SE8703023L - INTERMEDIATES FOR THE PREPARATION OF FLUORPROSTACYCLINES - Google Patents

INTERMEDIATES FOR THE PREPARATION OF FLUORPROSTACYCLINES

Info

Publication number
SE8703023L
SE8703023L SE8703023A SE8703023A SE8703023L SE 8703023 L SE8703023 L SE 8703023L SE 8703023 A SE8703023 A SE 8703023A SE 8703023 A SE8703023 A SE 8703023A SE 8703023 L SE8703023 L SE 8703023L
Authority
SE
Sweden
Prior art keywords
hydrogen
methyl
agents
trifluoromethyl
fluoro
Prior art date
Application number
SE8703023A
Other languages
Swedish (sv)
Other versions
SE8703023D0 (en
Inventor
G W Holland
H Maag
P Rosen
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of SE8703023D0 publication Critical patent/SE8703023D0/en
Publication of SE8703023L publication Critical patent/SE8703023L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • C07D307/937—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans with hydrocarbon or substituted hydrocarbon radicals directly attached in position 2, e.g. prostacyclins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)

Abstract

Compounds of the formula <IMAGE> wherein one of the double bonds indicated by broken lines is present in 4,5 or 5,6-position, R is hydrogen or lower alkyl, R<1> is methyl, hydrogen or hydroxy; R<2> is hydrogen, methyl or fluoro; and R<21> is hydrogen, fluoro, trifluoromethyl or methyl; with the proviso that when R<21> is trifluoromethyl, R<2> is hydrogen or methyl, their pharmaceutically acceptable salts, optical antipodes or racemates are useful as anti-secretory agents, anti-hypertensives, anti-ulcerogenic agents and blood platelet aggregation inhibiting agents.
SE8703023A 1981-03-11 1987-07-31 INTERMEDIATES FOR THE PREPARATION OF FLUORPROSTACYCLINES SE8703023L (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24281881A 1981-03-11 1981-03-11
US33779182A 1982-01-07 1982-01-07

Publications (2)

Publication Number Publication Date
SE8703023D0 SE8703023D0 (en) 1987-07-31
SE8703023L true SE8703023L (en) 1987-07-31

Family

ID=26935366

Family Applications (2)

Application Number Title Priority Date Filing Date
SE8201506A SE453294B (en) 1981-03-11 1982-03-10 PROSTACYCLINES, PROCEDURES FOR THEIR PRODUCTION AND PHARMACEUTICAL PREPARATIONS INCLUDING THE SUBSTANCES OF ANTISECRETORIC, ANTIUAL CEROGENE AND ANTI-PRESSURE-LOWERING EFFECTS
SE8703023A SE8703023L (en) 1981-03-11 1987-07-31 INTERMEDIATES FOR THE PREPARATION OF FLUORPROSTACYCLINES

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SE8201506A SE453294B (en) 1981-03-11 1982-03-10 PROSTACYCLINES, PROCEDURES FOR THEIR PRODUCTION AND PHARMACEUTICAL PREPARATIONS INCLUDING THE SUBSTANCES OF ANTISECRETORIC, ANTIUAL CEROGENE AND ANTI-PRESSURE-LOWERING EFFECTS

Country Status (19)

