ES2066853T3 - Procedimiento para la produccion de o2,2'-anhidro-1-(beta-d-arabinofuranosil)timina. - Google Patents

Procedimiento para la produccion de o2,2'-anhidro-1-(beta-d-arabinofuranosil)timina.

Info

Publication number
ES2066853T3
ES2066853T3 ES89306820T ES89306820T ES2066853T3 ES 2066853 T3 ES2066853 T3 ES 2066853T3 ES 89306820 T ES89306820 T ES 89306820T ES 89306820 T ES89306820 T ES 89306820T ES 2066853 T3 ES2066853 T3 ES 2066853T3
Authority
ES
Spain
Prior art keywords
beta
anhydro
thymine
arabinofuranosil
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89306820T
Other languages
English (en)
Inventor
Charles William Murtiashaw
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Application granted granted Critical
Publication of ES2066853T3 publication Critical patent/ES2066853T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/09—Pyrimidine radicals with arabinosyl as the saccharide radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Virology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

EN EL PROCEDIMIENTO DESCRITO SE FORMA UNA O2,2''-ANHIDRO-1((BETA)-D-ARABINOFURANOSIL)TIMINA, POR CONDENSACION DE UNA 2-AMINO(BETA)-ARABINOFURANO[1'',2'':4,5]-OXAZOLINA CON UN COMPUESTO DE FORMULA: (FIG. A), DONDE R1 ES ALQUILO C1-C4; X ES HALOGENO O OR2, DONDE R2 ES H, ALQUILO C1-C4 O FENILO; EN PRESENCIA DE UN DISOLVENTE ADECUADO A 0-150 (GRADOS) C APROXIMADAMENTE. TAMBIEN SE PUEDEN AÑADIR AGENTES CATALITICOS, TALES COMO DIMETILAMINO PIRIDINA Y TRIETILAMINA PARA ACEPERAR LA REACCION. TAMBIEN INTERMEDIOS PROTEGIDOS DE LOS ANHIDRONUCLEOSIDOS Y AMINOOXAZOLINAS.
ES89306820T 1988-07-12 1989-07-05 Procedimiento para la produccion de o2,2'-anhidro-1-(beta-d-arabinofuranosil)timina. Expired - Lifetime ES2066853T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/217,906 US5008384A (en) 1988-07-12 1988-07-12 Process for the production of O.sup. 2,2'-anhydro-1-(β-D-arabinofuranosyl)thymine

Publications (1)

Publication Number Publication Date
ES2066853T3 true ES2066853T3 (es) 1995-03-16

Family

ID=22812966

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89306820T Expired - Lifetime ES2066853T3 (es) 1988-07-12 1989-07-05 Procedimiento para la produccion de o2,2'-anhidro-1-(beta-d-arabinofuranosil)timina.

Country Status (21)

Country Link
US (1) US5008384A (es)
EP (1) EP0351126B1 (es)
JP (1) JPH075626B2 (es)
KR (1) KR910008112B1 (es)
CN (1) CN1039423A (es)
AT (1) ATE117314T1 (es)
AU (1) AU603042B2 (es)
CA (1) CA1315776C (es)
DD (2) DD284024A5 (es)
DE (1) DE68920648T2 (es)
DK (1) DK342189A (es)
ES (1) ES2066853T3 (es)
FI (1) FI893364A (es)
GR (1) GR3015293T3 (es)
HU (1) HUT50843A (es)
IE (1) IE65735B1 (es)
IL (1) IL90884A0 (es)
NO (1) NO892821L (es)
PT (1) PT91113B (es)
YU (1) YU138789A (es)
ZA (1) ZA895259B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3065350B2 (ja) * 1990-11-30 2000-07-17 ヤマサ醤油株式会社 １―（２，３―ジデオキシ―β―Ｄ―グリセロ―ペント―２―エノフラノシル）チミンの製造法
DE69415506T2 (de) * 1994-05-20 1999-08-12 Council Scient Ind Res Verfahren zur Herstellung von Beta-Thymidine
CN102241720B (zh) 2000-11-29 2014-01-29 三井化学株式会社 L-核酸衍生物及其合成方法
JP4430307B2 (ja) * 2001-03-30 2010-03-10 ブガン・フアーマシユーテイカル・カンパニー・リミテツド ２’−ハロ−β−Ｌ−アラビノフラノシルヌクレオシドの製造方法
DE10216426A1 (de) * 2002-04-12 2003-10-23 Boehringer Ingelheim Pharma Verfahren zur Herstellung von beta-L-2'Deoxy-Thymidin
CN1812995A (zh) 2003-04-28 2006-08-02 艾登尼科斯（开曼）有限公司 工业化规模的核苷合成
EP1639121A4 (en) 2003-06-30 2008-04-16 Idenix Cayman Ltd SYNTHESIS OF BETA-L-2-DESOXYNUCLEOSIDES
US20090018325A1 (en) 2006-03-15 2009-01-15 Jacques Cercus Process for preparing l-nucleic acid derivatives and intermediates thereof
CN104667279B (zh) 2008-03-03 2018-10-26 托斯克公司 减少毒性的甲氨蝶呤佐剂及其使用方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3322747A (en) * 1965-04-01 1967-05-30 Merck & Co Inc Thionocarbonate nucleosides
US3463850A (en) * 1967-01-03 1969-08-26 Merck & Co Inc Arabinofuranosyl 2-thiopyrimidines and pharmaceutical compositions thereof
US3658788A (en) * 1969-06-06 1972-04-25 Salk Inst For Biological Studi Aminooxazolines and products thereof and processes for synthesizing same
US3709874A (en) * 1970-03-19 1973-01-09 Syntex Corp 1-beta-d-arabinofuranosyl cytosine derivatives and methods of preparing
US3812098A (en) * 1970-03-19 1974-05-21 Syntex Inc O2,2'-anhydro-1-(beta-d-arabinofuranosyl)-cytosine derivatives and methods of making and related procedures
US3792040A (en) * 1970-03-19 1974-02-12 Syntex Corp Acyl derivatives of o2,2'-anhydro-1-(beta-d-arabinofuranosyl)-cytosines and methods of preparing
US3920630A (en) * 1970-09-24 1975-11-18 Upjohn Co 2,2{40 -Anhydro-ara-cytidine compounds and process of preparation
SE391183B (sv) * 1971-04-15 1977-02-07 Asahi Chemical Ind 2',3'-0-sulfinylcytidin och syraadditionssalter derav till anvendning som mellanprodukt for framstellning av 2,2'-anhydro-(1-beta-d-arabinofuranosyl) cytosin
US3978042A (en) * 1975-01-31 1976-08-31 The Upjohn Company Process for preparing cyclocytidine derivatives
US4140850A (en) * 1977-08-29 1979-02-20 The Upjohn Company 2,2'-Anhydrotriazine nucleosides and process for preparing the same
JPS5649398A (en) * 1979-09-28 1981-05-02 Yamasa Shoyu Co Ltd Preparation of 1-beta-d-arabinofuranosyl-2,2'-cyclothymine
JPS636557A (ja) * 1986-06-26 1988-01-12 Sharp Corp 微細パタ−ン形成方法

Also Published As

Publication number Publication date
GR3015293T3 (en) 1995-06-30
HUT50843A (en) 1990-03-28
ATE117314T1 (de) 1995-02-15
JPH0259598A (ja) 1990-02-28
PT91113B (pt) 1995-01-31
IE65735B1 (en) 1995-11-15
US5008384A (en) 1991-04-16
CA1315776C (en) 1993-04-06
DK342189A (da) 1990-01-15
NO892821L (no) 1990-01-15
IE892233L (en) 1990-01-12
DD284024A5 (de) 1990-10-31
DK342189D0 (da) 1989-07-11
DD292003A5 (de) 1991-07-18
AU3802089A (en) 1990-04-26
EP0351126A2 (en) 1990-01-17
CN1039423A (zh) 1990-02-07
KR900001704A (ko) 1990-02-27
EP0351126A3 (en) 1990-10-24
KR910008112B1 (ko) 1991-10-10
NO892821D0 (no) 1989-07-07
YU138789A (en) 1990-12-31
ZA895259B (en) 1991-02-27
IL90884A0 (en) 1990-02-09
FI893364A (fi) 1990-01-13
JPH075626B2 (ja) 1995-01-25
PT91113A (pt) 1990-02-08
EP0351126B1 (en) 1995-01-18
DE68920648T2 (de) 1995-05-18
AU603042B2 (en) 1990-11-01
FI893364A0 (fi) 1989-07-11
DE68920648D1 (de) 1995-03-02

Similar Documents

Publication Publication Date Title
FI852974L (fi) Nya n-hydroxylgruppen skyddande grupper och framstaellningsfoerfarande foer 3-acylamino-1-hydroxi-2-azetidinoner.
ES2038310T3 (es) Procedimiento para la sintesis de derivados de 3-tio-4-quinolona y sus compuestos intermedios.
DE69004164D1 (de) Diphenylharnstoffderivate.
DE69327567T2 (de) Verfahren zur Herstellung von Alanylglutamin
SE8302694D0 (sv) Immunomodulating agent
ES2066853T3 (es) Procedimiento para la produccion de o2,2'-anhidro-1-(beta-d-arabinofuranosil)timina.
IT1225484B (it) Procedimento di sintesi dell'amikacina
ES2031892T3 (es) Agentes antialergicos y antiinflamatorios.
KR910002865A (ko) 피라노벤즈옥사디아졸 화합물 및 그 광학적 분할방법
DE3780909T2 (de) 7-((meta-substituiert)-phenylglycin)-1-carba-1-dethia-cephalosporine.
DK0662475T3 (da) Fremgangsmåde til fremstilling af 2-perfluoralkyl-3-oxazolin-5-on.
ES2033816T3 (es) Procedimiento para preparar 2-alquil- o 2-fenil-1,4,5,6-tetrahidropirimidinas.
DE69001852T3 (de) Herstellung von Derivaten der Glutarsäure.
BR8005509A (pt) Processo de preparacao de compostos
DK0557519T3 (da) Fremgangsmåde til fremstilling af sulfonamidderivater af norbornan
DE3887643D1 (de) Herstellung von 2,3'-Anhydro-2'-deoxyuridinderivaten.
KR850004748A (ko) N-(4- 메톡시-2- 메틸페닐)-3-(5-니트로-2-퓨라닐) 프로펜아미드의 제조방법 및 그 구충약제 조성물
BR9101765A (pt) Processo para a preparacao de um composto

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 351126

Country of ref document: ES