KR890001808B1 - 우레아 및 티오우레아류의 제조방법 - Google Patents

우레아 및 티오우레아류의 제조방법 Download PDF

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Publication number
KR890001808B1
KR890001808B1 KR8205843A KR820005843A KR890001808B1 KR 890001808 B1 KR890001808 B1 KR 890001808B1 KR 8205843 A KR8205843 A KR 8205843A KR 820005843 A KR820005843 A KR 820005843A KR 890001808 B1 KR890001808 B1 KR 890001808B1
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KR
South Korea
Prior art keywords
group
alkyl
formula
compound
benzyl
Prior art date
Application number
KR8205843A
Other languages
English (en)
Korean (ko)
Other versions
KR840002773A (ko
Inventor
고오든 데브리이즈 버언
유진 가아지스 엘웃드
브라운 콘로우 랜섬
Original Assignee
죤 제이 헤이간
아메리칸 사이아나밋드 캄파니
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/342,693 external-priority patent/US4473579A/en
Priority claimed from US06/342,698 external-priority patent/US4387105A/en
Application filed by 죤 제이 헤이간, 아메리칸 사이아나밋드 캄파니 filed Critical 죤 제이 헤이간
Publication of KR840002773A publication Critical patent/KR840002773A/ko
Application granted granted Critical
Publication of KR890001808B1 publication Critical patent/KR890001808B1/ko

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C273/00—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C273/18—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas
    • C07C273/1809—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas with formation of the N-C(O)-N moiety
    • C07C273/1818—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas with formation of the N-C(O)-N moiety from -N=C=O and XNR'R"
    • C07C273/1827—X being H
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Furan Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
KR8205843A 1982-01-26 1982-12-28 우레아 및 티오우레아류의 제조방법 KR890001808B1 (ko)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US342.693 1982-01-26
US342.698 1982-01-26
US06/342,693 US4473579A (en) 1982-01-26 1982-01-26 Antiatherosclerotic tetrasubstituted ureas and thioureas
US342693 1982-01-26
US06/342,698 US4387105A (en) 1982-01-26 1982-01-26 Methods of treating atherosclerosis with dialkylureas and dialkylthioureas
US342698 1994-11-21

Publications (2)

Publication Number Publication Date
KR840002773A KR840002773A (ko) 1984-07-16
KR890001808B1 true KR890001808B1 (ko) 1989-05-23

Family

ID=26993144

Family Applications (1)

Application Number Title Priority Date Filing Date
KR8205843A KR890001808B1 (ko) 1982-01-26 1982-12-28 우레아 및 티오우레아류의 제조방법

Country Status (20)

Country Link
KR (1) KR890001808B1 (it)
AT (1) AT391313B (it)
AU (1) AU562699B2 (it)
CH (1) CH654571A5 (it)
DE (1) DE3247581A1 (it)
DK (1) DK160869C (it)
ES (2) ES8406422A1 (it)
FI (1) FI85013C (it)
FR (1) FR2521134B1 (it)
GB (1) GB2113684B (it)
GR (1) GR77186B (it)
HU (1) HU200746B (it)
IE (1) IE54683B1 (it)
IL (1) IL67417A (it)
IT (1) IT1203647B (it)
NL (1) NL8300269A (it)
NO (1) NO158417C (it)
PL (1) PL143836B1 (it)
PT (1) PT76138A (it)
SE (1) SE462653B (it)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2138804A (en) * 1983-04-27 1984-10-31 Sumitomo Chemical Co Fungicidal N-phenylcarbamates
GB2149394B (en) * 1983-07-19 1986-09-24 American Cyanamid Co Ureas
US4818899A (en) * 1986-12-03 1989-04-04 Minnesota Mining And Manufacturing Company Second harmonic generation by carbamic acid derivatives
DE68911203T2 (de) * 1988-03-30 1994-04-14 Warner Lambert Co N-[[(2,6-disubstituierte)phenyl]N'- arylalkyl] Harnstoffe als antihypercholesterolemische und antiatherosclerotische Mittel.
US5116848A (en) * 1988-03-30 1992-05-26 Warner-Lambert Company N-(((2,6-disubstituted)phenyl)-n-diarylalkyl)ureas as antihyperlipidemic and antiatherosclerotic agents
AU7317391A (en) * 1990-02-14 1991-09-03 Chugai Seiyaku Kabushiki Kaisha Inhibitor of denatured ldl formation
US5668136A (en) * 1990-09-25 1997-09-16 Eisai Co., Ltd. Trisubstituted benzene derivatives, composition and methods of treatment
HUT62558A (en) * 1991-07-01 1993-05-28 Sandoz Ag Process for producing n-phenylthiourea derivaties and pharmaceutical compositions comprising same
JP3612328B2 (ja) * 1992-07-20 2005-01-19 エーザイ株式会社 ベンゼン誘導体
AU8534198A (en) * 1997-08-05 1999-03-01 Novo Nordisk A/S Derivatives of 2,5- and 3,5-disubstituted anilines, their preparation and use
US6455566B1 (en) 1997-09-03 2002-09-24 Wyeth Substituted 1-aryl-3-heteroaryl-thioureas (or isothioureas) as antiatherosclerotic agents
TW415942B (en) * 1997-09-03 2000-12-21 American Home Prod Novel substituted 1-aryl-3-heteroaryl-thioureas and substituted 1-aryl-3-heteroaryl-isothioureas as antiatherosclerotic agents
CA2284864A1 (en) * 1998-01-21 1999-07-29 Zymogenetics, Inc. Dialkyl ureas as calcitonin mimetics
US8324396B2 (en) * 2007-07-10 2012-12-04 Amgen Inc. Derivatives of urea and related diamines, methods for their manufacture, and uses therefor

