리 안토니 뉴샘, 글락소 그룹 리미티드 filed Critical 베리 안토니 뉴샘
Publication of KR910002826A publication Critical patent/KR910002826A/ko
Application granted granted Critical
Publication of KR0122598B1 publication Critical patent/KR0122598B1/ko

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Abstract

내용 없음.

Description

푸란 유도체
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (22)

  1. 비스무트와 카브복실산의 복합체와 라니티딘 사이에 형성된 염. 또는 이러한 염의 용매화합물.
  2. 제1항에 있어서, 라니티딘과의 염 형성에 유용한 카르복실기 이외에도, 카르복실산이 분자내에 적어도 3개의 기능기를 갖는 염.
  3. 제1항에 있어서, 카르복실산이 시트르산, 타르타르산, 에틸렌디아민테트라아세트산, 프로필시트르산 또는 아가리신산인 염.
  4. 제1항에 있어서, 카르복실산이 시트르산 또는 타르타르산인 염.
  5. 제1항에 있어서, 카르복실산이 시트르산인 염.
  6. N-[2-[[[5-[(디메틸아미노)메틸]-2-푸라닐]메틸]티오]에틸]-N′-메틸]-2-니트로-1,1-에텐디아민-2-히드록시-1,2,3-프로판트리카르복실레이트 비스무트(3′)복합체, 및 그의 용매화합물.
  7. N-[2-[[[5-[(디메틸아미노)메틸]-2-푸라닐]메틸]티오]에틸]-N′-메틸]-2-니트로-1,1-에텐디아민 [R-R*R*)]-2,3-디히드록시부탄디오에이트 비스무트(3′)복합체, 및 그의 용매화합물.
  8. N-[2-[[[5-[(디메틸아미노)메틸]-2-푸라닐]메틸]티오]에틸]-N′-메틸]-2-니트로-1,1-에텐디아민-2-히드록시-1,2,3-노나데칸 트라카르복실레이트 비스무트(3′)복합체, 및 그의 용매화합물.
  9. N-[2-[[[5-[(디메틸아미노)메틸]-2-푸라닐]메틸]티오]에틸]-N′-메틸]-2-니트로-1,1-에텐디아민 N,N′-에탄디일비스[N-(카르복시메틸)글리신]비스무(3′)복합체, 및 그의 용매화합물.
  10. 적어도 1종의 제약상 허용되는 담체 또는 희석제와 함께 제1 내지 9항중 중 어느 하나의 항에 의한 염으로 되는 제약 조성물.
  11. 제10항에 있어서, 경구 투여에 적합한 형태의 제약 조성물.
  12. 제10항에 있어서, 정제 형태의 제약 조성물.
  13. 제11또는 제12항에 있어서, 단위 투여량 당 염 100mg 내지 1g을 함유한 단위 투여량 형태의 제약 조성물.
  14. 제11 또는 12항에 있어서, 단위 투여량 당 염 100 내지 800mg을 함유한 단위 투여량 형태의 제약 조성물.
  15. 제11 또는 12항에 있어서, 단위 투여량 당 염 150 내지 600mg을 함유한 단위 투여량 형태의 제약 조성물.
  16. 제1 내지 9항중 어느 하나의 항에 있어서, 유효치료제로서 사용하기위한 염.
  17. 라니티딘을 적합한 용매 중에서 비스무트 카르복실산 복합체와 반응시키고, 그리하여 형성된 염을 용액으로부터 분리시키는 것으로 되는, 제1 내지 9항중 어느 하나의 항에 의한 염의 제조 방법.
  18. 제17항에 있어서, 용매가 물인 방법.
  19. 제17내지 18항에 있어서, 반응을 승온에서 행하는 방법.
  20. 제17또는 18항에 있어서, 반응을 40내지 100℃의 온도에서 행하는 방법.
  21. 라이티딘을 비스무트 카르복실산 복합체와 반응시켜서 제조한, 비스무트와 카르복실산과의 복합체와 라이티딘 사이에 형성된 염 또는 이러한 용매화합물.
  22. 라니티딘을 비스무트와 시트르산과의 복합체와 반응시키겨 제조한 라니티딘 비스무트 시트레이트 또는 그의 용매화합물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019890010213A 1988-07-18 1989-07-18 푸란 유도체 KR0122598B1 (ko)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
GB8817098.0 1988-07-18
GB88-17098.0 1988-07-18
GB888817098A GB8817098D0 (en) 1988-07-18 1988-07-18 Chemical compounds
GB89-04686.6 1989-03-01
GB898904686A GB8904686D0 (en) 1989-03-01 1989-03-01 Chemical compounds
GB8904686.6 1989-03-01

Publications (2)

Publication Number Publication Date
KR910002826A true KR910002826A (ko) 1991-02-26
KR0122598B1 KR0122598B1 (ko) 1997-11-13

Family

ID=26294175

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019890010213A KR0122598B1 (ko) 1988-07-18 1989-07-18 푸란 유도체

Country Status (35)

