KR940021059A - 지질 대사 개선제 - Google Patents

지질 대사 개선제 Download PDF

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Publication number
KR940021059A
KR940021059A KR1019940006835A KR19940006835A KR940021059A KR 940021059 A KR940021059 A KR 940021059A KR 1019940006835 A KR1019940006835 A KR 1019940006835A KR 19940006835 A KR19940006835 A KR 19940006835A KR 940021059 A KR940021059 A KR 940021059A
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KR
South Korea
Prior art keywords
lipid metabolism
metabolism improvers
formula
acceptable salt
hydrogen atom
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KR1019940006835A
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English (en)
Other versions
KR100272483B1 (ko
Inventor
가즈미 오가따
다까히로 사까우에
야스꼬 우메가끼
리에 나가오
Original Assignee
요시다 쇼우지
센쥬 세이야꾸 가부시끼가이샤
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Application filed by 요시다 쇼우지, 센쥬 세이야꾸 가부시끼가이샤 filed Critical 요시다 쇼우지
Publication of KR940021059A publication Critical patent/KR940021059A/ko
Application granted granted Critical
Publication of KR100272483B1 publication Critical patent/KR100272483B1/ko

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/665—Phosphorus compounds having oxygen as a ring hetero atom, e.g. fosfomycin

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

본 발명은 하기 식의 인산 디에스테르 화합물 또는 그의 약리학적으로 허용 가능한 염을 함유하는 지질 대사 개선제에 관한 것이다.
[식중 R1, 및 R2는 동일하거나 상이하며 각기 수소원자 또는 메틸기를 나타낸다]
본 발명의 지질 대사 개선제는 트리글리세리드(TG), 비에스테르화 지방산(NEFA), 총 콜레스테롤(T-ch), 에스테르화 콜레스테롤(E-ch), 유리 콜레스테롤(F-ch), 총 지질(TL) 및 총 과산화물(LPC)의 혈장 농도를 감소시키며, 콜레스테롤 분획중에서는 고밀도 지단백질(HDL) 분획을 증가시키고 저밀도 지단백질(VLDL)분획을 감소시킨다. 그러므로, 조성물은 심근 경색, 협심증, 뇌경색, 뇌성 세동맥경화증 등의 동맥 경화증, 신증, 고혈압, 당뇨병, 비만증 및 기타 질환과 관련된 과지질혈증의 개선 및 여러 가지 뇌혈관 질환의 예방용으로 유리하게 사용할 수 있다.

Description

지질 대사 개선제
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (1)

  1. 하기 식의 인산 디에스테르 화합물 또는 그의 약리학적으로 허용 가능한 염을 함유하는 지질 대사 개선제.
    [식중 R1, 및 R2는 동일하거나 상이하며 각기 수소원자 또는 메틸기를 나타낸다]
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019940006835A 1993-03-31 1994-03-31 지질 대사 개선제 KR100272483B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP7381493 1993-03-31
JP93-73814 1993-03-31

Publications (2)

Publication Number Publication Date
KR940021059A true KR940021059A (ko) 1994-10-17
KR100272483B1 KR100272483B1 (ko) 2000-11-15

Family

ID=13529009

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019940006835A KR100272483B1 (ko) 1993-03-31 1994-03-31 지질 대사 개선제

Country Status (8)

Country Link
US (1) US5474991A (ko)
EP (1) EP0617963B1 (ko)
KR (1) KR100272483B1 (ko)
AT (1) ATE141508T1 (ko)
CA (1) CA2116198A1 (ko)
DE (1) DE69400382T2 (ko)
ES (1) ES2091057T3 (ko)
TW (1) TW252918B (ko)

