AR002300A1 - Compuestos heteroarilpiperazinas particularmente utiles como agentes antipsicoticos, composiciones, procedimientos par la preparacion y metodosterapeuticos de utilizacion de dichos compuestos. - Google Patents

Compuestos heteroarilpiperazinas particularmente utiles como agentes antipsicoticos, composiciones, procedimientos par la preparacion y metodosterapeuticos de utilizacion de dichos compuestos.

Info

Publication number
AR002300A1
AR002300A1 ARP960102884A AR10288496A AR002300A1 AR 002300 A1 AR002300 A1 AR 002300A1 AR P960102884 A ARP960102884 A AR P960102884A AR 10288496 A AR10288496 A AR 10288496A AR 002300 A1 AR002300 A1 AR 002300A1
Authority
AR
Argentina
Prior art keywords
compounds
alkyl
procedures
preparation
methodsterapeuticos
Prior art date
Application number
ARP960102884A
Other languages
English (en)
Inventor
Mark G Palermo
Lawrence L Martin
Peter A Nemoto
Original Assignee
Hoechst Marion Roussel Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Marion Roussel Inc filed Critical Hoechst Marion Roussel Inc
Publication of AR002300A1 publication Critical patent/AR002300A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Se describen compuestos de fórmula (I) donde: X es -OH, -OC(=O)alquilo (C1-C18), -OC(=O)arilo(C6-C10), -OC(=O)alquil(C1-C12)arilo(C6-C10), -OC(=O)NHalquilo(C1-C18), -OC(=O)alquil(C1-C12)cicloalquilo(C3-C8), -OC(=O)Oalquilo de (C1-C18) ó-OC(O= )-cicloalquilo de C3-C12, Y es H, halógeno, trifluormetilo,alcoxi de C1-C6, ciano o nitro; Z es O, NR1; R1 es hidrógeno, alquilo de C1-C6, formilo, -C(=O)alquilo (C1-C18) ó -C(=O)Oalquilo(C1-C18); m es 1, 2, 3 ó 4; y nes 1 ó 2; y p es 1 ó2;ysus sale s de adición de ácido farmacéuticamente aceptables.Dichos compuestos se incluyen en composiciones farmacéuticas quecomprenden un vehículo farmacéuticamente aceptable y son útiles en métodos de tratamiento para proporcionar unefecto antipsi cótico que comprenden inyectar aun mamífero una cantidad de dicha composición suficiente para producir el efecto deseado. También se describen procedimientos para la preparación dedichos compuestos.
ARP960102884A 1995-06-06 1996-06-04 Compuestos heteroarilpiperazinas particularmente utiles como agentes antipsicoticos, composiciones, procedimientos par la preparacion y metodosterapeuticos de utilizacion de dichos compuestos. AR002300A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US47040095A 1995-06-06 1995-06-06

Publications (1)

Publication Number Publication Date
AR002300A1 true AR002300A1 (es) 1998-03-11

Family

ID=23867483

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP960102884A AR002300A1 (es) 1995-06-06 1996-06-04 Compuestos heteroarilpiperazinas particularmente utiles como agentes antipsicoticos, composiciones, procedimientos par la preparacion y metodosterapeuticos de utilizacion de dichos compuestos.

Country Status (20)

