YU38399A - Supstituisani derivati 1,3-bis(cikloheksilmetil)-1,2,3,6-tetrahidro-2,6-diokso-9h-purin-8-il)fenila,njihovo dobijanje i upotreba za proizvodnju medikamenata za lečenje inflamatornih stanja i imuno poremećaja - Google Patents
Supstituisani derivati 1,3-bis(cikloheksilmetil)-1,2,3,6-tetrahidro-2,6-diokso-9h-purin-8-il)fenila,njihovo dobijanje i upotreba za proizvodnju medikamenata za lečenje inflamatornih stanja i imuno poremećajaInfo
- Publication number
- YU38399A YU38399A YU38399A YU38399A YU38399A YU 38399 A YU38399 A YU 38399A YU 38399 A YU38399 A YU 38399A YU 38399 A YU38399 A YU 38399A YU 38399 A YU38399 A YU 38399A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- treatment
- inflammatory conditions
- immune disorders
- purin
- cyclohexylmethyl
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Ophthalmology & Optometry (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Transplantation (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Jedinjenje formule (I) ili njegov solvat gde su: X je -O- ili -NH-; Q je (-CH2-)p, (-CH=CH) (-C=C-)p, a p je ceo broj od 0 do 4; R1 je vodonik ili metil; R2 i R3 su nezavisno, O ili S; n je ceo broj od 1 do 50; i R je vodonik ili metil. Ova serija kompleksnih estara i amida odabranih derivata fenilksantina inhibira izazivanje adhezije molekula na monoslojevima humanih endotelnih ćelija pupčane vene, pri vrlo niskim koncentracijama, koja su stoga indicirana za lečenje inflamatornih stanja i imuno poremećaja.[A compound of formula (I) or a solvate thereof wherein: X is -O- or -NH-; Q is (-CH2-)p, (-C=CH)p, (-CC-)p where p is an integer of from 0 to 4; R1 is hydrogen or methyl; R2 and R3 independently represent O or S; n is an integer of 1 to 50; and R is hydrogen or methyl. This series of complex esters and amides of selected phenyl xanthine derivatives inhibit the expression of adhesion molecules on human umbilical vein endothelial cell (HUVEC) monolayers at very low concentrations and which are therefore indicated for treatment of inflammatory conditions and immune disorders.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9703044.9A GB9703044D0 (en) | 1997-02-14 | 1997-02-14 | Phenyl xanthine esters and amides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| YU38399A true YU38399A (sh) | 2002-06-19 |
Family
ID=10807635
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YU38399A YU38399A (sh) | 1997-02-14 | 1998-02-12 | Supstituisani derivati 1,3-bis(cikloheksilmetil)-1,2,3,6-tetrahidro-2,6-diokso-9h-purin-8-il)fenila,njihovo dobijanje i upotreba za proizvodnju medikamenata za lečenje inflamatornih stanja i imuno poremećaja |
Country Status (38)
| Country | Link |
|---|---|
| US (3) | US6355646B1 (sh) |
| EP (1) | EP0970081B1 (sh) |
| JP (1) | JP2001511792A (sh) |
| KR (1) | KR100522639B1 (sh) |
| CN (1) | CN1140527C (sh) |
| AP (1) | AP1000A (sh) |
| AR (1) | AR011441A1 (sh) |
| AT (1) | ATE304542T1 (sh) |
| AU (1) | AU754456B2 (sh) |
| BG (1) | BG103722A (sh) |
| BR (1) | BR9807682B1 (sh) |
| CA (1) | CA2280730C (sh) |
| CO (1) | CO4940444A1 (sh) |
| CZ (1) | CZ298764B6 (sh) |
| DE (1) | DE69831559T2 (sh) |
| DK (1) | DK0970081T3 (sh) |
| EA (1) | EA199900648A1 (sh) |
| EE (1) | EE9900348A (sh) |
| ES (1) | ES2249822T3 (sh) |
| GB (1) | GB9703044D0 (sh) |
| HK (1) | HK1022907A1 (sh) |
| HR (1) | HRP980077A2 (sh) |
| HU (1) | HU225962B1 (sh) |
| ID (1) | ID22770A (sh) |
| IL (1) | IL131179A (sh) |
| IS (1) | IS5144A (sh) |
| MY (1) | MY118545A (sh) |
| NO (1) | NO325685B1 (sh) |
| NZ (1) | NZ336923A (sh) |
| PE (1) | PE58899A1 (sh) |
| PL (1) | PL188018B1 (sh) |
| SK (1) | SK110399A3 (sh) |
| TR (1) | TR199901942T2 (sh) |
