KR830007092A - 방사성 진단제 및 그의 비-방사성 담체 - Google Patents

방사성 진단제 및 그의 비-방사성 담체 Download PDF

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KR830007092A
KR830007092A KR1019810004574A KR810004574A KR830007092A KR 830007092 A KR830007092 A KR 830007092A KR 1019810004574 A KR1019810004574 A KR 1019810004574A KR 810004574 A KR810004574 A KR 810004574A KR 830007092 A KR830007092 A KR 830007092A
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South Korea
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pyridoxyl
amino acid
hydrogen
radioactive carrier
radioactive
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KR1019810004574A
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KR850001871B1 (ko
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마꼬도 아즈마
마사아끼 하즈에
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야마오까 세이사부로오
니홍 메지피직스 가부시기가이샤
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/65—One oxygen atom attached in position 3 or 5
    • C07D213/66—One oxygen atom attached in position 3 or 5 having in position 3 an oxygen atom and in each of the positions 4 and 5 a carbon atom bound to an oxygen, sulphur, or nitrogen atom, e.g. pyridoxal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

내용 없음

Description

방사성 진단제 및 그의 비-방사성 담체
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (12)

  1. R1과 R2가 각각 점선에 의해 둘러쌓여진 α-아미노산 잔유물에 존재하는 원자 또는 원자단애고, R3,R4,R5및 R6가 각각 수소원자, 할로겐원자, C1-C10알킬기 또는 최소한 한가지 소수기 또는 그것의 염과 치환된 C1-C10알킬기 및 과테크네툼산염을 위한 환원제인 일반식,
    의 N-피리독실-α-아미노산을 함유하는 비-방사성 담체.
  2. 제1항에 있어서 N-피리독실-α-아미노산이 R2와 R5가 각각 수소이고 R4가 히드록시메틸이며 R6가 메틸인 일반식(Ⅰ)의 한가지인 특허청구의 범위 1에 따른 비-방사성 담체.
  3. 제1항에 있어서 N-피리독실-α-아미노산ㅣ R2,R3와 R5가 각각 수소이며, R4가 히드록시메틸이고 R6가 메틸인 일반식(Ⅰ)의 한가지인 특허청구의 범위 1에 따른 비-방사성 담체.
  4. 제1항에 있어서 N-피리독실-α-아미노산의 R1이 수소, 메틸, 이소프로필, 1-메틸프로필, 2-메틸프로필, 2-카르복시에틸, 히드록시메틸, 1-히드록시에틸, 벤질 또는 4-히드록시벤질이고, R2,R3및 R5가 각각 수소이고, R4가 히드록시메틸이며, R6가 메틸인 일반식(Ⅰ)의 한가지인 청구범위 1에 따른 비-방사성 담체.
  5. 제1항에 있어서 N-피리독실-α-아미노산 R7,R8,R9,R10,R11및 R12가 각각 수소원자, 할로겐원자, C1-C5알킬기 또는 최소한 한가지 소수기와 치환된 C1-C5알킬기인 일반식,
    의 N-피리ㅣ독실-트립토판 유도체인 청구범위 1에 따른 비-방사성 담체.
  6. 제5항에 있어서 N-피리독실-트립토판 유도체가 R7,R8,R9,R11및 R12가 각각 수소이고 R10가 수소 또는 메틸인 일반식(Ⅱ)의 한가지인 청구범위 5에 따른 비-방사성 담체.
  7. 제1항에 있어서 과테크네튬산염을 위한 환원제가 제일주식염인 청구범위 1에 따른 비-방사성 담체.
  8. 제1항에 있어서 과테크네튬산염을 위한 환원제가 N-피리독실-α-아미노산 또는 그것의 염 1몰당 0.001 내지 1몰의 양으로 포함된 청구범위 1에 따른 비-방사성 담체.
  9. 제1항에 있어서 수용액 형태인 청구범위 1에 따른 비-방사성 담체.
  10. 제9항에 있어서 N-피리독실-α-아미노산 또는 그것의 염의 농도가 20mmol/ι 이하인 청구범위 9에 따른 비-방사성 담체.
  11. 제1항에 있어서 과테크네튬산염 형태의 99mTC와 청구범위 1에 따른 비-방사성 담체를 포함하는 99mTC표시 방사성 진단제.
  12. 제1항, 제11항에 있어서 투여시 수용액 0.5 내지 5ml의 부피에 대한 방사능이 0.1 내지 50mCi이고 과테크네튬산염 형태인 99mTC를 함유하는 수용액과 청구범위 1에 따른 비-방사성 담체를 접촉시킴으로써 제조되는 청구범위 11에 따른 99mTC-표시 방사성 진단제.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019810004574A 1980-11-27 1981-11-26 비-방사성 담체조성물 및 이를 사용한 방사성 진단제의 제조방법 KR850001871B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP55167135A JPS5791927A (en) 1980-11-27 1980-11-27 Technetium-99m labelled diagnosticum
JP80-167135 1980-11-27