Country Link
AT (1) AT381308B (en)
AU (2) AU558000B2 (en)
CA (1) CA1208634A (en)
CH (2) CH648556A5 (en)
DE (1) DE3208880A1 (en)
DK (1) DK104882A (en)
ES (1) ES8304934A1 (en)
FR (3) FR2503161B1 (en)
GB (2) GB2094310B (en)
HU (1) HU190684B (en)
IE (1) IE52388B1 (en)
IL (1) IL65177A (en)
IT (1) IT1195917B (en)
LU (1) LU83992A1 (en)
NL (1) NL8200992A (en)
NO (1) NO154494C (en)
NZ (1) NZ199912A (en)
PH (2) PH17410A (en)
SE (2) SE453294B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU190007B (en) * 1982-05-06 1986-08-28 Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt,Hu Process for producing new aromatic prostacylin analogues
DK40485A (en) * 1984-03-02 1985-09-03 Hoffmann La Roche Prostaglandin intermediates
US4634782A (en) * 1985-06-24 1987-01-06 Hoffmann-La Roche Inc. 7-fluoro-dihydro PGI compounds
US4680415A (en) * 1985-06-24 1987-07-14 Hoffmann-La Roche Inc. Intermediates for 7-fluoro dihydro PGI compounds
US4808734A (en) * 1986-12-01 1989-02-28 Hoffmann-La Roche Inc. 16-cycloalkyl-7-fluoro-prostacyclins
CH674363A5 (en) * 1986-12-01 1990-05-31 Hoffmann La Roche
RU2239925C1 (en) * 2003-09-03 2004-11-10 Анисимова Ирина Александровна Spark plug for internal-combustion engine

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL51189A (en) * 1976-02-04 1985-08-30 Upjohn Co Prostaglandin analogs
GB1583961A (en) * 1976-05-11 1981-02-04 Wellcome Found Prostacyclin and derivatives thereof
US4178367A (en) * 1977-02-21 1979-12-11 Ono Pharmaceutical Co. Ltd. Prostaglandin I2 analogues
DE2811950A1 (en) * 1978-03-18 1979-12-13 Hoechst Ag NEW PROSTACYCLIN ANALOGS
US4254042A (en) * 1979-07-05 1981-03-03 The Upjohn Company 19-Hydroxy-19-methyl-4,5-didehydro-PGI1 compounds
JPS56501319A (en) * 1979-10-10 1981-09-17
GB2084991B (en) * 1980-09-22 1984-06-20 Hoffmann La Roche Prostacyclins
US4565827A (en) * 1980-10-27 1986-01-21 Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara R.T. 7-Substituted PGI2 -derivatives and pharmaceutical compositions containing them
EP0054795B1 (en) * 1980-12-09 1987-07-15 Teijin Limited Novel halogenated prostacyclins, process for the production thereof, and pharmaceutical use thereof

Also Published As

Publication number Publication date
FR2515650A1 (en) 1983-05-06
NL8200992A (en) 1982-10-01
AU6855587A (en) 1987-05-07
NO154494B (en) 1986-06-23
IT1195917B (en) 1988-11-03
HU190684B (en) 1986-10-28
GB2094310A (en) 1982-09-15
DE3208880A1 (en) 1982-09-23
GB8426077D0 (en) 1984-11-21
LU83992A1 (en) 1983-11-17
ATA94982A (en) 1986-02-15
CH648556A5 (en) 1985-03-29
PH18584A (en) 1985-08-12
DK104882A (en) 1982-09-12
ES510286A0 (en) 1983-04-01
SE8201506L (en) 1982-09-12
GB2158822A (en) 1985-11-20
CH651033A5 (en) 1985-08-30
SE8703023D0 (en) 1987-07-31
IE52388B1 (en) 1987-10-14
FR2503161B1 (en) 1986-04-18
GB2094310B (en) 1985-07-03
IL65177A0 (en) 1982-05-31
PH17410A (en) 1984-08-08
NO154494C (en) 1986-10-01
NZ199912A (en) 1985-08-30
FR2515644A1 (en) 1983-05-06
FR2515650B1 (en) 1985-08-09
IL65177A (en) 1985-10-31
GB2158822B (en) 1986-06-18
CA1208634A (en) 1986-07-29
IE820547L (en) 1982-09-11
AT381308B (en) 1986-09-25
FR2515644B1 (en) 1984-05-25
ES8304934A1 (en) 1983-04-01
AU558000B2 (en) 1987-01-15
SE453294B (en) 1988-01-25
AU576441B2 (en) 1988-08-25
FR2503161A1 (en) 1982-10-08
NO820779L (en) 1982-09-13
AU8115682A (en) 1982-09-16
IT8219966A0 (en) 1982-03-04

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