DE69004164D1 - Diphenylharnstoffderivate. - Google Patents
Diphenylharnstoffderivate.Info
- Publication number
- DE69004164D1 DE69004164D1 DE90111195T DE69004164T DE69004164D1 DE 69004164 D1 DE69004164 D1 DE 69004164D1 DE 90111195 T DE90111195 T DE 90111195T DE 69004164 T DE69004164 T DE 69004164T DE 69004164 D1 DE69004164 D1 DE 69004164D1
- Authority
- DE
- Germany
- Prior art keywords
- carbon atoms
- alkyl group
- atom
- urea derivatives
- diphenyl urea
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C335/04—Derivatives of thiourea
- C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/30—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by halogen atoms, or by nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/32—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms
- C07C275/34—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms having nitrogen atoms of urea groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP15259489 | 1989-06-15 | ||
JP2106986A JPH0395153A (ja) | 1989-06-15 | 1990-04-23 | ジフェニル尿素誘導体 |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69004164D1 true DE69004164D1 (de) | 1993-12-02 |
DE69004164T2 DE69004164T2 (de) | 1994-04-21 |
Family
ID=26447071
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE90111195T Expired - Fee Related DE69004164T2 (de) | 1989-06-15 | 1990-06-13 | Diphenylharnstoffderivate. |
Country Status (10)
Country | Link |
---|---|
US (1) | US5063247A (de) |
EP (1) | EP0405233B1 (de) |
JP (1) | JPH0395153A (de) |
KR (1) | KR910000628A (de) |
AT (1) | ATE96426T1 (de) |
AU (1) | AU628583B2 (de) |
CA (1) | CA2018848A1 (de) |
DE (1) | DE69004164T2 (de) |
DK (1) | DK0405233T3 (de) |
ES (1) | ES2059893T3 (de) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL100915A (en) * | 1991-02-19 | 1996-03-31 | Erba Carlo Spa | Double-transformed urea and theories, their preparation and pharmaceutical preparations containing them |
US5420164A (en) * | 1991-04-04 | 1995-05-30 | Yoshitomi Pharmaceutical Industries, Ltd. | Cycloalkylurea compounds |
HUT62558A (en) * | 1991-07-01 | 1993-05-28 | Sandoz Ag | Process for producing n-phenylthiourea derivaties and pharmaceutical compositions comprising same |
DE4126662A1 (de) * | 1991-08-13 | 1993-02-18 | Boehringer Mannheim Gmbh | Neue 3,5-di-tert.butyl-4-hydroxyphenyl-derivate, verfahren zu ihrer herstellung und arzneimittel |
US5547966A (en) * | 1993-10-07 | 1996-08-20 | Bristol-Myers Squibb Company | Aryl urea and related compounds |
EP0742208A1 (de) * | 1995-05-05 | 1996-11-13 | Grelan Pharmaceutical Co., Ltd. | 2-Ureido-benzamid-Derivate |
AU679887B2 (en) * | 1995-09-11 | 1997-07-10 | Nihon Nohyaku Co., Ltd. | Azole derivatives, their use, production and usage |
EP0773218A1 (de) * | 1995-11-13 | 1997-05-14 | Mitsubishi Chemical Corporation | N-(Piperazinylalkoxyphenyl)-N'-phenylalkylharnstoffderivate als ACAT-Hemmer zur Atherosklerosebehandlung |
CA2197364A1 (en) * | 1996-02-15 | 1997-08-16 | Toshikazu Suzuki | Phenol compound and process for preparing the same |
US6344476B1 (en) | 1997-05-23 | 2002-02-05 | Bayer Corporation | Inhibition of p38 kinase activity by aryl ureas |
US8124630B2 (en) | 1999-01-13 | 2012-02-28 | Bayer Healthcare Llc | ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors |
CA2359244C (en) | 1999-01-13 | 2013-10-08 | Bayer Corporation | .omega.-carboxy aryl substituted diphenyl ureas as p38 kinase inhibitors |
ME00275B (me) | 1999-01-13 | 2011-02-10 | Bayer Corp | ω-KARBOKSIARIL SUPSTITUISANI DIFENIL KARBAMIDI KAO INHIBITORI RAF KINAZE |
WO2000042012A1 (en) * | 1999-01-13 | 2000-07-20 | Bayer Corporation | φ-CARBOXYARYL SUBSTITUTED DIPHENYL UREAS AS RAF KINASE INHIBITORS |
US7928239B2 (en) | 1999-01-13 | 2011-04-19 | Bayer Healthcare Llc | Inhibition of RAF kinase using quinolyl, isoquinolyl or pyridyl ureas |
JP5059275B2 (ja) * | 2000-08-10 | 2012-10-24 | 田辺三菱製薬株式会社 | 新規3置換尿素誘導体およびその医薬としての用途 |
US7067553B2 (en) | 2000-08-21 | 2006-06-27 | Pacific Corporation | Thiourea compounds and the pharmaceutical compositions containing the same |
AU8022901A (en) | 2000-08-21 | 2002-03-04 | Pacific Corp | Novel thiourea derivatives and the pharmaceutical compositions containing the same |
KR100407640B1 (ko) * | 2000-12-19 | 2003-12-01 | 주식회사 태평양 | 신규한 디페닐 아미드 유도체, 그의 제조방법 및 이를포함하는 약학 및 화장료 조성물 |
