KR840002645A - 안정된 방사성 진단제와 이를 위한 비방사성 캐리어 - Google Patents

안정된 방사성 진단제와 이를 위한 비방사성 캐리어 Download PDF

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Publication number
KR840002645A
KR840002645A KR1019820005405A KR820005405A KR840002645A KR 840002645 A KR840002645 A KR 840002645A KR 1019820005405 A KR1019820005405 A KR 1019820005405A KR 820005405 A KR820005405 A KR 820005405A KR 840002645 A KR840002645 A KR 840002645A
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South Korea
Prior art keywords
water
reducing agent
soluble reducing
agent
stable
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KR1019820005405A
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KR860000687B1 (ko
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마꼬도 아즈마 (외1)
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야마오까 세이자부로오
니홍 메지피직크스 가부시기 가이샤
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Publication of KR840002645A publication Critical patent/KR840002645A/ko
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Optics & Photonics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Public Health (AREA)
  • Medical Informatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Pathology (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Biophysics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

내용 없음.

Description

안정된 방사성 진단제와 이를 위한 비방사성 캐리어
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는99mTc-방사능의 농도와의 관계를 나타낸 그라프.

Claims (4)

  1. 킬레이트화제, 퍼테크네테이트를 위한 수용성 환원제 및 수용성 환원제 1mol당 약 100mol이상의 양이 아스코르브산과 에리소르브산 그리고 그것들이 약제로 사용가능한 염들과 에스테르들 중에서 선택된 안정제를 함유하는99mTc-표지 방사성 진단제의 제조에 사용되기 위한 안정된 비방사성 캐리어.
  2. 제1항에 있어서, 수용성 환원제가 제일주석염인 비방사성 캐리어.
  3. 킬레이트화제, 페테크네테이트를 위한 수용성 환원제 및 수용성 환원제 1mol당 약 100mol이상의 양의 아스코르브산과 에티소르브산 그리고 그것들의 약제로 사용가능한 염들과 에스테르들 중에서 선택된 안정제를 함유하는 비방사성 캐리어와98mTc-함유 퍼레크네테이트를 접촉시킴으로써 제조되는 안정된99mTc-표지 방사성 진단제.
  4. 제3항에 있어서, 수용성 환원제가 제일주석염인 안정된99mTc-표지 방사성 진단제.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR8205405A 1981-12-03 1982-12-02 안정된 방사성 진단제와 이를 위한 비방사성 캐리어 KR860000687B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP56195215A JPS5896031A (ja) 1981-12-03 1981-12-03 放射性診断剤およびその製造用組成物
JP56-195215 1981-12-03
JP81-195215 1981-12-03

Publications (2)

Publication Number Publication Date
KR840002645A true KR840002645A (ko) 1984-07-16
KR860000687B1 KR860000687B1 (ko) 1986-06-07

Family

ID=16337372

Family Applications (1)

Application Number Title Priority Date Filing Date
KR8205405A KR860000687B1 (ko) 1981-12-03 1982-12-02 안정된 방사성 진단제와 이를 위한 비방사성 캐리어

Country Status (7)

Country Link
US (1) US4489053A (ko)
EP (1) EP0081193B1 (ko)
JP (1) JPS5896031A (ko)
KR (1) KR860000687B1 (ko)
AU (1) AU532748B2 (ko)
CA (1) CA1202893A (ko)
DE (1) DE3270032D1 (ko)