Country Link
US (1) US5008256A (ko)
JP (1) JP2523185B2 (ko)
KR (1) KR0122598B1 (ko)
CN (1) CN1022626C (ko)
AT (1) AT398200B (ko)
AU (1) AU632052B2 (ko)
BE (1) BE1003254A5 (ko)
CA (1) CA1332610C (ko)
CH (1) CH679582A5 (ko)
CY (1) CY1650A (ko)
DE (1) DE3923638C2 (ko)
DK (1) DK168381B1 (ko)
EG (1) EG19368A (ko)
ES (1) ES2014175A6 (ko)
FI (1) FI90538C (ko)
FR (1) FR2634122B1 (ko)
GB (1) GB2220937B (ko)
GR (1) GR1000431B (ko)
HK (1) HK61392A (ko)
HU (2) HU206104B (ko)
IE (1) IE61076B1 (ko)
IL (1) IL91005A (ko)
IT (1) IT1231481B (ko)
LU (2) LU87557A1 (ko)
MX (1) MX174145B (ko)
MY (1) MY104055A (ko)
NL (2) NL192604C (ko)
NO (2) NO176319C (ko)
NZ (1) NZ229958A (ko)
PL (1) PL162391B1 (ko)
PT (1) PT91188B (ko)
SE (1) SE468715B (ko)
SG (1) SG51992G (ko)
YU (1) YU47021B (ko)
ZW (1) ZW8689A1 (ko)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3874917T2 (de) * 1987-03-09 1993-03-04 Procter & Gamble Zusammensetzungen und ihre verwendung zur behandlung von magen-darmstoerungen.
IL85472A (en) * 1987-03-09 1991-06-30 Procter & Gamble Pharmaceutical compositions for treating gastrointestinal disorders
AU641903B2 (en) * 1988-10-26 1993-10-07 Glaxo Group Limited Carboxylic acid derivatives
GB9004328D0 (en) * 1990-02-27 1990-04-25 Glaxo Group Ltd Chemical compounds
GB9009240D0 (en) * 1990-04-25 1990-06-20 Glaxo Group Ltd Chemical compounds
GB9009437D0 (en) * 1990-04-26 1990-06-20 Glaxo Group Ltd Chemical compounds
DK0540613T3 (da) * 1990-07-20 1996-04-01 Tillotts Pharma Ag Produkter og fremgangsmåder til behandling af fordøjelseskanalen
GB9019875D0 (en) * 1990-09-11 1990-10-24 Glaxo Group Ltd Pharmaceutical compositions
US5192752A (en) * 1991-01-14 1993-03-09 The Procter & Gamble Company Swallowable pharmaceutical compositions containing colloidal bismuth subcitrate
US5128140A (en) * 1991-01-14 1992-07-07 The Procter & Gamble Company Swallowable pharmaceutical compositions
GB9120131D0 (en) * 1991-09-20 1991-11-06 Glaxo Group Ltd Medicaments
DE69228738D1 (de) * 1991-12-06 1999-04-29 Glaxo Group Ltd Zusammensetzungen zur Behandlung von entzündlichen Zuständen oder Analgesie, die Ranitidin Wismuth Citrat und einen NSAID enthalten
AU1671295A (en) * 1994-12-19 1996-07-10 Lauteral Limited Combinations of ranitidine hydrochloride-form 1 and bismuth compounds
CN1177357A (zh) * 1995-01-26 1998-03-25 耐克麦德英梅金公司 铋化合物
GB9501560D0 (en) * 1995-01-26 1995-03-15 Nycomed Imaging As Contrast agents
EP1035192A1 (de) * 1999-01-26 2000-09-13 Stefan Graichen Additiv für einen Kühlschmierstoff
CN1102585C (zh) * 1999-04-28 2003-03-05 常州兰陵制药有限公司 雷尼替丁枸橼酸铋盐的制备方法
US20060100271A1 (en) * 2004-11-08 2006-05-11 Keith Whitehead Stabilized aqueous ranitidine compositions
CN100402514C (zh) * 2006-08-01 2008-07-16 丽珠医药集团股份有限公司 一种制备枸橼酸铋雷尼替丁的方法
CN101484132A (zh) * 2007-07-09 2009-07-15 柏树制药公司 具有合意口味的雷尼替丁制剂
CN102408398B (zh) * 2011-09-20 2012-12-05 江苏汉斯通药业有限公司 枸橼酸铋雷尼替丁的制备方法
US9731999B2 (en) 2011-09-23 2017-08-15 Iqbal Gill Chemical admixtures for hydraulic cements
ES2426539B1 (es) * 2012-04-18 2014-09-09 Dr Healthcare España, S. L. Uso de la diaminooxidasa para el tratamiento o la prevención del trastorno por deficit de atencion con hiperactividad (adhd)
CN103896888B (zh) * 2014-03-28 2015-11-18 常州兰陵制药有限公司 枸橼酸铋雷尼替丁的制备方法
EP2929884A1 (en) 2014-04-11 2015-10-14 Sanovel Ilac Sanayi ve Ticaret A.S. Pharmaceutical combinations of dabigatran and h2-receptor antagonists
EP2942058A1 (en) 2014-05-09 2015-11-11 Sanovel Ilac Sanayi ve Ticaret A.S. Pharmaceutical combinations of rivaroxaban and H2-receptor antagonists
CN107382921A (zh) * 2017-07-28 2017-11-24 常州兰陵制药有限公司 制备枸橼酸铋雷尼替丁的方法
WO2022034121A1 (en) 2020-08-11 2022-02-17 Université De Strasbourg H2 blockers targeting liver macrophages for the prevention and treatment of liver disease and cancer

