SE462653B - Substituerade karbamider, foerfarande foer framstaellning daerav, naemnda karbamider foer farmaceutisk anvaendning samt farmaceutisk komposition innehaallande naemnda karbamider - Google Patents

Substituerade karbamider, foerfarande foer framstaellning daerav, naemnda karbamider foer farmaceutisk anvaendning samt farmaceutisk komposition innehaallande naemnda karbamider

Info

Publication number
SE462653B
SE462653B SE8300370A SE8300370A SE462653B SE 462653 B SE462653 B SE 462653B SE 8300370 A SE8300370 A SE 8300370A SE 8300370 A SE8300370 A SE 8300370A SE 462653 B SE462653 B SE 462653B
Authority
SE
Sweden
Prior art keywords
urea
benzyl
butyl
alkyl
dimethylphenyl
Prior art date
Application number
SE8300370A
Other languages
English (en)
Swedish (sv)
Other versions
SE8300370L (sv
SE8300370D0 (sv
Inventor
V G Devries
E E Largis
R B Conrow
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/342,698 external-priority patent/US4387105A/en
Priority claimed from US06/342,693 external-priority patent/US4473579A/en
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of SE8300370D0 publication Critical patent/SE8300370D0/xx
Publication of SE8300370L publication Critical patent/SE8300370L/
Publication of SE462653B publication Critical patent/SE462653B/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C273/00—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C273/18—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas
    • C07C273/1809—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas with formation of the N-C(O)-N moiety
    • C07C273/1818—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas with formation of the N-C(O)-N moiety from -N=C=O and XNR'R"
    • C07C273/1827—X being H
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Furan Compounds (AREA)
SE8300370A 1982-01-26 1983-01-25 Substituerade karbamider, foerfarande foer framstaellning daerav, naemnda karbamider foer farmaceutisk anvaendning samt farmaceutisk komposition innehaallande naemnda karbamider SE462653B (sv)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/342,698 US4387105A (en) 1982-01-26 1982-01-26 Methods of treating atherosclerosis with dialkylureas and dialkylthioureas
US06/342,693 US4473579A (en) 1982-01-26 1982-01-26 Antiatherosclerotic tetrasubstituted ureas and thioureas

Publications (3)

Publication Number Publication Date
SE8300370D0 SE8300370D0 (sv) 1983-01-25
SE8300370L SE8300370L (sv) 1983-07-27
SE462653B true SE462653B (sv) 1990-08-06

Family

ID=26993144

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8300370A SE462653B (sv) 1982-01-26 1983-01-25 Substituerade karbamider, foerfarande foer framstaellning daerav, naemnda karbamider foer farmaceutisk anvaendning samt farmaceutisk komposition innehaallande naemnda karbamider

Country Status (20)

