IE820547L - Fluoro-prostacyclins - Google Patents

Fluoro-prostacyclins

Info

Publication number
IE820547L
IE820547L IE820547A IE54782A IE820547L IE 820547 L IE820547 L IE 820547L IE 820547 A IE820547 A IE 820547A IE 54782 A IE54782 A IE 54782A IE 820547 L IE820547 L IE 820547L
Authority
IE
Ireland
Prior art keywords
fluoro
methyl
hydrogen
prostacyclins
compounds
Prior art date
Application number
IE820547A
Other versions
IE52388B1 (en
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Priority to IE1773/86A priority Critical patent/IE52389B1/en
Publication of IE820547L publication Critical patent/IE820547L/en
Publication of IE52388B1 publication Critical patent/IE52388B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • C07D307/937—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans with hydrocarbon or substituted hydrocarbon radicals directly attached in position 2, e.g. prostacyclins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

The present invention relates to compounds of the general formula <IMAGE> wherein: R<6> is lower alkyl; R<11> is hydrogen, methyl or OR<41>; R<2> is methyl, hydrogen or fluoro; R<21> is fluoro, hydrogen, trifluoromethyl or methyl; X is halogen; and OR<41> is hydroxy or forms a hydrolyzable ether protecting group, with the proviso that when R<21> is trifluoromethyl, R<2> is hydrogen or methyl, and to their optical antipodes and racemates. These compounds are useful intermediates for the preparation of novel fluoro-prostacyclins of the general formula I. These compounds are useful in the preparation of the novel fluoro-prostacyclins disclosed in our copending application No. 8207004. [GB2158822A]
IE547/82A 1981-03-11 1982-03-10 Fluoro prostacyclins IE52388B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
IE1773/86A IE52389B1 (en) 1981-03-11 1982-03-10 Intermediates for the preparation of fluoro-phostacyclins

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24281881A 1981-03-11 1981-03-11
US33779182A 1982-01-07 1982-01-07

Publications (2)

Publication Number Publication Date
IE820547L true IE820547L (en) 1982-09-11
IE52388B1 IE52388B1 (en) 1987-10-14

Family

ID=26935366

Family Applications (1)

Application Number Title Priority Date Filing Date
IE547/82A IE52388B1 (en) 1981-03-11 1982-03-10 Fluoro prostacyclins

Country Status (19)

Country Link
AT (1) AT381308B (en)
AU (2) AU558000B2 (en)
CA (1) CA1208634A (en)
CH (2) CH648556A5 (en)
DE (1) DE3208880A1 (en)
DK (1) DK104882A (en)
ES (1) ES8304934A1 (en)
FR (3) FR2503161B1 (en)
GB (2) GB2094310B (en)
HU (1) HU190684B (en)
IE (1) IE52388B1 (en)
IL (1) IL65177A (en)
IT (1) IT1195917B (en)
LU (1) LU83992A1 (en)
NL (1) NL8200992A (en)
NO (1) NO154494C (en)
NZ (1) NZ199912A (en)
PH (2) PH17410A (en)
SE (2) SE453294B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU190007B (en) * 1982-05-06 1986-08-28 Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt,Hu Process for producing new aromatic prostacylin analogues
DK40485A (en) * 1984-03-02 1985-09-03 Hoffmann La Roche Prostaglandin intermediates
US4634782A (en) * 1985-06-24 1987-01-06 Hoffmann-La Roche Inc. 7-fluoro-dihydro PGI compounds
US4680415A (en) * 1985-06-24 1987-07-14 Hoffmann-La Roche Inc. Intermediates for 7-fluoro dihydro PGI compounds
US4808734A (en) * 1986-12-01 1989-02-28 Hoffmann-La Roche Inc. 16-cycloalkyl-7-fluoro-prostacyclins
CH674363A5 (en) * 1986-12-01 1990-05-31 Hoffmann La Roche
RU2239925C1 (en) * 2003-09-03 2004-11-10 Анисимова Ирина Александровна Spark plug for internal-combustion engine

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL51189A (en) * 1976-02-04 1985-08-30 Upjohn Co Prostaglandin analogs
GB1583961A (en) * 1976-05-11 1981-02-04 Wellcome Found Prostacyclin and derivatives thereof
US4178367A (en) * 1977-02-21 1979-12-11 Ono Pharmaceutical Co. Ltd. Prostaglandin I2 analogues
DE2811950A1 (en) * 1978-03-18 1979-12-13 Hoechst Ag NEW PROSTACYCLIN ANALOGS
US4254042A (en) * 1979-07-05 1981-03-03 The Upjohn Company 19-Hydroxy-19-methyl-4,5-didehydro-PGI1 compounds
JPS56501319A (en) * 1979-10-10 1981-09-17
GB2084991B (en) * 1980-09-22 1984-06-20 Hoffmann La Roche Prostacyclins
US4565827A (en) * 1980-10-27 1986-01-21 Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara R.T. 7-Substituted PGI2 -derivatives and pharmaceutical compositions containing them
EP0054795B1 (en) * 1980-12-09 1987-07-15 Teijin Limited Novel halogenated prostacyclins, process for the production thereof, and pharmaceutical use thereof

Also Published As

Publication number Publication date
FR2515650A1 (en) 1983-05-06
NL8200992A (en) 1982-10-01
AU6855587A (en) 1987-05-07
NO154494B (en) 1986-06-23
IT1195917B (en) 1988-11-03
HU190684B (en) 1986-10-28
GB2094310A (en) 1982-09-15
DE3208880A1 (en) 1982-09-23
GB8426077D0 (en) 1984-11-21
LU83992A1 (en) 1983-11-17
ATA94982A (en) 1986-02-15
CH648556A5 (en) 1985-03-29
PH18584A (en) 1985-08-12
DK104882A (en) 1982-09-12
ES510286A0 (en) 1983-04-01
SE8201506L (en) 1982-09-12
GB2158822A (en) 1985-11-20
CH651033A5 (en) 1985-08-30
SE8703023D0 (en) 1987-07-31
IE52388B1 (en) 1987-10-14
FR2503161B1 (en) 1986-04-18
GB2094310B (en) 1985-07-03
IL65177A0 (en) 1982-05-31
PH17410A (en) 1984-08-08
NO154494C (en) 1986-10-01
NZ199912A (en) 1985-08-30
FR2515644A1 (en) 1983-05-06
FR2515650B1 (en) 1985-08-09
IL65177A (en) 1985-10-31
GB2158822B (en) 1986-06-18
CA1208634A (en) 1986-07-29
AT381308B (en) 1986-09-25
FR2515644B1 (en) 1984-05-25
ES8304934A1 (en) 1983-04-01
AU558000B2 (en) 1987-01-15
SE453294B (en) 1988-01-25
AU576441B2 (en) 1988-08-25
FR2503161A1 (en) 1982-10-08
SE8703023L (en) 1987-07-31
NO820779L (en) 1982-09-13
AU8115682A (en) 1982-09-16
IT8219966A0 (en) 1982-03-04

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