KR920007639A - 방사능의약품 조성물의 제조방법 - Google Patents

방사능의약품 조성물의 제조방법 Download PDF

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Publication number
KR920007639A
KR920007639A KR1019910019246A KR910019246A KR920007639A KR 920007639 A KR920007639 A KR 920007639A KR 1019910019246 A KR1019910019246 A KR 1019910019246A KR 910019246 A KR910019246 A KR 910019246A KR 920007639 A KR920007639 A KR 920007639A
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KR
South Korea
Prior art keywords
water
reducing agent
soluble
radiopharmaceutical composition
soluble reducing
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KR1019910019246A
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English (en)
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KR0175305B1 (ko
Inventor
스스므 곤도
사카에 오카노
마코토 아즈마
Original Assignee
도키 가츠유키
니혼 메디피직스 가부시키가이샤
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Publication of KR920007639A publication Critical patent/KR920007639A/ko
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Publication of KR0175305B1 publication Critical patent/KR0175305B1/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

내용 없음

Description

방사능의 약품 조성물의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (3)

  1. (1)(a)HSCH2CO-NHCH2CP-NHCH2CO-NHCH2COOH(머르캅토아세틸글리실 글리실글리신, MAG3), (b)수용성 환원제, (c)수용성 환원제1몰당 70몰 이상의 수용성 안정제 및 (d)과테크네튬산염을 pH 약 8 내지 11에서 혼합하고 , 이 혼합물을 (2) 약 90° 내지 140℃의 온도에서 가열시키는 단계로 이루어지는 테크네튬 99m 킬레이트 착물을 함유하는 방사능의 약품 조성물의 제조방법.
  2. 제1항에 있어서, 수용성 환원제는 주석염인 방법.
  3. 제1항에 있어서, 수용성 안정제는 이스코르빈산 및 에리트로빈산과 이들의 제약적으로 허영되는 염 및 에스테르로 이루어진 그룹에서 하나 선택하여서 되는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019910019246A 1990-10-31 1991-10-31 방사능의약품 조성물의 제조방법 KR0175305B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2296563A JP2860157B2 (ja) 1990-10-31 1990-10-31 腎機能測定用の既放射能標識テクネチウムキレート注射剤の製造方法
JP90-296563 1990-10-31
JP296563/1990 1990-10-31

Publications (2)

Publication Number Publication Date
KR920007639A true KR920007639A (ko) 1992-05-27
KR0175305B1 KR0175305B1 (ko) 1999-02-18

Family

ID=17835168

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019910019246A KR0175305B1 (ko) 1990-10-31 1991-10-31 방사능의약품 조성물의 제조방법

Country Status (10)

