ATE117314T1 - Verfahren zur herstellung von o2,2'-anhydro-1- (beta-d-arabinofuranosyl)thymin. - Google Patents

Verfahren zur herstellung von o2,2'-anhydro-1- (beta-d-arabinofuranosyl)thymin.

Info

Publication number
ATE117314T1
ATE117314T1 AT89306820T AT89306820T ATE117314T1 AT E117314 T1 ATE117314 T1 AT E117314T1 AT 89306820 T AT89306820 T AT 89306820T AT 89306820 T AT89306820 T AT 89306820T AT E117314 T1 ATE117314 T1 AT E117314T1
Authority
AT
Austria
Prior art keywords
beta
arabinofuranosyl
anhydro
thymine
producing
Prior art date
Application number
AT89306820T
Other languages
English (en)
Inventor
Charles William Murtiashaw
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Application granted granted Critical
Publication of ATE117314T1 publication Critical patent/ATE117314T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/09—Pyrimidine radicals with arabinosyl as the saccharide radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Virology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
AT89306820T 1988-07-12 1989-07-05 Verfahren zur herstellung von o2,2'-anhydro-1- (beta-d-arabinofuranosyl)thymin. ATE117314T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/217,906 US5008384A (en) 1988-07-12 1988-07-12 Process for the production of O.sup. 2,2'-anhydro-1-(β-D-arabinofuranosyl)thymine

Publications (1)

Publication Number Publication Date
ATE117314T1 true ATE117314T1 (de) 1995-02-15

Family

ID=22812966

Family Applications (1)

Application Number Title Priority Date Filing Date
AT89306820T ATE117314T1 (de) 1988-07-12 1989-07-05 Verfahren zur herstellung von o2,2'-anhydro-1- (beta-d-arabinofuranosyl)thymin.

Country Status (21)

Country Link
US (1) US5008384A (de)
EP (1) EP0351126B1 (de)
JP (1) JPH075626B2 (de)
KR (1) KR910008112B1 (de)
CN (1) CN1039423A (de)
AT (1) ATE117314T1 (de)
AU (1) AU603042B2 (de)
CA (1) CA1315776C (de)
DD (2) DD292003A5 (de)
DE (1) DE68920648T2 (de)
DK (1) DK342189A (de)
ES (1) ES2066853T3 (de)
FI (1) FI893364A7 (de)
GR (1) GR3015293T3 (de)
HU (1) HUT50843A (de)
IE (1) IE65735B1 (de)
IL (1) IL90884A0 (de)
NO (1) NO892821L (de)
PT (1) PT91113B (de)
YU (1) YU138789A (de)
ZA (1) ZA895259B (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992009599A1 (fr) * 1990-11-30 1992-06-11 Yamasa Shoyu Kabushiki Kaisha PROCEDE DE PRODUCTION DE 1-(2,3-DIDESOXY-β-D-GLYCERO-PENT-2-ENOFURANOSYL)THYMINE
US5596087A (en) * 1994-05-20 1997-01-21 Council Of Scientific & Industrial Research Process for the preparation of beta thymidine
US7125983B2 (en) 2000-11-29 2006-10-24 Mitsui Chemicals, Inc. L-nucleic acid derivatives and process for the synthesis thereof
ES2243726T3 (es) * 2001-03-30 2005-12-01 Gilead Sciences, Inc. Procedimiento de preparacion de 2'-halo-beta-l-arabinofuranosil nucleosidos.
DE10216426A1 (de) * 2002-04-12 2003-10-23 Boehringer Ingelheim Pharma Verfahren zur Herstellung von beta-L-2'Deoxy-Thymidin
US7595390B2 (en) 2003-04-28 2009-09-29 Novartis Ag Industrially scalable nucleoside synthesis
EP1639121A4 (de) 2003-06-30 2008-04-16 Idenix Cayman Ltd Synthese von beta-l-2-desoxynukleosiden
BRPI0709401A2 (pt) 2006-03-15 2011-07-05 Novartis Ag processo para a preparação de derivados de ácido beta-nucléico e intermediários dos mesmos
US7998967B2 (en) 2008-03-03 2011-08-16 Tosk, Incorporated Methotrexate adjuvants to reduce toxicity and methods for using the same
US11446303B2 (en) 2019-06-21 2022-09-20 Tosk, Inc. Uridine phosphorylase (UPase) inhibitors for treatment of liver conditions

