IL41564A - Pharmaceutical compositions containing n-cyclohexylbenzylamine derivatives - Google Patents

Pharmaceutical compositions containing n-cyclohexylbenzylamine derivatives

Info

Publication number
IL41564A
IL41564A IL41564A IL4156473A IL41564A IL 41564 A IL41564 A IL 41564A IL 41564 A IL41564 A IL 41564A IL 4156473 A IL4156473 A IL 4156473A IL 41564 A IL41564 A IL 41564A
Authority
IL
Israel
Prior art keywords
composition
formula
compound
product
directions
Prior art date
Application number
IL41564A
Other versions
IL41564A0 (en
Original Assignee
Thomae Gmbh Dr K
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Thomae Gmbh Dr K filed Critical Thomae Gmbh Dr K
Publication of IL41564A0 publication Critical patent/IL41564A0/en
Publication of IL41564A publication Critical patent/IL41564A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

1420976 Pharmaceutical compositions DR KARL THOMAE GmbH 16 Feb 1973 [17 Feb 1972] 7795/73 Heading A5B A pharmaceutical composition comprises, as an active ingredient, a compound of formula: wherein R 1 represents H or a methyl group or a physiologically compatible acid addition salt thereof, a respiration analeptic and a pharmaceutical carrier or excipient. In an example, capsules contain N-(trans-p-hydroxycyclohexyl) - (2-amino-3, 5-dibromo-benzyl)- amine hydrochloride and N-(2-benzoylamino- 6-chloro-benzyl)-N-methyl-glycine morpholide hydrochloride. The compositions may be in forms suitable for oral, rectal or parenteral administration and may also contain antibiotics, bronchodilators, antitussives, antisilicosis agents, corticosteroids and antihistamines. [GB1420976A]

Claims (17)

1. A pharmaceutical composition for use in the treatment of oedematously atelectatic changes in the lung, said composition comprising as active ingredient a compound of the general formula (wherein represents a hydrogen atom or a methyl group) or a physiologically compatible acid addition salt thereof, together with a pharmaceutical excipient or carrier.
2. A composition as claimed in claim 1 wherein the compound of formula I is N-( trans--p_--hydroxycyclohexyl)-- ( 2-amino-3 , 5-dibromobenzyl )-amine or an acid addition salt thereof.
3. A composition as claimed in claim 1 or claim 2 which comprises a further active ingredient.
4. A composition as claimed in claim 3 wherein the further active ingredient is an antitussive, respiration analeptic, bronchodilator , antibiotic, anti-silicosis agent, co ticosteriod or antihistamine.
5. A composition as claimed in any one of the preceding claims ina form suitable for parenteral administration.
6. A composition as claimed in any one of the preceding claims in dosage unit form.
7. A composition as claimed in claim 6 containing 3 to AO mg of the compoi.md of formula I per dosage unit.
8. A composition as claimed in claim 6 containing 3 to 15 mg of the compound of formula I per dosage unit.
9. A composition as claimed in claim 1, substantially as described herein with reference to any one of the Exam les.
10. A pharmaceutical product comprising a composition as claimed in any one of the preceding claims in association with directions for the use thereof in' the treatment of oedematously atelectatic changes of the lung.
11. A product as claimed in claim 10 wherein the associated directions are printed or written and physically attached to a container for the composition.
12. A product as claimed in claim 10 in a container therefor with separate directions for the use thereof provided together with the container.
13. A composition as claimed in any of claims 10 to 12 wherein the associated directions state the pharmacological actions and indications of the compound of formula I contained therein in the treatment of prematurely born children.
14. A product as claimed in claim 13 wherein the associated directions include instructions for the use of the composition in the treatment of the astlima syndrome, pulmonary hyaline-membrane disease and/or postperfusional lung syndrome in prematurely born children.
15. A product as claimed in any one of claims 10 to 14 wherein the associated directions specify the administration of the composition in a dosage which contains from 2 to 16 mg of the compound of formula I per kg body weight.
16. A product as claimed in claim 15 wherein the. associated directions specify the administration of the compound of formula 1 2 to 5 times daily.
17. A product as claimed in claim 16 wherein the associated directions specify the administration of the compound of formula I 4 times daily.
IL41564A 1972-02-17 1973-02-16 Pharmaceutical compositions containing n-cyclohexylbenzylamine derivatives IL41564A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2207460A DE2207460C2 (en) 1972-02-17 1972-02-17 Use of hydroxycylohexylamine derivatives in the treatment of edematous atelectatic lung changes

Publications (2)

Publication Number Publication Date
IL41564A0 IL41564A0 (en) 1973-04-30
IL41564A true IL41564A (en) 1976-02-29

Family

ID=5836238

Family Applications (1)

Application Number Title Priority Date Filing Date
IL41564A IL41564A (en) 1972-02-17 1973-02-16 Pharmaceutical compositions containing n-cyclohexylbenzylamine derivatives

Country Status (8)

Country Link
AU (1) AU475165B2 (en)
BE (1) BE795585A (en)
DE (1) DE2207460C2 (en)
FR (1) FR2181742B1 (en)
GB (1) GB1420976A (en)
IE (1) IE37288B1 (en)
IL (1) IL41564A (en)
ZA (1) ZA731068B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3034975C2 (en) * 1980-09-17 1986-11-27 Dr. Karl Thomae Gmbh, 7950 Biberach Drug combination used to treat infectious respiratory diseases
JPS5888311A (en) * 1981-11-20 1983-05-26 Teijin Ltd Remedy for respiratory disease
CN102516096B (en) * 2011-11-28 2013-09-25 海南灵康制药有限公司 Refining method of hydrochloric acid ambroxol compound

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1593579B1 (en) * 1966-05-10 1972-02-03 Thomae Gmbh Dr K Hydroxy-cyclohexylamines, their physiologically acceptable acid addition salts and process for their preparation

Also Published As

Publication number Publication date
IE37288B1 (en) 1977-06-22
AU5227273A (en) 1974-08-22
GB1420976A (en) 1976-01-14
FR2181742A1 (en) 1973-12-07
AU475165B2 (en) 1976-08-12
IL41564A0 (en) 1973-04-30
FR2181742B1 (en) 1976-10-22
BE795585A (en) 1973-08-16
ZA731068B (en) 1974-11-27
DE2207460C2 (en) 1985-06-20
DE2207460A1 (en) 1973-08-23
IE37288L (en) 1973-08-17

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