KR840006204A - 벤즈아미도 유도체 및 그제조법 - Google Patents
벤즈아미도 유도체 및 그제조법 Download PDFInfo
- Publication number
- KR840006204A KR840006204A KR1019830004251A KR830004251A KR840006204A KR 840006204 A KR840006204 A KR 840006204A KR 1019830004251 A KR1019830004251 A KR 1019830004251A KR 830004251 A KR830004251 A KR 830004251A KR 840006204 A KR840006204 A KR 840006204A
- Authority
- KR
- South Korea
- Prior art keywords
- compound
- formula
- chlorine
- bromine
- applying
- Prior art date
Links
- 125000000043 benzamido group Chemical group [H]N([*])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims 16
- 229910052801 chlorine Inorganic materials 0.000 claims 6
- 239000000460 chlorine Substances 0.000 claims 6
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims 5
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 5
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims 5
- 229910052794 bromium Inorganic materials 0.000 claims 5
- 238000006243 chemical reaction Methods 0.000 claims 4
- 238000009472 formulation Methods 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 239000004480 active ingredient Substances 0.000 claims 3
- 125000000217 alkyl group Chemical group 0.000 claims 3
- 125000003277 amino group Chemical group 0.000 claims 3
- 125000004432 carbon atom Chemical group C* 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 238000005804 alkylation reaction Methods 0.000 claims 2
- 239000003153 chemical reaction reagent Substances 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 2
- 230000003287 optical effect Effects 0.000 claims 2
- ORZMSMCZBZARKY-UHFFFAOYSA-N 1,3,2$l^{6}-benzodioxathiole 2,2-dioxide Chemical group C1=CC=C2OS(=O)(=O)OC2=C1 ORZMSMCZBZARKY-UHFFFAOYSA-N 0.000 claims 1
- LBLYYCQCTBFVLH-UHFFFAOYSA-M 2-methylbenzenesulfonate Chemical group CC1=CC=CC=C1S([O-])(=O)=O LBLYYCQCTBFVLH-UHFFFAOYSA-M 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 241000208202 Linaceae Species 0.000 claims 1
- 235000004431 Linum usitatissimum Nutrition 0.000 claims 1
- 238000007126 N-alkylation reaction Methods 0.000 claims 1
- 229910019142 PO4 Inorganic materials 0.000 claims 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical group [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims 1
- FCMKFNXOHUYWRU-UHFFFAOYSA-N [Cl].[Cr] Chemical compound [Cl].[Cr] FCMKFNXOHUYWRU-UHFFFAOYSA-N 0.000 claims 1
- 230000029936 alkylation Effects 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 125000001309 chloro group Chemical group Cl* 0.000 claims 1
- 239000003405 delayed action preparation Substances 0.000 claims 1
- 230000032050 esterification Effects 0.000 claims 1
- 238000005886 esterification reaction Methods 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 238000007918 intramuscular administration Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical group [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 1
- 239000010452 phosphate Chemical group 0.000 claims 1
- 238000007920 subcutaneous administration Methods 0.000 claims 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
- C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C65/21—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyrrole Compounds (AREA)
- Lubricants (AREA)
- Medicinal Preparation (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (12)
- 식 Ⅲ의 화합물을 적용하는 식 Ⅱ의 화합물의 반응에 의하거나 식 C2H5-X 화합물을 적용하는 식 Ⅳ의 화합물의 N-알킬화에 의하거나 식 C2H5NH2화합물을 적용하는 식 Ⅴ의 화합물의 반응에 의하거나 식 Ⅵ의 화합물의 반응에 의하거나 염소/브롬 시약이나 알킬화시약을 적용하는 식 Ⅶ의 화합물의 반응에 의하거나 제1단계로 NaNO22를 적용하고 제2단계로 제1구리할로게나이드(염소/브롬)를 적용하는 식 Ⅷ의 화합물의 반응에 의하거나 식 CH3-B화합물을 적용하는 식 Ⅸ의 화합물의 0-알킬화에 의하거나 식 R-CO-Z' 화합물을 적용하는 식 X의 화합물의 에스테르화에 의해서 식 Ⅰ의 화합물이나 생리학적으로 알맞은 염이나 이들의 광학이성체(이상에서 산출된 화합물은 이들의 생리학적으로 알맞은 염 및/또는 이들의 순수한 입체이성체로됨)를 제조하는 방법.
-
-
-
- 여기서, R은 탄소원자가 6-18인 직쇄 또는 측쇄알킬기. R1은 수소, 염소, 브롬 또는 탄소원자가 1-3인 알킬기. R2는 염소, 브롬 또는 탄소원자가 1-3인 알킬기. -CO-Z는 아마성분의 형성하에 아미노기와 반응할 수 있는 반응기. X는 염소, 브롬, 설페이트, 포스페이트, 벤젠설페이트 또는 톨루엔설포네이트, Hal는 염소나크롬. R1'" 및 R2'"는 수소 또는 R1=R2. D1및 D2는 같거나 다른 것으로, 수소원자나 아미노기를 나타내며 이중 적어도 하나는 아미노기. B는 -(SO4)1/2, -(PO4)1/3 또는 할로겐. Z'는 염소나브롬.