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Publication number Priority date Publication date Assignee Title
US6162450A (en) * 1995-05-15 2000-12-19 Avon Products, Inc. Uses of ascorbyl-phosphoryl-cholesterol and compositions for practicing same
US5922335A (en) * 1995-05-15 1999-07-13 Avon Products, Inc. Uses for ascorbyl-phosphoryl-cholesterol in topical compositions
US5866147A (en) * 1995-05-15 1999-02-02 Avon Products, Inc. Ascorbyl-phosphoryl-cholesterol
KR100612398B1 (ko) * 2000-11-14 2006-08-16 바이탈 헬스 사이언시즈 피티와이 리미티드 포스페이트 유도체의 착체
AUPR549901A0 (en) * 2001-06-06 2001-07-12 Vital Health Sciences Pty Ltd Topical formulation containing tocopheryl phosphates
EP1420797A4 (en) * 2001-07-27 2005-03-02 Vital Health Sciences Pty Ltd DERMAL THERAPY USING PHOSPHATE DERIVATIVES OF ELECTRONIC TRANSFER AGENTS
ATE487456T1 (de) * 2001-12-13 2010-11-15 Vital Health Sciences Pty Ltd Transdermaler transport von verbindungen
AU2003225277A1 (en) * 2002-05-02 2003-11-17 Robert Harris Lipid removal from the body
AU2002950713A0 (en) * 2002-08-09 2002-09-12 Vital Health Sciences Pty Ltd Carrier
EP1589964B1 (en) * 2003-01-17 2011-11-23 Vital Health Sciences Pty Ltd. Compounds having anti-proliferative properties
AU2003901815A0 (en) * 2003-04-15 2003-05-01 Vital Health Sciences Pty Ltd Phosphate derivatives
NZ549567A (en) 2004-03-03 2009-10-30 Vital Health Sciences Pty Ltd Formulations comprising a tocopheryl phosphate tertiary amine alkaloid complex
AU2006220248B2 (en) * 2005-03-03 2012-06-21 Vital Health Sciences Pty Ltd Compounds having lipid lowering properties
CA2599424A1 (en) * 2005-03-03 2006-09-08 Vital Health Sciences Pty Ltd Compounds having anti-cancer properties
WO2006133506A1 (en) * 2005-06-17 2006-12-21 Vital Health Sciences Pty Ltd A carrier comprising one or more di and/or mono-(electron transfer agent) phosphate derivatives or complexes thereof
KR20080085839A (ko) * 2005-12-23 2008-09-24 바이탈 헬스 사이언시즈 피티와이 리미티드 사이토킨 조절 특성을 가진 화합물
US10071030B2 (en) 2010-02-05 2018-09-11 Phosphagenics Limited Carrier comprising non-neutralised tocopheryl phosphate
RU2553350C2 (ru) 2010-03-30 2015-06-10 Фосфейдженикс Лимитед Трансдермальные пластыри
WO2012122586A1 (en) 2011-03-15 2012-09-20 Phosphagenics Limited New composition
CN108601732A (zh) 2015-12-09 2018-09-28 磷肌酸有限公司 药物制剂
US20190330260A1 (en) 2016-12-21 2019-10-31 Avecho Biotechnology Limited Process

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59219295A (ja) * 1983-05-30 1984-12-10 Senjiyu Seiyaku Kk リン酸ジエステルまたはその塩およびそれらの製造法
JPS62205091A (ja) * 1986-03-04 1987-09-09 Senjiyu Seiyaku Kk 新規なリン酸ジエステルならびにその塩、その製造法およびそれを含有する製剤
JPH0781138B2 (ja) * 1986-12-02 1995-08-30 株式会社資生堂 抗酸化剤
JP2526059B2 (ja) * 1987-04-28 1996-08-21 千寿製薬株式会社 抗潰瘍剤
PH25859A (en) * 1988-01-11 1991-12-02 Takeda Chemical Industries Ltd Composition for treatment of ischemic disorder
UA19385A1 (uk) * 1989-04-27 1997-12-25 Сендзю Фармасьютікал Ко. Лтд. Фофоліпідhі похідhі та композиція, яка має аhтиоксидаhтhу та іhгібуючу активhість щодо пероксидів ліпідів
US5053222A (en) * 1989-06-07 1991-10-01 Shiseido Company Ltd. Hair cosmetic composition
US5231090A (en) * 1990-07-30 1993-07-27 University Of Miami Treatment for hypercholesterolemia
CA2099346A1 (en) * 1992-07-17 1994-01-18 Shinji Ohmori Lipid metabolism improving composition

Also Published As

Publication number Publication date
KR100272483B1 (ko) 2000-11-15
US5474991A (en) 1995-12-12
DE69400382T2 (de) 1996-12-19
TW252918B (ko) 1995-08-01
ES2091057T3 (es) 1996-10-16
EP0617963B1 (en) 1996-08-21
ATE141508T1 (de) 1996-09-15
DE69400382D1 (de) 1996-09-26
EP0617963A1 (en) 1994-10-05
CA2116198A1 (en) 1994-10-01

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