ES2171964T3 - Esteres dibenzodihidropiridinecarboxilicos y su uso en metodos de ensayo quimiluminiscente. - Google Patents
Esteres dibenzodihidropiridinecarboxilicos y su uso en metodos de ensayo quimiluminiscente.Info
- Publication number
- ES2171964T3 ES2171964T3 ES97930881T ES97930881T ES2171964T3 ES 2171964 T3 ES2171964 T3 ES 2171964T3 ES 97930881 T ES97930881 T ES 97930881T ES 97930881 T ES97930881 T ES 97930881T ES 2171964 T3 ES2171964 T3 ES 2171964T3
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- pct
- esters
- aryl
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/06—Ring systems of three rings
- C07D221/10—Aza-phenanthrenes
- C07D221/12—Phenanthridines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
- C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
- C12Q1/28—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase involving peroxidase
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/968—High energy substrates, e.g. fluorescent, chemiluminescent, radioactive
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/975—Kit
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Saccharide Compounds (AREA)
- Pyridine Compounds (AREA)
- Cosmetics (AREA)
Abstract
LA PRESENTE INVENCION SUMINISTRA NUEVOS ESTERES DIBENZODIHIDROPIRIDINCARBOXILICOS DE ACUERDO CON LAS FORMULAS (1) O (2), DONDE R 1 ES ALQUILO SUSTITUIDO O GRUPO CIANO; R 2 Y R 3 SON INDEPENDIENTEMENTE HIDROGENO, ALQUILO, ALQUILO SUSTITUIDO, ARILO O ARILO SUSTITUIDO; R 4 ES HIDROGENO, ALQUILO, ALQUILO SUSTITUIDO, ARILO O ARILO SUSTITUIDO; R 5 Y R 6 SON INDEPENDIENTEMENTE ALQUILO, ALCOXI U OTRO SUSTITUYENTE QUE SEA RELATIVAMENTE RESISTENTE A LA OXIDACION; M Y N SON ENTEROS DE 0 A 4; EN DONDE, SI M O N ES AL MENOS 2, DOS GRUPOS R 5 O R 6 PUEDEN ESTAR UNIDOS ENTRE SI; Y Z ES OXIGENO O AZUFRE. DICHOS NUEVOS COMPUESTOS SON UTILES COMO REACTIVOS QUIMIOLUMINISCENTES PARA DETECTAR LA PRESENCIA DE ACTIVIDAD PEROXIDASA A NIVELES EXTREMADAMENTE BAJOS (10 20 )MOL ES.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP96202022 | 1996-07-16 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2171964T3 true ES2171964T3 (es) | 2002-09-16 |
Family
ID=8224199
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES97930881T Expired - Lifetime ES2171964T3 (es) | 1996-07-16 | 1997-07-15 | Esteres dibenzodihidropiridinecarboxilicos y su uso en metodos de ensayo quimiluminiscente. |
Country Status (10)
Country | Link |
---|---|
US (1) | US6030803A (es) |
EP (1) | EP0915851B1 (es) |
JP (1) | JP3338061B2 (es) |
AT (1) | ATE214697T1 (es) |
CA (1) | CA2261032C (es) |
DE (1) | DE69711188T2 (es) |
DK (1) | DK0915851T3 (es) |
ES (1) | ES2171964T3 (es) |
PT (1) | PT915851E (es) |
WO (1) | WO1998002421A1 (es) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6410732B2 (en) * | 1996-01-16 | 2002-06-25 | Lumigen, Inc. | Processing and synthetic intermediates for preparing N-arylacridancarboxylic acid derivatives |
CN1173954C (zh) | 1996-01-16 | 2004-11-03 | 鲁米根公司 | 与磷酸酶反应产生化学发光的化合物、组合物和方法 |
JP4672144B2 (ja) * | 1998-08-11 | 2011-04-20 | シーメンス・ヘルスケア・ダイアグノスティックス・インコーポレーテッド | 近赤外化学発光性アクリジニウム化合物およびその使用。 |
US7186568B1 (en) | 2000-06-26 | 2007-03-06 | Lumigen Inc. | Electrochemiluminescence from acridan compounds |
US6897036B2 (en) * | 2002-06-06 | 2005-05-24 | Lumigen, Inc. | Fluorescent detection of peroxidase enzymes |
US7309615B2 (en) * | 2002-09-27 | 2007-12-18 | Siemens Medical Solutions Diagnostic | High quantum yield acridinium compounds and their uses in improving assay sensitivity |
US7319041B2 (en) * | 2002-09-27 | 2008-01-15 | Siemens Medical Solutions Diagnostic | Applications of acridinium compounds and derivatives in homogeneous assays |
