FI893364A - Foerfarande foer framstaellning av 02,2'-anhydro-1-(b-d-arabinofuranosyl)tymin. - Google Patents

Foerfarande foer framstaellning av 02,2'-anhydro-1-(b-d-arabinofuranosyl)tymin. Download PDF

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Publication number
FI893364A
FI893364A FI893364A FI893364A FI893364A FI 893364 A FI893364 A FI 893364A FI 893364 A FI893364 A FI 893364A FI 893364 A FI893364 A FI 893364A FI 893364 A FI893364 A FI 893364A
Authority
FI
Finland
Prior art keywords
arabinofuranosyl
anhydro
framstaellning
thyme
procedure
Prior art date
Application number
FI893364A
Other languages
English (en)
Other versions
FI893364A0 (fi
Inventor
Charles William Murtiashaw
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of FI893364A0 publication Critical patent/FI893364A0/fi
Publication of FI893364A publication Critical patent/FI893364A/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/09—Pyrimidine radicals with arabinosyl as the saccharide radical
FI893364A 1988-07-12 1989-07-11 Foerfarande foer framstaellning av 02,2'-anhydro-1-(b-d-arabinofuranosyl)tymin. FI893364A (fi)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/217,906 US5008384A (en) 1988-07-12 1988-07-12 Process for the production of O.sup. 2,2'-anhydro-1-(β-D-arabinofuranosyl)thymine

Publications (2)

Publication Number Publication Date
FI893364A0 FI893364A0 (fi) 1989-07-11
FI893364A true FI893364A (fi) 1990-01-13

Family

ID=22812966

Family Applications (1)

Application Number Title Priority Date Filing Date
FI893364A FI893364A (fi) 1988-07-12 1989-07-11 Foerfarande foer framstaellning av 02,2'-anhydro-1-(b-d-arabinofuranosyl)tymin.

Country Status (21)

Country Link
US (1) US5008384A (fi)
EP (1) EP0351126B1 (fi)
JP (1) JPH075626B2 (fi)
KR (1) KR910008112B1 (fi)
CN (1) CN1039423A (fi)
AT (1) ATE117314T1 (fi)
AU (1) AU603042B2 (fi)
CA (1) CA1315776C (fi)
DD (2) DD292003A5 (fi)
DE (1) DE68920648T2 (fi)
DK (1) DK342189A (fi)
ES (1) ES2066853T3 (fi)
FI (1) FI893364A (fi)
GR (1) GR3015293T3 (fi)
HU (1) HUT50843A (fi)
IE (1) IE65735B1 (fi)
IL (1) IL90884A0 (fi)
NO (1) NO892821L (fi)
PT (1) PT91113B (fi)
YU (1) YU138789A (fi)
ZA (1) ZA895259B (fi)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992009599A1 (en) * 1990-11-30 1992-06-11 Yamasa Shoyu Kabushiki Kaisha PROCESS FOR PRODUCING 1-(2,3-DIDEOXY-β-D-glycero-PENT-2-ENOFURANOSYL)THYMINE
DE69415506T2 (de) * 1994-05-20 1999-08-12 Council Scient Ind Res Verfahren zur Herstellung von Beta-Thymidine
CN102241720B (zh) 2000-11-29 2014-01-29 三井化学株式会社 L-核酸衍生物及其合成方法
CN1330660C (zh) * 2001-03-30 2007-08-08 三角药品公司 2＇－卤代－β－L－阿拉伯呋喃糖基核苷的制备方法
DE10216426A1 (de) * 2002-04-12 2003-10-23 Boehringer Ingelheim Pharma Verfahren zur Herstellung von beta-L-2'Deoxy-Thymidin
KR20060015542A (ko) 2003-04-28 2006-02-17 이데닉스 (케이만) 리미티드 산업 규모의 뉴클레오시드 합성
CA2531412A1 (en) 2003-06-30 2005-01-13 Idenix (Cayman) Limited Synthesis of .beta.-l-2'-deoxy nucleosides
WO2007104793A2 (en) 2006-03-15 2007-09-20 Novartis Ag Process for preparing l-nucleic acid derivatives and intermediates thereof
US7998967B2 (en) 2008-03-03 2011-08-16 Tosk, Incorporated Methotrexate adjuvants to reduce toxicity and methods for using the same

