KR880002868A - 피리도 피리미딘 디온 - Google Patents

피리도 피리미딘 디온 Download PDF

Info

Publication number
KR880002868A
KR880002868A KR870009100A KR870009100A KR880002868A KR 880002868 A KR880002868 A KR 880002868A KR 870009100 A KR870009100 A KR 870009100A KR 870009100 A KR870009100 A KR 870009100A KR 880002868 A KR880002868 A KR 880002868A
Authority
KR
South Korea
Prior art keywords
benzyl
compound
alkyl
pharmaceutically acceptable
composition
Prior art date
Application number
KR870009100A
Other languages
English (en)
Other versions
KR900003497B1 (ko
Inventor
아담스 로위 3세 존
Original Assignee
윌리암 지·맥크리
화이자 인코포레이티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 윌리암 지·맥크리, 화이자 인코포레이티드 filed Critical 윌리암 지·맥크리
Publication of KR880002868A publication Critical patent/KR880002868A/ko
Application granted granted Critical
Publication of KR900003497B1 publication Critical patent/KR900003497B1/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
    • C07D239/96—Two oxygen atoms

Abstract

내용 없음

Description

피리도 피리미딘 디온
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (6)

  1. 하기 일반식으로 표시되는 화합물 또는 그이 제약상 허용되는 산 부가염.
    식중, R1은 수소, C1-C3알킬, 시클로펜틸메틸, 시클로헥실메틸, 노르보닐메틸, [2.2.2]비시클로옥틸메틸 또는 벤질이고, 여기서 벤질의 페닐은 할로겐, 트리풀루오로메틸, 니트로, 카르복시 또는 CO2M에 의하여 임의로 치환되며, 여기서 M은 제약상 허용되는 양이온이고, Y는 카르복시, 카르보알콕시(여기서, 알콕시는 1-6개의 탄소 원자를 가짐), 카르보벤질옥시, 카르복스아미도, N-알킬카르복스아미드(여기서, 알킬은 1-6개의 탄소 원자를 가짐)또는 CO2M(여기서, M은 상기 정의한 바와 같음)이고, Z는 N 또는 CH이되 단, Z가 CH일 경우 R1은 벤질이고, Z가 CH일 경우, Y는 또는 C1-C3알킬에 의하여 임의로 치환된 테트라졸 또는 벤질이다.
  2. 제1항에 있어서, R1이 벤질이고, Z가 N 또는 CH이고 Y가 N-메틸카르복스아미도인 화합물.
  3. 제1항에 있어서, R1이 벤질이고, Z가 N 또는 CH이고 Y가 카르보메톡시인 화합물
  4. 우울증 또는 염증 치료에 유효한 양의 젭항의 화합물 및 제약상 허용되는 담체로 되는 것을 특징으로 하는 항우울증 작용을 갖는 조성물.
  5. 제4항에 있어서, R1이 벤질이고, Z가 N 또는 CH이고, Y가 N-메틸카르복스아미도인 것을 특징으로 하는 조성물.
  6. 제4항에 있어서, R1이 벤질이고, Z가 N 또는 CH이고, Y가 카르보메톡시인 것을 특징으로 하는 조성물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019870009100A 1986-08-21 1987-08-20 퀴나졸린디온 및 피리도피리미딘디온 및 이들을 함유하는 제약 조성물 KR900003497B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
USPCT/US86/01718 1986-08-21
US86/01718 1986-08-21
PCT/US1986/001718 WO1988001270A1 (en) 1986-08-21 1986-08-21 Pyridopyrimidinediones

Publications (2)

Publication Number Publication Date
KR880002868A true KR880002868A (ko) 1988-05-12
KR900003497B1 KR900003497B1 (ko) 1990-05-21

Family

ID=22195608

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019870009100A KR900003497B1 (ko) 1986-08-21 1987-08-20 퀴나졸린디온 및 피리도피리미딘디온 및 이들을 함유하는 제약 조성물

Country Status (25)