Country Link
KR (1) KR890001808B1 (it)
AT (1) AT391313B (it)
AU (1) AU562699B2 (it)
CH (1) CH654571A5 (it)
DE (1) DE3247581A1 (it)
DK (1) DK160869C (it)
ES (2) ES519246A0 (it)
FI (1) FI85013C (it)
FR (1) FR2521134B1 (it)
GB (1) GB2113684B (it)
GR (1) GR77186B (it)
HU (1) HU200746B (it)
IE (1) IE54683B1 (it)
IL (1) IL67417A (it)
IT (1) IT1203647B (it)
NL (1) NL8300269A (it)
NO (1) NO158417C (it)
PL (1) PL143836B1 (it)
PT (1) PT76138A (it)
SE (1) SE462653B (it)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2138804A (en) * 1983-04-27 1984-10-31 Sumitomo Chemical Co Fungicidal N-phenylcarbamates
GB2149394B (en) * 1983-07-19 1986-09-24 American Cyanamid Co Ureas
US4818899A (en) * 1986-12-03 1989-04-04 Minnesota Mining And Manufacturing Company Second harmonic generation by carbamic acid derivatives
US5116848A (en) * 1988-03-30 1992-05-26 Warner-Lambert Company N-(((2,6-disubstituted)phenyl)-n-diarylalkyl)ureas as antihyperlipidemic and antiatherosclerotic agents
EP0344425B1 (en) * 1988-03-30 1993-12-08 Warner-Lambert Company N-[[(2,6-disubstituted)phenyl]-N'- arylalkyl] ureas as antihypercholesterolemic and antiatherosclerotic agents
EP0515684A4 (en) * 1990-02-14 1993-04-21 Chugai Seiyaku Kabushiki Kaisha Inhibitor of denatured ldl formation
US5668136A (en) * 1990-09-25 1997-09-16 Eisai Co., Ltd. Trisubstituted benzene derivatives, composition and methods of treatment
HUT62558A (en) * 1991-07-01 1993-05-28 Sandoz Ag Process for producing n-phenylthiourea derivaties and pharmaceutical compositions comprising same
EP0609457B1 (en) * 1992-07-20 1997-10-29 Eisai Co., Ltd. Benzene derivative
EP1019367A1 (en) * 1997-08-05 2000-07-19 Novo Nordisk A/S Derivatives of 2,5- and 3,5-disubstituted anilines, their preparation and use
TW415942B (en) * 1997-09-03 2000-12-21 American Home Prod Novel substituted 1-aryl-3-heteroaryl-thioureas and substituted 1-aryl-3-heteroaryl-isothioureas as antiatherosclerotic agents
US6455566B1 (en) 1997-09-03 2002-09-24 Wyeth Substituted 1-aryl-3-heteroaryl-thioureas (or isothioureas) as antiatherosclerotic agents
WO1999037604A2 (en) * 1998-01-21 1999-07-29 Zymogenetics, Inc. Dialkyl ureas as calcitonin mimetics
JP5504484B2 (ja) * 2007-07-10 2014-05-28 アムジエン・インコーポレーテツド ウレア誘導体および関連ジアミン、これらの製造方法および使用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL92838C (it) * 1949-12-06
US2688039A (en) * 1952-02-08 1954-08-31 Ciba Pharm Prod Inc Halogen-containing di-(substituted phenyl)-thioureas
US3326663A (en) * 1964-09-25 1967-06-20 Shell Oil Co Herbicidal phenylureas
US3335142A (en) * 1965-07-07 1967-08-08 American Cyanamid Co Process for the preparation of n, n'-disubstituted ureas
US3659012A (en) * 1969-05-26 1972-04-25 Lilly Co Eli Methods of treating helminth infections with thiourea derivatives
US3728386A (en) * 1970-07-27 1973-04-17 Exxon Research Engineering Co N-cycloalkylalkyl and n-cycloalkyl substituted phenyl ureas and halo acetamides
US3928437A (en) * 1970-09-02 1975-12-23 Ciba Geigy Corp Phenoxy-phenyl, phenylthiophenyl, phenylsulfonylphenyl and phenylaminophenyl diaminothioureas
US3856952A (en) * 1973-03-01 1974-12-24 Pennwalt Corp Synergistic antimicrobial compositions employing certain n-(phenyl-carbamyl)amino-benzene sulfonyl flourides
US3903130A (en) * 1974-05-03 1975-09-02 Stauffer Chemical Co 1-Trifluormethylphenyl-3-dicyanophenyl urea
DE2928485A1 (de) * 1979-07-14 1981-01-29 Bayer Ag Verwendung von harnstoffderivaten als arzneimittel bei der behandlung von fettstoffwechselstoerungen

Also Published As

Publication number Publication date
DK160869C (da) 1991-10-14
CH654571A5 (de) 1986-02-28
GB8301863D0 (en) 1983-02-23
FI85013C (fi) 1992-02-25
DK28683A (da) 1983-07-27
FR2521134B1 (fr) 1987-01-09
NO158417B (no) 1988-05-30
NO830238L (no) 1983-07-27
GB2113684B (en) 1985-12-18
AU562699B2 (en) 1987-06-18
AU1068183A (en) 1983-08-04
IT1203647B (it) 1989-02-15
ES8406422A1 (es) 1984-08-01
HU200746B (en) 1990-08-28
ES519246A0 (es) 1984-08-01
IE54683B1 (en) 1990-01-03
AT391313B (de) 1990-09-25
SE8300370L (sv) 1983-07-27
SE8300370D0 (sv) 1983-01-25
FI830247L (fi) 1983-07-27
IE830146L (en) 1983-07-26
PL143836B1 (en) 1988-03-31
ATA23983A (de) 1990-03-15
NO158417C (no) 1988-09-07
GB2113684A (en) 1983-08-10
DK28683D0 (da) 1983-01-25
DE3247581A1 (de) 1983-08-04
KR890001808B1 (ko) 1989-05-23
PL240284A1 (en) 1985-01-02
KR840002773A (ko) 1984-07-16
IL67417A (en) 1989-10-31
IT8347605A0 (it) 1983-01-25
FI85013B (fi) 1991-11-15
GR77186B (it) 1984-09-11
FI830247A0 (fi) 1983-01-25
FR2521134A1 (fr) 1983-08-12
DK160869B (da) 1991-04-29
NL8300269A (nl) 1983-08-16
PT76138A (en) 1983-02-01
ES531508A0 (es) 1985-07-01
ES8505943A1 (es) 1985-07-01

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