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3322747A (en) * 1965-04-01 1967-05-30 Merck & Co Inc Thionocarbonate nucleosides
US3463850A (en) * 1967-01-03 1969-08-26 Merck & Co Inc Arabinofuranosyl 2-thiopyrimidines and pharmaceutical compositions thereof
US3658788A (en) * 1969-06-06 1972-04-25 Salk Inst For Biological Studi Aminooxazolines and products thereof and processes for synthesizing same
US3792040A (en) * 1970-03-19 1974-02-12 Syntex Corp Acyl derivatives of o2,2'-anhydro-1-(beta-d-arabinofuranosyl)-cytosines and methods of preparing
US3812098A (en) * 1970-03-19 1974-05-21 Syntex Inc O2,2'-anhydro-1-(beta-d-arabinofuranosyl)-cytosine derivatives and methods of making and related procedures
US3709874A (en) * 1970-03-19 1973-01-09 Syntex Corp 1-beta-d-arabinofuranosyl cytosine derivatives and methods of preparing
US3920630A (en) * 1970-09-24 1975-11-18 Upjohn Co 2,2{40 -Anhydro-ara-cytidine compounds and process of preparation
SE391183B (sv) * 1971-04-15 1977-02-07 Asahi Chemical Ind 2',3'-0-sulfinylcytidin och syraadditionssalter derav till anvendning som mellanprodukt for framstellning av 2,2'-anhydro-(1-beta-d-arabinofuranosyl) cytosin
US3978042A (en) * 1975-01-31 1976-08-31 The Upjohn Company Process for preparing cyclocytidine derivatives
US4140850A (en) * 1977-08-29 1979-02-20 The Upjohn Company 2,2'-Anhydrotriazine nucleosides and process for preparing the same
JPS5649398A (en) * 1979-09-28 1981-05-02 Yamasa Shoyu Co Ltd Preparation of 1-beta-d-arabinofuranosyl-2,2'-cyclothymine
JPS636557A (ja) * 1986-06-26 1988-01-12 Sharp Corp 微細パタ−ン形成方法

Also Published As

Publication number Publication date
DD284024A5 (de) 1990-10-31
DK342189D0 (da) 1989-07-11
ES2066853T3 (es) 1995-03-16
DD292003A5 (de) 1991-07-18
HUT50843A (en) 1990-03-28
DE68920648T2 (de) 1995-05-18
KR910008112B1 (ko) 1991-10-10
JPH075626B2 (ja) 1995-01-25
PT91113B (pt) 1995-01-31
NO892821D0 (no) 1989-07-07
US5008384A (en) 1991-04-16
YU138789A (en) 1990-12-31
EP0351126A2 (en) 1990-01-17
KR900001704A (ko) 1990-02-27
IL90884A0 (en) 1990-02-09
EP0351126A3 (en) 1990-10-24
IE65735B1 (en) 1995-11-15
CN1039423A (zh) 1990-02-07
JPH0259598A (ja) 1990-02-28
EP0351126B1 (en) 1995-01-18
DE68920648D1 (de) 1995-03-02
GR3015293T3 (en) 1995-06-30
IE892233L (en) 1990-01-12
ZA895259B (en) 1991-02-27
CA1315776C (en) 1993-04-06
ATE117314T1 (de) 1995-02-15
AU603042B2 (en) 1990-11-01
DK342189A (da) 1990-01-15
AU3802089A (en) 1990-04-26
NO892821L (no) 1990-01-15
FI893364A0 (fi) 1989-07-11
PT91113A (pt) 1990-02-08

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Legal Events

Date Code Title Description
FD Application lapsed

Owner name: PFIZER INC.