BR9807682B1 - composto, uso do mesmo, composiÇço farmacÊutica, e, processos para preparar um composto. - Google Patents
composto, uso do mesmo, composiÇço farmacÊutica, e, processos para preparar um composto.Info
- Publication number
- BR9807682B1 BR9807682B1 BRPI9807682-5A BR9807682A BR9807682B1 BR 9807682 B1 BR9807682 B1 BR 9807682B1 BR 9807682 A BR9807682 A BR 9807682A BR 9807682 B1 BR9807682 B1 BR 9807682B1
- Authority
- BR
- Brazil
- Prior art keywords
- compound
- preparing
- processes
- pharmaceutical composition
- pharmaceutical
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9703044.9A GB9703044D0 (en) | 1997-02-14 | 1997-02-14 | Phenyl xanthine esters and amides |
PCT/EP1998/000784 WO1998035966A1 (en) | 1997-02-14 | 1998-02-12 | Substituted (1,3-bis(cyclohexylmethyl)-1,2,3,6-tetrahydro-2,6-dioxo-9h-purin-8-yl)phenyl derivatives, their preparation and their use in the treatment of inflammatory conditions and immune disorders |
Publications (2)
Publication Number | Publication Date |
---|---|
BR9807682A BR9807682A (pt) | 2000-02-15 |
BR9807682B1 true BR9807682B1 (pt) | 2009-01-13 |
Family
ID=10807635
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI9807682-5A BR9807682B1 (pt) | 1997-02-14 | 1998-02-12 | composto, uso do mesmo, composiÇço farmacÊutica, e, processos para preparar um composto. |
Country Status (38)
Country | Link |
---|---|
US (3) | US6355646B1 (pt) |
EP (1) | EP0970081B1 (pt) |
JP (1) | JP2001511792A (pt) |
KR (1) | KR100522639B1 (pt) |
CN (1) | CN1140527C (pt) |
AP (1) | AP1000A (pt) |
AR (1) | AR011441A1 (pt) |
AT (1) | ATE304542T1 (pt) |
AU (1) | AU754456B2 (pt) |
BG (1) | BG103722A (pt) |
BR (1) | BR9807682B1 (pt) |
CA (1) | CA2280730C (pt) |
CO (1) | CO4940444A1 (pt) |
CZ (1) | CZ298764B6 (pt) |
DE (1) | DE69831559T2 (pt) |
DK (1) | DK0970081T3 (pt) |
EA (1) | EA199900648A1 (pt) |
EE (1) | EE9900348A (pt) |
ES (1) | ES2249822T3 (pt) |
GB (1) | GB9703044D0 (pt) |
HK (1) | HK1022907A1 (pt) |
HR (1) | HRP980077A2 (pt) |
HU (1) | HU225962B1 (pt) |
ID (1) | ID22770A (pt) |
IL (1) | IL131179A (pt) |
IS (1) | IS5144A (pt) |
MY (1) | MY118545A (pt) |
NO (1) | NO325685B1 (pt) |
NZ (1) | NZ336923A (pt) |
PE (1) | PE58899A1 (pt) |
PL (1) | PL188018B1 (pt) |
SK (1) | SK110399A3 (pt) |
TR (1) | TR199901942T2 (pt) |
TW (1) | TW520371B (pt) |
UA (1) | UA57767C2 (pt) |
WO (1) | WO1998035966A1 (pt) |
YU (1) | YU38399A (pt) |
ZA (1) | ZA981175B (pt) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9703044D0 (en) * | 1997-02-14 | 1997-04-02 | Glaxo Group Ltd | Phenyl xanthine esters and amides |
GB9817623D0 (en) | 1998-08-13 | 1998-10-07 | Glaxo Group Ltd | Pharmaceutical compounds |
US6545002B1 (en) * | 1999-06-01 | 2003-04-08 | University Of Virginia Patent Foundation | Substituted 8-phenylxanthines useful as antagonists of A2B adenosine receptors |
FR2804958B1 (fr) * | 2000-02-15 | 2005-07-08 | Hoechst Marion Roussel Inc | Derives de xanthine, leur procede de preparation et les intermediaires de ce procede, leur application comme medicament et les compositions pharmaceutiques les renfermant |
EP1372661B1 (en) * | 2001-02-28 | 2006-05-17 | SmithKline Beecham Corporation | Glycol derivatves of xanthines for treating irritable bowel syndrome |
US7125993B2 (en) * | 2001-11-09 | 2006-10-24 | Cv Therapeutics, Inc. | A2B adenosine receptor antagonists |
US20080318983A1 (en) * | 2001-11-09 | 2008-12-25 | Rao Kalla | A2b adenosine receptor antagonists |
US20040072848A1 (en) * | 2002-02-26 | 2004-04-15 | Huber Brian E | Methods of treating irritable bowel syndrome and functional dyspepsia |
