HUP9802492A2 - Antipszichotikus hatású benzizoxazol- és indazolszármazékok, eljárás előállításukra és az ezeket tartalmazó gyógyszerkészítmények - Google Patents
Antipszichotikus hatású benzizoxazol- és indazolszármazékok, eljárás előállításukra és az ezeket tartalmazó gyógyszerkészítményekInfo
- Publication number
- HUP9802492A2 HUP9802492A2 HU9802492A HUP9802492A HUP9802492A2 HU P9802492 A2 HUP9802492 A2 HU P9802492A2 HU 9802492 A HU9802492 A HU 9802492A HU P9802492 A HUP9802492 A HU P9802492A HU P9802492 A2 HUP9802492 A2 HU P9802492A2
- Authority
- HU
- Hungary
- Prior art keywords
- powder
- alkyl
- pipe powder
- pipe
- carbon atom
- Prior art date
Links
- KTZQTRPPVKQPFO-UHFFFAOYSA-N 1,2-benzoxazole Chemical compound C1=CC=C2C=NOC2=C1 KTZQTRPPVKQPFO-UHFFFAOYSA-N 0.000 title 1
- 239000000164 antipsychotic agent Substances 0.000 title 1
- 125000003453 indazolyl group Chemical class N1N=C(C2=C1C=CC=C2)* 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 239000000843 powder Substances 0.000 abstract 13
- 229910052799 carbon Inorganic materials 0.000 abstract 4
- 125000004432 carbon atom Chemical group C* 0.000 abstract 4
- GQPLMRYTRLFLPF-UHFFFAOYSA-N Nitrous Oxide Chemical compound [O-][N+]#N GQPLMRYTRLFLPF-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- -1 trifluoromethyl trifluoride Chemical compound 0.000 abstract 2
- XFXPMWWXUTWYJX-UHFFFAOYSA-N Cyanide Chemical compound N#[C-] XFXPMWWXUTWYJX-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000000561 anti-psychotic effect Effects 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 239000001272 nitrous oxide Substances 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
A találmány tárgya az (I) általánős képletű vegyületek, ahől aképletben X jelentése -OH-csőpőrt, -OC(=O)-alkilcsőpőrt, -OC(=O)-arilcsőpőrt, -OC(=O)-alkil-arilcsőpőrt, -OC(=O)NH-alkilcsőpőrt, -OC(=O)- alkil-ciklőalkil-csőpőrt, -OC(=O)O-alkilcsőpőrt vagy -OC(=O)-ciklőalkil-csőpőrt; Y jelentése hidrőgénatőm, halőgénatőm, triflűőr-metil-csőpőrt, 1-6szénatőmszámú alkőxicsőpőrt, cianőcsőpőrt vagy nitrőcsőpőrt; Z jelentése őxigénatőm vagy NR1-csőpőrt; R1 jelentése hidrőgénatőm, 1-6 szénatőmszámú alkilcsőpőrt,főrmilcsőpőrt, -C(=O)-(1-18 szénatőmszámú)-alkilcsőpőrt vagy -C(=O)O(1-18 szénatőmszámú)-alkilcsőpőrt; m jelentése 1, 2, 3 vagy 4; n jelentése 1 vagy 2 és p jelentése 1 vagy 2; és gyógyászatilag elfőgadható savaddíciós sói. A találmány szerintivegyületek antipszichőtikűs hatással rendelkeznek. ŕ
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US47040095A | 1995-06-06 | 1995-06-06 |
Publications (2)
Publication Number | Publication Date |
---|---|
HUP9802492A2 true HUP9802492A2 (hu) | 1999-09-28 |
HUP9802492A3 HUP9802492A3 (en) | 1999-10-28 |
Family
ID=23867483
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU9802492A HUP9802492A3 (en) | 1995-06-06 | 1996-05-14 | Benzisoxazole and indazole derivatives as antipsychotic agents, process for their preparation and pharmaceutical compositions containing the same |
Country Status (20)
Country | Link |
---|---|
US (3) | US5696113A (hu) |
EP (1) | EP0833820B1 (hu) |
JP (2) | JP3122469B2 (hu) |
KR (1) | KR100304179B1 (hu) |
AR (1) | AR002300A1 (hu) |
AT (1) | ATE199147T1 (hu) |
AU (1) | AU697953B2 (hu) |
CA (1) | CA2218663C (hu) |
DE (1) | DE69611783T2 (hu) |
DK (1) | DK0833820T3 (hu) |
ES (1) | ES2157442T3 (hu) |
GR (1) | GR3035663T3 (hu) |
HU (1) | HUP9802492A3 (hu) |
IL (1) | IL118530A0 (hu) |
MX (1) | MX9709451A (hu) |
NO (1) | NO975681L (hu) |
NZ (1) | NZ307958A (hu) |
PT (1) | PT833820E (hu) |
WO (2) | WO1996039405A1 (hu) |
ZA (1) | ZA964562B (hu) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6008348A (en) * | 1995-06-06 | 1999-12-28 | Hoechst Marion Roussel, Inc. | Antipsychotic agents, compositions and method of use |
TW487572B (en) * | 1996-05-20 | 2002-05-21 | Janssen Pharmaceutica Nv | Aqueous suspensions of 9-hydroxyrisperidone fatty acid esters |
UA72189C2 (uk) | 1997-11-17 | 2005-02-15 | Янссен Фармацевтика Н.В. | Фармацевтична композиція, що містить водну суспензію субмікронних ефірів 9-гідроксирисперидон жирних кислот |
US7253165B2 (en) * | 1999-09-14 | 2007-08-07 | Aventis Pharmaceuticals Inc. | Benzisoxazolyl-, pyridoisoxazolyl-and benzthienyl-phenoxy derivatives useful as D4 antagonists |
US7125903B1 (en) | 1999-09-14 | 2006-10-24 | Aventis Pharmaceuticals Inc. | Thienoisoxazolyl-and thienylpyrrazolyl-phenoxy substituted propyl derivatives useful as D4 antagonists |
US7091199B1 (en) | 1999-09-14 | 2006-08-15 | Aventis Pharmaceuticals Inc. | Thienoisoxazole phenoxy unsubstituted ethyl and propyl derivatives useful as d4 antagonists |
GB0117531D0 (en) * | 2001-02-16 | 2001-09-12 | Aventis Pharm Prod Inc | Novel heterocyclic amide derivatives and their use as dopamine D3 receptor ligands |
KR100627031B1 (ko) * | 2004-09-04 | 2006-09-21 | 주식회사 케이티프리텔 | 등산 정보 서비스 제공 방법 및 장치 |
DE102005038947A1 (de) * | 2005-05-18 | 2006-11-30 | Grünenthal GmbH | Substituierte Benzo[d]isoxazol-3-yl-amin-Verbindungen und deren Verwendung in Arzneimitteln |
KR100673033B1 (ko) * | 2005-06-21 | 2007-01-22 | (주) 엘지텔레콤 | 레저 전용 휴대 단말기 |
JP2010519171A (ja) | 2006-02-17 | 2010-06-03 | メモリー・ファーマシューティカルズ・コーポレイション | 5−ht6受容体親和性を有する化合物 |
KR20110076944A (ko) * | 2008-09-23 | 2011-07-06 | 에프. 호프만-라 로슈 아게 | 도파민 d3 수용체의 조절제로서 유용한 이속사졸로〔4,5〕피리딘-3-일-피페라진 유도체 |
AR077033A1 (es) * | 2009-06-11 | 2011-07-27 | Hoffmann La Roche | Compuestos inhibidores de las quinasas de janus y su uso en el tratamiento de enfermedades inmunologicas |
CN110117278B (zh) * | 2018-02-07 | 2022-07-19 | 石家庄以岭药业股份有限公司 | 烷氧基苯并五元(六元)杂环胺类化合物及其药物用途 |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4411901A (en) * | 1981-12-23 | 1983-10-25 | Mead Johnson & Company | Benzisothiazole and benzisoxazole piperazine derivatives |