Country Link
US (1) US4797403A (ko)
JP (1) JPH0625166B2 (ko)
KR (1) KR900003497B1 (ko)
CN (1) CN1014992B (ko)
AR (1) AR243513A1 (ko)
AT (1) AT388378B (ko)
AU (1) AU579047B2 (ko)
CA (1) CA1294618C (ko)
CS (1) CS268189B2 (ko)
DD (1) DD261598A5 (ko)
DK (1) DK433787A (ko)
EG (1) EG18270A (ko)
FI (1) FI84720C (ko)
HU (1) HU196798B (ko)
IE (1) IE59937B1 (ko)
IL (1) IL83569A (ko)
MX (1) MX7829A (ko)
MY (1) MY101821A (ko)
NO (1) NO165493C (ko)
NZ (1) NZ221502A (ko)
PH (1) PH23853A (ko)
PT (1) PT85555B (ko)
RU (1) RU1769758C (ko)
WO (1) WO1988001270A1 (ko)
ZA (1) ZA876172B (ko)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE63553T1 (de) * 1986-08-21 1991-06-15 Pfizer Chinazolindione und pyridopyrimidindione.
US5290780A (en) * 1991-01-30 1994-03-01 American Cyanamid Co. Angiotensin II receptor blocking 2,3,6 substituted quinazolinones
NZ322197A (en) * 1995-11-21 1999-02-25 Yamanouchi Pharma Co Ltd Pyrido[2,3-d] pyrimidine derivatives and pharmaceutical compositions thereof
GB0507298D0 (en) * 2005-04-11 2005-05-18 Novartis Ag Organic compounds
SA08280783B1 (ar) * 2007-01-11 2011-04-24 استرازينيكا ايه بي مشتقات بيريدوبيريميدين كمثبطات pde4
FR2943673B1 (fr) * 2009-03-27 2013-03-29 Sanofi Aventis Applications therapeutiques de derives de quinazolinedione
EP2686305B1 (en) 2011-03-14 2020-09-16 Impact Therapeutics, Inc. Quinazolinediones and their use
TWI527800B (zh) 2011-04-01 2016-04-01 南京英派藥業有限公司 作為聚（二磷酸腺苷酸－核醣）聚合酶（ｐａｒｐ）之抑制劑之１－（芳基甲基）喹唑啉－２，４（１ｈ，３ｈ）－二酮及其應用

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH490801A (de) * 1968-02-27 1970-05-31 Ciba Geigy Schädlingsbekämpfungsmittel und dessen Verwendung
US3794643A (en) * 1971-04-20 1974-02-26 Hisamitsu Pharmaceutical Co Quinazolinedione derivatives
GB1401549A (en) * 1972-07-07 1975-07-16 Hisamitsu Pharmaceutical Co Pyrido-2,3-d-pyrimidine-2,4-1h,3h- diones and methods of preparing them
US3922275A (en) * 1972-11-09 1975-11-25 Hisamitsu Pharmaceutical Co Pyrido{8 2,3-D{9 {0 pyrimidine-2,4(1H,3H)-diones
JPS5069096A (ko) * 1973-10-25 1975-06-09
JPS5649917B2 (ko) * 1973-12-18 1981-11-25
JPS5849559B2 (ja) * 1974-02-19 1983-11-05 ヒサミツセイヤク カブシキガイシヤ シンキナ ピリドピリミジンジオンユウドウタイノ セイゾウホウ
JPS50116493A (ko) * 1974-02-20 1975-09-11
JPS50157393A (ko) * 1974-05-24 1975-12-19
JPS5813551B2 (ja) * 1975-03-15 1983-03-14 ヒサミツセイヤク カブシキガイシヤ シンキナピリド （ ４，３−ｄ ） ピリミジンジオンユウドウタイノセイゾウホウ
US4266056A (en) * 1978-04-07 1981-05-05 Zoecon Corporation Phenyl uracils
DK167280B1 (da) * 1985-03-20 1993-10-04 Ciba Geigy Ag 3-aryluracilderivater, fremgangsmaade til fremstilling deraf, ukrudtsbekaempelsesmidler indeholdende disse derivater samt anvendelsen af derivaterne til ukrudtsbekaempelse
GB8524663D0 (en) * 1985-10-07 1985-11-13 Fujisawa Pharmaceutical Co Quinazoline derivatives

Also Published As

Publication number Publication date
RU1769758C (en) 1992-10-15
US4797403A (en) 1989-01-10
IE59937B1 (en) 1994-05-04
FI84720B (fi) 1991-09-30
DD261598A5 (de) 1988-11-02
CA1294618C (en) 1992-01-21
WO1988001270A1 (en) 1988-02-25
PT85555A (en) 1987-09-01
DK433787A (da) 1988-02-22
KR900003497B1 (ko) 1990-05-21
EG18270A (en) 1992-12-30
HU196798B (en) 1989-01-30
NO165493C (no) 1991-02-20
ZA876172B (en) 1989-03-29
JPS6360974A (ja) 1988-03-17
DK433787D0 (da) 1987-08-20
HUT44786A (en) 1988-04-28
PT85555B (pt) 1990-05-31
MX7829A (es) 1993-08-01
AU7724787A (en) 1988-03-10
NZ221502A (en) 1989-11-28
MY101821A (en) 1992-01-31
AU579047B2 (en) 1988-11-10
PH23853A (en) 1989-11-23
AT388378B (de) 1989-06-12
CN87105791A (zh) 1988-03-09
FI873608A0 (fi) 1987-08-20
NO873514L (no) 1988-02-22
NO873514D0 (no) 1987-08-20
CS268189B2 (en) 1990-03-14
CS597487A2 (en) 1989-05-12
NO165493B (no) 1990-11-12
FI84720C (fi) 1992-01-10
IL83569A0 (en) 1988-01-31
IE872239L (en) 1989-01-20
AR243513A1 (es) 1993-08-31
CN1014992B (zh) 1991-12-04
IL83569A (en) 1991-12-15
ATA263087A (de) 1988-11-15
FI873608A (fi) 1988-02-22
JPH0625166B2 (ja) 1994-04-06

Similar Documents

Publication Publication Date Title
AU557691B2 (en) 2-penem antibiotics and their oxa-aza-, and carba analogues
BR9806296B1 (pt) compostos de ácido sulfìnico, mistura, composição e uso dos mesmos.
BR9910297A (pt) Novos análogos graxos para o tratamento de diabetes
ES2118250T3 (es) Combinaciones germicidas de substancias activas.
PE107699A1 (es) Derivados de oxindol sustituidos
EA200000392A1 (ru) Химические соединения
AU6195090A (en) Combination of dihydroxyacetone and indole derivatives for imparting to the skin a coloration similar to a natural tan and process for use
PT804200E (pt) Uso de derivados de noribogaina para tratamento de dependencia quimica em mamiferos
KR880000400A (ko) 융합된 사이클릭 아제핀-2-온 유도체 및 그의 제조방법
KR840000236A (ko) 포유류의 국부용 제형의 수분 손실량을 극소화시키는 방법
KR870010864A (ko) O/w 형 에멀젼 조성물
PE79599A1 (es) Derivados de 5'-desoxicitidina
ES2171964T3 (es) Esteres dibenzodihidropiridinecarboxilicos y su uso en metodos de ensayo quimiluminiscente.
KR880002868A (ko) 피리도 피리미딘 디온
SE8404930L (sv) Vattenhaltiga kompositioner, som innehaller stabiliserade enzymer
KR890009962A (ko) 매뉴마이신 유도체, 이의 제조방법 및 용도
KR890008110A (ko) 피리미딘 유도체
KR830004320A (ko) 퀴나졸린 유도체의 제조방법
EA200001107A1 (ru) ПРОИЗВОДНЫЕ ОКТАГИДРО-6,10-ДИОКСО-6H-ПИРИДАЗИНО [1,2-a] [1,2] ДИАЗЕПИН-1-КАРБОНОВОЙ КИСЛОТЫ, СПОСОБ ПОЛУЧЕНИЯ И ИХ ПРИМЕНЕНИЕ ДЛЯ ПОЛУЧЕНИЯ ТЕРАПЕВТИЧЕСКИ АКТИВНЫХ СОЕДИНЕНИЙ
GB1531637A (en) Liquid crystalline composition
DE3750267T2 (de) Herstellung von Piperidinylcyclopentylheptensäure-Derivaten.
KR910000691A (ko) 간질치료제로서의 5-페닐-2-푸란 케톤의 용도
IE44449L (en) Morphanthridines
KR910011846A (ko) 디옥사닐피리딘
BR9406996A (pt) Enanciômero processo para preparar o mesmo processo para ciclizar um composto e composto intermediário

Legal Events

Date Code Title Description
A201 Request for examination
E902 Notification of reason for refusal
G160 Decision to publish patent application
E701 Decision to grant or registration of patent right
GRNT Written decision to grant
FPAY Annual fee payment

Payment date: 20030410

Year of fee payment: 14

LAPS Lapse due to unpaid annual fee