KR850000412A - 피리미딘 유도체의 제조방법 - Google Patents

피리미딘 유도체의 제조방법 Download PDF

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Publication number
KR850000412A
KR850000412A KR1019840003525A KR840003525A KR850000412A KR 850000412 A KR850000412 A KR 850000412A KR 1019840003525 A KR1019840003525 A KR 1019840003525A KR 840003525 A KR840003525 A KR 840003525A KR 850000412 A KR850000412 A KR 850000412A
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KR
South Korea
Prior art keywords
formula
compound
pharmaceutically acceptable
acceptable salt
pyrimidine derivative
Prior art date
Application number
KR1019840003525A
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English (en)
Other versions
KR860001764B1 (ko
Inventor
마추모토 캔
Original Assignee
아더 알. 웨일
일라이 릴리 앤드 캄파니
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Application filed by 아더 알. 웨일, 일라이 릴리 앤드 캄파니 filed Critical 아더 알. 웨일
Publication of KR850000412A publication Critical patent/KR850000412A/ko
Application granted granted Critical
Publication of KR860001764B1 publication Critical patent/KR860001764B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/26—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pain & Pain Management (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

내용 없음.

Description

피리미딘 유도체의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (3)

  1. (a) 일반식(Ⅲ)의 엔아민온을 일반식(IV)의 벤즈아미딘과 염기 존재하에 반응시키거나, (b) R이 요오도인 일반식(I)의 화합물을 비스(트리플루오로메틸)수은, 구리 및 N-메틸-2-피롤리디논과 함께 가열하여 R이 트리플루오로 메틸인 일반식(I)의 화합물을 제조하거나, (c) 일반식(I)의 화합물을 염화시킴을 특징으로 하며, 일반식(I)의 화합물 또는 이들의 약제학적으로 허용되는 염을 제조하는 방법.
    상기식에서, R은 수소, 트리플루오로메틸, 플루오로, 클로로, 브로모 또는 요오도이다.
  2. 제1항에 있어서, 2-(4-플루오로페닐)-4,5-비스(4-메톡시페닐)-피리미딘 또는 이들의 약제학적으로 허용되는 염을 제조하는 방법.
  3. 제1항에 있어서, 2-(4-클로로페닐)-4,5-비스(4-메톡시페닐) 피리미딘 또는 이들의 약제학적으로 허용되는 염을 제조하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019840003525A 1983-06-22 1984-06-22 피리미딘 유도체의 제조방법 KR860001764B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/506,932 US4500533A (en) 1983-06-22 1983-06-22 2,4,5-Triaryl pyrimidines and a method of treating pain, fever, thrombosis, inflammation and arthritis
US506,932 1983-06-22

Publications (2)

Publication Number Publication Date
KR850000412A true KR850000412A (ko) 1985-02-27
KR860001764B1 KR860001764B1 (ko) 1986-10-21

Family

ID=24016553

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019840003525A KR860001764B1 (ko) 1983-06-22 1984-06-22 피리미딘 유도체의 제조방법

Country Status (9)

Country Link
US (1) US4500533A (ko)
EP (1) EP0130046A1 (ko)
JP (1) JPS6013767A (ko)
KR (1) KR860001764B1 (ko)
DK (1) DK300884A (ko)
GB (1) GB2142025B (ko)
GR (1) GR82683B (ko)
HU (1) HUT34962A (ko)
IL (1) IL72144A0 (ko)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0811329B2 (ja) * 1988-06-13 1996-02-07 オークマ株式会社 雌ねじの加工方法
US6096748A (en) 1996-03-13 2000-08-01 Smithkline Beecham Corporation Pyrimidine compounds useful in treating cytokine mediated diseases
AR048564A1 (es) * 1996-12-05 2006-05-10 Amgen Inc Compuestos de pirimidina sustituidos,composicion farmaceutica y usos para la fabricacion de medicamentos particularmente para el tratamiento de enfermedades mediadas por tnf-alfa, il-1 beta, il-6 y/o il-8
AR038955A1 (es) * 1996-12-05 2005-02-02 Amgen Inc Compuestos de pirimidinona y piridona sustituidos y metodos para su uso
US6410729B1 (en) 1996-12-05 2002-06-25 Amgen Inc. Substituted pyrimidine compounds and methods of use
EP1314732A3 (en) * 1996-12-05 2004-01-02 Amgen Inc. Substituted pyrimidine compounds and their use
US8563525B2 (en) 2004-01-12 2013-10-22 Natrogen Therapeutics International, Inc. Methods of treating an inflammatory-related disease
US20050154046A1 (en) * 2004-01-12 2005-07-14 Longgui Wang Methods of treating an inflammatory-related disease
US7582670B2 (en) * 2001-12-13 2009-09-01 Natrogen Therapeutics, Inc. Methods of treating an inflammatory-related disease
WO2004009560A1 (en) * 2002-07-22 2004-01-29 Orchid Chemicals & Pharmaceuticals Ltd Novel bio-active molecules
CN101426268B (zh) * 2007-11-02 2010-08-25 大唐移动通信设备有限公司 导频资源分配方法、系统和设备

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH484918A (de) * 1965-10-28 1970-01-31 Ciba Geigy Verfahren zur Herstellung heterocyclischer, Aethylendoppelbindungen enthaltender Verbindungen
US3558626A (en) * 1968-07-08 1971-01-26 Sandoz Ag 2-(4 - (diphenyl-2-pyrimidinyl)phenoxy) lower aliphatic monocarbocyclic acids and esters
US4153703A (en) * 1977-06-30 1979-05-08 Uniroyal, Inc. Method of controlling insects and acarids with certain aryl-substituted thiazoles
US4197306A (en) * 1977-06-30 1980-04-08 Uniroyal, Inc. Aryl-substituted thiazoles
US4168315A (en) * 1977-09-28 1979-09-18 The Upjohn Company Dianisyl thiazole compound, compositions and method of antithrombotic treatment
EP0005219B1 (en) * 1978-04-24 1981-07-22 A/S Dumex (Dumex Ltd.) Arylimidazoles, their synthesis and pharmaceutical or veterinary preparations containing them
US4322428A (en) * 1980-04-02 1982-03-30 Eli Lilly And Company 2(4-Fluorophenyl)-4,5,-bis(4-methoxyphenyl)thiazole and method of use
US4330552A (en) * 1980-11-06 1982-05-18 E. I. Du Pont De Nemours And Company Antiinflammatory 4,5-diaryl-2-arylthioimidazoles

Also Published As

Publication number Publication date
EP0130046A1 (en) 1985-01-02
HUT34962A (en) 1985-05-28
KR860001764B1 (ko) 1986-10-21
DK300884A (da) 1984-12-23
GB2142025B (en) 1986-11-12
US4500533A (en) 1985-02-19
JPS6013767A (ja) 1985-01-24
GR82683B (ko) 1985-05-17
GB2142025A (en) 1985-01-09
GB8415821D0 (en) 1984-07-25
IL72144A0 (en) 1984-10-31
DK300884D0 (da) 1984-06-20

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