HUP9901984A2 - sPLA2 Inhibitor hatású naftil-acetamidok, alkalmazásuk és a vegyületeket tartalmazó gyógyszerkészítmények - Google Patents

sPLA2 Inhibitor hatású naftil-acetamidok, alkalmazásuk és a vegyületeket tartalmazó gyógyszerkészítmények

Info

Publication number
HUP9901984A2
HUP9901984A2 HU9901984A HUP9901984A HUP9901984A2 HU P9901984 A2 HUP9901984 A2 HU P9901984A2 HU 9901984 A HU9901984 A HU 9901984A HU P9901984 A HUP9901984 A HU P9901984A HU P9901984 A2 HUP9901984 A2 HU P9901984A2
Authority
HU
Hungary
Prior art keywords
pipe powder
general formula
compounds
pharmaceutical compositions
compositions containing
Prior art date
Application number
HU9901984A
Other languages
English (en)
Inventor
Theodore Goodson
Richard Waltz Harper
David K. Herron
Original Assignee
Eli Lilly And Co.,
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9602267.8A external-priority patent/GB9602267D0/en
Application filed by Eli Lilly And Co., filed Critical Eli Lilly And Co.,
Publication of HUP9901984A2 publication Critical patent/HUP9901984A2/hu
Publication of HUP9901984A3 publication Critical patent/HUP9901984A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/08—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to hydrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C235/34—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C233/11—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Otolaryngology (AREA)
  • Epidemiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

A találmány szerinti vegyületek (I) általánős képletében R1 és R2mindegyikének jelentése egymástól függetlenül hidrőgénatőm vagykölcsönhatásba nem lépő szűbsztitűens, azzal a feltétellel, hőgy R1vagy R2 legalább egiykének jelentése hidrőgénatőm, R3 jelentésehidrőgénatőm, -O(CH2)nY általánős képletű csőpőrt, (a) általánősképletű csőpőrt, (b) általánős képletű csőpőrt, ahől n jelentése 2-4közötti egész szám, és Y jelentése -CO2H csőpőrt, -PO3H2 csőpőrt vagy-SO3H csőpőrt, és X jelentése őxigénatőm vagy -CH2 csőpőrt. Atalálmány szerinti vegyület inhibiálja az sPLA2 mediált zsírsav-kibőcsátást emlősökben, és így gyógyszerként alkalmazzák. (I) (a) (b) ŕ
HU9901984A 1995-12-13 1996-12-09 Naphthyl acetamides as spla2 inhibitors, use thereof and pharmaceutical compositions containing these compounds HUP9901984A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US855895P 1995-12-13 1995-12-13
GBGB9602267.8A GB9602267D0 (en) 1996-02-05 1996-02-05 Naphthyl acetamides as sPLA2 inhibitors

Publications (2)

Publication Number Publication Date
HUP9901984A2 true HUP9901984A2 (hu) 1999-10-28
HUP9901984A3 HUP9901984A3 (en) 2001-01-29

Family

ID=26308607

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9901984A HUP9901984A3 (en) 1995-12-13 1996-12-09 Naphthyl acetamides as spla2 inhibitors, use thereof and pharmaceutical compositions containing these compounds

Country Status (17)

