KR850000400A - 피리딘 유도체 - Google Patents
피리딘 유도체 Download PDFInfo
- Publication number
- KR850000400A KR850000400A KR1019840003526A KR840003526A KR850000400A KR 850000400 A KR850000400 A KR 850000400A KR 1019840003526 A KR1019840003526 A KR 1019840003526A KR 840003526 A KR840003526 A KR 840003526A KR 850000400 A KR850000400 A KR 850000400A
- Authority
- KR
- South Korea
- Prior art keywords
- bis
- pyridine
- methoxyphenyl
- pharmaceutically acceptable
- compound
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/30—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Pain & Pain Management (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Rheumatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
내용 없음.
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (7)
- 다음 일반식(IV) 화합물을 하이드록실아민 또는 그의 염과 함께 반응시키거나, R가 요오드인 다음 일반식(I) 화합물을 비스(트리플루오로메틸)수은과 N-메틸-2-필로리디논과 함께 반응시켜서 R가 트리플루오로메틸인 일반식(I)화합물을 수득하거나, 일반식(I) 화합물을 염으로 전환시키는 것을 특징으로하여 일반식(I)의 화합물 또는 그의 약제학적으로 허용되는 염을 제조하는 방법.상기 일반식에서, R는 수소, 트리플루오로메틸, 플루오로, 클로로, 블로모 또는 요오드이다.
- 제1항에 있어서, 6-(4-플루오로페닐)-2,3-비스-(4-메톡시페닐)피리딘 또는 그의 약학적으로 허용되는 염제조에 이용되는 방법.
- 제1항에 있어서, 6-(4-클로로페닐)-2,3-비스(4-메톡시페닐) 피리딘 또는 그의 약학적으로 허용되는 염 제조에 이용되는 방법.
- 제1항에 있어서, 6-(4-블로모페닐)-2,3-비스-(4-메톡시페닐) 피리딘 또는 그의 약학적으로 허용되는 제조에 이용되는 방법.
- 제1항에 있어서, 6-(4-트리플루오로메틸페닐)-2,3-비스(4-메톡시페닐) 피리딘 또는 약학적으로 허용되는 염 제조에 이용되는 방법.
- 제1항에 있어서, 6-(4-요오도페닐)-2,3-비스(4-메톡시페닐) 피리딘 또는 약학적으로 허용되는 염제조에 이용되는 방법.
- 제1항에 있어서, 6-페닐-2,3-비스(4-메톡시페닐) 피리딘 제조에 이용되는 방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US506933 | 1983-06-22 | ||
US06/506,933 US4533666A (en) | 1983-06-22 | 1983-06-22 | 6-Phenyl-2,3-bis-(4-methoxyphenyl)-pyridine derivatives having anti-inflammatory activity |
US506,933 | 1983-06-22 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR850000400A true KR850000400A (ko) | 1985-02-27 |
KR860001602B1 KR860001602B1 (ko) | 1986-10-13 |
Family
ID=24016558
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019840003526A KR860001602B1 (ko) | 1983-06-22 | 1984-06-22 | 피리딘 유도체의 제조방법 |
Country Status (9)
Country | Link |
---|---|
US (1) | US4533666A (ko) |
EP (1) | EP0130044A1 (ko) |
JP (1) | JPS6013759A (ko) |
KR (1) | KR860001602B1 (ko) |
DK (1) | DK300784A (ko) |
GB (1) | GB2142023B (ko) |
GR (1) | GR82377B (ko) |
HU (1) | HU192560B (ko) |
IL (1) | IL72145A0 (ko) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5171737A (en) * | 1989-03-03 | 1992-12-15 | The Liposome Company, Inc. | Emulsions |
US5686470A (en) * | 1995-02-10 | 1997-11-11 | Weier; Richard M. | 2, 3-substituted pyridines for the treatment of inflammation |
US6515014B2 (en) | 1995-06-02 | 2003-02-04 | G. D. Searle & Co. | Thiophene substituted hydroxamic acid derivatives as cyclooxygenase-2 and 5-lipoxygenase inhibitors |
US6512121B2 (en) | 1998-09-14 | 2003-01-28 | G.D. Searle & Co. | Heterocyclo substituted hydroxamic acid derivatives as cyclooxygenase-2 and 5-lipoxygenase inhibitors |
CA2223154A1 (en) | 1995-06-02 | 1996-12-05 | G.D. Searle & Co. | Heterocyclo substituted hydroxamic acid derivatives as cyclooxygenase-2 and 5-lipoxygenase inhibitors |
US6677364B2 (en) | 1998-04-20 | 2004-01-13 | G.D. Searle & Co. | Substituted sulfonylphenylheterocycles as cyclooxygenase-2 and 5-lipoxygenase inhibitors |
US6174901B1 (en) | 1998-12-18 | 2001-01-16 | Amgen Inc. | Substituted pyridine and pyridazine compounds and methods of use |
