GB2158822B - Intermediates for the preparation of fluoro-prostacyclins - Google Patents

Intermediates for the preparation of fluoro-prostacyclins

Info

Publication number
GB2158822B
GB2158822B GB08426077A GB8426077A GB2158822B GB 2158822 B GB2158822 B GB 2158822B GB 08426077 A GB08426077 A GB 08426077A GB 8426077 A GB8426077 A GB 8426077A GB 2158822 B GB2158822 B GB 2158822B
Authority
GB
United Kingdom
Prior art keywords
prostacyclins
intermediates
fluoro
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB08426077A
Other versions
GB2158822A (en
GB8426077D0 (en
Inventor
George William Holland
Hans Maag
Perry Rosen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of GB8426077D0 publication Critical patent/GB8426077D0/en
Publication of GB2158822A publication Critical patent/GB2158822A/en
Application granted granted Critical
Publication of GB2158822B publication Critical patent/GB2158822B/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • C07D307/937—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans with hydrocarbon or substituted hydrocarbon radicals directly attached in position 2, e.g. prostacyclins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
GB08426077A 1981-03-11 1984-10-16 Intermediates for the preparation of fluoro-prostacyclins Expired GB2158822B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24281881A 1981-03-11 1981-03-11
US33779182A 1982-01-07 1982-01-07

Publications (3)

Publication Number Publication Date
GB8426077D0 GB8426077D0 (en) 1984-11-21
GB2158822A GB2158822A (en) 1985-11-20
GB2158822B true GB2158822B (en) 1986-06-18

Family

ID=26935366

Family Applications (2)

Application Number Title Priority Date Filing Date
GB8207044A Expired GB2094310B (en) 1981-03-11 1982-03-10 Novel fluoro-prostacyclins
GB08426077A Expired GB2158822B (en) 1981-03-11 1984-10-16 Intermediates for the preparation of fluoro-prostacyclins

Family Applications Before (1)

Application Number Title Priority Date Filing Date
GB8207044A Expired GB2094310B (en) 1981-03-11 1982-03-10 Novel fluoro-prostacyclins

Country Status (19)

Country Link
AT (1) AT381308B (en)
AU (2) AU558000B2 (en)
CA (1) CA1208634A (en)
CH (2) CH648556A5 (en)
DE (1) DE3208880A1 (en)
DK (1) DK104882A (en)
ES (1) ES510286A0 (en)
FR (3) FR2503161B1 (en)
GB (2) GB2094310B (en)
HU (1) HU190684B (en)
IE (1) IE52388B1 (en)
IL (1) IL65177A (en)
IT (1) IT1195917B (en)
LU (1) LU83992A1 (en)
NL (1) NL8200992A (en)
NO (1) NO154494C (en)
NZ (1) NZ199912A (en)
PH (2) PH17410A (en)
SE (2) SE453294B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU190007B (en) * 1982-05-06 1986-08-28 Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt,Hu Process for producing new aromatic prostacylin analogues
DK40485A (en) * 1984-03-02 1985-09-03 Hoffmann La Roche Prostaglandin intermediates
US4634782A (en) * 1985-06-24 1987-01-06 Hoffmann-La Roche Inc. 7-fluoro-dihydro PGI compounds
US4680415A (en) * 1985-06-24 1987-07-14 Hoffmann-La Roche Inc. Intermediates for 7-fluoro dihydro PGI compounds
US4808734A (en) * 1986-12-01 1989-02-28 Hoffmann-La Roche Inc. 16-cycloalkyl-7-fluoro-prostacyclins
CH674363A5 (en) * 1986-12-01 1990-05-31 Hoffmann La Roche
RU2239925C1 (en) * 2003-09-03 2004-11-10 Анисимова Ирина Александровна Spark plug for internal-combustion engine

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL51189A (en) * 1976-02-04 1985-08-30 Upjohn Co Prostaglandin analogs
GB1583961A (en) * 1976-05-11 1981-02-04 Wellcome Found Prostacyclin and derivatives thereof
US4178367A (en) * 1977-02-21 1979-12-11 Ono Pharmaceutical Co. Ltd. Prostaglandin I2 analogues
DE2811950A1 (en) * 1978-03-18 1979-12-13 Hoechst Ag NEW PROSTACYCLIN ANALOGS
US4254042A (en) * 1979-07-05 1981-03-03 The Upjohn Company 19-Hydroxy-19-methyl-4,5-didehydro-PGI1 compounds
JPS56501319A (en) * 1979-10-10 1981-09-17
GB2084991B (en) * 1980-09-22 1984-06-20 Hoffmann La Roche Prostacyclins
US4565827A (en) * 1980-10-27 1986-01-21 Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara R.T. 7-Substituted PGI2 -derivatives and pharmaceutical compositions containing them
US4472428A (en) * 1980-12-09 1984-09-18 Teijin Limited Halogenated prostacyclins pharmaceutical use thereof and hydroxy intermediates therefore

Also Published As

Publication number Publication date
NZ199912A (en) 1985-08-30
AU576441B2 (en) 1988-08-25
IE52388B1 (en) 1987-10-14
IL65177A0 (en) 1982-05-31
SE8703023D0 (en) 1987-07-31
AU558000B2 (en) 1987-01-15
IL65177A (en) 1985-10-31
PH18584A (en) 1985-08-12
DE3208880A1 (en) 1982-09-23
FR2503161A1 (en) 1982-10-08
CH648556A5 (en) 1985-03-29
GB2158822A (en) 1985-11-20
DK104882A (en) 1982-09-12
IT1195917B (en) 1988-11-03
AU8115682A (en) 1982-09-16
CA1208634A (en) 1986-07-29
FR2503161B1 (en) 1986-04-18
AU6855587A (en) 1987-05-07
AT381308B (en) 1986-09-25
PH17410A (en) 1984-08-08
FR2515650B1 (en) 1985-08-09
NO154494B (en) 1986-06-23
ES8304934A1 (en) 1983-04-01
SE8201506L (en) 1982-09-12
SE8703023L (en) 1987-07-31
FR2515650A1 (en) 1983-05-06
NO820779L (en) 1982-09-13
GB2094310B (en) 1985-07-03
FR2515644A1 (en) 1983-05-06
HU190684B (en) 1986-10-28
IT8219966A0 (en) 1982-03-04
GB2094310A (en) 1982-09-15
IE820547L (en) 1982-09-11
NO154494C (en) 1986-10-01
ATA94982A (en) 1986-02-15
SE453294B (en) 1988-01-25
FR2515644B1 (en) 1984-05-25
LU83992A1 (en) 1983-11-17
NL8200992A (en) 1982-10-01
CH651033A5 (en) 1985-08-30
ES510286A0 (en) 1983-04-01
GB8426077D0 (en) 1984-11-21

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Legal Events

Date Code Title Description
732 Registration of transactions, instruments or events in the register (sect. 32/1977)
PCNP Patent ceased through non-payment of renewal fee