IT1180220B - Miscela di composti diastereoisomeri, ottenuti da (-)-5-(1-idrossi-1-metiletil)-2-metil-2-cicloesen-1-one, avente attivita' mucosecretolitica, procedimento per la sua preparazione e composizioni farmaceutiche che la contengono - Google Patents

Miscela di composti diastereoisomeri, ottenuti da (-)-5-(1-idrossi-1-metiletil)-2-metil-2-cicloesen-1-one, avente attivita' mucosecretolitica, procedimento per la sua preparazione e composizioni farmaceutiche che la contengono

Info

Publication number
IT1180220B
IT1180220B IT22257/84A IT2225784A IT1180220B IT 1180220 B IT1180220 B IT 1180220B IT 22257/84 A IT22257/84 A IT 22257/84A IT 2225784 A IT2225784 A IT 2225784A IT 1180220 B IT1180220 B IT 1180220B
Authority
IT
Italy
Prior art keywords
methyl
hydroxy
mixture
contain
pharmaceutical compositions
Prior art date
Application number
IT22257/84A
Other languages
English (en)
Other versions
IT8422257A0 (it
Inventor
Mora Camillo Corvi
Original Assignee
Corvi Camillo Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Corvi Camillo Spa filed Critical Corvi Camillo Spa
Priority to IT22257/84A priority Critical patent/IT1180220B/it
Publication of IT8422257A0 publication Critical patent/IT8422257A0/it
Priority to US06/746,559 priority patent/US4596894A/en
Priority to EP85107579A priority patent/EP0170839B1/en
Priority to DE8585107579T priority patent/DE3572649D1/de
Priority to AT85107579T priority patent/ATE45939T1/de
Priority to KR1019850005443A priority patent/KR920001788B1/ko
Priority to JP60172534A priority patent/JPS6147432A/ja
Application granted granted Critical
Publication of IT1180220B publication Critical patent/IT1180220B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/36—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal
    • C07C29/38—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal by reaction with aldehydes or ketones
    • C07C29/40—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal by reaction with aldehydes or ketones with compounds containing carbon-to-metal bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/10—Expectorants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C35/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C35/02—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring monocyclic
    • C07C35/08—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring monocyclic containing a six-membered rings
    • C07C35/18—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring monocyclic containing a six-membered rings with unsaturation at least in the ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/29—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups
    • C07C45/292—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups with chromium derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Steroid Compounds (AREA)
IT22257/84A 1984-08-08 1984-08-08 Miscela di composti diastereoisomeri, ottenuti da (-)-5-(1-idrossi-1-metiletil)-2-metil-2-cicloesen-1-one, avente attivita' mucosecretolitica, procedimento per la sua preparazione e composizioni farmaceutiche che la contengono IT1180220B (it)

Priority Applications (7)

Application Number Priority Date Filing Date Title
IT22257/84A IT1180220B (it) 1984-08-08 1984-08-08 Miscela di composti diastereoisomeri, ottenuti da (-)-5-(1-idrossi-1-metiletil)-2-metil-2-cicloesen-1-one, avente attivita' mucosecretolitica, procedimento per la sua preparazione e composizioni farmaceutiche che la contengono
US06/746,559 US4596894A (en) 1984-08-08 1985-06-19 Mixture of diasteroisomer compounds, as obtained from (-)-5-(1-hydroxy-1-methylethyl)-2-methyl-2-cyclohexene-1-one, having mucosecretolytic activity, a process for its preparation and pharmaceutical compositions containing the same
EP85107579A EP0170839B1 (en) 1984-08-08 1985-06-19 A mixture of diastereoisomer compounds, as obtained from (-)-5-(1-hydroxy-1-methylethyl)-2-methyl-2-cyclohexene-1-one, having mucose-cretolytic activity, a process for its preparation and pharmaceutical compositions containing the same
DE8585107579T DE3572649D1 (en) 1984-08-08 1985-06-19 A mixture of diastereoisomer compounds, as obtained from (-)-5-(1-hydroxy-1-methylethyl)-2-methyl-2-cyclohexene-1-one, having mucose-cretolytic activity, a process for its preparation and pharmaceutical compositions containing the same
AT85107579T ATE45939T1 (de) 1984-08-08 1985-06-19 Mischung von diastereoisomeren verbindungen, erhalten aus (-)-5-(1-hydroxy-1-methylaethyl)-2methyl-2-cyclohexen-1-on mit mucosecretolytischer wirkung, ihr herstellungsverfahren und diese enthaltende pharmazeutische kompositionen.
KR1019850005443A KR920001788B1 (ko) 1984-08-08 1985-07-29 (-)-5-(1-하이드록시-1-메틸에틸)-2-메틸-2-싸이클로헥센-1-온에서 유도된 디아스테레오머 혼합물의 제조 방법
JP60172534A JPS6147432A (ja) 1984-08-08 1985-08-07 ジアステレオマー化合物の混合物

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT22257/84A IT1180220B (it) 1984-08-08 1984-08-08 Miscela di composti diastereoisomeri, ottenuti da (-)-5-(1-idrossi-1-metiletil)-2-metil-2-cicloesen-1-one, avente attivita' mucosecretolitica, procedimento per la sua preparazione e composizioni farmaceutiche che la contengono

Publications (2)

Publication Number Publication Date
IT8422257A0 IT8422257A0 (it) 1984-08-08
IT1180220B true IT1180220B (it) 1987-09-23

Family

ID=11193758

Family Applications (1)

Application Number Title Priority Date Filing Date
IT22257/84A IT1180220B (it) 1984-08-08 1984-08-08 Miscela di composti diastereoisomeri, ottenuti da (-)-5-(1-idrossi-1-metiletil)-2-metil-2-cicloesen-1-one, avente attivita' mucosecretolitica, procedimento per la sua preparazione e composizioni farmaceutiche che la contengono

Country Status (7)

Country Link
US (1) US4596894A (it)
EP (1) EP0170839B1 (it)
JP (1) JPS6147432A (it)
KR (1) KR920001788B1 (it)
AT (1) ATE45939T1 (it)
DE (1) DE3572649D1 (it)
IT (1) IT1180220B (it)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH681060A5 (it) * 1990-08-22 1993-01-15 Riace Ets
KR102427155B1 (ko) 2015-08-25 2022-07-29 삼성디스플레이 주식회사 레이저 결정화 장치

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2949489A (en) * 1958-06-23 1960-08-16 Fmc Corp Preparation of sobrerol
CH568951A5 (it) * 1970-04-17 1975-11-14 Corvi Camillo Spa

Also Published As

Publication number Publication date
JPS6147432A (ja) 1986-03-07
JPS647057B2 (it) 1989-02-07
IT8422257A0 (it) 1984-08-08
EP0170839A3 (en) 1987-06-03
KR920001788B1 (ko) 1992-03-02
ATE45939T1 (de) 1989-09-15
EP0170839A2 (en) 1986-02-12
KR860001778A (ko) 1986-03-22
US4596894A (en) 1986-06-24
EP0170839B1 (en) 1989-08-30
DE3572649D1 (en) 1989-10-05

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