US7732153B2 (en) * | 2006-05-09 | 2010-06-08 | Beckman Coulter, Inc. | Nonseparation assay methods |
US7799534B2 (en) * | 2006-05-09 | 2010-09-21 | Beckman Coulter, Inc. | Nonseparation assay methods |
EP2997976A1 (en) | 2007-07-27 | 2016-03-23 | Armagen Technologies, Inc. | Methods and compositions for increasing alpha-l-iduronidase activity in the cns |
WO2009062027A1 (en) * | 2007-11-07 | 2009-05-14 | Beckman Coulter, Inc. | Nonseparation assay methods using peroxide generating enzymes |
BRPI1008760B1 (pt) | 2009-02-27 | 2019-12-10 | Beckman Coulter Inc | método de ensaio e kit para um analito em uma amostra e sistema para realizar o método de ensaio |
MX2011009020A (es) | 2009-02-27 | 2011-09-29 | Beckman Coulter Inc | Ensayo sin separacion con inhibidores de señal selectiva. |
US20110097723A1 (en) * | 2009-09-19 | 2011-04-28 | Qun Liu | Methods and reagents for analyte detection |
DK2485761T3 (da) | 2009-10-09 | 2019-05-06 | Armagen Inc | Fremgangsmåder og sammensætninger til øgning af iduronat-2-sulfatase-aktivitet i CNS |
WO2012028167A2 (en) | 2010-05-20 | 2012-03-08 | Innohyphen Bv | Acridinium ester chemiluminescence upon reductive triggering |
CN104230804B (zh) * | 2014-08-30 | 2016-05-25 | 云南民族大学 | 化学发光物aps-5关键中间体的制备方法 |
US10538589B2 (en) | 2015-01-14 | 2020-01-21 | Armagen Inc. | Methods and compositions for increasing N-acetylglucosaminidase (NAGLU) activity in the CNS using a fusion antibody comprising an anti-human insulin receptor antibody and NAGLU |
JP2021531458A (ja) | 2018-07-13 | 2021-11-18 | スリーエム イノベイティブ プロパティズ カンパニー | アッセイ |
US11320424B2 (en) | 2018-07-13 | 2022-05-03 | 3M Innovative Properties Company | Specific binding chemiluminescent assay |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3645292C2 (de) * | 1986-08-22 | 1997-12-11 | Hoechst Ag | Chemilumineszenzimmunoassays und ein Verfahren zu ihrer Herstellung |
NZ227506A (en) * | 1987-12-31 | 1992-06-25 | London Diagnostics Inc | Specific binding assays using chemiluminescent compounds |
US4950613A (en) * | 1988-02-26 | 1990-08-21 | Gen-Probe Incorporated | Proteted chemiluminescent labels |
JP2859451B2 (ja) * | 1991-01-11 | 1999-02-17 | 太平洋セメント株式会社 | N−フルオロピリジニウム塩の製造方法 |
US5491072A (en) * | 1993-05-17 | 1996-02-13 | Lumigen, Inc. | N-alkylacridan carboxyl derivatives useful for chemiluminescent detection |
-
1997
- 1997-07-15 DK DK97930881T patent/DK0915851T3/da active
- 1997-07-15 WO PCT/NL1997/000417 patent/WO1998002421A1/en active IP Right Grant
- 1997-07-15 AT AT97930881T patent/ATE214697T1/de active
- 1997-07-15 JP JP50588198A patent/JP3338061B2/ja not_active Expired - Fee Related
- 1997-07-15 DE DE69711188T patent/DE69711188T2/de not_active Expired - Lifetime
- 1997-07-15 ES ES97930881T patent/ES2171964T3/es not_active Expired - Lifetime
- 1997-07-15 CA CA002261032A patent/CA2261032C/en not_active Expired - Fee Related
- 1997-07-15 US US09/214,514 patent/US6030803A/en not_active Expired - Lifetime
- 1997-07-15 EP EP97930881A patent/EP0915851B1/en not_active Expired - Lifetime
- 1997-07-15 PT PT97930881T patent/PT915851E/pt unknown
Also Published As
Publication number | Publication date |
---|---|
PT915851E (pt) | 2002-09-30 |
WO1998002421A1 (en) | 1998-01-22 |
US6030803A (en) | 2000-02-29 |
ATE214697T1 (de) | 2002-04-15 |
DK0915851T3 (da) | 2002-04-29 |
EP0915851A1 (en) | 1999-05-19 |
EP0915851B1 (en) | 2002-03-20 |
JPH11514006A (ja) | 1999-11-30 |
DE69711188D1 (de) | 2002-04-25 |
DE69711188T2 (de) | 2002-09-05 |
CA2261032A1 (en) | 1998-01-22 |
CA2261032C (en) | 2003-11-25 |
JP3338061B2 (ja) | 2002-10-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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