WO2003068229A1 (en) | 2002-02-11 | 2003-08-21 | Bayer Pharmaceuticals Corporation | Pyridine, quinoline, and isoquinoline n-oxides as kinase inhibitors |
CN1318404C (zh) | 2002-02-11 | 2007-05-30 | 拜耳制药公司 | 作为激酶抑制剂的芳基脲类化合物 |
JP4636486B2 (ja) | 2002-02-11 | 2011-02-23 | バイエル、ファーマシューテイカルズ、コーポレイション | 脈管形成阻害活性を有するアリール尿素 |
UY28213A1 (es) | 2003-02-28 | 2004-09-30 | Bayer Pharmaceuticals Corp | Nuevos derivados de cianopiridina útiles en el tratamiento de cáncer y otros trastornos. |
ATE366108T1 (de) | 2003-05-20 | 2007-07-15 | Bayer Pharmaceuticals Corp | Diaryl-harnstoffe für durch pdgfr vermittelte krankheiten |
PL1663978T3 (pl) | 2003-07-23 | 2008-04-30 | Bayer Healthcare Llc | Fluoropodstawiony omega-karboksyarylodifenylomocznik do leczenia i profilaktyki chorób i stanów |
MXPA06012394A (es) | 2004-04-30 | 2007-01-31 | Bayer Pharmaceuticals Corp | Derivados de pirazolilurea sustituidos utiles en el tratamiento de cancer. |
JP4602003B2 (ja) * | 2004-06-18 | 2010-12-22 | 富士フイルム株式会社 | チオウレア化合物、ベンゾチアゾール化合物、及びベンゾチアゾリン化合物の製造方法 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3579578A (en) * | 1966-07-08 | 1971-05-18 | Givaudan Corp | 3,4-dihalo-3' and 4'-lower alkylcarbanilides |
FR2070252A5 (en) * | 1969-11-03 | 1971-09-10 | Givaudan & Cie Sa | Bacteriostatic carbanilides |
US3860645A (en) * | 1973-05-23 | 1975-01-14 | Givaudan Corp | Bacteriostatic substituted carbanilides |
US4218438A (en) * | 1979-02-14 | 1980-08-19 | Eli Lilly And Company | Anticoccidial combinations comprising nicarbazin and the polyether antibiotics |
DE2928485A1 (de) * | 1979-07-14 | 1981-01-29 | Bayer Ag | Verwendung von harnstoffderivaten als arzneimittel bei der behandlung von fettstoffwechselstoerungen |
EP0049538A3 (de) * | 1979-07-14 | 1982-10-13 | Bayer Ag | Verwendung von Thioharnstoffderivaten als Arzneimittel bei der Behandlung von Fettstoffwechselstörungen |
US4387105A (en) * | 1982-01-26 | 1983-06-07 | American Cyanamid Company | Methods of treating atherosclerosis with dialkylureas and dialkylthioureas |
US5003106A (en) * | 1983-07-19 | 1991-03-26 | American Cyanamid Company | Antiatherosclerotic ureas and thioureas |
IE61716B1 (en) * | 1987-06-02 | 1994-11-30 | Warner Lambert Co | Antihyperlipidemic and antiatherosclerotic urea compounds |
ATE61574T1 (de) * | 1987-07-02 | 1991-03-15 | Warner Lambert Co | N-((2,6-disubstituierte)-phenyl>-harnstoff und - carbamat-inhibitoren der acyl-coenzym a:cholesterol-acyltransferase. |
ES2060682T3 (es) * | 1988-03-30 | 1994-12-01 | Warner Lambert Co | N-((fenil(2,6-disubstituido))-n'-aril)ureas como agentes antihipercolesterolemicos y antiateroscleroticos. |
US4868210A (en) * | 1988-03-30 | 1989-09-19 | Warner-Lambert Company | Antihyperlipidemic and antiatherosclerotic compounds and compositions |
US5116848A (en) * | 1988-03-30 | 1992-05-26 | Warner-Lambert Company | N-(((2,6-disubstituted)phenyl)-n-diarylalkyl)ureas as antihyperlipidemic and antiatherosclerotic agents |
GB8908063D0 (en) * | 1989-04-11 | 1989-05-24 | Beecham Group Plc | Novel compounds |
-
1990
- 1990-04-23 JP JP2106986A patent/JPH0395153A/ja active Pending
- 1990-06-12 CA CA002018848A patent/CA2018848A1/en not_active Abandoned
- 1990-06-13 AT AT90111195T patent/ATE96426T1/de not_active IP Right Cessation
- 1990-06-13 DE DE90111195T patent/DE69004164T2/de not_active Expired - Fee Related
- 1990-06-13 EP EP90111195A patent/EP0405233B1/de not_active Expired - Lifetime
- 1990-06-13 AU AU57009/90A patent/AU628583B2/en not_active Ceased
- 1990-06-13 US US07/537,302 patent/US5063247A/en not_active Expired - Fee Related
- 1990-06-13 ES ES90111195T patent/ES2059893T3/es not_active Expired - Lifetime
- 1990-06-13 DK DK90111195.5T patent/DK0405233T3/da active
- 1990-06-13 KR KR1019900008802A patent/KR910000628A/ko not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
DE69004164T2 (de) | 1994-04-21 |
EP0405233B1 (de) | 1993-10-27 |
JPH0395153A (ja) | 1991-04-19 |
CA2018848A1 (en) | 1990-12-15 |
ES2059893T3 (es) | 1994-11-16 |
EP0405233A1 (de) | 1991-01-02 |
KR910000628A (ko) | 1991-01-29 |
US5063247A (en) | 1991-11-05 |
DK0405233T3 (da) | 1993-12-20 |
AU5700990A (en) | 1990-12-20 |
AU628583B2 (en) | 1992-09-17 |
ATE96426T1 (de) | 1993-11-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |