SE8201506L - Nya fluorprostacykliner - Google Patents
Nya fluorprostacyklinerInfo
- Publication number
- SE8201506L SE8201506L SE8201506A SE8201506A SE8201506L SE 8201506 L SE8201506 L SE 8201506L SE 8201506 A SE8201506 A SE 8201506A SE 8201506 A SE8201506 A SE 8201506A SE 8201506 L SE8201506 L SE 8201506L
- Authority
- SE
- Sweden
- Prior art keywords
- hydrogen
- methyl
- agents
- trifluoromethyl
- fluoro
- Prior art date
Links
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- 239000001257 hydrogen Substances 0.000 abstract 5
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 125000001153 fluoro group Chemical group F* 0.000 abstract 2
- 150000002431 hydrogen Chemical class 0.000 abstract 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000003276 anti-hypertensive effect Effects 0.000 abstract 1
- 230000000026 anti-ulcerogenic effect Effects 0.000 abstract 1
- 239000002220 antihypertensive agent Substances 0.000 abstract 1
- 229940030600 antihypertensive agent Drugs 0.000 abstract 1
- 210000001772 blood platelet Anatomy 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000003287 optical effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 208000010110 spontaneous platelet aggregation Diseases 0.000 abstract 1
- 239000002731 stomach secretion inhibitor Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
- C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
- C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
- C07D307/937—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans with hydrocarbon or substituted hydrocarbon radicals directly attached in position 2, e.g. prostacyclins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24281881A | 1981-03-11 | 1981-03-11 | |
| US33779182A | 1982-01-07 | 1982-01-07 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SE8201506L true SE8201506L (sv) | 1982-09-12 |
| SE453294B SE453294B (sv) | 1988-01-25 |
Family
ID=26935366
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE8201506A SE453294B (sv) | 1981-03-11 | 1982-03-10 | Prostacykliner, forfarande for deras framstellning samt farmaceutiska preparat innehallande nemnda foreningar med antisekretorisk, antiulcerogen och blodtryckssenkande verkan |
| SE8703023A SE8703023L (sv) | 1981-03-11 | 1987-07-31 | Mellanprodukter for framstellning av fluorprostacykliner |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE8703023A SE8703023L (sv) | 1981-03-11 | 1987-07-31 | Mellanprodukter for framstellning av fluorprostacykliner |
Country Status (19)
| Country | Link |
|---|---|
| AT (1) | AT381308B (sv) |
| AU (2) | AU558000B2 (sv) |
| CA (1) | CA1208634A (sv) |
| CH (2) | CH651033A5 (sv) |
| DE (1) | DE3208880A1 (sv) |
| DK (1) | DK104882A (sv) |
| ES (1) | ES510286A0 (sv) |
| FR (3) | FR2503161B1 (sv) |
| GB (2) | GB2094310B (sv) |
| HU (1) | HU190684B (sv) |
| IE (1) | IE52388B1 (sv) |
| IL (1) | IL65177A (sv) |
| IT (1) | IT1195917B (sv) |
| LU (1) | LU83992A1 (sv) |
| NL (1) | NL8200992A (sv) |
| NO (1) | NO154494C (sv) |
| NZ (1) | NZ199912A (sv) |
| PH (2) | PH17410A (sv) |
| SE (2) | SE453294B (sv) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU190007B (en) * | 1982-05-06 | 1986-08-28 | Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt,Hu | Process for producing new aromatic prostacylin analogues |
| DK40485A (da) * | 1984-03-02 | 1985-09-03 | Hoffmann La Roche | Prostaglandin-mellemprodukter |
| US4680415A (en) * | 1985-06-24 | 1987-07-14 | Hoffmann-La Roche Inc. | Intermediates for 7-fluoro dihydro PGI compounds |