US20060182692A1 (en) | 2003-12-16 | 2006-08-17 | Fishburn C S | Chemically modified small molecules |
AU2004299138B2 (en) * | 2003-12-16 | 2010-03-25 | Nektar Therapeutics | Chemically Modified Small Molecules |
AU2012227249B2 (en) * | 2003-12-16 | 2014-10-02 | Nektar Therapeutics | Chemically modified small molecules |
WO2005102976A1 (en) * | 2004-04-21 | 2005-11-03 | Smithkline Beecham Corporation | Process for preparing nonaethylene glycol monomethyl ether |
MX2007002437A (es) * | 2004-09-01 | 2007-08-14 | Cv Therapeutics Inc | Metodo para el sanado de heridas utilizando antagonistas del receptor de adenosina a2b. |
US20070059740A1 (en) * | 2005-08-26 | 2007-03-15 | Linden Joel M | Method of targeting a2b adenosine receptor antagonist therapy |
US8193200B2 (en) * | 2007-01-04 | 2012-06-05 | University Of Virginia Patent Foundation | Antagonists of A2B adenosine receptors for treatment of inflammatory bowel disease |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8510758D0 (en) | 1985-04-27 | 1985-06-05 | Wellcome Found | Compounds |
US4968672A (en) | 1987-01-02 | 1990-11-06 | The United States Of America As Represented By The Department Of Health And Human Services | Adenosine receptor prodrugs |
US5015647A (en) | 1987-04-24 | 1991-05-14 | Burroughs Wellcome Co. | Method for treating viral infections |
GB8826595D0 (en) | 1988-11-14 | 1988-12-21 | Beecham Wuelfing Gmbh & Co Kg | Active compounds |
GB8906792D0 (en) | 1989-03-23 | 1989-05-10 | Beecham Wuelfing Gmbh & Co Kg | Treatment and compounds |
NZ240644A (en) | 1990-11-21 | 1994-08-26 | Smithkline Beecham Corp | Use of xanthine derivatives to inhibit the production of tumour necrosis factor (tnf) |
GB9210839D0 (en) * | 1992-05-21 | 1992-07-08 | Smithkline Beecham Plc | Novel compounds |
TW252044B (pt) * | 1992-08-10 | 1995-07-21 | Boehringer Ingelheim Kg | |
JP2613355B2 (ja) * | 1992-09-28 | 1997-05-28 | 協和醗酵工業株式会社 | パーキンソン氏病治療剤 |
GB9415529D0 (en) * | 1994-08-01 | 1994-09-21 | Wellcome Found | Phenyl xanthine derivatives |
DE19535504A1 (de) | 1995-09-25 | 1997-03-27 | Bayer Ag | Substituierte Xanthine |
ES2185837T3 (es) * | 1996-06-07 | 2003-05-01 | Hoechst Ag | Utilizacion de derivados de teofilina para el tratamiento y la profilaxis de las enfermedades de choque, nuevos compuestos de xantina y procedimientos para su produccion. |
GB9703044D0 (en) * | 1997-02-14 | 1997-04-02 | Glaxo Group Ltd | Phenyl xanthine esters and amides |
US6117878A (en) | 1998-02-24 | 2000-09-12 | University Of Virginia | 8-phenyl- or 8-cycloalkyl xanthine antagonists of A2B human adenosine receptors |
AU2640999A (en) | 1998-02-26 | 1999-09-15 | Zenyaku Kogyo Kabushiki Kaisha | 1-azaindolizine derivatives |
GB9817623D0 (en) * | 1998-08-13 | 1998-10-07 | Glaxo Group Ltd | Pharmaceutical compounds |
RU2002119574A (ru) | 1999-12-23 | 2004-01-10 | Нитромед, Инк. (Us) | Нитрозированные и нитрозилированные ингибиторы циклооксигеназы-2, композиции на их основе и способы их применения |
US6751206B1 (en) * | 2000-06-29 | 2004-06-15 | Qualcomm Incorporated | Method and apparatus for beam switching in a wireless communication system |
-
1997
- 1997-02-14 GB GBGB9703044.9A patent/GB9703044D0/en active Pending
-
1998
- 1998-02-11 MY MYPI98000546A patent/MY118545A/en unknown
- 1998-02-11 CO CO98007044A patent/CO4940444A1/es unknown
- 1998-02-11 PE PE1998000099A patent/PE58899A1/es not_active Application Discontinuation
- 1998-02-12 BR BRPI9807682-5A patent/BR9807682B1/pt not_active IP Right Cessation
- 1998-02-12 WO PCT/EP1998/000784 patent/WO1998035966A1/en active IP Right Grant
