KR850000412A - 피리미딘 유도체의 제조방법 - Google Patents

피리미딘 유도체의 제조방법 Download PDF

Info

Publication number
KR850000412A
KR850000412A KR1019840003525A KR840003525A KR850000412A KR 850000412 A KR850000412 A KR 850000412A KR 1019840003525 A KR1019840003525 A KR 1019840003525A KR 840003525 A KR840003525 A KR 840003525A KR 850000412 A KR850000412 A KR 850000412A
Authority
KR
South Korea
Prior art keywords
formula
compound
pharmaceutically acceptable
acceptable salt
pyrimidine derivative
Prior art date
Application number
KR1019840003525A
Other languages
English (en)
Other versions
KR860001764B1 (ko
Inventor
마추모토 캔
Original Assignee
아더 알. 웨일
일라이 릴리 앤드 캄파니
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 아더 알. 웨일, 일라이 릴리 앤드 캄파니 filed Critical 아더 알. 웨일
Publication of KR850000412A publication Critical patent/KR850000412A/ko
Application granted granted Critical
Publication of KR860001764B1 publication Critical patent/KR860001764B1/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/26—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pain & Pain Management (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

내용 없음.

Description

피리미딘 유도체의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (3)

  1. (a) 일반식(Ⅲ)의 엔아민온을 일반식(IV)의 벤즈아미딘과 염기 존재하에 반응시키거나, (b) R이 요오도인 일반식(I)의 화합물을 비스(트리플루오로메틸)수은, 구리 및 N-메틸-2-피롤리디논과 함께 가열하여 R이 트리플루오로 메틸인 일반식(I)의 화합물을 제조하거나, (c) 일반식(I)의 화합물을 염화시킴을 특징으로 하며, 일반식(I)의 화합물 또는 이들의 약제학적으로 허용되는 염을 제조하는 방법.
    상기식에서, R은 수소, 트리플루오로메틸, 플루오로, 클로로, 브로모 또는 요오도이다.
  2. 제1항에 있어서, 2-(4-플루오로페닐)-4,5-비스(4-메톡시페닐)-피리미딘 또는 이들의 약제학적으로 허용되는 염을 제조하는 방법.
  3. 제1항에 있어서, 2-(4-클로로페닐)-4,5-비스(4-메톡시페닐) 피리미딘 또는 이들의 약제학적으로 허용되는 염을 제조하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019840003525A 1983-06-22 1984-06-22 피리미딘 유도체의 제조방법 KR860001764B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/506,932 US4500533A (en) 1983-06-22 1983-06-22 2,4,5-Triaryl pyrimidines and a method of treating pain, fever, thrombosis, inflammation and arthritis
US506,932 1983-06-22

Publications (2)

Publication Number Publication Date
KR850000412A true KR850000412A (ko) 1985-02-27
KR860001764B1 KR860001764B1 (ko) 1986-10-21

Family

ID=24016553

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019840003525A KR860001764B1 (ko) 1983-06-22 1984-06-22 피리미딘 유도체의 제조방법

Country Status (9)

Country Link
US (1) US4500533A (ko)
EP (1) EP0130046A1 (ko)
JP (1) JPS6013767A (ko)
KR (1) KR860001764B1 (ko)
DK (1) DK300884A (ko)
GB (1) GB2142025B (ko)
GR (1) GR82683B (ko)
HU (1) HUT34962A (ko)
IL (1) IL72144A0 (ko)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0811329B2 (ja) * 1988-06-13 1996-02-07 オークマ株式会社 雌ねじの加工方法
EP0888335A4 (en) * 1996-03-13 2002-01-02 Smithkline Beecham Corp NEW PYRIMIDINE COMPOUNDS AND THEIR USE IN THE TREATMENT OF CYTOKININ MEDIATOR DISEASES
CZ296911B6 (cs) * 1996-12-05 2006-07-12 Amgen Inc. Substituovaný pyrimidin, jeho pouzití a farmaceutický prostredek na jeho bázi
US6410729B1 (en) 1996-12-05 2002-06-25 Amgen Inc. Substituted pyrimidine compounds and methods of use
EP1314731A3 (en) * 1996-12-05 2004-01-02 Amgen Inc. Substituted pyrimidine compounds and their use
WO1998024782A2 (en) * 1996-12-05 1998-06-11 Amgen Inc. Substituted pyrimidine compounds and their use
US7582670B2 (en) * 2001-12-13 2009-09-01 Natrogen Therapeutics, Inc. Methods of treating an inflammatory-related disease
US20050154046A1 (en) * 2004-01-12 2005-07-14 Longgui Wang Methods of treating an inflammatory-related disease
US8563525B2 (en) 2004-01-12 2013-10-22 Natrogen Therapeutics International, Inc. Methods of treating an inflammatory-related disease
AU2003249484A1 (en) * 2002-07-22 2004-02-09 Orchid Chemicals And Pharmaceuticals Ltd Novel bio-active molecules
CN101426268B (zh) * 2007-11-02 2010-08-25 大唐移动通信设备有限公司 导频资源分配方法、系统和设备