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1565966A (en) * 1976-08-04 1980-04-23 Allen & Hanburys Ltd Aminoalkyl furan derivatives
FR2531706A1 (fr) * 1982-08-13 1984-02-17 Sanofi Sa Benzamides, leurs sels, procede pour leur preparation et compositions pharmaceutiques les renfermant
BE905235A (fr) * 1986-08-05 1986-12-01 Hasunor Ag Ascorbates antagonistes des recepteurs h2 et leur procede de preparation.
IT1215325B (it) * 1987-01-07 1990-02-08 Barisintex Sa Composti antagonisti di recettori -h2 e procedimento per la loro preparazione.
IL85472A (en) * 1987-03-09 1991-06-30 Procter & Gamble Pharmaceutical compositions for treating gastrointestinal disorders
DE3874917T2 (de) * 1987-03-09 1993-03-04 Procter & Gamble Zusammensetzungen und ihre verwendung zur behandlung von magen-darmstoerungen.
DE3710462A1 (de) * 1987-03-30 1988-10-13 Heumann Pharma Gmbh & Co Pharmazeutische zubereitung zur behandlung von erkrankungen des magen-darm-traktes
GB9004328D0 (en) * 1990-02-27 1990-04-25 Glaxo Group Ltd Chemical compounds
GB9009437D0 (en) * 1990-04-26 1990-06-20 Glaxo Group Ltd Chemical compounds

Also Published As

Publication number Publication date
LU87557A1 (fr) 1990-07-24
GB8916288D0 (en) 1989-08-31
FI893448A (fi) 1990-01-19
FI90538B (fi) 1993-11-15
DE3923638C2 (de) 1995-11-23
ZW8689A1 (en) 1990-02-21
NZ229958A (en) 1991-09-25
DK351789A (da) 1990-01-19
NL8901840A (nl) 1990-02-16
HK61392A (en) 1992-08-21
GB2220937B (en) 1991-11-27
FR2634122A1 (fr) 1990-01-19
DK351789D0 (da) 1989-07-17
NL970046I1 (nl) 1998-03-02
FR2634122B1 (fr) 1993-11-19
NO1998007I1 (no) 1998-02-05
MX174145B (es) 1994-04-25
ATA172889A (de) 1994-02-15
DK168381B1 (da) 1994-03-21
CH679582A5 (ko) 1992-03-13
MY104055A (en) 1993-10-30
MX16829A (es) 1993-10-01
JPH02117684A (ja) 1990-05-02
LU88722I2 (fr) 1996-08-23
JP2523185B2 (ja) 1996-08-07
SE8902550D0 (sv) 1989-07-17
FI893448A0 (fi) 1989-07-17
NL192604C (nl) 1997-11-04
FI90538C (fi) 1994-02-25
HU206104B (en) 1992-08-28
GR1000431B (el) 1992-07-30
CY1650A (en) 1992-12-11
AU632052B2 (en) 1992-12-17
IE61076B1 (en) 1994-09-21
CN1039419A (zh) 1990-02-07
AU3817889A (en) 1990-01-18
NL970046I2 (nl) 1998-04-01
US5008256A (en) 1991-04-16
SE8902550L (sv) 1990-01-19
YU142789A (en) 1991-04-30
GB2220937A (en) 1990-01-24
IL91005A (en) 1994-10-07
NO176319C (no) 1995-03-15
AT398200B (de) 1994-10-25
SG51992G (en) 1992-07-24
IL91005A0 (en) 1990-02-09
NO892936L (no) 1990-01-19
EG19368A (en) 1995-02-28
IE892309L (en) 1990-01-18
HUT52082A (en) 1990-06-28
HU211173A9 (en) 1995-11-28
NO176319B (no) 1994-12-05
NO892936D0 (no) 1989-07-17
NL192604B (nl) 1997-07-01
KR0122598B1 (ko) 1997-11-13
CN1022626C (zh) 1993-11-03
ES2014175A6 (es) 1990-06-16
PT91188B (pt) 1995-03-01
CA1332610C (en) 1994-10-18
PT91188A (pt) 1990-02-08
PL162391B1 (pl) 1993-10-30
DE3923638A1 (de) 1990-03-01
GR890100454A (en) 1990-06-27
IT8948196A0 (it) 1989-07-17
YU47021B (sh) 1994-11-15
BE1003254A5 (fr) 1992-02-11
IT1231481B (it) 1991-12-07
SE468715B (sv) 1993-03-08

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