ATE40684T1 - (benzoyl-4-piperidino)-2-phenyl-1alkanolderivate, ihre herstellung und ihre verwendung als heilmittel. - Google Patents
(benzoyl-4-piperidino)-2-phenyl-1alkanolderivate, ihre herstellung und ihre verwendung als heilmittel.Info
- Publication number
- ATE40684T1 ATE40684T1 AT86401000T AT86401000T ATE40684T1 AT E40684 T1 ATE40684 T1 AT E40684T1 AT 86401000 T AT86401000 T AT 86401000T AT 86401000 T AT86401000 T AT 86401000T AT E40684 T1 ATE40684 T1 AT E40684T1
- Authority
- AT
- Austria
- Prior art keywords
- phenyl
- 1alkanol
- piperidino
- medicines
- benzoyl
- Prior art date
Links
- 239000003814 drug Substances 0.000 title 1
- -1 4-methoxy - 3,5-dimethylphenyl Chemical group 0.000 abstract 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 4
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
- 125000005808 2,4,6-trimethoxyphenyl group Chemical group [H][#6]-1=[#6](-[#8]C([H])([H])[H])-[#6](-*)=[#6](-[#8]C([H])([H])[H])-[#6]([H])=[#6]-1-[#8]C([H])([H])[H] 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 150000002431 hydrogen Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
- C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Neurology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Hospice & Palliative Care (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychiatry (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Organic Insulating Materials (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8507270A FR2581993B1 (fr) | 1985-05-14 | 1985-05-14 | Derives de (benzoyl-4 piperidino)-2 phenyl-1 alcanols, leur preparation et leur application en therapeutique |
| EP86401000A EP0202164B1 (de) | 1985-05-14 | 1986-05-12 | (Benzoyl-4-piperidino)-2-phenyl-1-alkanolderivate, ihre Herstellung und ihre Verwendung als Heilmittel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE40684T1 true ATE40684T1 (de) | 1989-02-15 |
Family
ID=9319247
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT86401000T ATE40684T1 (de) | 1985-05-14 | 1986-05-12 | (benzoyl-4-piperidino)-2-phenyl-1alkanolderivate, ihre herstellung und ihre verwendung als heilmittel. |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US4711899A (de) |
| EP (1) | EP0202164B1 (de) |
| JP (1) | JPS61260063A (de) |
| KR (1) | KR860008976A (de) |
| AT (1) | ATE40684T1 (de) |
| AU (1) | AU584701B2 (de) |
| DE (1) | DE3662044D1 (de) |
| DK (1) | DK220386A (de) |
| ES (2) | ES8802138A1 (de) |
| FI (1) | FI861995A7 (de) |
| FR (1) | FR2581993B1 (de) |
| GR (1) | GR861253B (de) |
| HU (1) | HU195640B (de) |
| IL (1) | IL78773A (de) |
| NO (1) | NO861897L (de) |
| NZ (1) | NZ216145A (de) |
| PT (1) | PT82569B (de) |
| ZA (1) | ZA863533B (de) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR910006138B1 (ko) * | 1986-09-30 | 1991-08-16 | 에자이 가부시끼가이샤 | 환상아민 유도체 |
| JP2573195B2 (ja) * | 1986-09-30 | 1997-01-22 | エーザイ株式会社 | 環状アミン誘導体 |
| US4870083A (en) * | 1987-11-24 | 1989-09-26 | Merrell Dow Pharmaceuticals Inc. | 1,4-Disubstituted-piperidinyl compounds useful as analgesics and muscle relaxants |
| US5166211A (en) * | 1987-12-17 | 1992-11-24 | Merrell Dow Pharmaceuticals Inc. | Method of using 1,4-disubstituted piperidinyl compounds in the treatment of coronary vasospasons and variant angina |
| US5093341A (en) * | 1987-12-17 | 1992-03-03 | Merrell Dow Pharmaceuticals Inc. | N-aralkyl piperidine derivatives useful as antithrombolytic agents |
| US5064838A (en) * | 1988-01-21 | 1991-11-12 | Merrell Dow Pharmaceuticals | 1,4-disubstituted-piperidinyl compounds as pain relievers |