Country Link
US (1) US6160175A (hu)
EP (1) EP0779271B1 (hu)
JP (1) JP2000501739A (hu)
KR (1) KR19990072110A (hu)
AT (1) ATE203744T1 (hu)
AU (1) AU1289797A (hu)
BR (1) BR9612347A (hu)
CA (1) CA2240395A1 (hu)
DE (1) DE69614232T2 (hu)
DK (1) DK0779271T3 (hu)
ES (1) ES2159347T3 (hu)
GR (1) GR3036988T3 (hu)
HU (1) HUP9901984A3 (hu)
IL (1) IL124866A (hu)
MX (1) MX9804751A (hu)
PT (1) PT779271E (hu)
WO (1) WO1997021664A1 (hu)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6177440B1 (en) 1996-10-30 2001-01-23 Eli Lilly And Company Substituted tricyclics
US6713645B1 (en) * 1996-10-30 2004-03-30 Eli Lilly And Company Substituted tricyclics
US5916922A (en) * 1996-12-03 1999-06-29 Eli Lilly And Company Phenyl glyoxamides as SPLA2 inhibitors
US6353128B1 (en) 1996-12-03 2002-03-05 Eli Lilly And Company Phenyl acetamides as sPLA2 inhibitors
AU3054399A (en) 1998-03-31 1999-10-25 Shionogi & Co., Ltd. Pyrrolo(1,2-a)pyrazine sPLA2 inhibitor
IL129484A0 (en) * 1998-04-17 2000-02-29 Lilly Co Eli Substituted tricyclics
DZ2769A1 (fr) * 1998-04-17 2003-12-01 Lilly Co Eli Composés tricycliques substitués.
EP1085021A4 (en) 1998-05-21 2003-01-08 Shionogi & Co DERIVATIVES OF PYRROLO 1,2-B] PYRIDAZINE, WITH INHIBITOR EFFECT ON SPLA 2?
US7098237B1 (en) 1998-10-14 2006-08-29 Shionogi & Co., Ltd. Remedies for ischemia reperfusion injury
JP4636521B2 (ja) 1999-07-19 2011-02-23 塩野義製薬株式会社 ｓＰＬＡ２阻害作用を有する三環系化合物
US6673781B1 (en) 1999-08-02 2004-01-06 Shionogi & Co., Ltd. Tricyclic compounds having sPLA2-inhibitory activities
WO2001014378A1 (fr) 1999-08-23 2001-03-01 Shionogi & Co., Ltd. DERIVES DE PYRROLOTRIAZINE A ACTIVITES INHIBANT sPLA¿2?
WO2001036420A1 (fr) 1999-11-15 2001-05-25 Shionogi & Co., Ltd. Derives d'aza-indolizine tricyclique ayant un effet inhibiteur sur spla¿2?
AU2001267825A1 (en) 2000-06-29 2002-01-08 Shionogi And Co., Ltd. Remedies for cirrhosis
WO2002000621A1 (fr) 2000-06-29 2002-01-03 Shionogi & Co., Ltd. Composes inhibiteurs de la spla2 de type x
TWI314457B (hu) 2001-03-19 2009-09-11 Shionogi & Co
US20060064279A1 (en) * 2004-09-17 2006-03-23 Eric Baum Algorithm for retrieval of ocean surface temperature, wind speed and wind direction from remote microwave radiometric measurements

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3820463A1 (de) * 1988-06-16 1989-12-21 Basf Ag Strahlungsempfindliche, ethylenisch ungesaettigte, copolymerisierbare verbindungen und verfahren zu deren herstellung
FR2658818B1 (fr) * 1990-02-27 1993-12-31 Adir Cie Nouveaux derives a structure naphtalenique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.

Also Published As

Publication number Publication date
GR3036988T3 (en) 2002-01-31
IL124866A0 (en) 1999-01-26
AU1289797A (en) 1997-07-03
MX9804751A (es) 1998-10-31
HUP9901984A3 (en) 2001-01-29
PT779271E (pt) 2001-11-30
EP0779271A1 (en) 1997-06-18
DK0779271T3 (da) 2001-10-08
ES2159347T3 (es) 2001-10-01
JP2000501739A (ja) 2000-02-15
WO1997021664A1 (en) 1997-06-19
US6160175A (en) 2000-12-12
KR19990072110A (ko) 1999-09-27
CA2240395A1 (en) 1997-06-19
BR9612347A (pt) 1999-07-13
DE69614232T2 (de) 2002-01-10
DE69614232D1 (de) 2001-09-06
IL124866A (en) 2002-08-14
EP0779271B1 (en) 2001-08-01
ATE203744T1 (de) 2001-08-15

