KR840008355A - 히단토인 유도체의 제조방법 - Google Patents

히단토인 유도체의 제조방법

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Publication number
KR840008355A
KR840008355A KR1019840002240A KR840002240A KR840008355A KR 840008355 A KR840008355 A KR 840008355A KR 1019840002240 A KR1019840002240 A KR 1019840002240A KR 840002240 A KR840002240 A KR 840002240A KR 840008355 A KR840008355 A KR 840008355A
Authority
KR
South Korea
Prior art keywords
spiro
fluoro
chroman
dion
hydantoin
Prior art date
Application number
KR1019840002240A
Other languages
English (en)
Other versions
KR860000915B1 (ko
Inventor
사쥐스 레인하아드
Original Assignee
테렌스 제이. 갈라줘
화이자 인코퍼레이티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 테렌스 제이. 갈라줘, 화이자 인코퍼레이티드 filed Critical 테렌스 제이. 갈라줘
Publication of KR840008355A publication Critical patent/KR840008355A/ko
Application granted granted Critical
Publication of KR860000915B1 publication Critical patent/KR860000915B1/ko

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/96—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings spiro-condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

내용 없음.

Description

히단토인 유도체의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (10)

  1. (a) 4S-6-플루오르-스피로-[크로만-4,4′-이미다졸리딘]-2′, 5′-디온의 6위치를 불소, 염소, 또는 브롬원소로 할로겐화하여 상응하는 6-플루오로-8-할로 유도체를 생성키거나; (b) 계속해서 단계(a)에서 생성된 화합물을 중수소 또는 삼중수소로 촉매적 환원반응시켜 목적하는 6-플루오로-8-듀테로 또는 6-플루오로-8-트리티오 최종 생성물을 수득하고; 경우에 따라, 생성된 일반식(I)이 스피로-히단토인 화합물을 상응하는 약물학적으로 허용되는 염기부가염으로 전환시킴을 특징으로 하여, 일반식(I)의 비대칭성 스피로-히단토인의 우선성 이성체 및 그의 약물학적으로 허용되는 양이온과의 염기부가 염을 제조하는 방법.
    상기식에서 X는 중수소, 삼중수소 또는 할로겐이다.
  2. 제1항에 있어서, 단계(a)의 할로겐화 반응을 반응-불환성 유기용매 중, 약 -50 내지 50℃의 온도에서 수행함을 특징으로 하는 방법.
  3. 제2항에 있어서, 용매가 빙초산임을 특징으로 하는 방법.
  4. 제2항에 있어서, 용매가 디메틸포롬 아마이드임을 특징으로 하는 방법.
  5. 제1항에 있어서, 단계(b)의 촉매적 환원반응을 귀금속 촉매의 존재하, 저급 알칸올 용매중에서 수행함을 특징으로 하는 방법.
  6. 제5항에 있어서, 촉매가 팔라듐임을 특징으로 하는 방법.
  7. 제1항에 있어서, 단계(a)에서 수득된 스피로-히단토인 화합물이 4S-6,8-디플루오로-스피로-[크로만-4, 4′-이미다졸리딘]-2′, 5′-디온임을 특징으로 하는 방법.
  8. 제1항에 있어서, 단계(a)에서 수득된 스피로-히단토인 화합물이 4S-6-플루오르-8-클로로-스피로-[크로만-4, 4′-이미다졸리디]-2′, 5′-디온임을 특징으로 하는 방법.
  9. 제1항에 있어서, 단계(b)에서 수득된 스피로-히단토인 화합물이 4S-6-플루오로-8-듀테로-스피로-[크로만-4, 4′-이미다졸린]-2′, 5′-디온임을 특징으로 하는 방법.
  10. 제1항에 있어서, 단계(b)에서 수득된 스피로-히단토인 화합물이 4S-6-플루오로-8-트리티오-스피로-[크로만-4, 4′-이미다졸리디]-2′, 5′-디온임을 특징으로 하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019840002240A 1983-04-27 1984-04-26 히단토인 유도체의 제조방법 KR860000915B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US488,947 1983-04-27
US06/488,947 US4474967A (en) 1983-04-27 1983-04-27 8-Deutero and 8-tritio-substituted derivatives of D-4S-6-fluoro-spiro-[chroman-4,4'-imidazolidine]-2',5'-dione
US488947 1983-04-27