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US4707353A (en) * 1982-12-08 1987-11-17 Mallinckrodt, Inc. Radiographic imaging agents
US4510125A (en) * 1982-12-08 1985-04-09 Mallinckrodt, Inc. Process for making lyophilized radiographic imaging kit
EP0111414A3 (en) * 1982-12-08 1985-05-02 Mallinckrodt, Inc. (a Delaware corporation) Radiographic imaging agents
JPS59199636A (ja) * 1983-04-26 1984-11-12 Nippon Mejifuijitsukusu Kk 放射性診断剤
US4942231A (en) * 1984-05-24 1990-07-17 Mallinckrodt, Inc. Method of preparing a chlorinated, brominated, radio-brominated, iodinated and/or radioiodinated aromatic or heteroaromatic compound
AR246956A1 (es) 1987-05-08 1994-10-31 Salutar Inc Compuesto quelante, un intermediario para preparar el mismo, y un procedimiento para preparar una composicion de medio de contraste.
US5091169A (en) * 1987-05-08 1992-02-25 Salutar, Inc. Dipyridoxyl phosphate NMRI contrast agent compositions
US5130431A (en) * 1987-05-08 1992-07-14 Salutar, Inc. Dipyriodoxyl phosphate chelating compound intermediates
US4992555A (en) * 1987-05-08 1991-02-12 Salutar, Inc. Certain dipyridylphosphate chelatable compounds capable of forming metal ion chelates
US4992554A (en) * 1987-05-08 1991-02-12 Salutar, Inc. Dipyridoxyl phosphate chelating compounds
US4880615A (en) * 1988-11-25 1989-11-14 Merck & Co., Inc. Stabilized radiopharmaceutical compositions
GB8902362D0 (en) * 1989-02-03 1989-03-22 Amersham Int Plc Cationic complexes of technetium-99m
US5219556A (en) * 1990-07-09 1993-06-15 Mallinckrodt Medical, Inc. Stabilized therapeutic radiopharmaceutical complexes
JP2860157B2 (ja) * 1990-10-31 1999-02-24 日本メジフィジックス株式会社 腎機能測定用の既放射能標識テクネチウムキレート注射剤の製造方法
AU7312694A (en) * 1994-06-03 1996-01-04 Mallinckrodt Medical, Inc. Rapidly clearing technetium-99m phosphonate skeletal imaging agents
CN1063344C (zh) * 1995-07-27 2001-03-21 北京市肿瘤防治研究所 一种肿瘤阳性显像剂锝-99m标记平阳霉素用药盒
US6027710A (en) * 1996-09-18 2000-02-22 Nihon Medi-Physiscs Co., Ltd. Radiation-protecting agent
US7229603B2 (en) * 2004-06-17 2007-06-12 Anazaohealth Corporation Stablilized and lyophilized radiopharmaceutical agents
WO2006085941A1 (en) * 2004-06-17 2006-08-17 Anazaohealth Corporation Copper-complex isonitrile positron emission tomography (pet) imaging agent and method
GB0427392D0 (en) * 2004-12-15 2005-01-19 Amersham Plc Stabilised 99mTc compositions
US9321095B2 (en) 2010-06-30 2016-04-26 General Electric Company Apparatuses and methods for cutting porous substrates

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU485693B2 (en) * 1973-08-24 1976-02-05 The Council Ofthe Institute Of Medical And Veterinary Science, Andthe Universityof Adelaide Gariti Cancer Foundation New radiopharmaceuticals for cholescintigraphy
US4364920A (en) * 1975-04-30 1982-12-21 Medi-Physics, Inc. Stable diagnostic reagents
ZA761944B (en) * 1975-04-30 1977-03-30 Procter & Gamble Stable radiographic scanning agents
US4233284A (en) * 1978-03-31 1980-11-11 The Procter & Gamble Company Stabilized radiographic scanning agents
US4232000A (en) * 1978-06-28 1980-11-04 The Procter & Gamble Company Radioactive scanning agents with stabilizer
US4229427A (en) * 1978-06-28 1980-10-21 The Procter & Gamble Company Radioactive scanning agents with hydroquinone stabilizer
US4247534A (en) * 1978-07-31 1981-01-27 The Procter & Gamble Company Radiographic scanning agent
JPS5750928A (en) * 1980-09-13 1982-03-25 Nippon Mejifuijitsukusu Kk Diagnostic agent for scanning bone
JP2627291B2 (ja) * 1987-02-20 1997-07-02 武田薬品工業株式会社 安定化された殺虫・殺菌農薬組成物

Also Published As

Publication number Publication date
EP0081193B1 (en) 1986-03-19
KR860000687B1 (ko) 1986-06-07
AU9103482A (en) 1983-06-09
JPH0233019B2 (ko) 1990-07-25
AU532748B2 (en) 1983-10-13
JPS5896031A (ja) 1983-06-07
EP0081193A2 (en) 1983-06-15
DE3270032D1 (en) 1986-04-24
US4489053A (en) 1984-12-18
EP0081193A3 (en) 1984-03-07
CA1202893A (en) 1986-04-08

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