US4806649A (en) * | 1983-08-22 | 1989-02-21 | Hoechst-Roussel Pharmaceuticals, Inc. | 3-(piperidinyl)- and 3- (pyrrolidinyl)-1H-indazoles |
US4670447A (en) * | 1983-08-22 | 1987-06-02 | Hoechst-Roussel Pharmaceuticals Inc. | Antipsychotic 3-(piperidinyl)- and 3-(pyrrolidinyl)-1H-indazoles |
US4853470A (en) * | 1983-08-22 | 1989-08-01 | Hoechst-Roussel Pharmaceuticals, Inc. | 3-(piperidinyl)- and 3-(pyrrolidinyl)-1H-indazoles |
US4590196A (en) * | 1984-08-23 | 1986-05-20 | Bristol-Myers Company | Analgesic 1,2-benzisothiazol-3-ylpiperazine derivatives |
MX174210B (es) * | 1987-02-17 | 1994-04-28 | Pfizer | Procedimiento para la preparacion de compuestos arilpiperazinil-alquilenfenil-p-heterociclicos |
EP0302423A3 (en) * | 1987-08-07 | 1991-01-09 | Hoechst-Roussel Pharmaceuticals Incorporated | 1-phenyl-3-(1-piperazinyl)-1h-indazoles, a process and intermediates for their preparation, and the use thereof as medicaments |
NZ233525A (en) * | 1989-05-15 | 1991-09-25 | Janssen Pharmaceutica Nv | Piperidinyl, pyrrolidinyl and piperazinyl alkylphenol ethers and pharmaceutical compositions |
US5364866A (en) * | 1989-05-19 | 1994-11-15 | Hoechst-Roussel Pharmaceuticals, Inc. | Heteroarylpiperidines, pyrrolidines and piperazines and their use as antipsychotics and analetics |
DK0402644T3 (da) * | 1989-05-19 | 1996-01-02 | Hoechst Roussel Pharma | N-(Aryloxyalkyl)-heteroarylpiperidiner og -heteroarylpiperaziner, fremgangsmåde til deres fremstilli ng samt deres anvendelse som medikamenter |
US4954503A (en) * | 1989-09-11 | 1990-09-04 | Hoechst-Roussel Pharmaceuticals, Inc. | 3-(1-substituted-4-piperazinyl)-1H-indazoles |
US5077405A (en) * | 1989-09-11 | 1991-12-31 | Hoechst-Roussel Pharmaceuticals Incorporated | 3-(1-Substituted-4-piperazinyl)-1H-indazoles |
FR2671350A1 (fr) * | 1991-01-08 | 1992-07-10 | Adir | Nouveaux derives de benzisoxazole et de benzisothiazole, leur procede de preparation, et les compositions pharmaceutiques les renfermant. |
DE69232907T2 (de) * | 1991-03-28 | 2003-05-15 | Eisai Co Ltd | Neue heterocyclische/cyclische amine |
US5177088A (en) * | 1991-04-17 | 1993-01-05 | Hoechst-Roussel Pharmaceuticals Incorporated | Substituted 3-(pyridinylamino)-indoles |
US5328920A (en) * | 1991-04-17 | 1994-07-12 | Hoechst-Roussel Pharmaceuticals Incorporated | Substituted (pyridinylamino)-indoles |
US5206366A (en) * | 1992-08-26 | 1993-04-27 | Pfizer Inc. | Process for preparing aryl piperazinyl-heterocyclic compounds |
US5494908A (en) * | 1992-11-23 | 1996-02-27 | Hoechst-Roussel Pharmaceutical Incorporated | Substituted 3-(aminoalkylamino)-1,2-benzisoxazoles and related compounds |
-
1996
- 1996-05-14 WO PCT/US1996/007319 patent/WO1996039405A1/en not_active Application Discontinuation
