GR1000431B - Μεθοδος παραγωγης παραγωγων φουρανιου. - Google Patents
Μεθοδος παραγωγης παραγωγων φουρανιου.Info
- Publication number
- GR1000431B GR1000431B GR890100454A GR890100454A GR1000431B GR 1000431 B GR1000431 B GR 1000431B GR 890100454 A GR890100454 A GR 890100454A GR 890100454 A GR890100454 A GR 890100454A GR 1000431 B GR1000431 B GR 1000431B
- Authority
- GR
- Greece
- Prior art keywords
- salts
- acid
- ranitidine
- furan derivatives
- diseases
- Prior art date
Links
- 150000002240 furans Chemical class 0.000 title 1
- 150000003839 salts Chemical class 0.000 abstract 4
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 abstract 3
- 150000001735 carboxylic acids Chemical class 0.000 abstract 2
- VMXUWOKSQNHOCA-LCYFTJDESA-N ranitidine Chemical compound [O-][N+](=O)/C=C(/NC)NCCSCC1=CC=C(CN(C)C)O1 VMXUWOKSQNHOCA-LCYFTJDESA-N 0.000 abstract 2
- 229960000620 ranitidine Drugs 0.000 abstract 2
- HZLCGUXUOFWCCN-UHFFFAOYSA-N 2-hydroxynonadecane-1,2,3-tricarboxylic acid Chemical compound CCCCCCCCCCCCCCCCC(C(O)=O)C(O)(C(O)=O)CC(O)=O HZLCGUXUOFWCCN-UHFFFAOYSA-N 0.000 abstract 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 abstract 1
- 208000018522 Gastrointestinal disease Diseases 0.000 abstract 1
- 241000590002 Helicobacter pylori Species 0.000 abstract 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 abstract 1
- 229940040563 agaric acid Drugs 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 230000001262 anti-secretory effect Effects 0.000 abstract 1
- 229910052797 bismuth Inorganic materials 0.000 abstract 1
- JCXGWMGPZLAOME-UHFFFAOYSA-N bismuth atom Chemical compound [Bi] JCXGWMGPZLAOME-UHFFFAOYSA-N 0.000 abstract 1
- 230000001120 cytoprotective effect Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 239000011975 tartaric acid Substances 0.000 abstract 1
- 235000002906 tartaric acid Nutrition 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Furan Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Η εφεύρεση σχετίζεται με άλατα, που σχηματίζονται μεταξύ ρανιτιδίνης και ενός συμπλόκου βισμουθίου με ένα καρβοξυλικό οξύ, καθώς και με τα ένυδρα αυτών των αλάτων. Παραδείγματα καταλλήλων καρβοξυλικών οξέων είναι το κιτρικά οξέα, τρυγικό οξύ και αγαρικινικό οξύ. Τα άλατα χρησιμοποιούνται στην θεραπεία γαστροεντερικών παθήσεων, ιδιαίτερα δε σε παθήσεις γαστροδωδεκαδακτύλου. Τα άλατα δείχνουν αντι-εκκριτική δράση που συνδέεται με την ρανιτιδίνη μαζί με αντιβακτηριακή δράση έναντι του CAMPYLOBACTER PYLORI, ενώ επίσης αυτά επιδεικνύουν και κυτταροπροστατευτικές ιδότητες. ω
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB888817098A GB8817098D0 (en) | 1988-07-18 | 1988-07-18 | Chemical compounds |
GB898904686A GB8904686D0 (en) | 1989-03-01 | 1989-03-01 | Chemical compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
GR890100454A GR890100454A (en) | 1990-06-27 |
GR1000431B true GR1000431B (el) | 1992-07-30 |
Family
ID=26294175
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GR890100454A GR1000431B (el) | 1988-07-18 | 1989-07-17 | Μεθοδος παραγωγης παραγωγων φουρανιου. |
Country Status (35)
Country | Link |
---|---|
US (1) | US5008256A (el) |
JP (1) | JP2523185B2 (el) |
KR (1) | KR0122598B1 (el) |
CN (1) | CN1022626C (el) |
AT (1) | AT398200B (el) |
AU (1) | AU632052B2 (el) |
BE (1) | BE1003254A5 (el) |
CA (1) | CA1332610C (el) |
CH (1) | CH679582A5 (el) |
CY (1) | CY1650A (el) |
DE (1) | DE3923638C2 (el) |
DK (1) | DK168381B1 (el) |
EG (1) | EG19368A (el) |
ES (1) | ES2014175A6 (el) |
FI (1) | FI90538C (el) |
FR (1) | FR2634122B1 (el) |
GB (1) | GB2220937B (el) |
GR (1) | GR1000431B (el) |
HK (1) | HK61392A (el) |
HU (2) | HU206104B (el) |
IE (1) | IE61076B1 (el) |
IL (1) | IL91005A (el) |
IT (1) | IT1231481B (el) |
LU (2) | LU88722I2 (el) |
MX (1) | MX174145B (el) |
MY (1) | MY104055A (el) |
