ATE67497T1 - Verfahren zur herstellung von thiazolidinedionderivaten. - Google Patents
Verfahren zur herstellung von thiazolidinedionderivaten.Info
- Publication number
- ATE67497T1 ATE67497T1 AT87306425T AT87306425T ATE67497T1 AT E67497 T1 ATE67497 T1 AT E67497T1 AT 87306425 T AT87306425 T AT 87306425T AT 87306425 T AT87306425 T AT 87306425T AT E67497 T1 ATE67497 T1 AT E67497T1
- Authority
- AT
- Austria
- Prior art keywords
- compound
- chem
- formula
- given above
- meaning given
- Prior art date
Links
- 150000001467 thiazolidinediones Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 10
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000005278 alkyl sulfonyloxy group Chemical group 0.000 abstract 1
- 125000005279 aryl sulfonyloxy group Chemical group 0.000 abstract 1
- 238000010531 catalytic reduction reaction Methods 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 230000002140 halogenating effect Effects 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 150000003461 sulfonyl halides Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/30—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- General Chemical & Material Sciences (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Endocrinology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP17427886 | 1986-07-24 | ||
| EP19870306425 EP0257781B1 (de) | 1986-07-24 | 1987-07-20 | Verfahren zur Herstellung von Thiazolidinedion-Derivaten |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE67497T1 true ATE67497T1 (de) | 1991-10-15 |
Family
ID=15975864
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT87306425T ATE67497T1 (de) | 1986-07-24 | 1987-07-20 | Verfahren zur herstellung von thiazolidinedionderivaten. |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US4812570A (de) |
| EP (1) | EP0257781B1 (de) |
| JP (1) | JP2611244B2 (de) |
| KR (1) | KR950008312B1 (de) |
| AT (1) | ATE67497T1 (de) |
| DE (1) | DE3773089D1 (de) |
| ES (1) | ES2037718T3 (de) |
| GR (1) | GR3003381T3 (de) |
| HU (1) | HU198043B (de) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1988009661A1 (en) * | 1987-06-10 | 1988-12-15 | Pfizer Inc. | Oxazolidin-2-one derivatives as hypoglycemic agents |
| US4956374A (en) * | 1988-07-29 | 1990-09-11 | Bristol-Myers Company | Polysubstituted thiazolylpyridine carboxyamide antifungal antibiotic |
| GB8919417D0 (en) * | 1989-08-25 | 1989-10-11 | Beecham Group Plc | Novel compounds |
| US5053420A (en) * | 1989-10-13 | 1991-10-01 | Pershadsingh Harrihar A | Thiazolidine derivatives for the treatment of hypertension |
| EP0454501B1 (de) * | 1990-04-27 | 2001-09-05 | Sankyo Company Limited | Benzylidenthiazolidinderivate, ihre Herstellung und ihre Anwendung als Lipidperoxid-Inhibitoren |
| JP2687811B2 (ja) * | 1991-03-25 | 1997-12-08 | 武田薬品工業株式会社 | エーテル類の製造法 |
| DE69202715T2 (de) * | 1991-03-25 | 1995-11-23 | Takeda Chemical Industries Ltd | Verfahren zur Herstellung von Ethern. |
| FR2680512B1 (fr) * | 1991-08-20 | 1995-01-20 | Adir | Nouveaux derives de 2,4-thiazolidinedione, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
| WO1993013095A1 (en) * | 1991-12-20 | 1993-07-08 | The Upjohn Company | A reduction method for substituted 5-methylene-thiazolidinediones |
| WO1993022445A1 (en) * | 1992-05-05 | 1993-11-11 | The Upjohn Company | A process for producing pioglitazone metabolite |
| US5594015A (en) * | 1994-06-22 | 1997-01-14 | Regents Of The University Of California | Thiazolidine derivatives for the treatment of psoriasis |
| US5952509A (en) * | 1996-06-27 | 1999-09-14 | Takeda Chemical Industries, Ltd. | Production of benzaldehyde compounds |