- 1996-05-14 ES ES96915782T patent/ES2157442T3/es not_active Expired - Lifetime
- 1996-05-14 AT AT96915782T patent/ATE199147T1/de not_active IP Right Cessation
- 1996-05-14 JP JP09500630A patent/JP3122469B2/ja not_active Expired - Fee Related
- 1996-05-14 KR KR1019970708743A patent/KR100304179B1/ko not_active IP Right Cessation
- 1996-05-14 PT PT96915782T patent/PT833820E/pt unknown
- 1996-05-14 WO PCT/US1996/006851 patent/WO1996039397A1/en active IP Right Grant
- 1996-05-14 AU AU57464/96A patent/AU697953B2/en not_active Ceased
- 1996-05-14 HU HU9802492A patent/HUP9802492A3/hu unknown
- 1996-05-14 DK DK96915782T patent/DK0833820T3/da active
- 1996-05-14 JP JP9500561A patent/JP3057763B2/ja not_active Expired - Fee Related
- 1996-05-14 NZ NZ307958A patent/NZ307958A/xx unknown
- 1996-05-14 EP EP96915782A patent/EP0833820B1/en not_active Expired - Lifetime
- 1996-05-14 MX MX9709451A patent/MX9709451A/es unknown
- 1996-05-14 DE DE69611783T patent/DE69611783T2/de not_active Expired - Fee Related
- 1996-05-14 CA CA002218663A patent/CA2218663C/en not_active Expired - Fee Related
- 1996-06-02 IL IL11853096A patent/IL118530A0/xx unknown
- 1996-06-03 ZA ZA964562A patent/ZA964562B/xx unknown
- 1996-06-04 AR ARP960102884A patent/AR002300A1/es unknown
- 1996-06-27 US US08/672,127 patent/US5696113A/en not_active Expired - Fee Related
-
1997
- 1997-09-02 US US08/921,480 patent/US5852022A/en not_active Expired - Fee Related
- 1997-12-05 NO NO975681A patent/NO975681L/no not_active Application Discontinuation
-
1998
- 1998-09-11 US US09/150,971 patent/US5965554A/en not_active Expired - Fee Related
-
2001
- 2001-03-29 GR GR20010400513T patent/GR3035663T3/el not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
HUP9802492A3 (en) | 1999-10-28 |
KR19990022264A (ko) | 1999-03-25 |
GR3035663T3 (en) | 2001-06-29 |
NO975681D0 (no) | 1997-12-05 |
EP0833820A1 (en) | 1998-04-08 |
IL118530A0 (en) | 1996-10-16 |
DE69611783D1 (de) | 2001-03-22 |
DK0833820T3 (da) | 2001-04-17 |
AU697953B2 (en) | 1998-10-22 |
PT833820E (pt) | 2001-07-31 |
ATE199147T1 (de) | 2001-02-15 |
US5965554A (en) | 1999-10-12 |
DE69611783T2 (de) | 2001-09-20 |
ZA964562B (en) | 1996-12-12 |
ES2157442T3 (es) | 2001-08-16 |
MX9709451A (es) | 1998-02-28 |
CA2218663A1 (en) | 1996-12-12 |
NO975681L (no) | 1998-02-05 |
NZ307958A (en) | 1999-02-25 |
US5852022A (en) | 1998-12-22 |
JPH11507030A (ja) | 1999-06-22 |
KR100304179B1 (ko) | 2001-11-22 |
JP3057763B2 (ja) | 2000-07-04 |
WO1996039397A1 (en) | 1996-12-12 |
CA2218663C (en) | 2001-07-31 |
US5696113A (en) | 1997-12-09 |
AU5746496A (en) | 1996-12-24 |
WO1996039405A1 (en) | 1996-12-12 |
JPH11506728A (ja) | 1999-06-15 |
AR002300A1 (es) | 1998-03-11 |
EP0833820B1 (en) | 2001-02-14 |
JP3122469B2 (ja) | 2001-01-09 |
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