KR880001657B1 - 카보스티릴 화합물의 제조방법 - Google Patents

카보스티릴 화합물의 제조방법 Download PDF

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Publication number
KR880001657B1
KR880001657B1 KR1019810004359A KR810004359A KR880001657B1 KR 880001657 B1 KR880001657 B1 KR 880001657B1 KR 1019810004359 A KR1019810004359 A KR 1019810004359A KR 810004359 A KR810004359 A KR 810004359A KR 880001657 B1 KR880001657 B1 KR 880001657B1
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KR
South Korea
Prior art keywords
group
formula
compound
linkage
carbostyryl
Prior art date
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Expired
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KR1019810004359A
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English (en)
Korean (ko)
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KR830007644A (ko
Inventor
미찌아끼 도미나가
양영웅
히데노리 오가와
가즈유끼 나까가와
Original Assignee
오쯔까 세이야꾸 가부시끼가이샤
오쯔까 아끼히꼬
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP55159016A external-priority patent/JPS5782390A/ja
Priority claimed from JP55179950A external-priority patent/JPS57102888A/ja
Application filed by 오쯔까 세이야꾸 가부시끼가이샤, 오쯔까 아끼히꼬 filed Critical 오쯔까 세이야꾸 가부시끼가이샤
Publication of KR830007644A publication Critical patent/KR830007644A/ko
Application granted granted Critical
Publication of KR880001657B1 publication Critical patent/KR880001657B1/ko
Expired legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/24—Oxygen atoms attached in position 8
    • C07D215/26—Alcohols; Ethers thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/24—Oxygen atoms attached in position 8
    • C07D215/26—Alcohols; Ethers thereof
    • C07D215/28—Alcohols; Ethers thereof with halogen atoms or nitro radicals in positions 5, 6 or 7
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/24—Oxygen atoms attached in position 8
    • C07D215/26—Alcohols; Ethers thereof
    • C07D215/32—Esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
KR1019810004359A 1980-11-11 1981-11-11 카보스티릴 화합물의 제조방법 Expired KR880001657B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP159016 1980-11-11
JP55159016A JPS5782390A (en) 1980-11-11 1980-11-11 Carbostyril derivative
JP179950 1980-12-18
JP55179950A JPS57102888A (en) 1980-12-18 1980-12-18 Carbostyril derivative

Publications (2)

Publication Number Publication Date
KR830007644A KR830007644A (ko) 1983-11-04
KR880001657B1 true KR880001657B1 (ko) 1988-09-05

Family

ID=26485945

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019810004359A Expired KR880001657B1 (ko) 1980-11-11 1981-11-11 카보스티릴 화합물의 제조방법

Country Status (19)

