KR860001778A - (-)-5-(1-하이드록시-1-메틸에틸)-2-메틸-2-싸이클로헥센-1-온에서 유도된 디아스테레오머 혼합물의 제조방법 - Google Patents

(-)-5-(1-하이드록시-1-메틸에틸)-2-메틸-2-싸이클로헥센-1-온에서 유도된 디아스테레오머 혼합물의 제조방법 Download PDF

Info

Publication number
KR860001778A
KR860001778A KR1019850005443A KR850005443A KR860001778A KR 860001778 A KR860001778 A KR 860001778A KR 1019850005443 A KR1019850005443 A KR 1019850005443A KR 850005443 A KR850005443 A KR 850005443A KR 860001778 A KR860001778 A KR 860001778A
Authority
KR
South Korea
Prior art keywords
hydroxy
tetramethyl
cyclohexene
methanol
cyclohexen
Prior art date
Application number
KR1019850005443A
Other languages
English (en)
Other versions
KR920001788B1 (ko
Inventor
코르비 모라 까밀로
Original Assignee
도트·피에르 루이기 코르비 모라
까밀로 코르비 에스·피·에이
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 도트·피에르 루이기 코르비 모라, 까밀로 코르비 에스·피·에이 filed Critical 도트·피에르 루이기 코르비 모라
Publication of KR860001778A publication Critical patent/KR860001778A/ko
Application granted granted Critical
Publication of KR920001788B1 publication Critical patent/KR920001788B1/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/36—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal
    • C07C29/38—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal by reaction with aldehydes or ketones
    • C07C29/40—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal by reaction with aldehydes or ketones with compounds containing carbon-to-metal bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/10—Expectorants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C35/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C35/02—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring monocyclic
    • C07C35/08—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring monocyclic containing a six-membered rings
    • C07C35/18—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring monocyclic containing a six-membered rings with unsaturation at least in the ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/29—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups
    • C07C45/292—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups with chromium derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

내용 없음

Description

(-)-5-(1-하이드록시-1-메틸에틸)-2-메틸-2-싸이클로헥센-1-온에서 유도된 디아스테레오머 혼합물의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (2)

  1. 에틸에티르내의 (-)-5-(1-하이드록시-1-메틸에틸)-2-메틸-2-싸이클로헥센-1-온을 -30℃에서 5% 메틸리튬의 에테르 용액과 반응시키고, 반응혼합물을 12시간동안 상온에서 교반하고, 물로 세척하고, 증발 건조하고, 이소프로필 에테르로 정제하여 디아스테레오며 혼합물을 얻는 것을 특징으로 하는 44.44%(1S-5R)-5-하이드록시-α,α-4,5-테트라메틸-3-싸이클로헥센-1-메탄올 및 55.55%(1S-5S)-5-하이드록시-α,α-4,5-테트라메틸-3-싸이클로헥센-1-메탄올로 구성된 디아스테레오머 혼합물을 제조하는 방법.
  2. 44.44%(1S-5R)-5-하이드록시-α,α-4,5-테트라메틸-3-싸이클로헥센-1-메탄올 및 55.55%(1S-5S)-5-하이드록시-α,α-4,5-테트라메틸-3-싸이클로헥센-1-메탄올의 디아스테레오머 혼합물이 6 : 4 싸이클로헥산/에틸 아세테이트로 용출하는 실리카겔 크로마토그래피에 의해서 분리되는 것을 특징으로 하는 (1S-5R)-5-하이드록시-α,α-4,5-테트라메틸-3-싸이클로헥센-1-메탄올 및 (1S-5S)-5-하이드록시-α,α-4,5-테트라메틸-3-싸이클로헥센-1-메탄올로 구성된 디아스테레오머를 제조하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019850005443A 1984-08-08 1985-07-29 (-)-5-(1-하이드록시-1-메틸에틸)-2-메틸-2-싸이클로헥센-1-온에서 유도된 디아스테레오머 혼합물의 제조 방법 KR920001788B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IT22257/84A IT1180220B (it) 1984-08-08 1984-08-08 Miscela di composti diastereoisomeri, ottenuti da (-)-5-(1-idrossi-1-metiletil)-2-metil-2-cicloesen-1-one, avente attivita' mucosecretolitica, procedimento per la sua preparazione e composizioni farmaceutiche che la contengono
IT22257-A/84 1984-08-08
IT22257A/84 1984-08-08

