ES8607312A1 - Un procedimiento para la preparacion de un compuesto seleccionado entre el grupo formado por los isomeros dextrogiros de espiro-hidantoinas asimetricas - Google Patents
Un procedimiento para la preparacion de un compuesto seleccionado entre el grupo formado por los isomeros dextrogiros de espiro-hidantoinas asimetricasInfo
- Publication number
- ES8607312A1 ES8607312A1 ES531873A ES531873A ES8607312A1 ES 8607312 A1 ES8607312 A1 ES 8607312A1 ES 531873 A ES531873 A ES 531873A ES 531873 A ES531873 A ES 531873A ES 8607312 A1 ES8607312 A1 ES 8607312A1
- Authority
- ES
- Spain
- Prior art keywords
- derivatives
- tritio
- deutero
- drug
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/96—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings spiro-condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- General Chemical & Material Sciences (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Endocrinology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE LOS ISOMEROS DEXTROGIROS DE ESPIRO-HIDANTOINAS ASIMETRICAS Y DE SUS SALES BASICAS FISIOLOGICAMENTE COMPATIBLES, DE FORMULA (I), EN LA QUE X ES DEUTERIO, TRITIO O HALOGENO. CONSISTE EN LA REACCION DE HALOGENACION DE 4S-6-FLUOR-ESPIRO CROMAN-4,4K-IMIDAZOLIDIN-2,5K-DIONA EN LA POSICION 8 POR TRATAMIENTO CON FLUOR, CLORO O BROMO, EN UN DISOLVENTE INERTE A LA REACCION, A UNA TEMPERATURA COMPRENDIDA ENTRE C50JC Y 50JC; SEGUIDA DE LA REDUCCION CATALITICA DEL COMPUESTO OBTENIDO CON DEUTERIO O TRITIO, EN UN ALCANOL INFERIOR, EN PRESENCIA DE UN CATALIZADOR DE METAL NOBLE, COMO PALADIO. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS PARA EL TRATAMIENTO DE LAS COMPLICACIONES DE LA DIABETES CRONICA.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/488,947 US4474967A (en) | 1983-04-27 | 1983-04-27 | 8-Deutero and 8-tritio-substituted derivatives of D-4S-6-fluoro-spiro-[chroman-4,4'-imidazolidine]-2',5'-dione |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8607312A1 true ES8607312A1 (es) | 1986-06-01 |
| ES531873A0 ES531873A0 (es) | 1986-06-01 |
Family
ID=23941785
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES531873A Expired ES8607312A1 (es) | 1983-04-27 | 1984-04-25 | Un procedimiento para la preparacion de un compuesto seleccionado entre el grupo formado por los isomeros dextrogiros de espiro-hidantoinas asimetricas |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US4474967A (es) |
| EP (1) | EP0124327A3 (es) |
| JP (1) | JPS59205384A (es) |
| KR (1) | KR860000915B1 (es) |
| AU (1) | AU542142B2 (es) |
| CA (1) | CA1226866A (es) |
| CS (1) | CS250661B2 (es) |
| DD (1) | DD219772A5 (es) |
| DK (1) | DK208284A (es) |
| ES (1) | ES8607312A1 (es) |
| FI (1) | FI841657A (es) |
| GR (1) | GR81491B (es) |
| HU (1) | HU191755B (es) |
| IL (1) | IL71656A (es) |
| NO (1) | NO841627L (es) |
| NZ (1) | NZ207959A (es) |
| PH (1) | PH22869A (es) |
| PL (1) | PL142759B1 (es) |
| PT (1) | PT78476B (es) |
| SU (1) | SU1240362A3 (es) |
| YU (1) | YU43358B (es) |
| ZA (1) | ZA843091B (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0172719B1 (en) * | 1984-08-20 | 1988-09-21 | Pfizer Inc. | Process for the production as asymmetric hydantoins |
| US4841079A (en) * | 1987-08-07 | 1989-06-20 | Pfizer, Inc. | Process for the production of asymmetric hydantoins |
| US5059693A (en) * | 1989-10-06 | 1991-10-22 | Pfizer Inc. | Process for making 3-aroyl-2-oxindole-1-carboxamides |
| GB9317764D0 (en) * | 1993-08-26 | 1993-10-13 | Pfizer Ltd | Therapeutic compound |
