WO1991006293A3 - Composition containing 2,3-butanedione monoxime and method for reversibly arresting muscle activity - Google Patents
Composition containing 2,3-butanedione monoxime and method for reversibly arresting muscle activity Download PDFInfo
- Publication number
- WO1991006293A3 WO1991006293A3 PCT/US1990/006241 US9006241W WO9106293A3 WO 1991006293 A3 WO1991006293 A3 WO 1991006293A3 US 9006241 W US9006241 W US 9006241W WO 9106293 A3 WO9106293 A3 WO 9106293A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- arresting
- reversibly
- muscle activity
- composition containing
- butanedione monoxime
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/15—Oximes (>C=N—O—); Hydrazines (>N—N<); Hydrazones (>N—N=) ; Imines (C—N=C)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
- A01N1/0205—Chemical aspects
- A01N1/021—Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
- A01N1/0205—Chemical aspects
- A01N1/021—Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
- A01N1/0226—Physiologically active agents, i.e. substances affecting physiological processes of cells and tissue to be preserved, e.g. anti-oxidants or nutrients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Environmental Sciences (AREA)
- Wood Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Dentistry (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Biophysics (AREA)
- Physiology (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US43061489A | 1989-11-01 | 1989-11-01 | |
US430,614 | 1989-11-01 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1991006293A2 WO1991006293A2 (en) | 1991-05-16 |
WO1991006293A3 true WO1991006293A3 (en) | 1991-06-13 |
Family
ID=23708314
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1990/006241 WO1991006293A2 (en) | 1989-11-01 | 1990-11-01 | Composition containing 2,3-butanedione monoxime and method for reversibly arresting muscle activity |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO1991006293A2 (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2723818B1 (en) * | 1994-08-25 | 1999-03-05 | Implants & Instr Chirurg | INFUSION COMPOSITION FOR IMPROVING THE PRESERVATION OF LIVING ORGANS |
AU4990599A (en) * | 1998-07-14 | 2000-02-07 | Brigham And Women's Hospital | Upregulation of type iii endothelial cell nitric oxide synthase by agents that disrupt actin cytoskeletal organization |
GB0028414D0 (en) | 2000-11-22 | 2001-01-03 | Univ Leeds | Flush preservation solution |
-
1990
- 1990-11-01 WO PCT/US1990/006241 patent/WO1991006293A2/en active Application Filing
Non-Patent Citations (11)
Title |
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AM. J. PHYSIOL., Vol. 255, No. 1, part 2, 1988, THE AMERICAN PHYSIOLOGICAL SOCIETY, W.G. NAYLER et al., "The Stunned Myo-Cardium: Effect of Electrical and Mechanical Arrest and Osmolarity", pages H60-H69. * |
BIOPHYSICAL JOURNAL, Vol. 47, No. 2, part 2, T-Pos197, February 1985, The Rockefeller University Press, T.B. WARREN et al., "Effects of 2,3-Butanedione Monoxime (BDM) on Force Production and Myosin Light Chain Phosphorylation (MYLCP) in Mammalian Smooth and Skeletal Muscle"; & 29TH ANN. MEET. BIOPHYS. SOC., Baltimore, 24-28 Feb 1985, see page 295a. * |
CHEMICAL ABSTRACTS, Vol. 102, No. 23, abstract 199072c, 10 June 1985, (Columbus, Ohio, US), T. LI et al., "Effects of Diacetyl Monoxime on Cardiac Excitation-Contraction Coupling"; & J. PHARMACOL. EXP. THER. 1985, 232(3), 688-95, see page 173. * |
CHEMICAL ABSTRACTS, Vol. 108, No. 13, 106325y, 28 March 1988, (Columbus, Ohio, US), M.W. FRYER et al., "Paralysis of Skeletal Muscle by Butanedione Monoxime, a Chemical Phosphatase"; & PFLUEGERS ARCH. 1988, 411(1), 76-9, see page 53. * |
CHEMICAL ABSTRACTS, Vol. 109, No. 23, 208977a, 5 December 1988, (Columbus, Ohio, US), C.S. PACKER et al., "The Effect of 2,3-Butanedione Monoxime (BDM) in Smooth Muscle Mechanical Properties"; & PFLUEGERS ARCH. 1988, 412(6), 659-64, see page 471. * |
CIRC. RES., Vol. 65, No. 5, November 1989, L.A. MULIERI et al., "Protection of Human Left Ventricular Myocardium from Cutting Injury with 2,3-Butanedione Monoxime", pages 1441-1444. * |
DIALOG INFORMATION SERVICES FILE 155, (Medline), Accession No. 02957493, J.R. WILLIAMSON et al., "Contribution of Tissue Acidosis to Ischemic Injury in the Perfused Rat Heart"; & CIRCULATION, Mar. 1976, 53(3 Suppl. 1), p. 3-14. * |
DIALOG INFORMATION SERVICES FILE 155, (Medline), Accession No. 04841582, PH SUGDEN et al., "The Effect of Glucose, Acatate, Lactate and Insulin on Protein Degradation in the Perfused Rat Heart"; & BIOCHEM J, 15 Sep. 1982, 206(3), p. 467-72. * |
LABORATORY INVESTIGATION, Vol. 58, No. 6, 1988, THE UNITED STATES AND CANADIAN ACADEMY OF PATHOLOGY INC, (US), J.S. ELZ et al., "Contractile Activity and Reperfusion-Induced Calcium Gain After Ischemia in the Isolated Rat Heart", pages 653-659. * |
PFLUEGERS ARCH., Vol. 416, No. 1-2, April 1990, SPRINGER-VERLAG, E.M. BLANCHARD et al., "The Effect of 2,3-Butanedione Monoxime on Initial Beat, Tension, and Aequorin Light Output of Ferret Papillary Muscles", pages 219-221. * |
THE AMERICAN JOURNAL OF CARDIOLOGY, Vol. 63, No. 10, 7 March 1989, J.S. ELZ et al., "Reperfusion-Induced Calcium Gain After Ischemia", pages 7E-13E. * |
Also Published As
Publication number | Publication date |
---|---|
WO1991006293A2 (en) | 1991-05-16 |
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