- 제1항에 있어서, 활성성분으로써 상기 화합물이나 생리학적으로 알맞은 염이나 이들의 광학이성체를 구성하는 제제.
- 제2항에 있어서, 일정용량 형태의 제제.
- 제2항 내지 제3항에 있어서, 제약학적으로 알맞은 담체와 화합하는 활성성분을 구성하는 제제.
- 축적질(depot)제제 형태의 제제.
- 피하투여나 근육내 투여용제제.
- 제1항에 있어서, 활성성분으로써 식 Ⅰ의 화합물을 구성하는 제제를 제조하기위해 상기 화합물이나 이들의 생리학적으로 알맞은 염을 이용하는 방법.
- ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE8205135A SE8205135D0 (sv) | 1982-09-09 | 1982-09-09 | Benzamido-derivatives |
| SE8205135-0 | 1982-09-09 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR840006204A true KR840006204A (ko) | 1984-11-22 |
| KR900008316B1 KR900008316B1 (ko) | 1990-11-12 |
Family
ID=20347777
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019830004251A KR900008316B1 (ko) | 1982-09-09 | 1983-09-09 | 벤즈아미도 유도체의 제조방법 |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US4937260A (ko) |
| EP (1) | EP0117384B1 (ko) |
| JP (1) | JPS5967260A (ko) |
| KR (1) | KR900008316B1 (ko) |
| AT (1) | ATE39482T1 (ko) |
| BG (1) | BG37992A3 (ko) |
| CA (1) | CA1207776A (ko) |
| CS (1) | CS239943B2 (ko) |
| CY (1) | CY1461A (ko) |
| DD (1) | DD211552A5 (ko) |
| DE (1) | DE3378761D1 (ko) |
| DK (1) | DK157846C (ko) |
| ES (1) | ES525488A0 (ko) |
| FI (1) | FI78905C (ko) |
| GB (1) | GB2126585B (ko) |
| GR (1) | GR79666B (ko) |
| HK (1) | HK14589A (ko) |
| HU (1) | HU189745B (ko) |
| IE (1) | IE55907B1 (ko) |
| IL (1) | IL69682A (ko) |
| MY (1) | MY8700304A (ko) |
| NO (1) | NO161853C (ko) |
| NZ (1) | NZ205527A (ko) |
| PH (1) | PH18900A (ko) |
| PL (1) | PL139342B1 (ko) |
| PT (1) | PT77310B (ko) |
| RO (1) | RO86674B (ko) |
| SE (1) | SE8205135D0 (ko) |
| SU (1) | SU1342412A3 (ko) |
| ZA (1) | ZA836280B (ko) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE8400478D0 (sv) * | 1984-01-31 | 1984-01-31 | Astra Laekemedel Ab | Oxysalicylamido derivatives |
| US5240957A (en) * | 1984-01-31 | 1993-08-31 | Astra Lakemedel Akteibolag | Oxysalicylamido derivatives |
| US4772459A (en) * | 1986-09-09 | 1988-09-20 | Erbamont, Inc. | Method for controlling emesis caused by chemotherapeutic agents and antiemetic agents useful therein |
| US5186921A (en) * | 1989-04-17 | 1993-02-16 | Trustees Of The University Of Pennsylvania | Dopamine receptor ligands and image agents |
| US5122361A (en) * | 1989-04-17 | 1992-06-16 | Trustees Of The University Of Pennsylvania | Dopamine receptor ligands and imaging agents |
| US5911970A (en) | 1993-05-06 | 1999-06-15 | Research Corporation Technologies, Inc. | Methods for cancer imaging and therapy using benzamine compounds |
| WO1994026314A1 (en) * | 1993-05-06 | 1994-11-24 | John Christy S | Compounds for cancer imaging and therapy |
| US6517811B2 (en) | 1993-05-06 | 2003-02-11 | Research Corporation Technologies, Inc. | Compounds for cancer imaging and therapy |
| US5993777A (en) * | 1993-05-06 | 1999-11-30 | Research Corporation Technologies, Inc. | Benzamide compounds for cancer imaging and therapy |
| DK72693D0 (da) * | 1993-06-18 | 1993-06-18 | Lundbeck & Co As H | Compounds |
| KR20080055111A (ko) | 2006-12-14 | 2008-06-19 | 제일모직주식회사 | 컬러필터용 안료분산액 조성물 및 이를 이용하여 제조된컬러 촬상 소자용 컬러필터 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3342826A (en) * | 1964-01-13 | 1967-09-19 | Ile De France | Heterocyclic aminoalkyl benzamides |
| BE695272A (ko) * | 1967-03-09 | 1967-09-11 | ||
| CH507938A (fr) * | 1968-08-01 | 1971-05-31 | Ile De France | Procédé de préparation de benzamides hétérocycliques |
| US3793030A (en) * | 1971-09-02 | 1974-02-19 | Ricoh Kk | Process for producing diazotype light-sensitive material |
| US3914418A (en) * | 1971-09-02 | 1975-10-21 | Merck & Co Inc | Methods of controlling liver fluke infections |
| US3862139A (en) * | 1972-06-23 | 1975-01-21 | Delmar Chem | Heterocyclic benzamide compounds |