Country Link
US (3) US5696113A (es)
EP (1) EP0833820B1 (es)
JP (2) JP3057763B2 (es)
KR (1) KR100304179B1 (es)
AR (1) AR002300A1 (es)
AT (1) ATE199147T1 (es)
AU (1) AU697953B2 (es)
CA (1) CA2218663C (es)
DE (1) DE69611783T2 (es)
DK (1) DK0833820T3 (es)
ES (1) ES2157442T3 (es)
GR (1) GR3035663T3 (es)
HU (1) HUP9802492A3 (es)
IL (1) IL118530A0 (es)
MX (1) MX9709451A (es)
NO (1) NO975681L (es)
NZ (1) NZ307958A (es)
PT (1) PT833820E (es)
WO (2) WO1996039397A1 (es)
ZA (1) ZA964562B (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6008348A (en) * 1995-06-06 1999-12-28 Hoechst Marion Roussel, Inc. Antipsychotic agents, compositions and method of use
TW487572B (en) * 1996-05-20 2002-05-21 Janssen Pharmaceutica Nv Aqueous suspensions of 9-hydroxyrisperidone fatty acid esters
UA72189C2 (uk) 1997-11-17 2005-02-15 Янссен Фармацевтика Н.В. Фармацевтична композиція, що містить водну суспензію субмікронних ефірів 9-гідроксирисперидон жирних кислот
US7091199B1 (en) 1999-09-14 2006-08-15 Aventis Pharmaceuticals Inc. Thienoisoxazole phenoxy unsubstituted ethyl and propyl derivatives useful as d4 antagonists
US7253165B2 (en) * 1999-09-14 2007-08-07 Aventis Pharmaceuticals Inc. Benzisoxazolyl-, pyridoisoxazolyl-and benzthienyl-phenoxy derivatives useful as D4 antagonists
US7125903B1 (en) 1999-09-14 2006-10-24 Aventis Pharmaceuticals Inc. Thienoisoxazolyl-and thienylpyrrazolyl-phenoxy substituted propyl derivatives useful as D4 antagonists
GB0117531D0 (en) * 2001-02-16 2001-09-12 Aventis Pharm Prod Inc Novel heterocyclic amide derivatives and their use as dopamine D3 receptor ligands
KR100627031B1 (ko) * 2004-09-04 2006-09-21 주식회사 케이티프리텔 등산 정보 서비스 제공 방법 및 장치
DE102005038947A1 (de) * 2005-05-18 2006-11-30 Grünenthal GmbH Substituierte Benzo[d]isoxazol-3-yl-amin-Verbindungen und deren Verwendung in Arzneimitteln
KR100673033B1 (ko) * 2005-06-21 2007-01-22 (주) 엘지텔레콤 레저 전용 휴대 단말기
CA2637531A1 (en) 2006-02-17 2007-08-30 Memory Pharmaceuticals Corporation Compounds having 5-ht6 receptor affinity
CN102164927A (zh) * 2008-09-23 2011-08-24 弗·哈夫曼-拉罗切有限公司 用作多巴胺d3受体调节剂的异唑并[4,5]吡啶-3-基-哌嗪衍生物
TW201103904A (en) * 2009-06-11 2011-02-01 Hoffmann La Roche Janus kinase inhibitor compounds and methods
CN110117278B (zh) * 2018-02-07 2022-07-19 石家庄以岭药业股份有限公司 烷氧基苯并五元(六元)杂环胺类化合物及其药物用途

Family Cites Families (18)