| ATE223219T1 (de) | 1998-01-30 | 2002-09-15 | R Tech Ueno Ltd | Ophthalmische zubereitung |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3821383A (en) * | 1972-07-10 | 1974-06-28 | Ayerst Mckenna & Harrison | Compositions for and a method of treating diabetic complications |
| US4117230A (en) * | 1976-10-18 | 1978-09-26 | Pfizer Inc. | Hydantoin derivatives as therapeutic agents |
| CA1088945A (en) * | 1976-10-18 | 1980-11-04 | Pfizer Limited | Hydantoin derivatives as therapeutic agents |
| US4130714A (en) * | 1977-05-23 | 1978-12-19 | Pfizer Inc. | Hydantoin therapeutic agents |
| US4248882A (en) * | 1980-02-12 | 1981-02-03 | Pfizer Inc. | Treating diabetes-associated complications with hydantoin amines |
| JPS5745185A (en) * | 1980-07-21 | 1982-03-13 | Eisai Co Ltd | Hydantoin derivative and its preparation |
-
1983
- 1983-04-27 US US06/488,947 patent/US4474967A/en not_active Expired - Fee Related
-
1984
- 1984-04-19 EP EP84302667A patent/EP0124327A3/en not_active Withdrawn
- 1984-04-24 PL PL1984247379A patent/PL142759B1/pl unknown
- 1984-04-24 PT PT78476A patent/PT78476B/pt unknown
- 1984-04-24 DD DD84262257A patent/DD219772A5/de not_active IP Right Cessation
- 1984-04-25 CA CA000452774A patent/CA1226866A/en not_active Expired
- 1984-04-25 ES ES531873A patent/ES8607312A1/es not_active Expired
- 1984-04-25 NO NO841627A patent/NO841627L/no unknown
- 1984-04-25 SU SU843732823A patent/SU1240362A3/ru active
- 1984-04-26 NZ NZ207959A patent/NZ207959A/en unknown
- 1984-04-26 PH PH30605A patent/PH22869A/en unknown
- 1984-04-26 KR KR1019840002240A patent/KR860000915B1/ko active IP Right Grant
- 1984-04-26 IL IL71656A patent/IL71656A/xx not_active IP Right Cessation
- 1984-04-26 DK DK208284A patent/DK208284A/da not_active Application Discontinuation
- 1984-04-26 HU HU841622A patent/HU191755B/hu not_active IP Right Cessation
- 1984-04-26 CS CS843101A patent/CS250661B2/cs unknown
- 1984-04-26 ZA ZA843091A patent/ZA843091B/xx unknown
- 1984-04-26 GR GR74517A patent/GR81491B/el unknown
- 1984-04-26 FI FI841657A patent/FI841657A/fi not_active Application Discontinuation
- 1984-04-26 YU YU741/84A patent/YU43358B/xx unknown
- 1984-04-26 AU AU27263/84A patent/AU542142B2/en not_active Ceased
- 1984-04-27 JP JP59086040A patent/JPS59205384A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| SU1240362A3 (ru) | 1986-06-23 |
| PH22869A (en) | 1989-01-19 |
| DK208284D0 (da) | 1984-04-26 |
| PT78476A (en) | 1984-05-01 |
| YU43358B (en) | 1989-06-30 |
| US4474967A (en) | 1984-10-02 |
| KR860000915B1 (ko) | 1986-07-18 |
| JPS59205384A (ja) | 1984-11-20 |
| EP0124327A2 (en) | 1984-11-07 |
| DK208284A (da) | 1984-10-28 |
| PT78476B (en) | 1986-08-28 |
| EP0124327A3 (en) | 1985-07-31 |
| CA1226866A (en) | 1987-09-15 |
| HUT34197A (en) | 1985-02-28 |
| ZA843091B (en) | 1985-12-24 |
| KR840008355A (ko) | 1984-12-14 |
| DD219772A5 (de) | 1985-03-13 |
| NO841627L (no) | 1984-10-29 |
| PL247379A1 (en) | 1985-03-26 |
| AU2726384A (en) | 1984-11-01 |
| HU191755B (en) | 1987-04-28 |
| FI841657A0 (fi) | 1984-04-26 |
| YU74184A (en) | 1986-10-31 |
| GR81491B (es) | 1984-12-11 |
| IL71656A (en) | 1987-10-20 |
| AU542142B2 (en) | 1985-02-07 |
| ES531873A0 (es) | 1986-06-01 |
| PL142759B1 (en) | 1987-11-30 |
| CS250661B2 (en) | 1987-05-14 |
| FI841657A (fi) | 1984-10-28 |
| IL71656A0 (en) | 1984-07-31 |
| NZ207959A (en) | 1987-04-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Patent lapsed |
Effective date: 19960401 |