| FR2640266B2 (fr) * | 1988-07-12 | 1992-07-10 | Synthelabo | Derives de (hydroxy-1 piperidinyl-2 alkyl) indolones-2, quinoleinones-2, benzo(b)azepinones-2 et benzimidazolones-2, leur preparation et leur application en therapeutique |
| FR2634206B1 (fr) * | 1988-07-12 | 1992-05-15 | Synthelabo | Derives de (hydroxy-1 piperidinyl-2 alkyl) indolones-2 et quinoleinones-2, leur preparation et leur application en therapeutique |
| GB8823775D0 (en) * | 1988-10-11 | 1988-11-16 | Scras | New 2-carbonyl substituted n n'-di-(trimethoxybenzoyl)piperazines |
| GB8823776D0 (en) * | 1988-10-11 | 1988-11-16 | Scras | New 2-methoxycarbonyl sustituted n n'-di-(trimethoxybenzoyl)piperazines |
| US5055470A (en) * | 1989-06-01 | 1991-10-08 | Bristol-Myers Squibb Co. | Method of treatment of ischemia in brain |
| US4994460A (en) * | 1989-06-01 | 1991-02-19 | Bristol-Myers Squibb Co. | Agents for treatment of brain ischemia |
| NZ236501A (en) * | 1989-12-21 | 1992-12-23 | Merrell Dow Pharma | Piperidine derivatives and antithrombotic compositions |
| US5292752A (en) * | 1989-12-21 | 1994-03-08 | Merrell Dow Pharmaceuticals Inc. | Antithrombotic compounds |
| US5306723A (en) * | 1990-05-10 | 1994-04-26 | Pfizer Inc. | Neuroprotective indolone and related derivatives |
| US5478846A (en) * | 1990-06-07 | 1995-12-26 | Merrell Dow Pharmaceuticals Inc. | 1-piperidinyl alkanoylanyl sulfonamides for treatment of cardiac arrhythmia |
| AU650031B2 (en) * | 1990-06-07 | 1994-06-09 | Aventisub Ii Inc. | 1-Piperidinyl alkanoylarylsulfonamide derivatives |
| US5512584A (en) * | 1991-04-16 | 1996-04-30 | Basf Aktiengesellschaft | 1,3,4-trisubstituted piperidine derivatives, the preparation and use thereof |
| FR2678269B1 (fr) * | 1991-06-27 | 1995-01-13 | Synthelabo | Derives de 1-(4-chlorophenyl)-2-[4-(2-phenylethyl)piperidin-1-yl]ethanol, leur application et leur preparation en therapeutique. |
| FR2688504B1 (fr) * | 1992-03-13 | 1995-05-05 | Synthelabo | Derives de 2-(piperidin-1-yl)ethanol, leur preparation et leur application en therapeutique. |
| US5436255A (en) * | 1992-07-23 | 1995-07-25 | Pfizer Inc. | Method of treating diseases susceptable to treatment by blocking NMDA-receptors |
| US5498610A (en) * | 1992-11-06 | 1996-03-12 | Pfizer Inc. | Neuroprotective indolone and related derivatives |
| JP2866743B2 (ja) * | 1994-01-31 | 1999-03-08 | フアイザー・インコーポレイテツド | 神経保護化合物 |
| FR2737494B1 (fr) * | 1995-08-04 | 1997-08-29 | Synthelabo | Derives de benzenesulfonamide, leur preparation et leur application en therapeutique |
| US6770659B2 (en) * | 2002-08-26 | 2004-08-03 | Sk Corporation | Benzoyl piperidine compounds |
| US20050158270A1 (en) * | 2004-01-15 | 2005-07-21 | Seren Frantz | Pearlizer concentrate and its use in personal care compositions |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH491917A (de) * | 1968-01-11 | 1970-06-15 | Geigy Ag J R | Verfahren zur Herstellung von neuen Piperidinderivaten |
| US3632767A (en) * | 1968-02-12 | 1972-01-04 | Mallinckrodt Chemical Works | Treatment of depression with 4-substituted piperidines |
| US3576810A (en) * | 1968-06-20 | 1971-04-27 | Robins Co Inc A H | 1-substituted-3-(-4)-aroylpiperidines |
| BE791088A (fr) * | 1971-11-09 | 1973-03-01 | Richardson Merrell Inc | Nouveaux derives d'aryl (piperidyl-4) cetone, utiles notamment comme analgesiques et anticoagulants, et leur procede de preparation |
| US4101662A (en) * | 1973-05-03 | 1978-07-18 | A. H. Robins Company, Incorporated | Method for inhibiting emesis and compositions therefor |
| GB1535791A (en) * | 1975-05-07 | 1978-12-13 | Ferrosan Ab | Derivatives of 4-piperidinol |