Publications (2)

Publication Number Publication Date
KR830007092A true KR830007092A (ko) 1983-10-14
KR850001871B1 KR850001871B1 (ko) 1985-12-28

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Country Status (7)

Country Link
US (1) US4440739A (ko)
EP (1) EP0053347B1 (ko)
JP (1) JPS5791927A (ko)
KR (1) KR850001871B1 (ko)
AU (1) AU528640B2 (ko)
CA (1) CA1186624A (ko)
DE (1) DE3166729D1 (ko)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE26071T1 (de) * 1982-06-10 1987-04-15 Mallinckrodt Inc Roentgen-sichtbarmachungsmittel.
US4666697A (en) * 1982-12-08 1987-05-19 Nihon Medi-Physics Co., Ltd. Radioactive diagnostic agent
US4842845A (en) * 1987-05-08 1989-06-27 Salutar, Inc. Radioactive metal chelates for dipyridoxyl phosphate
AR246956A1 (es) * 1987-05-08 1994-10-31 Salutar Inc Compuesto quelante, un intermediario para preparar el mismo, y un procedimiento para preparar una composicion de medio de contraste.
US4992554A (en) * 1987-05-08 1991-02-12 Salutar, Inc. Dipyridoxyl phosphate chelating compounds
US4992555A (en) * 1987-05-08 1991-02-12 Salutar, Inc. Certain dipyridylphosphate chelatable compounds capable of forming metal ion chelates
US5091169A (en) * 1987-05-08 1992-02-25 Salutar, Inc. Dipyridoxyl phosphate NMRI contrast agent compositions
US5130431A (en) * 1987-05-08 1992-07-14 Salutar, Inc. Dipyriodoxyl phosphate chelating compound intermediates
FR2655339B2 (fr) * 1989-04-19 1992-04-10 Medgenix Group Sa Composes et complexes utiles notamment en imagerie medicale.
US5342925A (en) * 1991-01-30 1994-08-30 The Dow Chemical Company Radioactive compositions for soft tissue tumors
US5336482A (en) * 1991-12-05 1994-08-09 The Du Pont Merck Pharmaceutical Company Technetium-99m complexes with N-substituted 3-hydroxy-4-pyridinones
US20020102280A1 (en) * 2000-11-29 2002-08-01 Anderson David M. Solvent systems for pharmaceutical agents

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3740418A (en) * 1970-07-01 1973-06-19 Squibb & Sons Inc Radioactive scanning preparation
AU485693B2 (en) * 1973-08-24 1976-02-05 The Council Ofthe Institute Of Medical And Veterinary Science, Andthe Universityof Adelaide Gariti Cancer Foundation New radiopharmaceuticals for cholescintigraphy
JPS53148541A (en) * 1977-05-07 1978-12-25 Nihon Mediphysics Co Ltd Radioactive diagnostic agent labelled by technesiumm99m
US4215045A (en) * 1978-06-29 1980-07-29 The United States Of America As Represented By The United States Department Of Energy 123m Te-Labeled biochemicals and method of preparation
US4298591A (en) * 1979-04-03 1981-11-03 The United States Of America As Represented By The United States Department Of Energy Instantaneous radioiodination of rose bengal at room temperature and a cold kit therefor

Also Published As

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US4440739A (en) 1984-04-03
EP0053347A3 (en) 1982-09-15
EP0053347A2 (en) 1982-06-09
AU7795981A (en) 1982-06-03
KR850001871B1 (ko) 1985-12-28
DE3166729D1 (en) 1984-11-22
JPS5791927A (en) 1982-06-08
CA1186624A (en) 1985-05-07
JPS6126971B2 (ko) 1986-06-23
AU528640B2 (en) 1983-05-05
EP0053347B1 (en) 1984-10-17

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