Similar Documents

Publication Publication Date Title
HUP9901984A2 (hu) sPLA2 Inhibitor hatású naftil-acetamidok, alkalmazásuk és a vegyületeket tartalmazó gyógyszerkészítmények
HUP0104867A2 (hu) Gyulladásos betegségek kezelésére használható heterociklusos vegyületek, eljárás előállításukra és ilyen vegyületeket tartalmazó gyógyászati készítmények és alkalmazásuk
HUP9902341A2 (hu) Herpeszvírus elleni hatású fenil-tiazol-származékok, előállításuk és alkalmazásuk, a vegyületeket tartalmazó gyógyszerkészítmények
HUP0302943A2 (hu) Új heterociklusos vegyületek, előállításuk és alkalmazásuk gyógyszerekként, különösen antibakteriális szerekként
HUP0302962A2 (hu) Béta-karbolinszármazékok, ezeket a vegyületeket tartalmazó gyógyászati készítmények és a vegyületek alkalmazása
TR200400376T4 (tr) Yeni, ilaç olarak kullanılabilen antikolinerjikler ve bunların imalatı için yöntem
HUP0100615A2 (hu) Szubsztituált 2-(2,6-dioxo-3-fluoro-piperidin-3-il)-izoindolinok és ezek alkalmazása TNFalfa-szint csökkentésére
HUP0300434A2 (hu) Oxazolszármazékok és alkalmazásuk tirozin-kináz-inhibitorként, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények
FI972628A (fi) Uudet sulfonamidit
SE9100342D0 (sv) Novel steroid esters
NZ332608A (en) alkyl 17-alpha-dichloroacetoxy-11- beta-hydroxy-androsta-1,4-diene-3-one-17-beta-carboxylates and medicaments
HUP0000980A2 (hu) Akril-nitril-vegyületek, eljárás előállításukra, valamint akril-nitril- vegyületeket tartalmazó peszticidek
HUP9801356A2 (hu) Triciklusos (2-hidroxi-2-metil-3,3,3-trifluor-propanoil)-amino-benzoxepin-, -benzotiepin-, -benzocikloheptén-, -indén-származékok és az ezeket tartalmazó gyógyszerkészítmények
HUP9900390A2 (hu) Szerin-proteáz-inhibitorok és ezeket tartalmazó gyógyszerkészítmények
ES2171964T3 (es) Esteres dibenzodihidropiridinecarboxilicos y su uso en metodos de ensayo quimiluminiscente.
ES8105696A1 (es) Procedimiento para la preparacion de polieterpoliaminas
EA200400708A1 (ru) Ингибиторы 11-бета-гидроксистероиддегидрогеназы типа 1
YU38399A (sh) Supstituisani derivati 1,3-bis(cikloheksilmetil)-1,2,3,6-tetrahidro-2,6-diokso-9h-purin-8-il)fenila,njihovo dobijanje i upotreba za proizvodnju medikamenata za lečenje inflamatornih stanja i imuno poremećaja
TR200100603T2 (tr) Pirazin bileşikleri
ATE168105T1 (de) Melamine derivate zur verwendung in der behandlung von krebs
HUP9802492A2 (hu) Antipszichotikus hatású benzizoxazol- és indazolszármazékok, eljárás előállításukra és az ezeket tartalmazó gyógyszerkészítmények
ZA816259B (en) 2-(1,4-benzodioxan-2-ylalkyl)imidazoles useful as antidepressants
ES2027550A6 (es) Procedimiento para preparar derivados de glicerol.
HUP9700983A2 (hu) 1,4-Diaril-2-fluor-2-butén-származékok, intermedierjeik, előállításuk és alkalmazásuk, valamint hatóanyagként ezeket a vegyületeket tartalmazó inszekticid és akaricid készítmények
HUP9902120A2 (hu) sPLA2 inhibitor hatású naftil-glioxamidok