- 1998-02-12 CA CA002280730A patent/CA2280730C/en not_active Expired - Fee Related
- 1998-02-12 ID IDW990879A patent/ID22770A/id unknown
- 1998-02-12 US US09/367,313 patent/US6355646B1/en not_active Expired - Lifetime
- 1998-02-12 AU AU66221/98A patent/AU754456B2/en not_active Ceased
- 1998-02-12 PL PL98335135A patent/PL188018B1/pl unknown
- 1998-02-12 TR TR1999/01942T patent/TR199901942T2/xx unknown
- 1998-02-12 HU HU0000894A patent/HU225962B1/hu not_active IP Right Cessation
- 1998-02-12 KR KR10-1999-7007276A patent/KR100522639B1/ko not_active IP Right Cessation
- 1998-02-12 CZ CZ0288799A patent/CZ298764B6/cs not_active IP Right Cessation
- 1998-02-12 DK DK98908090T patent/DK0970081T3/da active
- 1998-02-12 CN CNB988039419A patent/CN1140527C/zh not_active Expired - Fee Related
- 1998-02-12 AP APAP/P/1999/001622A patent/AP1000A/en active
- 1998-02-12 JP JP53534098A patent/JP2001511792A/ja not_active Ceased
- 1998-02-12 ZA ZA9801175A patent/ZA981175B/xx unknown
- 1998-02-12 YU YU38399A patent/YU38399A/sh unknown
- 1998-02-12 EA EA199900648A patent/EA199900648A1/ru unknown
- 1998-02-12 NZ NZ336923A patent/NZ336923A/en unknown
- 1998-02-12 ES ES98908090T patent/ES2249822T3/es not_active Expired - Lifetime
- 1998-02-12 AT AT98908090T patent/ATE304542T1/de active
- 1998-02-12 EE EEP199900348A patent/EE9900348A/xx unknown
- 1998-02-12 EP EP98908090A patent/EP0970081B1/en not_active Expired - Lifetime
- 1998-02-12 DE DE69831559T patent/DE69831559T2/de not_active Expired - Lifetime
- 1998-02-12 SK SK1103-99A patent/SK110399A3/sk unknown
- 1998-02-12 IL IL13117998A patent/IL131179A/en not_active IP Right Cessation
- 1998-02-13 HR HR9703044.9A patent/HRP980077A2/hr not_active Application Discontinuation
- 1998-02-13 AR ARP980100664A patent/AR011441A1/es active IP Right Grant
- 1998-02-24 TW TW087102632A patent/TW520371B/zh not_active IP Right Cessation
- 1998-12-02 UA UA99084601A patent/UA57767C2/uk unknown
-
1999
- 1999-07-30 IS IS5144A patent/IS5144A/is unknown
- 1999-08-13 NO NO19993915A patent/NO325685B1/no not_active IP Right Cessation
- 1999-09-09 BG BG103722A patent/BG103722A/xx unknown
-
2000
- 2000-03-29 HK HK00101936A patent/HK1022907A1/xx not_active IP Right Cessation
-
2001
- 2001-06-01 US US09/872,546 patent/US6437124B1/en not_active Expired - Fee Related
-
2002
- 2002-06-17 US US10/174,414 patent/US7002012B2/en not_active Expired - Fee Related
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Legal Events
Date | Code | Title | Description |
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B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 9A ANUIDADE |
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B08H | Application fees: decision cancelled [chapter 8.8 patent gazette] |
Free format text: REFERENTE AO DESPACHO PUBLICADO NA RPI 1908 DE 31/07/2007 POR TER SIDO INDEVIDO. |
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B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
B15K | Others concerning applications: alteration of classification |
Free format text: ALTERADA DE INT.CL.8: C07D 473/06, A61K 31/522, A61P 11/06, A61P 11/08, A61P 19/02, A61P 17/06, A61P 1/00, A61P 37/00, A61P 37/06, A61P 9/10 Ipc: C07D 473/06 (2007.10), A61K 31/522 (2007.10), A61P |
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B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 13/01/2009, OBSERVADAS AS CONDICOES LEGAIS. |
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B21F | Lapse acc. art. 78, item iv - on non-payment of the annual fees in time | ||
B24J | Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12) |