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3322747A (en) * 1965-04-01 1967-05-30 Merck & Co Inc Thionocarbonate nucleosides
US3463850A (en) * 1967-01-03 1969-08-26 Merck & Co Inc Arabinofuranosyl 2-thiopyrimidines and pharmaceutical compositions thereof
US3658788A (en) * 1969-06-06 1972-04-25 Salk Inst For Biological Studi Aminooxazolines and products thereof and processes for synthesizing same
US3812098A (en) * 1970-03-19 1974-05-21 Syntex Inc O2,2'-anhydro-1-(beta-d-arabinofuranosyl)-cytosine derivatives and methods of making and related procedures
US3792040A (en) * 1970-03-19 1974-02-12 Syntex Corp Acyl derivatives of o2,2'-anhydro-1-(beta-d-arabinofuranosyl)-cytosines and methods of preparing
US3709874A (en) * 1970-03-19 1973-01-09 Syntex Corp 1-beta-d-arabinofuranosyl cytosine derivatives and methods of preparing
US3920630A (en) * 1970-09-24 1975-11-18 Upjohn Co 2,2{40 -Anhydro-ara-cytidine compounds and process of preparation
SE391183B (sv) * 1971-04-15 1977-02-07 Asahi Chemical Ind 2',3'-0-sulfinylcytidin och syraadditionssalter derav till anvendning som mellanprodukt for framstellning av 2,2'-anhydro-(1-beta-d-arabinofuranosyl) cytosin
US3978042A (en) * 1975-01-31 1976-08-31 The Upjohn Company Process for preparing cyclocytidine derivatives
US4140850A (en) * 1977-08-29 1979-02-20 The Upjohn Company 2,2'-Anhydrotriazine nucleosides and process for preparing the same
JPS5649398A (en) * 1979-09-28 1981-05-02 Yamasa Shoyu Co Ltd Preparation of 1-beta-d-arabinofuranosyl-2,2'-cyclothymine
JPS636557A (ja) * 1986-06-26 1988-01-12 Sharp Corp 微細パタ−ン形成方法

Also Published As

Publication number Publication date
KR910008112B1 (ko) 1991-10-10
DD292003A5 (de) 1991-07-18
ZA895259B (en) 1991-02-27
JPH075626B2 (ja) 1995-01-25
NO892821D0 (no) 1989-07-07
DE68920648D1 (de) 1995-03-02
US5008384A (en) 1991-04-16
DD284024A5 (de) 1990-10-31
PT91113A (pt) 1990-02-08
HUT50843A (en) 1990-03-28
IL90884A0 (en) 1990-02-09
YU138789A (en) 1990-12-31
DK342189A (da) 1990-01-15
DK342189D0 (da) 1989-07-11
KR900001704A (ko) 1990-02-27
EP0351126B1 (de) 1995-01-18
AU603042B2 (en) 1990-11-01
CN1039423A (zh) 1990-02-07
EP0351126A2 (de) 1990-01-17
DE68920648T2 (de) 1995-05-18
NO892821L (no) 1990-01-15
GR3015293T3 (en) 1995-06-30
FI893364A7 (fi) 1990-01-13
PT91113B (pt) 1995-01-31
EP0351126A3 (en) 1990-10-24
JPH0259598A (ja) 1990-02-28
IE892233L (en) 1990-01-12
CA1315776C (en) 1993-04-06
ES2066853T3 (es) 1995-03-16
IE65735B1 (en) 1995-11-15
AU3802089A (en) 1990-04-26
FI893364A0 (fi) 1989-07-11

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee