ES2171964T3 - Esteres dibenzodihidropiridinecarboxilicos y su uso en metodos de ensayo quimiluminiscente. - Google Patents

Esteres dibenzodihidropiridinecarboxilicos y su uso en metodos de ensayo quimiluminiscente.

Info

Publication number
ES2171964T3
ES2171964T3 ES97930881T ES97930881T ES2171964T3 ES 2171964 T3 ES2171964 T3 ES 2171964T3 ES 97930881 T ES97930881 T ES 97930881T ES 97930881 T ES97930881 T ES 97930881T ES 2171964 T3 ES2171964 T3 ES 2171964T3
Authority
ES
Spain
Prior art keywords
alkyl
pct
esters
aryl
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97930881T
Other languages
English (en)
Inventor
Marjorie Jacquemijns
Gijsbert Zomer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nederlanden Staat
Original Assignee
Nederlanden Staat
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nederlanden Staat filed Critical Nederlanden Staat
Application granted granted Critical
Publication of ES2171964T3 publication Critical patent/ES2171964T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/10—Aza-phenanthrenes
    • C07D221/12—Phenanthridines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
    • C12Q1/28—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase involving peroxidase
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/968—High energy substrates, e.g. fluorescent, chemiluminescent, radioactive
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/975—Kit

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Cosmetics (AREA)
  • Pyridine Compounds (AREA)

Abstract

LA PRESENTE INVENCION SUMINISTRA NUEVOS ESTERES DIBENZODIHIDROPIRIDINCARBOXILICOS DE ACUERDO CON LAS FORMULAS (1) O (2), DONDE R 1 ES ALQUILO SUSTITUIDO O GRUPO CIANO; R 2 Y R 3 SON INDEPENDIENTEMENTE HIDROGENO, ALQUILO, ALQUILO SUSTITUIDO, ARILO O ARILO SUSTITUIDO; R 4 ES HIDROGENO, ALQUILO, ALQUILO SUSTITUIDO, ARILO O ARILO SUSTITUIDO; R 5 Y R 6 SON INDEPENDIENTEMENTE ALQUILO, ALCOXI U OTRO SUSTITUYENTE QUE SEA RELATIVAMENTE RESISTENTE A LA OXIDACION; M Y N SON ENTEROS DE 0 A 4; EN DONDE, SI M O N ES AL MENOS 2, DOS GRUPOS R 5 O R 6 PUEDEN ESTAR UNIDOS ENTRE SI; Y Z ES OXIGENO O AZUFRE. DICHOS NUEVOS COMPUESTOS SON UTILES COMO REACTIVOS QUIMIOLUMINISCENTES PARA DETECTAR LA PRESENCIA DE ACTIVIDAD PEROXIDASA A NIVELES EXTREMADAMENTE BAJOS (10 20 )MOL ES.
ES97930881T 1996-07-16 1997-07-15 Esteres dibenzodihidropiridinecarboxilicos y su uso en metodos de ensayo quimiluminiscente. Expired - Lifetime ES2171964T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP96202022 1996-07-16

Publications (1)

Publication Number Publication Date
ES2171964T3 true ES2171964T3 (es) 2002-09-16

Family

ID=8224199

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97930881T Expired - Lifetime ES2171964T3 (es) 1996-07-16 1997-07-15 Esteres dibenzodihidropiridinecarboxilicos y su uso en metodos de ensayo quimiluminiscente.

Country Status (10)

Country Link
US (1) US6030803A (es)
EP (1) EP0915851B1 (es)
JP (1) JP3338061B2 (es)
AT (1) ATE214697T1 (es)
CA (1) CA2261032C (es)
DE (1) DE69711188T2 (es)
DK (1) DK0915851T3 (es)
ES (1) ES2171964T3 (es)
PT (1) PT915851E (es)
WO (1) WO1998002421A1 (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU716233B2 (en) 1996-01-16 2000-02-24 Lumigen, Inc. Compounds, compositions and methods for generating chemiluminescence with phosphatase enzymes
US6410732B2 (en) 1996-01-16 2002-06-25 Lumigen, Inc. Processing and synthetic intermediates for preparing N-arylacridancarboxylic acid derivatives
AU5473999A (en) 1998-08-11 2000-03-06 Bayer Corporation Near infrared chemiluminescent acridinium compounds and uses thereof
US7186568B1 (en) 2000-06-26 2007-03-06 Lumigen Inc. Electrochemiluminescence from acridan compounds
US6897036B2 (en) * 2002-06-06 2005-05-24 Lumigen, Inc. Fluorescent detection of peroxidase enzymes
US7319041B2 (en) * 2002-09-27 2008-01-15 Siemens Medical Solutions Diagnostic Applications of acridinium compounds and derivatives in homogeneous assays
US7309615B2 (en) * 2002-09-27 2007-12-18 Siemens Medical Solutions Diagnostic High quantum yield acridinium compounds and their uses in improving assay sensitivity
US7732153B2 (en) * 2006-05-09 2010-06-08 Beckman Coulter, Inc. Nonseparation assay methods
US7799534B2 (en) * 2006-05-09 2010-09-21 Beckman Coulter, Inc. Nonseparation assay methods
JP5901877B2 (ja) 2007-07-27 2016-04-13 アーメイゲン・テクノロジーズ・インコーポレイテッドＡｒｍａｇｅｎ Ｔｅｃｈｎｏｌｏｇｉｅｓ， Ｉｎｃ． 中枢神経系のα−Ｌ−イデュロニダーゼ活性を増加させるための方法および組成物
US20100240070A1 (en) * 2007-11-07 2010-09-23 Beckman Coulter, Inc. Nonseparation Assay Methods Using Peroxide Generating Enzymes
US9029092B2 (en) 2009-02-27 2015-05-12 Beckman Coulter, Inc. Solution phase homogeneous assays
CN102333885A (zh) * 2009-02-27 2012-01-25 贝克曼考尔特公司 使用选择性信号抑制剂的非分离式测定
US20110097723A1 (en) * 2009-09-19 2011-04-28 Qun Liu Methods and reagents for analyte detection
ES2725200T3 (es) 2009-10-09 2019-09-20 Armagen Inc Métodos y composiciones para aumentar la actividad de iduronato 2-sulfatasa en el SNC
WO2012028167A2 (en) 2010-05-20 2012-03-08 Innohyphen Bv Acridinium ester chemiluminescence upon reductive triggering
CN104230804B (zh) * 2014-08-30 2016-05-25 云南民族大学 化学发光物aps-5关键中间体的制备方法
US10538589B2 (en) 2015-01-14 2020-01-21 Armagen Inc. Methods and compositions for increasing N-acetylglucosaminidase (NAGLU) activity in the CNS using a fusion antibody comprising an anti-human insulin receptor antibody and NAGLU
CN112400025A (zh) 2018-07-13 2021-02-23 3M创新有限公司 测定
CN112400113B (zh) 2018-07-13 2022-04-15 3M创新有限公司 特异性结合化学发光测定法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3628573C2 (de) * 1986-08-22 1994-10-13 Hoechst Ag Chemilumineszierende Acridinderivate, Verfahren zu deren Herstellung und ihre Verwendung in Lumineszenzimmunoassays
NZ227506A (en) * 1987-12-31 1992-06-25 London Diagnostics Inc Specific binding assays using chemiluminescent compounds
US4950613A (en) * 1988-02-26 1990-08-21 Gen-Probe Incorporated Proteted chemiluminescent labels
JP2859451B2 (ja) * 1991-01-11 1999-02-17 太平洋セメント株式会社 Ｎ−フルオロピリジニウム塩の製造方法
US5491072A (en) * 1993-05-17 1996-02-13 Lumigen, Inc. N-alkylacridan carboxyl derivatives useful for chemiluminescent detection

Also Published As

Publication number Publication date
CA2261032C (en) 2003-11-25
CA2261032A1 (en) 1998-01-22
EP0915851A1 (en) 1999-05-19
PT915851E (pt) 2002-09-30
DK0915851T3 (da) 2002-04-29
WO1998002421A1 (en) 1998-01-22
JP3338061B2 (ja) 2002-10-28
EP0915851B1 (en) 2002-03-20
DE69711188T2 (de) 2002-09-05
JPH11514006A (ja) 1999-11-30
US6030803A (en) 2000-02-29
ATE214697T1 (de) 2002-04-15
DE69711188D1 (de) 2002-04-25

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