| IT1070992B (it) * | 1973-12-21 | 1985-04-02 | Italfarmaco Spa | Processo per la preparazione della i etil 2 2 metossi 5 sulfamoil benzamidometil pirrolidina |
| FR2294698A1 (fr) * | 1974-12-18 | 1976-07-16 | Synthelabo | Nouveaux derives des methoxy-2 benzamides substitues, leurs sels, leur preparation et les medicaments qui en renferment |
| CA1039731A (en) * | 1974-12-18 | 1978-10-03 | Synthelabo | Process for preparing new 2-methoxy-benzamide derivatives |
| US4029678A (en) * | 1975-12-08 | 1977-06-14 | Hoffmann-La Roche Inc. | Asymmetric synthesis |
| JPS5319447A (en) * | 1976-08-07 | 1978-02-22 | Igeta Seikou Kk | Manufacture of endless wire rope |
| NZ186175A (en) * | 1977-01-27 | 1980-03-05 | Shionogi & Co | Meta-sulphonamidobenzamide derivatives |
| FR2440946A2 (fr) * | 1978-01-20 | 1980-06-06 | Ile De France | Nouveaux benzamides heterocycliques substitues, leurs procedes de preparation et leur application comme modificateurs du comportement |
| SE411118B (sv) * | 1978-03-23 | 1979-12-03 | Astra Laekemedel Ab | Ett forfarande for framstellning av 2,6-dialkoxibensamider med terapentiska egenskaper |
| FR2438650A1 (fr) * | 1978-10-11 | 1980-05-09 | Ile De France | N-(1-methyl 2-pyrrolidinyl methyl) 2,3-dimethoxy 5-methylsulfamoyl benzamide et ses derives, leurs methodes de preparation et leur application dans le traitement des troubles du bas appareil urinaire |
| IT1141095B (it) * | 1980-11-27 | 1986-10-01 | Ravizza Spa | Processo di risoluzione della sulpiride racema |
| SE8101536L (sv) * | 1981-03-11 | 1982-09-12 | Astra Laekemedel Ab | Bensamid-derivat |
| JPH0331704A (ja) * | 1989-06-29 | 1991-02-12 | Matsushita Electric Ind Co Ltd | 位置合わせ装置 |
-
1982
- 1982-09-09 SE SE8205135A patent/SE8205135D0/xx unknown
-
1983
- 1983-08-18 AT AT83850215T patent/ATE39482T1/de active
- 1983-08-18 DE DE8383850215T patent/DE3378761D1/de not_active Expired
- 1983-08-18 EP EP83850215A patent/EP0117384B1/en not_active Expired
- 1983-08-24 ZA ZA836280A patent/ZA836280B/xx unknown
- 1983-09-01 CS CS836362A patent/CS239943B2/cs unknown
- 1983-09-05 PH PH29491A patent/PH18900A/en unknown
- 1983-09-06 IE IE2094/83A patent/IE55907B1/en not_active IP Right Cessation
- 1983-09-06 DK DK403883A patent/DK157846C/da not_active IP Right Cessation
- 1983-09-07 PL PL1983243670A patent/PL139342B1/pl unknown
- 1983-09-07 IL IL69682A patent/IL69682A/xx unknown
- 1983-09-07 DD DD83254597A patent/DD211552A5/de not_active IP Right Cessation
- 1983-09-07 FI FI833206A patent/FI78905C/fi not_active IP Right Cessation
- 1983-09-08 ES ES525488A patent/ES525488A0/es active Granted
- 1983-09-08 SU SU833643500A patent/SU1342412A3/ru active
- 1983-09-08 NO NO833219A patent/NO161853C/no unknown
- 1983-09-08 JP JP58164275A patent/JPS5967260A/ja active Granted
- 1983-09-08 GB GB08324080A patent/GB2126585B/en not_active Expired
- 1983-09-08 HU HU833144A patent/HU189745B/hu not_active IP Right Cessation
- 1983-09-08 CA CA000436275A patent/CA1207776A/en not_active Expired
- 1983-09-08 PT PT77310A patent/PT77310B/pt not_active IP Right Cessation
- 1983-09-08 NZ NZ205527A patent/NZ205527A/en unknown
- 1983-09-08 BG BG8362309A patent/BG37992A3/xx unknown
- 1983-09-09 GR GR72413A patent/GR79666B/el unknown
- 1983-09-09 KR KR1019830004251A patent/KR900008316B1/ko not_active IP Right Cessation
- 1983-09-09 RO RO112024A patent/RO86674B/ro unknown
-
1987
- 1987-12-30 MY MY304/87A patent/MY8700304A/xx unknown
-
1988
- 1988-01-27 US US07/148,104 patent/US4937260A/en not_active Expired - Fee Related
-
1989
- 1989-02-16 HK HK145/89A patent/HK14589A/xx unknown
- 1989-07-21 CY CY1461A patent/CY1461A/xx unknown
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