| US4634782A (en) * | 1985-06-24 | 1987-01-06 | Hoffmann-La Roche Inc. | 7-fluoro-dihydro PGI compounds |
| US4808734A (en) * | 1986-12-01 | 1989-02-28 | Hoffmann-La Roche Inc. | 16-cycloalkyl-7-fluoro-prostacyclins |
| CH674363A5 (sv) * | 1986-12-01 | 1990-05-31 | Hoffmann La Roche | |
| RU2239925C1 (ru) * | 2003-09-03 | 2004-11-10 | Анисимова Ирина Александровна | Свеча зажигания для двигателя внутреннего сгорания |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL51189A (en) * | 1976-02-04 | 1985-08-30 | Upjohn Co | Prostaglandin analogs |
| GB1583961A (en) * | 1976-05-11 | 1981-02-04 | Wellcome Found | Prostacyclin and derivatives thereof |
| US4178367A (en) * | 1977-02-21 | 1979-12-11 | Ono Pharmaceutical Co. Ltd. | Prostaglandin I2 analogues |
| DE2811950A1 (de) * | 1978-03-18 | 1979-12-13 | Hoechst Ag | Neue analoga von prostacyclin |
| US4254042A (en) * | 1979-07-05 | 1981-03-03 | The Upjohn Company | 19-Hydroxy-19-methyl-4,5-didehydro-PGI1 compounds |
| WO1981001002A1 (en) * | 1979-10-10 | 1981-04-16 | Univ Chicago | Fluoro-substituted prostaglandins and prostacyclins |
| GB2084991B (en) * | 1980-09-22 | 1984-06-20 | Hoffmann La Roche | Prostacyclins |
| GB2088856B (en) * | 1980-10-27 | 1984-06-27 | Chinoin Gyogyszer Es Vegyeszet | 7-substituted pg12-derivatives their preparation and pharmaceutical compositions containing them |
| DE3176313D1 (en) * | 1980-12-09 | 1987-08-20 | Teijin Ltd | Novel halogenated prostacyclins, process for the production thereof, and pharmaceutical use thereof |
-
1982
- 1982-02-10 CH CH4762/84A patent/CH651033A5/de not_active IP Right Cessation
- 1982-02-10 CH CH816/82A patent/CH648556A5/de not_active IP Right Cessation
- 1982-03-03 PH PH26939A patent/PH17410A/en unknown
- 1982-03-04 NZ NZ199912A patent/NZ199912A/en unknown
- 1982-03-04 IT IT19966/82A patent/IT1195917B/it active
- 1982-03-05 AU AU81156/82A patent/AU558000B2/en not_active Ceased
- 1982-03-05 IL IL65177A patent/IL65177A/xx unknown
- 1982-03-08 CA CA000397775A patent/CA1208634A/en not_active Expired
- 1982-03-09 HU HU82714A patent/HU190684B/hu not_active IP Right Cessation
- 1982-03-09 FR FR8203922A patent/FR2503161B1/fr not_active Expired
- 1982-03-10 GB GB8207044A patent/GB2094310B/en not_active Expired
- 1982-03-10 DK DK104882A patent/DK104882A/da not_active Application Discontinuation
- 1982-03-10 AT AT0094982A patent/AT381308B/de not_active IP Right Cessation
- 1982-03-10 NO NO820779A patent/NO154494C/no unknown
- 1982-03-10 NL NL8200992A patent/NL8200992A/nl not_active Application Discontinuation
- 1982-03-10 SE SE8201506A patent/SE453294B/sv not_active IP Right Cessation
- 1982-03-10 LU LU83992A patent/LU83992A1/de unknown
- 1982-03-10 ES ES510286A patent/ES510286A0/es active Granted
- 1982-03-10 IE IE547/82A patent/IE52388B1/en unknown
- 1982-03-11 DE DE19823208880 patent/DE3208880A1/de not_active Ceased
- 1982-11-08 FR FR8218671A patent/FR2515644A1/fr active Granted
- 1982-11-08 FR FR8218672A patent/FR2515650B1/fr not_active Expired
-
1983
- 1983-10-04 PH PH29657A patent/PH18584A/en unknown
-
1984
- 1984-10-16 GB GB08426077A patent/GB2158822B/en not_active Expired
-
1987
- 1987-02-05 AU AU68555/87A patent/AU576441B2/en not_active Ceased
- 1987-07-31 SE SE8703023A patent/SE8703023L/sv not_active Application Discontinuation
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| NUG | Patent has lapsed |
Ref document number: 8201506-6 Effective date: 19910117 Format of ref document f/p: F |