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Publication number Priority date Publication date Assignee Title
US4411901A (en) * 1981-12-23 1983-10-25 Mead Johnson & Company Benzisothiazole and benzisoxazole piperazine derivatives
US4853470A (en) * 1983-08-22 1989-08-01 Hoechst-Roussel Pharmaceuticals, Inc. 3-(piperidinyl)- and 3-(pyrrolidinyl)-1H-indazoles
US4670447A (en) * 1983-08-22 1987-06-02 Hoechst-Roussel Pharmaceuticals Inc. Antipsychotic 3-(piperidinyl)- and 3-(pyrrolidinyl)-1H-indazoles
US4806649A (en) * 1983-08-22 1989-02-21 Hoechst-Roussel Pharmaceuticals, Inc. 3-(piperidinyl)- and 3- (pyrrolidinyl)-1H-indazoles
US4590196A (en) * 1984-08-23 1986-05-20 Bristol-Myers Company Analgesic 1,2-benzisothiazol-3-ylpiperazine derivatives
MX174210B (es) * 1987-02-17 1994-04-28 Pfizer Procedimiento para la preparacion de compuestos arilpiperazinil-alquilenfenil-p-heterociclicos
EP0302423A3 (en) * 1987-08-07 1991-01-09 Hoechst-Roussel Pharmaceuticals Incorporated 1-phenyl-3-(1-piperazinyl)-1h-indazoles, a process and intermediates for their preparation, and the use thereof as medicaments
NZ233525A (en) * 1989-05-15 1991-09-25 Janssen Pharmaceutica Nv Piperidinyl, pyrrolidinyl and piperazinyl alkylphenol ethers and pharmaceutical compositions
US5364866A (en) * 1989-05-19 1994-11-15 Hoechst-Roussel Pharmaceuticals, Inc. Heteroarylpiperidines, pyrrolidines and piperazines and their use as antipsychotics and analetics
DE69021645T2 (de) * 1989-05-19 1996-02-22 Hoechst-Roussel Pharmaceuticals Inc., Somerville, N.J. N-(aryloxyalkyl)heteroarylpiperidine und -heteroarylpiperazine, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikamente.
US4954503A (en) * 1989-09-11 1990-09-04 Hoechst-Roussel Pharmaceuticals, Inc. 3-(1-substituted-4-piperazinyl)-1H-indazoles
US5077405A (en) * 1989-09-11 1991-12-31 Hoechst-Roussel Pharmaceuticals Incorporated 3-(1-Substituted-4-piperazinyl)-1H-indazoles
FR2671350A1 (fr) * 1991-01-08 1992-07-10 Adir Nouveaux derives de benzisoxazole et de benzisothiazole, leur procede de preparation, et les compositions pharmaceutiques les renfermant.
ATE231505T1 (de) * 1991-03-28 2003-02-15 Eisai Co Ltd Neue heterocyclische/cyclische amine
US5177088A (en) * 1991-04-17 1993-01-05 Hoechst-Roussel Pharmaceuticals Incorporated Substituted 3-(pyridinylamino)-indoles
US5328920A (en) * 1991-04-17 1994-07-12 Hoechst-Roussel Pharmaceuticals Incorporated Substituted (pyridinylamino)-indoles
US5206366A (en) * 1992-08-26 1993-04-27 Pfizer Inc. Process for preparing aryl piperazinyl-heterocyclic compounds
US5494908A (en) * 1992-11-23 1996-02-27 Hoechst-Roussel Pharmaceutical Incorporated Substituted 3-(aminoalkylamino)-1,2-benzisoxazoles and related compounds

Also Published As

Publication number Publication date
DK0833820T3 (da) 2001-04-17
GR3035663T3 (en) 2001-06-29
EP0833820B1 (en) 2001-02-14
US5696113A (en) 1997-12-09
WO1996039397A1 (en) 1996-12-12
KR100304179B1 (ko) 2001-11-22
ATE199147T1 (de) 2001-02-15
DE69611783D1 (de) 2001-03-22
JP3122469B2 (ja) 2001-01-09
NO975681D0 (no) 1997-12-05
ZA964562B (en) 1996-12-12
EP0833820A1 (en) 1998-04-08
CA2218663C (en) 2001-07-31
JPH11506728A (ja) 1999-06-15
NZ307958A (en) 1999-02-25
WO1996039405A1 (en) 1996-12-12
IL118530A0 (en) 1996-10-16
AU697953B2 (en) 1998-10-22
DE69611783T2 (de) 2001-09-20
MX9709451A (es) 1998-02-28
HUP9802492A2 (hu) 1999-09-28
AU5746496A (en) 1996-12-24
HUP9802492A3 (en) 1999-10-28
NO975681L (no) 1998-02-05
PT833820E (pt) 2001-07-31
US5965554A (en) 1999-10-12
CA2218663A1 (en) 1996-12-12
ES2157442T3 (es) 2001-08-16
US5852022A (en) 1998-12-22
JP3057763B2 (ja) 2000-07-04
KR19990022264A (ko) 1999-03-25
JPH11507030A (ja) 1999-06-22

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