| AU8539398A (en) * | 1997-06-18 | 1999-01-04 | Smithkline Beecham Plc | Treatment of diabetes with thiazolidinedione and metformin |
| KR20080011356A (ko) | 1997-06-18 | 2008-02-01 | 스미스클라인비이참피이엘시이 | 티아졸리딘디온 및 술포닐우레아를 사용한 당뇨병의 치료 |
| GB9715295D0 (en) * | 1997-07-18 | 1997-09-24 | Smithkline Beecham Plc | Novel method of treatment |
| GB9715306D0 (en) * | 1997-07-18 | 1997-09-24 | Smithkline Beecham Plc | Novel method of treatment |
| GB9723295D0 (en) | 1997-11-04 | 1998-01-07 | Smithkline Beecham Plc | Novel process |
| US7091359B2 (en) | 1997-11-04 | 2006-08-15 | Smithkline Beecham Plc | Process for the preparation of thiazolidinedione derivatives |
| GB9726568D0 (en) * | 1997-12-16 | 1998-02-11 | Smithkline Beecham Plc | Novel pharmaceutical |
| GB9824893D0 (en) * | 1998-11-12 | 1999-01-06 | Smithkline Beckman Corp | Novel method of treatment |
| DZ2937A1 (fr) * | 1998-11-12 | 2004-03-15 | Smithkline Beecham Plc | Compositions nouvelles de sensibilidants à l'insuline. |
| CA2351058A1 (en) * | 1998-11-12 | 2000-05-25 | Smithkline Beecham P.L.C. | Pharmaceutical composition for modified release of an insulin sensitiser and another antidiabetic agent |
| WO2001002377A1 (en) * | 1999-07-01 | 2001-01-11 | Geron Corporation | Telomerase inhibitors and methods of their use |
| JP2001072592A (ja) | 1999-07-01 | 2001-03-21 | Kyowa Hakko Kogyo Co Ltd | テロメラーゼ阻害剤 |
| GB0014969D0 (en) | 2000-06-19 | 2000-08-09 | Smithkline Beecham Plc | Novel method of treatment |
| US6452014B1 (en) | 2000-12-22 | 2002-09-17 | Geron Corporation | Telomerase inhibitors and methods of their use |
| FR2820741A1 (fr) * | 2001-02-14 | 2002-08-16 | Ppg Sipsy | Procede de preparation de composes derives de thiazolidinedione, d'oxazolidinedione ou d'hydantoine |
| FR2820742B1 (fr) * | 2001-02-14 | 2005-03-11 | Ppg Sipsy | Procede de preparation de composes derives de thiazolidinedione, d'oxazolidinedione ou d'hydantoine |
| IL162460A0 (en) * | 2001-12-20 | 2005-11-20 | Teva Pharma | Hydrogenation of precursors to thiazolidinedione antihyperglycemics |
| TR200302265T1 (tr) * | 2002-06-19 | 2004-08-23 | Eös Eczacibaşi Özgün Ki̇myasal Ürünler San. Ve Ti̇c. A.Ş. | Sübstitiye fenil eterlerin üretimi için proses |
| EP1521753B1 (de) * | 2002-07-16 | 2007-09-05 | Cadila Healthcare Ltd. | Prozess zur herstellung von pioglitazon via verschiedene zwischenstufen |
| US8993773B2 (en) | 2002-07-16 | 2015-03-31 | Cadila Healthcare Limited | Process to prepare pioglitazone via several novel intermediates |
| US7232828B2 (en) * | 2002-08-10 | 2007-06-19 | Bethesda Pharmaceuticals, Inc. | PPAR Ligands that do not cause fluid retention, edema or congestive heart failure |
| WO2004066952A2 (en) * | 2003-01-29 | 2004-08-12 | Incyte Corporation | Benzoxazole, benzothiazole, and benzimidazole derivatives for the treatment of cancer and other diseases |
| HUP0304096A2 (hu) * | 2003-12-19 | 2005-08-29 | Richter Gedeon Vegyészeti Gyár Rt. | Eljárás pioglitazon hidrogénklorid előállítására és intermedierjei |
| WO2005080387A2 (en) | 2004-02-20 | 2005-09-01 | Synthon B.V. | Processes for making pioglitazone and compounds of the processes |
| US7435741B2 (en) * | 2006-05-09 | 2008-10-14 | Teva Pharmaceutical Industries, Ltd. | 2-N{5-[[4-[2-(methyl-2-pyridinylamino) ethoxy] phenyl]methyl]-2,4-thiazolidinedione} butanedioic acid, methods of preparation and compositions with rosiglitazone maleate |
| US20160331729A9 (en) * | 2007-04-11 | 2016-11-17 | Omeros Corporation | Compositions and methods for prophylaxis and treatment of addictions |
| US11241420B2 (en) | 2007-04-11 | 2022-02-08 | Omeros Corporation | Compositions and methods for prophylaxis and treatment of addictions |