NL (2) | NL192604C (el) |
NO (2) | NO176319C (el) |
NZ (1) | NZ229958A (el) |
PL (1) | PL162391B1 (el) |
PT (1) | PT91188B (el) |
SE (1) | SE468715B (el) |
SG (1) | SG51992G (el) |
YU (1) | YU47021B (el) |
ZW (1) | ZW8689A1 (el) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL85472A (en) * | 1987-03-09 | 1991-06-30 | Procter & Gamble | Pharmaceutical compositions for treating gastrointestinal disorders |
DE3874917T2 (de) * | 1987-03-09 | 1993-03-04 | Procter & Gamble | Zusammensetzungen und ihre verwendung zur behandlung von magen-darmstoerungen. |
AU641903B2 (en) * | 1988-10-26 | 1993-10-07 | Glaxo Group Limited | Carboxylic acid derivatives |
GB9004328D0 (en) * | 1990-02-27 | 1990-04-25 | Glaxo Group Ltd | Chemical compounds |
GB9009240D0 (en) * | 1990-04-25 | 1990-06-20 | Glaxo Group Ltd | Chemical compounds |
GB9009437D0 (en) * | 1990-04-26 | 1990-06-20 | Glaxo Group Ltd | Chemical compounds |
DK0540613T3 (da) * | 1990-07-20 | 1996-04-01 | Tillotts Pharma Ag | Produkter og fremgangsmåder til behandling af fordøjelseskanalen |
GB9019875D0 (en) * | 1990-09-11 | 1990-10-24 | Glaxo Group Ltd | Pharmaceutical compositions |
US5192752A (en) * | 1991-01-14 | 1993-03-09 | The Procter & Gamble Company | Swallowable pharmaceutical compositions containing colloidal bismuth subcitrate |
US5128140A (en) * | 1991-01-14 | 1992-07-07 | The Procter & Gamble Company | Swallowable pharmaceutical compositions |
GB9120131D0 (en) * | 1991-09-20 | 1991-11-06 | Glaxo Group Ltd | Medicaments |
EP0550083B1 (en) * | 1991-12-06 | 1999-03-24 | Glaxo Group Limited | Medicaments for treating inflammatory conditions or for analgesia containing a NSAID and ranitidine bismuth citrate |
AU1671295A (en) * | 1994-12-19 | 1996-07-10 | Lauteral Limited | Combinations of ranitidine hydrochloride-form 1 and bismuth compounds |
GB9501560D0 (en) | 1995-01-26 | 1995-03-15 | Nycomed Imaging As | Contrast agents |
JPH10512877A (ja) * | 1995-01-26 | 1998-12-08 | ニコムド イメージング エイ/エス | ビスマス化合物 |
EP1035192A1 (de) * | 1999-01-26 | 2000-09-13 | Stefan Graichen | Additiv für einen Kühlschmierstoff |
CN1102585C (zh) * | 1999-04-28 | 2003-03-05 | 常州兰陵制药有限公司 | 雷尼替丁枸橼酸铋盐的制备方法 |
US20060100271A1 (en) * | 2004-11-08 | 2006-05-11 | Keith Whitehead | Stabilized aqueous ranitidine compositions |
CN100402514C (zh) * | 2006-08-01 | 2008-07-16 | 丽珠医药集团股份有限公司 | 一种制备枸橼酸铋雷尼替丁的方法 |
AU2007216671B2 (en) * | 2007-07-09 | 2009-07-16 | Cypress Pharmaceutical, Inc. | Pleasant-tasting ranitidine formulation |
CN102408398B (zh) * | 2011-09-20 | 2012-12-05 | 江苏汉斯通药业有限公司 | 枸橼酸铋雷尼替丁的制备方法 |
US9731999B2 (en) | 2011-09-23 | 2017-08-15 | Iqbal Gill | Chemical admixtures for hydraulic cements |
ES2426539B1 (es) * | 2012-04-18 | 2014-09-09 | Dr Healthcare España, S. L. | Uso de la diaminooxidasa para el tratamiento o la prevención del trastorno por deficit de atencion con hiperactividad (adhd) |
CN103896888B (zh) * | 2014-03-28 | 2015-11-18 | 常州兰陵制药有限公司 | 枸橼酸铋雷尼替丁的制备方法 |
WO2015155297A1 (en) | 2014-04-11 | 2015-10-15 | Sanovel Ilac Sanayi Ve Ticaret A.S. | Pharmaceutical combinations of dabigatran and h2-receptor antagonists |
EP2942058A1 (en) | 2014-05-09 | 2015-11-11 | Sanovel Ilac Sanayi ve Ticaret A.S. | Pharmaceutical combinations of rivaroxaban and H2-receptor antagonists |
CN107382921A (zh) * | 2017-07-28 | 2017-11-24 | 常州兰陵制药有限公司 | 制备枸橼酸铋雷尼替丁的方法 |
US20230349922A1 (en) | 2020-08-11 | 2023-11-02 | Université De Strasbourg | H2 Blockers Targeting Liver Macrophages for the Prevention and Treatment of Liver Disease and Cancer |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1565966A (en) * | 1976-08-04 | 1980-04-23 | Allen & Hanburys Ltd | Aminoalkyl furan derivatives |
FR2531706A1 (fr) * | 1982-08-13 | 1984-02-17 | Sanofi Sa | Benzamides, leurs sels, procede pour leur preparation et compositions pharmaceutiques les renfermant |