US20030105144A1 (en) | 2001-04-17 | 2003-06-05 | Ping Gao | Stabilized oral pharmaceutical composition |
US6956132B2 (en) * | 2001-08-03 | 2005-10-18 | Ishihara Sangyo Kaisha. Ltd. | Process for producing 2-phenylacetophenone derivatives and precursors therefor |
EP1492784A4 (en) * | 2002-03-28 | 2006-03-29 | Merck & Co Inc | SUBSTITUTED 2,3-DIPHENYLPYRIDINES |
US7329401B2 (en) * | 2002-04-15 | 2008-02-12 | The Regents Of The University Of California | Cyclooxygenase-2 selective agents useful as imaging probes and related methods |
WO2004094379A2 (en) * | 2003-04-16 | 2004-11-04 | Amgen Inc. | 3-phenyl-4- (pyrimidin-2-yl) -6- (piperidin-4-yl) derivatives and related compounds as tnf-alpha and il-1 inhibitors for the treatment of inflammations |
US11066398B2 (en) * | 2013-12-11 | 2021-07-20 | The Scripps Research Institute | Small molecule c-Myc inhibitors |
US11791748B2 (en) | 2019-07-24 | 2023-10-17 | Tdk Corporation | Smart wheel energy harvester |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2416295C3 (de) * | 1974-04-04 | 1980-01-10 | Studiengesellschaft Kohle Mbh, 4330 Muelheim | Verfahren zur Herstellung von ein- oder mehrfach substituierten Pyridinen durch katalytische Mischcyclisierung von Alkinen mit Nitrilen in Gegenwart einer Kobalt-Komplexverbindung |
US4153703A (en) * | 1977-06-30 | 1979-05-08 | Uniroyal, Inc. | Method of controlling insects and acarids with certain aryl-substituted thiazoles |
US4197306A (en) * | 1977-06-30 | 1980-04-08 | Uniroyal, Inc. | Aryl-substituted thiazoles |
US4168315A (en) * | 1977-09-28 | 1979-09-18 | The Upjohn Company | Dianisyl thiazole compound, compositions and method of antithrombotic treatment |
EP0005219B1 (en) * | 1978-04-24 | 1981-07-22 | A/S Dumex (Dumex Ltd.) | Arylimidazoles, their synthesis and pharmaceutical or veterinary preparations containing them |
US4322428A (en) * | 1980-04-02 | 1982-03-30 | Eli Lilly And Company | 2(4-Fluorophenyl)-4,5,-bis(4-methoxyphenyl)thiazole and method of use |
US4330552A (en) * | 1980-11-06 | 1982-05-18 | E. I. Du Pont De Nemours And Company | Antiinflammatory 4,5-diaryl-2-arylthioimidazoles |
-
1983
- 1983-06-22 US US06/506,933 patent/US4533666A/en not_active Expired - Fee Related
-
1984
- 1984-06-18 GR GR75048A patent/GR82377B/el unknown
- 1984-06-18 IL IL72145A patent/IL72145A0/xx unknown
- 1984-06-20 DK DK300784A patent/DK300784A/da not_active Application Discontinuation
- 1984-06-21 HU HU842404A patent/HU192560B/hu unknown
- 1984-06-21 JP JP59129069A patent/JPS6013759A/ja active Pending
- 1984-06-21 EP EP84304186A patent/EP0130044A1/en not_active Ceased
- 1984-06-21 GB GB08415819A patent/GB2142023B/en not_active Expired
- 1984-06-22 KR KR1019840003526A patent/KR860001602B1/ko active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
GB2142023A (en) | 1985-01-09 |
IL72145A0 (en) | 1984-10-31 |
HUT34449A (en) | 1985-03-28 |
GB2142023B (en) | 1986-10-08 |
HU192560B (en) | 1987-06-29 |
JPS6013759A (ja) | 1985-01-24 |
DK300784D0 (da) | 1984-06-20 |
GB8415819D0 (en) | 1984-07-25 |
GR82377B (ko) | 1984-12-13 |
KR860001602B1 (ko) | 1986-10-13 |
US4533666A (en) | 1985-08-06 |
EP0130044A1 (en) | 1985-01-02 |
DK300784A (da) | 1984-12-23 |
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E701 | Decision to grant or registration of patent right |