KR890000389A - 류코트리엔 길항제 중간체의 제조방법 - Google Patents
류코트리엔 길항제 중간체의 제조방법 Download PDFInfo
- Publication number
- KR890000389A KR890000389A KR1019880007200A KR880007200A KR890000389A KR 890000389 A KR890000389 A KR 890000389A KR 1019880007200 A KR1019880007200 A KR 1019880007200A KR 880007200 A KR880007200 A KR 880007200A KR 890000389 A KR890000389 A KR 890000389A
- Authority
- KR
- South Korea
- Prior art keywords
- reaction mixture
- temperature
- acetic acid
- acid
- resorcinol
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/257—Ethers having an ether-oxygen atom bound to carbon atoms both belonging to six-membered aromatic rings
- C07C43/295—Ethers having an ether-oxygen atom bound to carbon atoms both belonging to six-membered aromatic rings containing hydroxy or O-metal groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
- C07C49/82—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups
- C07C49/83—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups polycyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
- C07C45/46—Friedel-Crafts reactions
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
내용 없음
Claims (5)
- 레졸시놀을 반응 혼합물의 약 비점 내지 약 75℃의 온도에서 약 1시간 내지 약 5일동안 각각 a) 아세트산 또는 프로피온산 및 b) 브롬화수소산과 결합시킴을 특징으로 하여, 1,3-(디하이드록시)-4-(아세틸-또는 프로피오닐) 벤젠을 제조하는 방법.
- 제1항에 있어서, 레졸시놀을 반응 혼합물의 약 비점 내지 약 75℃의 온도에서 약 1시간 내지 약 5일 동안 아세트산 및 브롬화 수소산과 결합시킴으로써 1,3-디하이드록시-4-아세틸벤젠을 제조하는 방법.
- 제1 또는 2항에 있어서, 온도가 약 80 내지 약 90℃인 방법.
- 제1 내지 3항중의 어느 한 항에 있어서, 반응 혼합물이, 빙초산에 용해된 브롬화수소 가스를 함유하는 방법.
- 제1항 내지 제4항중 어느 한 항에 따라 제조된 화합물.※참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6489787A | 1987-06-19 | 1987-06-19 | |
| US07/064,897 | 1987-06-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR890000389A true KR890000389A (ko) | 1989-03-14 |
Family
ID=22058947
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019880007200A KR890000389A (ko) | 1987-06-19 | 1988-06-16 | 류코트리엔 길항제 중간체의 제조방법 |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP0295883B1 (ko) |
| JP (1) | JPS6416741A (ko) |
| KR (1) | KR890000389A (ko) |
| AT (1) | ATE66454T1 (ko) |
| CA (1) | CA1300169C (ko) |
| DE (1) | DE3864325D1 (ko) |
| ES (1) | ES2029883T3 (ko) |
| GR (1) | GR3002591T3 (ko) |
| HU (1) | HU200582B (ko) |
| IL (1) | IL86747A (ko) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0314531D0 (en) * | 2003-03-11 | 2003-07-30 | Unilever Plc | Process for the preparation of a cosmetic active |
| EP1961727A1 (de) * | 2007-02-26 | 2008-08-27 | Bayer CropScience AG | Verfahren zur Herstellung von 2,4-Dihydroxyphenyl-4-methoxybenzyl-ketonen |
| JP2008266374A (ja) * | 2007-04-17 | 2008-11-06 | Daicel Chem Ind Ltd | 多糖アシレートの製造方法、及び高純度多糖アシレート |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0167286A1 (en) * | 1984-06-04 | 1986-01-08 | Celanese Corporation | Process for producing 4-hydroxyacetophenone |
-
1988
- 1988-06-15 EP EP88305445A patent/EP0295883B1/en not_active Expired - Lifetime
- 1988-06-15 IL IL86747A patent/IL86747A/xx unknown
- 1988-06-15 DE DE8888305445T patent/DE3864325D1/de not_active Expired - Lifetime
- 1988-06-15 ES ES198888305445T patent/ES2029883T3/es not_active Expired - Lifetime
- 1988-06-15 CA CA000569500A patent/CA1300169C/en not_active Expired - Lifetime
- 1988-06-15 AT AT88305445T patent/ATE66454T1/de not_active IP Right Cessation
- 1988-06-16 HU HU883093A patent/HU200582B/hu not_active IP Right Cessation
- 1988-06-16 KR KR1019880007200A patent/KR890000389A/ko not_active Application Discontinuation
- 1988-06-17 JP JP63151066A patent/JPS6416741A/ja active Pending
-
1991
- 1991-08-22 GR GR91401189T patent/GR3002591T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA1300169C (en) | 1992-05-05 |
| ES2029883T3 (es) | 1992-10-01 |
| EP0295883B1 (en) | 1991-08-21 |
| ATE66454T1 (de) | 1991-09-15 |
| IL86747A (en) | 1992-06-21 |
| JPS6416741A (en) | 1989-01-20 |
| EP0295883A1 (en) | 1988-12-21 |
| DE3864325D1 (de) | 1991-09-26 |
| GR3002591T3 (en) | 1993-01-25 |
| IL86747A0 (en) | 1988-11-30 |
| HUT47518A (en) | 1989-03-28 |
| HU200582B (en) | 1990-07-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A201 | Request for examination | ||
| E902 | Notification of reason for refusal | ||
| E601 | Decision to refuse application |