Country Link
US (1) US5245018A (ko)
EP (1) EP0483704B1 (ko)
JP (1) JP2860157B2 (ko)
KR (1) KR0175305B1 (ko)
AT (1) ATE121632T1 (ko)
AU (1) AU638363B2 (ko)
CA (1) CA2054263C (ko)
DE (1) DE69109235T2 (ko)
DK (1) DK0483704T3 (ko)
ES (1) ES2074200T3 (ko)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5208007A (en) * 1988-11-22 1993-05-04 Board Of Regents Of The University Of Oklahoma Isotopic tracer composition and method for making and using same
US5443815A (en) * 1991-11-27 1995-08-22 Diatech, Inc. Technetium-99m labeled peptides for imaging
US7238340B1 (en) 1991-11-27 2007-07-03 Cis Bio International Monoamine, diamide, thiol-containing metal chelating agents
US5849261A (en) * 1991-02-08 1998-12-15 Diatide, Inc. Radiolabeled vasoactive intestinal peptides for diagnosis and therapy
US5783170A (en) * 1991-11-27 1998-07-21 Diatide, Inc. Peptide-metal chelate conjugates
DE69529988T2 (de) * 1994-05-02 2003-12-11 Diatide Inc Technetium-99m markierte bildformungsmittel
IL113610A0 (en) * 1994-06-03 1995-08-31 Immunomedics Inc A method of radiolabeling a protein, radiolabeled proteins prepared thereby and diagnostic kits containing the same
US5746996A (en) * 1994-06-03 1998-05-05 Immunomedics, Inc. Thiolation of peptides for radionuclide-based radiodetection and radiotherapy
US5986074A (en) * 1996-05-06 1999-11-16 Emory University Metal chelates as pharmaceutical imaging agents, processes of making such and uses thereof
US5924973A (en) 1996-09-26 1999-07-20 The Trustees Of Columbia University In The City Of New York Method of treating a disease process in a luminal structure
CN100418585C (zh) * 2003-07-24 2008-09-17 伯拉考成像股份公司 稳定的放射性药物组合物及制备方法
US20080228004A1 (en) * 2004-02-13 2008-09-18 Blauwhoff Mart-Jan T Ligand Protection for Mercaptoacetyl Triglycine
GB0427392D0 (en) 2004-12-15 2005-01-19 Amersham Plc Stabilised 99mTc compositions
WO2008115337A1 (en) * 2007-03-19 2008-09-25 Mallinckrodt Inc. Sulfur-protected mercaptoacetylglycylglycylglycine
BRPI0800492B8 (pt) * 2008-01-31 2021-05-25 Univ Minas Gerais radiofármaco e sua composição farmacêutica para tratamento e diagnóstico de câncer
GB201402132D0 (en) * 2014-02-07 2014-03-26 South African Nuclear Energy A method of producing ethylenedicysteine deoxyglucosamine (ECDG) or a salt thereof and its application in a kit
US9850183B2 (en) 2014-06-27 2017-12-26 Reiley Pharmaceuticals, Inc. Conjugates derived from non-steroidal anti-inflammatory drugs and methods of use thereof in imaging
WO2016111834A1 (en) 2015-01-09 2016-07-14 Reiley Pharmaceuticals, Inc. Cox-2-targeting, platinum-containing conjugates and their use in the treatment of tumors and cancers

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3171920D1 (en) * 1981-09-16 1985-09-26 Nihon Mediphysics Co Ltd Radioactive diagnostic agent and its preparation
JPS5896031A (ja) * 1981-12-03 1983-06-07 Nippon Mejifuijitsukusu Kk 放射性診断剤およびその製造用組成物
US4510125A (en) * 1982-12-08 1985-04-09 Mallinckrodt, Inc. Process for making lyophilized radiographic imaging kit
US4638051A (en) * 1984-04-30 1987-01-20 The Johns Hopkins University Brain imaging radiopharmaceuticals
US4980147A (en) * 1984-06-25 1990-12-25 University Of Utah Research Foundation Radiolabeled technetium chelates for use in renal function determinations
ES2017088B3 (es) * 1986-05-28 1991-01-01 Mallinckrodt Inc (A Missouri Corporation) Quelatos de tecnecio a utilizar para determinar la funcion renal.
US4883862A (en) * 1988-04-13 1989-11-28 Albert Einstein College Of Medicine - Of Yeshiva University Mercaptosuccinyl glycyl-glycyl-glycine a complex thereof with Tc-99m, and methods of making the same
US4925650A (en) * 1988-11-16 1990-05-15 Mallinckrodt, Inc. Technetium -99m complex for examining the renal function
DE59006132D1 (de) * 1989-10-30 1994-07-21 Verein Fuer Kernverfahrenstech Kit (nichtradioaktive Vorstufe) zur Herstellung einer enantiomeren Form des Nierenfunktionsdiagnostikums Technetium-99m-Mercaptoacetyltriglycin (99m-Tc-MAG-3) und Verfahren zur Herstellung des Kits.
CA2080685A1 (en) * 1990-04-17 1991-10-18 Alfons Verbruggen Method and kit for preparing technetium-99m complexes

Also Published As

Publication number Publication date
DK0483704T3 (da) 1995-05-22
AU638363B2 (en) 1993-06-24
KR0175305B1 (ko) 1999-02-18
AU8690991A (en) 1992-05-07
EP0483704A1 (en) 1992-05-06
DE69109235T2 (de) 1995-09-28
EP0483704B1 (en) 1995-04-26
DE69109235D1 (de) 1995-06-01
CA2054263C (en) 2001-05-29
US5245018A (en) 1993-09-14
CA2054263A1 (en) 1992-05-01
ES2074200T3 (es) 1995-09-01
ATE121632T1 (de) 1995-05-15
JP2860157B2 (ja) 1999-02-24
JPH04169540A (ja) 1992-06-17

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