IL71656A - 8-substituted 4s-6-fluoro-spiro(chroman-4,4'imidazolidine)-2',5'-diones - Google Patents

8-substituted 4s-6-fluoro-spiro(chroman-4,4'imidazolidine)-2',5'-diones

Info

Publication number
IL71656A
IL71656A IL71656A IL7165684A IL71656A IL 71656 A IL71656 A IL 71656A IL 71656 A IL71656 A IL 71656A IL 7165684 A IL7165684 A IL 7165684A IL 71656 A IL71656 A IL 71656A
Authority
IL
Israel
Prior art keywords
diones
chroman
imidazolidine
spiro
fluoro
Prior art date
Application number
IL71656A
Other languages
English (en)
Other versions
IL71656A0 (en
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of IL71656A0 publication Critical patent/IL71656A0/xx
Publication of IL71656A publication Critical patent/IL71656A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/96—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings spiro-condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
IL71656A 1983-04-27 1984-04-26 8-substituted 4s-6-fluoro-spiro(chroman-4,4'imidazolidine)-2',5'-diones IL71656A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/488,947 US4474967A (en) 1983-04-27 1983-04-27 8-Deutero and 8-tritio-substituted derivatives of D-4S-6-fluoro-spiro-[chroman-4,4'-imidazolidine]-2',5'-dione

Publications (2)

Publication Number Publication Date
IL71656A0 IL71656A0 (en) 1984-07-31
IL71656A true IL71656A (en) 1987-10-20

Family

ID=23941785

Family Applications (1)

Application Number Title Priority Date Filing Date
IL71656A IL71656A (en) 1983-04-27 1984-04-26 8-substituted 4s-6-fluoro-spiro(chroman-4,4'imidazolidine)-2',5'-diones

Country Status (22)

Country Link
US (1) US4474967A (es)
EP (1) EP0124327A3 (es)
JP (1) JPS59205384A (es)
KR (1) KR860000915B1 (es)
AU (1) AU542142B2 (es)
CA (1) CA1226866A (es)
CS (1) CS250661B2 (es)
DD (1) DD219772A5 (es)
DK (1) DK208284A (es)
ES (1) ES8607312A1 (es)
FI (1) FI841657A (es)
GR (1) GR81491B (es)
HU (1) HU191755B (es)
IL (1) IL71656A (es)
NO (1) NO841627L (es)
NZ (1) NZ207959A (es)
PH (1) PH22869A (es)
PL (1) PL142759B1 (es)
PT (1) PT78476B (es)
SU (1) SU1240362A3 (es)
YU (1) YU43358B (es)
ZA (1) ZA843091B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0172719B1 (en) * 1984-08-20 1988-09-21 Pfizer Inc. Process for the production as asymmetric hydantoins
US4841079A (en) * 1987-08-07 1989-06-20 Pfizer, Inc. Process for the production of asymmetric hydantoins
US5059693A (en) * 1989-10-06 1991-10-22 Pfizer Inc. Process for making 3-aroyl-2-oxindole-1-carboxamides
GB9317764D0 (en) * 1993-08-26 1993-10-13 Pfizer Ltd Therapeutic compound
WO1999038497A2 (en) * 1998-01-30 1999-08-05 R-Tech Ueno, Ltd. Ophthalmic composition

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3821383A (en) * 1972-07-10 1974-06-28 Ayerst Mckenna & Harrison Compositions for and a method of treating diabetic complications
CA1088945A (en) * 1976-10-18 1980-11-04 Pfizer Limited Hydantoin derivatives as therapeutic agents
US4117230A (en) * 1976-10-18 1978-09-26 Pfizer Inc. Hydantoin derivatives as therapeutic agents
US4130714A (en) * 1977-05-23 1978-12-19 Pfizer Inc. Hydantoin therapeutic agents
US4248882A (en) * 1980-02-12 1981-02-03 Pfizer Inc. Treating diabetes-associated complications with hydantoin amines
JPS5745185A (en) * 1980-07-21 1982-03-13 Eisai Co Ltd Hydantoin derivative and its preparation

Also Published As

Publication number Publication date
EP0124327A2 (en) 1984-11-07
HU191755B (en) 1987-04-28
JPS59205384A (ja) 1984-11-20
DD219772A5 (de) 1985-03-13
KR840008355A (ko) 1984-12-14
ZA843091B (en) 1985-12-24
PL142759B1 (en) 1987-11-30
PL247379A1 (en) 1985-03-26
HUT34197A (en) 1985-02-28
YU74184A (en) 1986-10-31
ES8607312A1 (es) 1986-06-01
DK208284A (da) 1984-10-28
FI841657A (fi) 1984-10-28
EP0124327A3 (en) 1985-07-31
IL71656A0 (en) 1984-07-31
ES531873A0 (es) 1986-06-01
NZ207959A (en) 1987-04-30
DK208284D0 (da) 1984-04-26
AU2726384A (en) 1984-11-01
FI841657A0 (fi) 1984-04-26
NO841627L (no) 1984-10-29
YU43358B (en) 1989-06-30
AU542142B2 (en) 1985-02-07
KR860000915B1 (ko) 1986-07-18
CS250661B2 (en) 1987-05-14
SU1240362A3 (ru) 1986-06-23
PT78476A (en) 1984-05-01
PH22869A (en) 1989-01-19
US4474967A (en) 1984-10-02
GR81491B (es) 1984-12-11
PT78476B (en) 1986-08-28
CA1226866A (en) 1987-09-15

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Legal Events

Date Code Title Description
MM9K Patent not in force due to non-payment of renewal fees