| TW (1) | TW520371B (sh) |
| UA (1) | UA57767C2 (sh) |
| WO (1) | WO1998035966A1 (sh) |
| YU (1) | YU38399A (sh) |
| ZA (1) | ZA981175B (sh) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9703044D0 (en) * | 1997-02-14 | 1997-04-02 | Glaxo Group Ltd | Phenyl xanthine esters and amides |
| GB9817623D0 (en) | 1998-08-13 | 1998-10-07 | Glaxo Group Ltd | Pharmaceutical compounds |
| US6545002B1 (en) * | 1999-06-01 | 2003-04-08 | University Of Virginia Patent Foundation | Substituted 8-phenylxanthines useful as antagonists of A2B adenosine receptors |
| FR2804958B1 (fr) * | 2000-02-15 | 2005-07-08 | Hoechst Marion Roussel Inc | Derives de xanthine, leur procede de preparation et les intermediaires de ce procede, leur application comme medicament et les compositions pharmaceutiques les renfermant |
| ES2262798T3 (es) * | 2001-02-28 | 2006-12-01 | Smithkline Beecham Corporation | Derivados glicolicos de xantinas para tratar el sindrome del intestino irritable. |
| US20080318983A1 (en) * | 2001-11-09 | 2008-12-25 | Rao Kalla | A2b adenosine receptor antagonists |
| US7125993B2 (en) * | 2001-11-09 | 2006-10-24 | Cv Therapeutics, Inc. | A2B adenosine receptor antagonists |
| US20040072848A1 (en) * | 2002-02-26 | 2004-04-15 | Huber Brian E | Methods of treating irritable bowel syndrome and functional dyspepsia |
| AU2012227249B2 (en) * | 2003-12-16 | 2014-10-02 | Nektar Therapeutics | Chemically modified small molecules |
| PL1694363T3 (pl) * | 2003-12-16 | 2014-07-31 | Nektar Therapeutics | Monodyspersyjne kompozycje PEGylowanego naloksolu |
| US20060182692A1 (en) | 2003-12-16 | 2006-08-17 | Fishburn C S | Chemically modified small molecules |
| WO2005102976A1 (en) * | 2004-04-21 | 2005-11-03 | Smithkline Beecham Corporation | Process for preparing nonaethylene glycol monomethyl ether |
| WO2006028810A2 (en) * | 2004-09-01 | 2006-03-16 | Cv Therapeutics, Inc. | Method of wound healing using a2b adenosine receptor antagonists |
| US20070059740A1 (en) * | 2005-08-26 | 2007-03-15 | Linden Joel M | Method of targeting a2b adenosine receptor antagonist therapy |
| US8193200B2 (en) * | 2007-01-04 | 2012-06-05 | University Of Virginia Patent Foundation | Antagonists of A2B adenosine receptors for treatment of inflammatory bowel disease |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8510758D0 (en) | 1985-04-27 | 1985-06-05 | Wellcome Found | Compounds |
| US4968672A (en) | 1987-01-02 | 1990-11-06 | The United States Of America As Represented By The Department Of Health And Human Services | Adenosine receptor prodrugs |
| US5015647A (en) | 1987-04-24 | 1991-05-14 | Burroughs Wellcome Co. | Method for treating viral infections |
| GB8826595D0 (en) | 1988-11-14 | 1988-12-21 | Beecham Wuelfing Gmbh & Co Kg | Active compounds |
| GB8906792D0 (en) | 1989-03-23 | 1989-05-10 | Beecham Wuelfing Gmbh & Co Kg | Treatment and compounds |
| NZ240644A (en) | 1990-11-21 | 1994-08-26 | Smithkline Beecham Corp | Use of xanthine derivatives to inhibit the production of tumour necrosis factor (tnf) |
| GB9210839D0 (en) * | 1992-05-21 | 1992-07-08 | Smithkline Beecham Plc | Novel compounds |
| TW252044B (sh) * | 1992-08-10 | 1995-07-21 | Boehringer Ingelheim Kg | |
| JP2613355B2 (ja) | 1992-09-28 | 1997-05-28 | 協和醗酵工業株式会社 | パーキンソン氏病治療剤 |
| GB9415529D0 (en) | 1994-08-01 | 1994-09-21 | Wellcome Found | Phenyl xanthine derivatives |
| DE19535504A1 (de) | 1995-09-25 | 1997-03-27 | Bayer Ag | Substituierte Xanthine |
| SI0812844T1 (en) | 1996-06-07 | 2003-02-28 | Hoechst Aktiengesellschaft | Use of theophyllin derivatives for the treatment and prophylaxis fo shock conditions, novel xanthine compounds and processes for the production thereof |