Country Link
US (1) US4414390A (enExample)
EP (1) EP0052016B1 (enExample)
KR (1) KR880001657B1 (enExample)
AT (1) AT382376B (enExample)
AU (1) AU547586B2 (enExample)
CA (1) CA1164459A (enExample)
CH (1) CH653684A5 (enExample)
DE (1) DE3152512T1 (enExample)
DK (1) DK157193C (enExample)
ES (1) ES8301967A1 (enExample)
FI (1) FI71145C (enExample)
IT (1) IT8149680A0 (enExample)
MX (1) MX6802E (enExample)
NO (1) NO157819C (enExample)
PH (1) PH17158A (enExample)
PT (1) PT73959B (enExample)
SE (1) SE440653B (enExample)
SU (1) SU1215621A3 (enExample)
WO (1) WO1982001706A1 (enExample)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4636502A (en) * 1982-12-27 1987-01-13 Eli Lilly And Company Methods of producing a positive inotropic effect or vasodilation by administration of 2-phenyl imidazo pyrimidines and pyrazines
US4537889A (en) * 1982-12-27 1985-08-27 Eli Lilly And Company Inotropic agents
GB8305245D0 (en) * 1983-02-25 1983-03-30 Fujisawa Pharmaceutical Co Imidazo-heterocyclic compounds
US4533734A (en) * 1983-11-10 1985-08-06 Eli Lilly And Company Inotropic agents
US4710507A (en) * 1983-12-22 1987-12-01 Pfizer Inc. Quinolone inotropic agents
CA1292234C (en) * 1984-05-29 1991-11-19 Simon Fraser Campbell Heterocyclic-substituted quinolone inotropic agents
US4721721A (en) * 1984-12-18 1988-01-26 Rorer Pharmaceutical Corporation 6-(4-thiazole) compounds, cardiotonic compositions including the same, and their uses
FR2580646A1 (fr) * 1985-04-19 1986-10-24 Synthelabo Derives de 2(1h)-quinolinone, leur preparation et leur application en therapeutique
US4666913A (en) * 1985-11-22 1987-05-19 William H. Rorer, Inc. Hydroxy and aminothiazolyl-benzodiazinone compounds, cardiotonic compositions including the same, and their uses
GB8529362D0 (en) * 1985-11-28 1986-01-02 Pfizer Ltd Quinolone cardiac stimulants
GB8619902D0 (en) * 1986-08-15 1986-09-24 Pfizer Ltd Quinolone cardiac stimulants
GB8709448D0 (en) * 1987-04-21 1987-05-28 Pfizer Ltd Heterobicyclic quinoline derivatives
CN1046725C (zh) * 1994-06-20 1999-11-24 武田药品工业株式会社 稠合的咪唑化合物,它们的制备和应用
US5552412A (en) * 1995-01-09 1996-09-03 Pfizer Inc 5-substitued-6-cyclic-5,6,7,8-tetrahydronaphthalen2-ol compounds which are useful for treating osteoporosis
DE10117184A1 (de) * 2001-04-05 2002-10-17 Gruenenthal Gmbh Substituierte Imidazol[1,2-a]-pyridin-3-yl-amid- und -aminverbindungen
DE10247271A1 (de) * 2002-10-10 2004-08-26 Grünenthal GmbH Substituierte C-Imidazo[1,2-a]pyridin-3-yle
PE20050211A1 (es) * 2003-04-02 2005-04-27 Novartis Ag Procedimiento para preparar oxi-(1h)-quinolin-2-onas 5-(alfa-haloacetil)-8-sustituidas
DE102005019181A1 (de) * 2005-04-25 2006-10-26 Novartis Ag Peptid-Deformylase (PDF) Inhibitoren 1
WO2010032195A1 (en) 2008-09-16 2010-03-25 Csir Imidazopyridines and imidazopyrimidines as hiv-i reverse transcriptase inhibitors
ES2362894B1 (es) * 2009-11-16 2012-05-21 Ferrer Internacional S.A. Procedimiento de preparación del �?cido 4-nitro-oxi-metil-benzoico.
US10188108B2 (en) 2015-04-08 2019-01-29 Bayer Cropscience Aktiengesellschaft Fused bicyclic heterocycle derivatives as pesticides
JP2018525371A (ja) 2015-07-30 2018-09-06 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ アリール置換された二環式ヘテロアリール化合物
JP7058256B2 (ja) * 2016-07-14 2022-04-21 ブリストル－マイヤーズ スクイブ カンパニー 二環式ヘテロアリール置換化合物
WO2018013776A1 (en) 2016-07-14 2018-01-18 Bristol-Myers Squibb Company Tricyclic heteroaryl-substituted quinoline and azaquinoline compounds as par4 inhibitors

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1473819A (en) * 1976-01-28 1977-05-18 Gallardo Antonio Sa Derivatives of imidazo 1,2-a pyridine
EP0007525A1 (de) * 1978-07-18 1980-02-06 Hoechst Aktiengesellschaft 2-(4-Aminopiperidino)-3,4-dihydrochinoline, Verfahren zu ihrer Herstellung, pharmazeutische Präparate auf Basis dieser Verbindungen sowie ihre Verwendung
ES8100016A1 (es) * 1978-07-18 1980-04-01 Hoechst Ag Procedimiento para la preparacion de nuevos derivados de 1-(4-aminopiperidino)-3,4-dihidroisoquinoleina.
JPS5553284A (en) * 1978-10-12 1980-04-18 Yoshitomi Pharmaceut Ind Ltd Pyridazinone derivative
GB2031404A (en) * 1978-10-17 1980-04-23 Yoshitomi Pharmaceutical Pyridazinone compounds

Also Published As

Publication number Publication date
FI822471L (fi) 1982-07-12
PT73959A (en) 1981-12-01
FI71145B (fi) 1986-08-14
AU547586B2 (en) 1985-10-24
FI71145C (fi) 1986-11-24
DE3152512T1 (de) 1982-11-18
MX6802E (es) 1986-07-29
FI822471A0 (fi) 1982-07-12
IT8149680A0 (it) 1981-11-11
CA1164459A (en) 1984-03-27
NO157819C (no) 1988-05-25
SE8204237D0 (sv) 1982-07-08
SE8204237L (sv) 1982-07-08
US4414390A (en) 1983-11-08
DK157193B (da) 1989-11-20
KR830007644A (ko) 1983-11-04
NO157819B (no) 1988-02-15
NO822391L (no) 1982-07-09
DK157193C (da) 1990-04-09
AU7808581A (en) 1982-06-07
DE3152512C2 (enExample) 1991-01-03
PH17158A (en) 1984-06-13
DK307482A (da) 1982-07-08
ES507545A0 (es) 1983-02-01
PT73959B (en) 1983-04-18
WO1982001706A1 (en) 1982-05-27
SU1215621A3 (ru) 1986-02-28
ATA908381A (de) 1986-07-15
AT382376B (de) 1987-02-25
EP0052016A1 (en) 1982-05-19
EP0052016B1 (en) 1984-09-05
ES8301967A1 (es) 1983-02-01
CH653684A5 (fr) 1986-01-15
SE440653B (sv) 1985-08-12

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