BE905235A (fr) * | 1986-08-05 | 1986-12-01 | Hasunor Ag | Ascorbates antagonistes des recepteurs h2 et leur procede de preparation. |
IT1215325B (it) * | 1987-01-07 | 1990-02-08 | Barisintex Sa | Composti antagonisti di recettori -h2 e procedimento per la loro preparazione. |
DE3874917T2 (de) * | 1987-03-09 | 1993-03-04 | Procter & Gamble | Zusammensetzungen und ihre verwendung zur behandlung von magen-darmstoerungen. |
IL85472A (en) * | 1987-03-09 | 1991-06-30 | Procter & Gamble | Pharmaceutical compositions for treating gastrointestinal disorders |
DE3710462A1 (de) * | 1987-03-30 | 1988-10-13 | Heumann Pharma Gmbh & Co | Pharmazeutische zubereitung zur behandlung von erkrankungen des magen-darm-traktes |
GB9004328D0 (en) * | 1990-02-27 | 1990-04-25 | Glaxo Group Ltd | Chemical compounds |
GB9009437D0 (en) * | 1990-04-26 | 1990-06-20 | Glaxo Group Ltd | Chemical compounds |
-
1989
- 1989-07-14 CH CH2647/89A patent/CH679582A5/fr not_active IP Right Cessation
- 1989-07-17 IE IE230989A patent/IE61076B1/en not_active IP Right Cessation
- 1989-07-17 PT PT91188A patent/PT91188B/pt not_active IP Right Cessation
- 1989-07-17 PL PL28062889A patent/PL162391B1/pl unknown
- 1989-07-17 IT IT8948196A patent/IT1231481B/it active Protection Beyond IP Right Term
- 1989-07-17 IL IL9100589A patent/IL91005A/en not_active IP Right Cessation
- 1989-07-17 CN CN89104959A patent/CN1022626C/zh not_active Expired - Fee Related
- 1989-07-17 NL NL8901840A patent/NL192604C/nl not_active IP Right Cessation
- 1989-07-17 BE BE8900773A patent/BE1003254A5/fr not_active IP Right Cessation
- 1989-07-17 ZW ZW86/89A patent/ZW8689A1/xx unknown
- 1989-07-17 NZ NZ229958A patent/NZ229958A/xx unknown
- 1989-07-17 FI FI893448A patent/FI90538C/fi not_active IP Right Cessation
- 1989-07-17 MY MYPI89000969A patent/MY104055A/en unknown
- 1989-07-17 ES ES8902517A patent/ES2014175A6/es not_active Expired - Fee Related
- 1989-07-17 MX MX1682989A patent/MX174145B/es unknown
- 1989-07-17 CA CA000605843A patent/CA1332610C/en not_active Expired - Fee Related
- 1989-07-17 US US07/380,378 patent/US5008256A/en not_active Expired - Lifetime
- 1989-07-17 LU LU88722C patent/LU88722I2/fr unknown
- 1989-07-17 AU AU38178/89A patent/AU632052B2/en not_active Ceased
- 1989-07-17 FR FR8909575A patent/FR2634122B1/fr not_active Expired - Fee Related
- 1989-07-17 EG EG34289A patent/EG19368A/xx active
- 1989-07-17 GR GR890100454A patent/GR1000431B/el not_active IP Right Cessation
- 1989-07-17 DK DK351789A patent/DK168381B1/da not_active IP Right Cessation
- 1989-07-17 DE DE3923638A patent/DE3923638C2/de not_active Expired - Fee Related
- 1989-07-17 SE SE8902550A patent/SE468715B/sv not_active IP Right Cessation
- 1989-07-17 AT AT0172889A patent/AT398200B/de not_active IP Right Cessation
- 1989-07-17 LU LU87557A patent/LU87557A1/fr active Protection Beyond IP Right Term
- 1989-07-17 HU HU893595A patent/HU206104B/hu unknown
- 1989-07-17 NO NO892936A patent/NO176319C/no not_active IP Right Cessation
- 1989-07-17 GB GB8916288A patent/GB2220937B/en not_active Expired - Lifetime
- 1989-07-17 JP JP1184402A patent/JP2523185B2/ja not_active Expired - Lifetime
- 1989-07-17 YU YU142789A patent/YU47021B/sh unknown
- 1989-07-18 KR KR1019890010213A patent/KR0122598B1/ko not_active IP Right Cessation
-
1992
- 1992-05-09 SG SG519/92A patent/SG51992G/en unknown
- 1992-08-13 HK HK613/92A patent/HK61392A/xx not_active IP Right Cessation
- 1992-12-11 CY CY1650A patent/CY1650A/xx unknown
-
1995
- 1995-06-12 HU HU95P/P00186P patent/HU211173A9/hu unknown
-
1997
- 1997-12-18 NL NL970046C patent/NL970046I2/nl unknown
-
1998
- 1998-02-05 NO NO1998007C patent/NO1998007I1/no unknown
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ML | Lapse due to non-payment of fees |