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH484918A (de) * 1965-10-28 1970-01-31 Ciba Geigy Verfahren zur Herstellung heterocyclischer, Aethylendoppelbindungen enthaltender Verbindungen
US3558626A (en) * 1968-07-08 1971-01-26 Sandoz Ag 2-(4 - (diphenyl-2-pyrimidinyl)phenoxy) lower aliphatic monocarbocyclic acids and esters
US4153703A (en) * 1977-06-30 1979-05-08 Uniroyal, Inc. Method of controlling insects and acarids with certain aryl-substituted thiazoles
US4197306A (en) * 1977-06-30 1980-04-08 Uniroyal, Inc. Aryl-substituted thiazoles
US4168315A (en) * 1977-09-28 1979-09-18 The Upjohn Company Dianisyl thiazole compound, compositions and method of antithrombotic treatment
DE2960506D1 (en) * 1978-04-24 1981-10-29 Dumex Ltd As Arylimidazoles, their synthesis and pharmaceutical or veterinary preparations containing them
US4322428A (en) * 1980-04-02 1982-03-30 Eli Lilly And Company 2(4-Fluorophenyl)-4,5,-bis(4-methoxyphenyl)thiazole and method of use
US4330552A (en) * 1980-11-06 1982-05-18 E. I. Du Pont De Nemours And Company Antiinflammatory 4,5-diaryl-2-arylthioimidazoles

Also Published As

Publication number Publication date
HUT34962A (en) 1985-05-28
DK300884D0 (da) 1984-06-20
KR860001764B1 (ko) 1986-10-21
GR82683B (ko) 1985-05-17
IL72144A0 (en) 1984-10-31
JPS6013767A (ja) 1985-01-24
GB2142025B (en) 1986-11-12
GB2142025A (en) 1985-01-09
GB8415821D0 (en) 1984-07-25
EP0130046A1 (en) 1985-01-02
US4500533A (en) 1985-02-19
DK300884A (da) 1984-12-23

Similar Documents

Publication Publication Date Title
EA200100826A1 (ru) 16-галогенопроизводные эпотилона, способ их получения и их применение в фармацевтике
KR850000412A (ko) 피리미딘 유도체의 제조방법
ATE40684T1 (de) (benzoyl-4-piperidino)-2-phenyl-1alkanolderivate, ihre herstellung und ihre verwendung als heilmittel.
PT91574A (pt) Procede de preparation de n-cycloalkyle benzyamines utiles comme medicaments
KR850000400A (ko) 피리딘 유도체
SE8503415D0 (sv) Novel isoindolinyl-alkyl-piperazines
GB2104890B (en) Pyridinecarbinols, their preparation and fungicides containing them
DE3266708D1 (en) Pyridazinone derivatives, process for their preparation and their use as fungicides
KR870003994A (ko) 도파민-β-하이드록시라제 억제제
ATE46150T1 (de) Mikrobizide 1-fluor-1-azolyl-2,2diarylethanderivate.
SE8101311L (sv) Heterocykliska foreningar
DK113183D0 (da) Kroneetherforbindelser, deres fremstilling og anvendelse
AU547858B2 (en) Azole fungicides
ATE12487T1 (de) Chlorierte betaketoester, ihre herstellung und anwendung.
SE8204348L (sv) N-fenylpyrazolderivat
SE8201506L (sv) Nya fluorprostacykliner
KR870004006A (ko) 5-아릴-2,4-디알킬-3h-1,2,4-트리아졸-3-티온 및 이의 제조 방법
KR890005076A (ko) 티아디아진 유도체, 그의 제조방법 및 그 화합물을 함유하는 살충제
KR850000380A (ko) 터페닐 유도체의 제조방법
ATE82749T1 (de) 2-cyano-2-alkoximino-acetamide.
KR830005188A (ko) 혈당강하성 구아닐 아미딘의 제조방법
KR830004290A (ko) 3-하이드라지노-6-py-피리다진이나 그의 산부가염의 제조방법
DE3772006D1 (de) Aralkyl-4h-1,2,4-triazolderivate.
DK0527314T3 (da) Fremgangsmåde til fremstilling af 2-aryl-2H-1,2,3-triazoler
KR890005126A (ko) 할로알킬 티아졸의 제조방법 및 이 방법으로 제조한 할로알킬 티아졸

Legal Events

Date Code Title Description
E902 Notification of reason for refusal
G160 Decision to publish patent application
E701 Decision to grant or registration of patent right
NORF Unpaid initial registration fee