| RU2492858C2 (ru) | 2007-04-11 | 2013-09-20 | Омерос Корпорейшн | Композиции и способы профилактики и лечения зависимостей |
| WO2008142706A2 (en) * | 2007-05-18 | 2008-11-27 | Matrix Laboratories Ltd | Novel process for the synthesis of pioglitazone and its salts thereof |
| JP2009023572A (ja) * | 2007-07-23 | 2009-02-05 | Hitachi Ltd | 移動車両 |
| US20090118514A1 (en) * | 2007-11-06 | 2009-05-07 | Raghupathi Reddy Anumula | Processes for preparing pioglitazone and its pharmaceutically acceptable salts |
| KR20170093264A (ko) | 2009-03-11 | 2017-08-14 | 오메로스 코포레이션 | 중독의 예방 및 치료용 조성물 및 방법 |
| US10429384B2 (en) | 2010-01-22 | 2019-10-01 | Dana-Farber Cancer Institute, Inc. | Compositions, kits, and methods for identification, assessment, prevention, and therapy of metabolic disorders |
| US20120094959A1 (en) | 2010-10-19 | 2012-04-19 | Bonnie Blazer-Yost | Treatment of cystic diseases |
| WO2012153312A1 (en) | 2011-05-11 | 2012-11-15 | Ranbaxy Laboratories Limited | Process for the purification of pioglitazone |
| JP2013241361A (ja) * | 2012-05-21 | 2013-12-05 | Tokuyama Corp | ５−ベンジル−２，４−チアゾリジンジオン誘導体の製造方法 |
| AU2013340478B2 (en) | 2012-11-05 | 2018-08-23 | Commissariat A L'energie Atomique Et Aux Energies Alternatives (Cea) | Combination of an anti-cancer agent such as a tyrosinekinase inhibitor and a STAT5 antagonist, preferably a thiazolidinedione, for eliminating hematologic cancer stem cells in vivo and for preventing hematologic cancer relapse |
| JP6060916B2 (ja) | 2014-02-12 | 2017-01-18 | マツダ株式会社 | 自動車の前部整流構造 |
| WO2016071727A1 (en) | 2014-11-04 | 2016-05-12 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for the prevention and the treatment of rapidly progressive glomerulonephritis |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4582839A (en) * | 1984-03-21 | 1986-04-15 | Takeda Chemical Industries, Ltd. | 2,4-thiazolidinediones |
| CN1003445B (zh) * | 1984-10-03 | 1989-03-01 | 武田药品工业株式会社 | 噻唑烷二酮衍生物，其制备方法和用途 |
| AR240698A1 (es) * | 1985-01-19 | 1990-09-28 | Takeda Chemical Industries Ltd | Procedimiento para preparar compuestos de 5-(4-(2-(5-etil-2-piridil)-etoxi)benzil)-2,4-tiazolidindiona y sus sales |
-
1987
- 1987-07-14 US US07/073,695 patent/US4812570A/en not_active Expired - Lifetime
- 1987-07-20 EP EP19870306425 patent/EP0257781B1/de not_active Expired - Lifetime
- 1987-07-20 DE DE8787306425T patent/DE3773089D1/de not_active Expired - Lifetime
- 1987-07-20 AT AT87306425T patent/ATE67497T1/de not_active IP Right Cessation
- 1987-07-20 ES ES198787306425T patent/ES2037718T3/es not_active Expired - Lifetime
- 1987-07-23 JP JP62184859A patent/JP2611244B2/ja not_active Expired - Lifetime
- 1987-07-23 KR KR1019870008026A patent/KR950008312B1/ko not_active Expired - Lifetime
- 1987-07-24 HU HU873411A patent/HU198043B/hu unknown
-
1988
- 1988-12-29 US US07/291,782 patent/US4898947A/en not_active Ceased
-
1991
- 1991-12-18 GR GR91402068T patent/GR3003381T3/el unknown
-
1997
- 1997-10-10 US US08/948,515 patent/USRE36575E/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| GR3003381T3 (en) | 1993-02-17 |
| JPS63139182A (ja) | 1988-06-10 |
| JP2611244B2 (ja) | 1997-05-21 |
| KR950008312B1 (ko) | 1995-07-27 |
| US4898947A (en) | 1990-02-06 |
| HU198043B (en) | 1989-07-28 |
| US4812570A (en) | 1989-03-14 |
| EP0257781A1 (de) | 1988-03-02 |
| HUT47571A (en) | 1989-03-28 |
| USRE36575E (en) | 2000-02-15 |
| KR880001647A (ko) | 1988-04-25 |
| EP0257781B1 (de) | 1991-09-18 |
| DE3773089D1 (de) | 1991-10-24 |
| ES2037718T3 (es) | 1993-07-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| EETV | Partially withdrawn | ||
| EELA | Cancelled due to lapse of time |