Publications (2)

Publication Number Publication Date
KR860001778A true KR860001778A (ko) 1986-03-22
KR920001788B1 KR920001788B1 (ko) 1992-03-02

Family

ID=11193758

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019850005443A KR920001788B1 (ko) 1984-08-08 1985-07-29 (-)-5-(1-하이드록시-1-메틸에틸)-2-메틸-2-싸이클로헥센-1-온에서 유도된 디아스테레오머 혼합물의 제조 방법

Country Status (7)

Country Link
US (1) US4596894A (ko)
EP (1) EP0170839B1 (ko)
JP (1) JPS6147432A (ko)
KR (1) KR920001788B1 (ko)
AT (1) ATE45939T1 (ko)
DE (1) DE3572649D1 (ko)
IT (1) IT1180220B (ko)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH681060A5 (ko) * 1990-08-22 1993-01-15 Riace Ets
KR102427155B1 (ko) 2015-08-25 2022-07-29 삼성디스플레이 주식회사 레이저 결정화 장치

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2949489A (en) * 1958-06-23 1960-08-16 Fmc Corp Preparation of sobrerol
CH568951A5 (ko) * 1970-04-17 1975-11-14 Corvi Camillo Spa

Also Published As

Publication number Publication date
EP0170839B1 (en) 1989-08-30
EP0170839A2 (en) 1986-02-12
KR920001788B1 (ko) 1992-03-02
IT1180220B (it) 1987-09-23
DE3572649D1 (en) 1989-10-05
JPS6147432A (ja) 1986-03-07
US4596894A (en) 1986-06-24
IT8422257A0 (it) 1984-08-08
EP0170839A3 (en) 1987-06-03
JPS647057B2 (ko) 1989-02-07
ATE45939T1 (de) 1989-09-15

Similar Documents

Publication Publication Date Title
KR860001778A (ko) (-)-5-(1-하이드록시-1-메틸에틸)-2-메틸-2-싸이클로헥센-1-온에서 유도된 디아스테레오머 혼합물의 제조방법
IE39521L (en) Preparation of 2,2,6,6-tetramethyl-4-oxopiperidine
SU638597A1 (ru) 4-Метил-2-пропенилтетрагидропиранол-4 в качестве душистого вещества дл парфюмерных композиций
IT1058547B (it) Procedimento di ciclizzazione del deidrolinalolo e prodotti ottenuti con tale procedimento
KR860002959A (ko) 제초제 중간화합물의 제법
KR840002771A (ko) 인슐린, 인슐린 유도체 및 불순물의 혼합물을 분리하는 방법
ATE14875T1 (de) Herstellung von diaminodiphenylethern.
GB1387908A (en) Polymerisable anthranilic acid esters
JPS552650A (en) Heterocyclic benzamide compound and its preparation
GB1515614A (en) Preparation of m-benzoylhydratropic acid and an intermediate therefor
ATE34169T1 (de) Verfahren zur herstellung von methyl-nmethylanthranilat.
JPS5430156A (en) Synthesis of benzamide derivative
KR850006428A (ko) 에리드로마이신 아세트산염의 제조방법
ES456325A1 (es) Un procedimiento para la preparacion de nuevos derivados delacido 4-hidroxi-2-quinolinon-3-carboxilico.
KR900009684A (ko) β-시토스테롤의 제조방법
KR860002473A (ko) 4-메틸-5-티오포름아미디노메틸이미다졸 디하이드로클로라이드의 제조방법
JPS52106857A (en) Preparation of 1,3-disubstituted-2-azetidinones
ES2004522A6 (es) Nuevo procedimiento para la preparacion de 4-(6' - metoxi-2'-naftil)butan-2-ona.
JPS5359638A (en) Preparation of adrenalone
KR870005008A (ko) 4'-O-테트라히드로피라닐아드리아마이신 b의 제조방법
JPS5217447A (en) Process for preparation of trans-4- aminomethylcyclohexane-carboxylic acid ester
KR850007276A (ko) 신규의 항생물질 6270의 제조법
KR850008493A (ko) N-포르밀-디티오포스폰산 아미드의 제조방법
KR920007967A (ko) 케탈의 연속 제조방법
JPS5271430A (en) Preparation of alkylphenylsulfide

Legal Events

Date Code Title Description
A201 Request for examination
G160 Decision to publish patent application
E701 Decision to grant or registration of patent right
NORF Unpaid initial registration fee