| US4035369A (en) * | 1975-10-08 | 1977-07-12 | Janssen Pharmaceutica N.V. | 1-Benzazolylalkyl-4-substituted-piperidines |
| CH602642A5 (de) * | 1975-11-14 | 1978-07-31 | Orgamol Sa | |
| FR2408602A2 (fr) * | 1977-11-15 | 1979-06-08 | Synthelabo | Nouveaux derives de piperidine et leur methode de preparation |
| US4335127A (en) * | 1979-01-08 | 1982-06-15 | Janssen Pharmaceutica, N.V. | Piperidinylalkyl quinazoline compounds, composition and method of use |
| US4198419A (en) * | 1979-01-10 | 1980-04-15 | American Hoechst Corporation | Phenylthiophenylpiperidines |
| US4443451A (en) * | 1981-07-15 | 1984-04-17 | Janssen Pharmaceutica N.V. | Bicyclic pyrimidin-5-one derivatives |
| FR2534580A1 (fr) * | 1982-10-13 | 1984-04-20 | Synthelabo | Derives de phenyl-1 piperidino-2 propanol, leur preparation, et medicaments qui les contiennent |
| DK159420C (da) * | 1983-03-09 | 1991-03-11 | Ciba Geigy Ag | N-(piperidinyl-alkyl)-carboxamider og salte deraf, farmaceutiske praeparater indeholdende disse forbindelser samt anvendelsen af forbindelserne til fremstilling af antipsykotiske farmaceutiske praeparater |
| US4458076A (en) * | 1983-05-31 | 1984-07-03 | Hoechst-Roussel Pharmaceuticals | 3-(4-Piperidinyl)-1,2-benzisothiazoles |
-
1985
- 1985-05-14 FR FR8507270A patent/FR2581993B1/fr not_active Expired
-
1986
- 1986-05-12 AT AT86401000T patent/ATE40684T1/de active
- 1986-05-12 EP EP86401000A patent/EP0202164B1/de not_active Expired
- 1986-05-12 DE DE8686401000T patent/DE3662044D1/de not_active Expired
- 1986-05-13 DK DK220386A patent/DK220386A/da not_active Application Discontinuation
- 1986-05-13 US US06/862,715 patent/US4711899A/en not_active Expired - Fee Related
- 1986-05-13 JP JP61110463A patent/JPS61260063A/ja active Pending
- 1986-05-13 NZ NZ216145A patent/NZ216145A/xx unknown
- 1986-05-13 AU AU57406/86A patent/AU584701B2/en not_active Ceased
- 1986-05-13 ES ES554895A patent/ES8802138A1/es not_active Expired
- 1986-05-13 HU HU861975A patent/HU195640B/hu not_active IP Right Cessation
- 1986-05-13 GR GR861253A patent/GR861253B/el unknown
- 1986-05-13 KR KR1019860003714A patent/KR860008976A/ko not_active Withdrawn
- 1986-05-13 FI FI861995A patent/FI861995A7/fi not_active Application Discontinuation
- 1986-05-13 PT PT82569A patent/PT82569B/pt unknown
- 1986-05-13 IL IL78773A patent/IL78773A/xx unknown
- 1986-05-13 ZA ZA863533A patent/ZA863533B/xx unknown
- 1986-05-13 NO NO861897A patent/NO861897L/no unknown
-
1987
- 1987-06-08 ES ES557582A patent/ES8801631A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| HUT40790A (en) | 1987-02-27 |
| AU5740686A (en) | 1986-11-20 |
| DE3662044D1 (en) | 1989-03-16 |
| EP0202164B1 (de) | 1989-02-08 |
| AU584701B2 (en) | 1989-06-01 |
| ES8801631A1 (es) | 1988-02-16 |
| GR861253B (en) | 1986-09-10 |
| IL78773A0 (en) | 1986-08-31 |
| PT82569A (fr) | 1986-06-01 |
| KR860008976A (ko) | 1986-12-19 |
| IL78773A (en) | 1990-09-17 |
| NO861897L (no) | 1986-11-17 |
| ES557582A0 (es) | 1988-02-16 |
| FI861995A0 (fi) | 1986-05-13 |
| DK220386D0 (da) | 1986-05-13 |
| NZ216145A (en) | 1988-10-28 |
| PT82569B (fr) | 1988-04-12 |
| FR2581993B1 (fr) | 1988-03-18 |
| ES8802138A1 (es) | 1988-04-01 |
| HU195640B (en) | 1988-06-28 |
| ZA863533B (en) | 1986-12-30 |
| ES554895A0 (es) | 1988-04-01 |
| FI861995A7 (fi) | 1986-11-15 |
| DK220386A (da) | 1986-11-15 |
| EP0202164A1 (de) | 1986-11-20 |
| FR2581993A1 (fr) | 1986-11-21 |
| US4711899A (en) | 1987-12-08 |
| JPS61260063A (ja) | 1986-11-18 |
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