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL92838C (it) * 1949-12-06
US2688039A (en) * 1952-02-08 1954-08-31 Ciba Pharm Prod Inc Halogen-containing di-(substituted phenyl)-thioureas
US3326663A (en) * 1964-09-25 1967-06-20 Shell Oil Co Herbicidal phenylureas
US3335142A (en) * 1965-07-07 1967-08-08 American Cyanamid Co Process for the preparation of n, n'-disubstituted ureas
US3659012A (en) * 1969-05-26 1972-04-25 Lilly Co Eli Methods of treating helminth infections with thiourea derivatives
US3728386A (en) * 1970-07-27 1973-04-17 Exxon Research Engineering Co N-cycloalkylalkyl and n-cycloalkyl substituted phenyl ureas and halo acetamides
US3928437A (en) * 1970-09-02 1975-12-23 Ciba Geigy Corp Phenoxy-phenyl, phenylthiophenyl, phenylsulfonylphenyl and phenylaminophenyl diaminothioureas
US3856952A (en) * 1973-03-01 1974-12-24 Pennwalt Corp Synergistic antimicrobial compositions employing certain n-(phenyl-carbamyl)amino-benzene sulfonyl flourides
US3903130A (en) * 1974-05-03 1975-09-02 Stauffer Chemical Co 1-Trifluormethylphenyl-3-dicyanophenyl urea
DE2928485A1 (de) * 1979-07-14 1981-01-29 Bayer Ag Verwendung von harnstoffderivaten als arzneimittel bei der behandlung von fettstoffwechselstoerungen

Also Published As

Publication number Publication date
GR77186B (it) 1984-09-11
DE3247581A1 (de) 1983-08-04
IT8347605A0 (it) 1983-01-25
FR2521134B1 (fr) 1987-01-09
NO158417B (no) 1988-05-30
SE462653B (sv) 1990-08-06
DK160869B (da) 1991-04-29
SE8300370L (sv) 1983-07-27
NO830238L (no) 1983-07-27
FI830247A0 (fi) 1983-01-25
IE54683B1 (en) 1990-01-03
NL8300269A (nl) 1983-08-16
SE8300370D0 (sv) 1983-01-25
PL143836B1 (en) 1988-03-31
IE830146L (en) 1983-07-26
GB2113684A (en) 1983-08-10
KR840002773A (ko) 1984-07-16
CH654571A5 (de) 1986-02-28
FI830247L (fi) 1983-07-27
DK28683D0 (da) 1983-01-25
PL240284A1 (en) 1985-01-02
DK160869C (da) 1991-10-14
ES531508A0 (es) 1985-07-01
DK28683A (da) 1983-07-27
AU1068183A (en) 1983-08-04
HU200746B (en) 1990-08-28
ES8505943A1 (es) 1985-07-01
ATA23983A (de) 1990-03-15
FI85013B (fi) 1991-11-15
AU562699B2 (en) 1987-06-18
ES519246A0 (es) 1984-08-01
ES8406422A1 (es) 1984-08-01
IT1203647B (it) 1989-02-15
NO158417C (no) 1988-09-07
IL67417A (en) 1989-10-31
GB2113684B (en) 1985-12-18
FI85013C (fi) 1992-02-25
PT76138A (en) 1983-02-01
FR2521134A1 (fr) 1983-08-12
GB8301863D0 (en) 1983-02-23
AT391313B (de) 1990-09-25

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