YU138789A - Process for obtaining o(¦2),2-anhydro-1-(b-d-arabinofuranozyl)-timine - Google Patents

Process for obtaining o(¦2),2-anhydro-1-(b-d-arabinofuranozyl)-timine

Info

Publication number
YU138789A
YU138789A YU01387/89A YU138789A YU138789A YU 138789 A YU138789 A YU 138789A YU 01387/89 A YU01387/89 A YU 01387/89A YU 138789 A YU138789 A YU 138789A YU 138789 A YU138789 A YU 138789A
Authority
YU
Yugoslavia
Prior art keywords
anhydro
arabinofuranozyl
timine
obtaining
beta
Prior art date
Application number
YU01387/89A
Other languages
English (en)
Inventor
C W Murtiashaw
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of YU138789A publication Critical patent/YU138789A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/09—Pyrimidine radicals with arabinosyl as the saccharide radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Virology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Plural Heterocyclic Compounds (AREA)
YU01387/89A 1988-07-12 1989-07-11 Process for obtaining o(¦2),2-anhydro-1-(b-d-arabinofuranozyl)-timine YU138789A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/217,906 US5008384A (en) 1988-07-12 1988-07-12 Process for the production of O.sup. 2,2'-anhydro-1-(β-D-arabinofuranosyl)thymine

Publications (1)

Publication Number Publication Date
YU138789A true YU138789A (en) 1990-12-31

Family

ID=22812966

Family Applications (1)

Application Number Title Priority Date Filing Date
YU01387/89A YU138789A (en) 1988-07-12 1989-07-11 Process for obtaining o(¦2),2-anhydro-1-(b-d-arabinofuranozyl)-timine

Country Status (21)

Country Link
US (1) US5008384A (fi)
EP (1) EP0351126B1 (fi)
JP (1) JPH075626B2 (fi)
KR (1) KR910008112B1 (fi)
CN (1) CN1039423A (fi)
AT (1) ATE117314T1 (fi)
AU (1) AU603042B2 (fi)
CA (1) CA1315776C (fi)
DD (2) DD292003A5 (fi)
DE (1) DE68920648T2 (fi)
DK (1) DK342189A (fi)
ES (1) ES2066853T3 (fi)
FI (1) FI893364A (fi)
GR (1) GR3015293T3 (fi)
HU (1) HUT50843A (fi)
IE (1) IE65735B1 (fi)
IL (1) IL90884A0 (fi)
NO (1) NO892821L (fi)
PT (1) PT91113B (fi)
YU (1) YU138789A (fi)
ZA (1) ZA895259B (fi)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992009599A1 (en) * 1990-11-30 1992-06-11 Yamasa Shoyu Kabushiki Kaisha PROCESS FOR PRODUCING 1-(2,3-DIDEOXY-β-D-glycero-PENT-2-ENOFURANOSYL)THYMINE
DE69415506T2 (de) * 1994-05-20 1999-08-12 Council Scient Ind Res Verfahren zur Herstellung von Beta-Thymidine
CN102241720B (zh) 2000-11-29 2014-01-29 三井化学株式会社 L-核酸衍生物及其合成方法
DE60204859T2 (de) * 2001-03-30 2006-04-27 Gilead Sciences, Inc., Foster City Verfahren zur Herstellung von 2'-Halo-beta-L-arabino-furanosylnucleosiden
DE10216426A1 (de) * 2002-04-12 2003-10-23 Boehringer Ingelheim Pharma Verfahren zur Herstellung von beta-L-2'Deoxy-Thymidin
CN1812995A (zh) 2003-04-28 2006-08-02 艾登尼科斯（开曼）有限公司 工业化规模的核苷合成
BRPI0412031A (pt) 2003-06-30 2006-09-19 Idenix Cayman Ltd sìntese de beta-l-2'-deóxi-nucleosìdeos
WO2007104793A2 (en) 2006-03-15 2007-09-20 Novartis Ag Process for preparing l-nucleic acid derivatives and intermediates thereof
CA2729613C (en) 2008-03-03 2017-02-07 Tosk, Incorporated Methotrexate adjuvants to reduce toxicity and methods for using the same

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3322747A (en) * 1965-04-01 1967-05-30 Merck & Co Inc Thionocarbonate nucleosides
US3463850A (en) * 1967-01-03 1969-08-26 Merck & Co Inc Arabinofuranosyl 2-thiopyrimidines and pharmaceutical compositions thereof
US3658788A (en) * 1969-06-06 1972-04-25 Salk Inst For Biological Studi Aminooxazolines and products thereof and processes for synthesizing same
US3792040A (en) * 1970-03-19 1974-02-12 Syntex Corp Acyl derivatives of o2,2'-anhydro-1-(beta-d-arabinofuranosyl)-cytosines and methods of preparing
US3812098A (en) * 1970-03-19 1974-05-21 Syntex Inc O2,2'-anhydro-1-(beta-d-arabinofuranosyl)-cytosine derivatives and methods of making and related procedures
US3709874A (en) * 1970-03-19 1973-01-09 Syntex Corp 1-beta-d-arabinofuranosyl cytosine derivatives and methods of preparing
US3920630A (en) * 1970-09-24 1975-11-18 Upjohn Co 2,2{40 -Anhydro-ara-cytidine compounds and process of preparation
SE391183B (sv) * 1971-04-15 1977-02-07 Asahi Chemical Ind 2',3'-0-sulfinylcytidin och syraadditionssalter derav till anvendning som mellanprodukt for framstellning av 2,2'-anhydro-(1-beta-d-arabinofuranosyl) cytosin
US3978042A (en) * 1975-01-31 1976-08-31 The Upjohn Company Process for preparing cyclocytidine derivatives
US4140850A (en) * 1977-08-29 1979-02-20 The Upjohn Company 2,2'-Anhydrotriazine nucleosides and process for preparing the same
JPS5649398A (en) * 1979-09-28 1981-05-02 Yamasa Shoyu Co Ltd Preparation of 1-beta-d-arabinofuranosyl-2,2'-cyclothymine
JPS636557A (ja) * 1986-06-26 1988-01-12 Sharp Corp 微細パタ−ン形成方法

Also Published As

Publication number Publication date
KR910008112B1 (ko) 1991-10-10
AU603042B2 (en) 1990-11-01
NO892821D0 (no) 1989-07-07
DE68920648D1 (de) 1995-03-02
ZA895259B (en) 1991-02-27
GR3015293T3 (en) 1995-06-30
IL90884A0 (en) 1990-02-09
US5008384A (en) 1991-04-16
IE65735B1 (en) 1995-11-15
JPH075626B2 (ja) 1995-01-25
FI893364A0 (fi) 1989-07-11
ES2066853T3 (es) 1995-03-16
PT91113A (pt) 1990-02-08
DD284024A5 (de) 1990-10-31
DE68920648T2 (de) 1995-05-18
IE892233L (en) 1990-01-12
EP0351126A3 (en) 1990-10-24
KR900001704A (ko) 1990-02-27
ATE117314T1 (de) 1995-02-15
NO892821L (no) 1990-01-15
FI893364A (fi) 1990-01-13
PT91113B (pt) 1995-01-31
EP0351126B1 (en) 1995-01-18
EP0351126A2 (en) 1990-01-17
DK342189D0 (da) 1989-07-11
AU3802089A (en) 1990-04-26
JPH0259598A (ja) 1990-02-28
CN1039423A (zh) 1990-02-07
HUT50843A (en) 1990-03-28
DD292003A5 (de) 1991-07-18
CA1315776C (en) 1993-04-06
DK342189A (da) 1990-01-15

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