Publications (2)

Publication Number Publication Date
KR840008355A true KR840008355A (ko) 1984-12-14
KR860000915B1 KR860000915B1 (ko) 1986-07-18

Family

ID=23941785

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019840002240A KR860000915B1 (ko) 1983-04-27 1984-04-26 히단토인 유도체의 제조방법

Country Status (22)

Country Link
US (1) US4474967A (ko)
EP (1) EP0124327A3 (ko)
JP (1) JPS59205384A (ko)
KR (1) KR860000915B1 (ko)
AU (1) AU542142B2 (ko)
CA (1) CA1226866A (ko)
CS (1) CS250661B2 (ko)
DD (1) DD219772A5 (ko)
DK (1) DK208284A (ko)
ES (1) ES8607312A1 (ko)
FI (1) FI841657A (ko)
GR (1) GR81491B (ko)
HU (1) HU191755B (ko)
IL (1) IL71656A (ko)
NO (1) NO841627L (ko)
NZ (1) NZ207959A (ko)
PH (1) PH22869A (ko)
PL (1) PL142759B1 (ko)
PT (1) PT78476B (ko)
SU (1) SU1240362A3 (ko)
YU (1) YU43358B (ko)
ZA (1) ZA843091B (ko)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE37371T1 (de) * 1984-08-20 1988-10-15 Pfizer Verfahren zur herstellung asymmetrischer hydantoine.
US4841079A (en) * 1987-08-07 1989-06-20 Pfizer, Inc. Process for the production of asymmetric hydantoins
US5059693A (en) * 1989-10-06 1991-10-22 Pfizer Inc. Process for making 3-aroyl-2-oxindole-1-carboxamides
GB9317764D0 (en) * 1993-08-26 1993-10-13 Pfizer Ltd Therapeutic compound
ATE223219T1 (de) * 1998-01-30 2002-09-15 R Tech Ueno Ltd Ophthalmische zubereitung

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3821383A (en) * 1972-07-10 1974-06-28 Ayerst Mckenna & Harrison Compositions for and a method of treating diabetic complications
US4117230A (en) * 1976-10-18 1978-09-26 Pfizer Inc. Hydantoin derivatives as therapeutic agents
CA1088945A (en) * 1976-10-18 1980-11-04 Pfizer Limited Hydantoin derivatives as therapeutic agents
US4130714A (en) * 1977-05-23 1978-12-19 Pfizer Inc. Hydantoin therapeutic agents
US4248882A (en) * 1980-02-12 1981-02-03 Pfizer Inc. Treating diabetes-associated complications with hydantoin amines
JPS5745185A (en) * 1980-07-21 1982-03-13 Eisai Co Ltd Hydantoin derivative and its preparation

Also Published As

Publication number Publication date
US4474967A (en) 1984-10-02
JPS59205384A (ja) 1984-11-20
EP0124327A3 (en) 1985-07-31
HUT34197A (en) 1985-02-28
NZ207959A (en) 1987-04-30
DD219772A5 (de) 1985-03-13
ES8607312A1 (es) 1986-06-01
DK208284A (da) 1984-10-28
YU43358B (en) 1989-06-30
GR81491B (ko) 1984-12-11
DK208284D0 (da) 1984-04-26
CS250661B2 (en) 1987-05-14
YU74184A (en) 1986-10-31
ES531873A0 (es) 1986-06-01
PH22869A (en) 1989-01-19
KR860000915B1 (ko) 1986-07-18
PL247379A1 (en) 1985-03-26
FI841657A0 (fi) 1984-04-26
SU1240362A3 (ru) 1986-06-23
HU191755B (en) 1987-04-28
IL71656A (en) 1987-10-20
PT78476B (en) 1986-08-28
PT78476A (en) 1984-05-01
CA1226866A (en) 1987-09-15
AU542142B2 (en) 1985-02-07
AU2726384A (en) 1984-11-01
IL71656A0 (en) 1984-07-31
PL142759B1 (en) 1987-11-30
EP0124327A2 (en) 1984-11-07
NO841627L (no) 1984-10-29
ZA843091B (en) 1985-12-24
FI841657A (fi) 1984-10-28

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