| GB9703044D0 (en) * | 1997-02-14 | 1997-04-02 | Glaxo Group Ltd | Phenyl xanthine esters and amides |
| US6117878A (en) | 1998-02-24 | 2000-09-12 | University Of Virginia | 8-phenyl- or 8-cycloalkyl xanthine antagonists of A2B human adenosine receptors |
| WO1999043673A1 (fr) | 1998-02-26 | 1999-09-02 | Zenyaku Kogyo Kabushiki Kaisha | Derives de 1-aza-indolizine |
| GB9817623D0 (en) * | 1998-08-13 | 1998-10-07 | Glaxo Group Ltd | Pharmaceutical compounds |
| NZ519781A (en) | 1999-12-23 | 2004-04-30 | Nitromed Inc | Nitrosated and nitrosylated cyclooxygenase-2 inhibitors, compositions and methods of use |
| US6751206B1 (en) * | 2000-06-29 | 2004-06-15 | Qualcomm Incorporated | Method and apparatus for beam switching in a wireless communication system |
-
1997
- 1997-02-14 GB GBGB9703044.9A patent/GB9703044D0/en active Pending
-
1998
- 1998-02-11 CO CO98007044A patent/CO4940444A1/es unknown
- 1998-02-11 PE PE1998000099A patent/PE58899A1/es not_active Application Discontinuation
- 1998-02-11 MY MYPI98000546A patent/MY118545A/en unknown
- 1998-02-12 PL PL98335135A patent/PL188018B1/pl unknown
- 1998-02-12 US US09/367,313 patent/US6355646B1/en not_active Expired - Lifetime
- 1998-02-12 ES ES98908090T patent/ES2249822T3/es not_active Expired - Lifetime
- 1998-02-12 EA EA199900648A patent/EA199900648A1/ru unknown
- 1998-02-12 DE DE69831559T patent/DE69831559T2/de not_active Expired - Lifetime
- 1998-02-12 EP EP98908090A patent/EP0970081B1/en not_active Expired - Lifetime
- 1998-02-12 ZA ZA9801175A patent/ZA981175B/xx unknown
- 1998-02-12 AT AT98908090T patent/ATE304542T1/de active
- 1998-02-12 JP JP53534098A patent/JP2001511792A/ja not_active Ceased
- 1998-02-12 EE EEP199900348A patent/EE9900348A/xx unknown
- 1998-02-12 CZ CZ0288799A patent/CZ298764B6/cs not_active IP Right Cessation
- 1998-02-12 TR TR1999/01942T patent/TR199901942T2/xx unknown
- 1998-02-12 KR KR10-1999-7007276A patent/KR100522639B1/ko not_active IP Right Cessation
- 1998-02-12 CN CNB988039419A patent/CN1140527C/zh not_active Expired - Fee Related
- 1998-02-12 IL IL13117998A patent/IL131179A/en not_active IP Right Cessation
- 1998-02-12 ID IDW990879A patent/ID22770A/id unknown
- 1998-02-12 HU HU0000894A patent/HU225962B1/hu not_active IP Right Cessation
- 1998-02-12 SK SK1103-99A patent/SK110399A3/sk unknown
- 1998-02-12 AP APAP/P/1999/001622A patent/AP1000A/en active
- 1998-02-12 BR BRPI9807682-5A patent/BR9807682B1/pt not_active IP Right Cessation
- 1998-02-12 CA CA002280730A patent/CA2280730C/en not_active Expired - Fee Related
- 1998-02-12 WO PCT/EP1998/000784 patent/WO1998035966A1/en active IP Right Grant
- 1998-02-12 NZ NZ336923A patent/NZ336923A/en unknown
- 1998-02-12 DK DK98908090T patent/DK0970081T3/da active
- 1998-02-12 YU YU38399A patent/YU38399A/sh unknown
- 1998-02-12 AU AU66221/98A patent/AU754456B2/en not_active Ceased
- 1998-02-13 HR HR9703044.9A patent/HRP980077A2/hr not_active Application Discontinuation
- 1998-02-13 AR ARP980100664A patent/AR011441A1/es active IP Right Grant
- 1998-02-24 TW TW087102632A patent/TW520371B/zh not_active IP Right Cessation
- 1998-12-02 UA UA99084601A patent/UA57767C2/uk unknown
-
1999
- 1999-07-30 IS IS5144A patent/IS5144A/is unknown
- 1999-08-13 NO NO19993915A patent/NO325685B1/no not_active IP Right Cessation
- 1999-09-09 BG BG103722A patent/BG103722A/xx unknown
-
2000
- 2000-03-29 HK HK00101936A patent/HK1022907A1/xx not_active IP Right Cessation
-
2001
- 2001-06-01 US US09/872,546 patent/US6437124B1/en not_active Expired - Fee Related
-
2002
- 2002-06-17 US US10/174,414 patent/US7002012B2/en not_active Expired - Fee Related
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