KR840000763B1 - 2-아미노-3-벤조일-페닐아세트아미드의 제조방법 - Google Patents

2-아미노-3-벤조일-페닐아세트아미드의 제조방법 Download PDF

Info

Publication number
KR840000763B1
KR840000763B1 KR1019800003740A KR800003740A KR840000763B1 KR 840000763 B1 KR840000763 B1 KR 840000763B1 KR 1019800003740 A KR1019800003740 A KR 1019800003740A KR 800003740 A KR800003740 A KR 800003740A KR 840000763 B1 KR840000763 B1 KR 840000763B1
Authority
KR
South Korea
Prior art keywords
amino
solution
phenylacetamide
benzoyl
added
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
KR1019800003740A
Other languages
English (en)
Korean (ko)
Other versions
KR830004210A (ko
Inventor
쥬니어 제임스 로버트 쉥클린
알렌 샴블리 드와이트
알란 월쉬 데비드
Original Assignee
에이. 에이치. 로빈스 캄파니 인코포레이티드
알. 피. 울프
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 에이. 에이치. 로빈스 캄파니 인코포레이티드, 알. 피. 울프 filed Critical 에이. 에이치. 로빈스 캄파니 인코포레이티드
Publication of KR830004210A publication Critical patent/KR830004210A/ko
Application granted granted Critical
Publication of KR840000763B1 publication Critical patent/KR840000763B1/ko
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
KR1019800003740A 1979-09-26 1980-09-25 2-아미노-3-벤조일-페닐아세트아미드의 제조방법 Expired KR840000763B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US7886079A 1979-09-26 1979-09-26
US078,860 1979-09-26
US78860 1979-09-26

Publications (2)

Publication Number Publication Date
KR830004210A KR830004210A (ko) 1983-07-06
KR840000763B1 true KR840000763B1 (ko) 1984-06-08

Family

ID=22146633

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019800003740A Expired KR840000763B1 (ko) 1979-09-26 1980-09-25 2-아미노-3-벤조일-페닐아세트아미드의 제조방법

Country Status (36)

Country Link
JP (1) JPS5657751A (cs)
KR (1) KR840000763B1 (cs)
AT (1) AT374170B (cs)
AU (1) AU532359B2 (cs)
BE (1) BE885393A (cs)
BR (1) BR8006042A (cs)
CA (1) CA1128512A (cs)
CH (1) CH646138A5 (cs)
CS (1) CS227012B2 (cs)
DE (1) DE3035688A1 (cs)
DK (1) DK154136C (cs)
EG (1) EG15020A (cs)
ES (2) ES495329A0 (cs)
FI (1) FI72967C (cs)
FR (1) FR2465710A1 (cs)
GB (1) GB2059963B (cs)
GR (1) GR70049B (cs)
HK (1) HK59383A (cs)
HU (1) HU183215B (cs)
IE (1) IE50268B1 (cs)
IL (1) IL60999A (cs)
IN (3) IN151313B (cs)
IT (1) IT1133823B (cs)
KE (1) KE3307A (cs)
LU (1) LU82797A1 (cs)
MX (1) MX7159E (cs)
NL (1) NL8005346A (cs)
NO (1) NO152128C (cs)
NZ (1) NZ195061A (cs)
PH (1) PH22628A (cs)
PL (1) PL128998B1 (cs)
PT (1) PT71839B (cs)
SE (1) SE448626B (cs)
SG (1) SG42983G (cs)
YU (3) YU41734B (cs)
ZA (1) ZA805476B (cs)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL61945A (en) * 1980-02-19 1984-09-30 Robins Co Inc A H 2-amino-3-(hydroxy(phenyl)methyl)phenylacetic acids,esters and amides and pharmaceutical compositions containing them
US6646001B2 (en) 1997-12-19 2003-11-11 Alcon Manufacturing, Ltd. Use of non-steroidal anti-inflammatory agents in combination with prostaglandin FP receptor agonists to treat glaucoma and ocular hypertension
US6066671A (en) 1997-12-19 2000-05-23 Alcon Laboratories, Inc. Treatment of GLC1A glaucoma with 3-benzoyl-phenylacetic acids, esters, or amides
GB9727523D0 (en) * 1997-12-31 1998-02-25 Pharmacia & Upjohn Spa Alpha-aminoamide derivatives useful as analgesic agents
AR030345A1 (es) * 2000-08-14 2003-08-20 Alcon Inc Metodo de tratamiento de desordenes relacionados con angiogenesis
EP1423168B1 (en) 2001-09-03 2006-02-08 Newron Pharmaceuticals S.p.A. Pharmaceutical composition comprising gabapentin or an analogue thereof and an alpha-aminoamide and its analgesic use
EP1438956A1 (en) 2003-01-16 2004-07-21 Newron Pharmaceuticals S.p.A. Alpha-aminoamide derivatives useful as antimigraine agents
CZ301776B6 (cs) * 2009-06-08 2010-06-16 Farmak, A.S. Postup prípravy 2-amino-3-benzoylfenylacetamidu (nepafenacu) s minimem vedlejších produktu
CN112794809B (zh) * 2019-11-14 2023-12-29 南京济群医药科技股份有限公司 一种高纯度奈帕芬胺中间体的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1226344A (cs) * 1967-07-31 1971-03-24
CH577461A5 (cs) * 1975-08-13 1976-07-15 Robins Co Inc A H
IL61945A (en) * 1980-02-19 1984-09-30 Robins Co Inc A H 2-amino-3-(hydroxy(phenyl)methyl)phenylacetic acids,esters and amides and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
AU532359B2 (en) 1983-09-29
AU6211680A (en) 1981-04-02
PH22628A (en) 1988-10-28
FI803002A7 (fi) 1981-03-27
KR830004210A (ko) 1983-07-06
SG42983G (en) 1985-01-11
LU82797A1 (fr) 1982-05-10
NO152128C (no) 1985-08-07
YU41734B (en) 1987-12-31
HK59383A (en) 1983-12-02
DK405780A (da) 1981-03-27
CH646138A5 (fr) 1984-11-15
ES8200329A1 (es) 1981-10-16
YU73183A (en) 1983-12-31
BE885393A (fr) 1981-01-16
IN151313B (cs) 1983-03-26
FI72967C (fi) 1987-08-10
PL226919A1 (cs) 1982-02-01
FR2465710B1 (cs) 1984-10-12
YU73083A (en) 1983-12-31
DK154136C (da) 1989-03-06
PT71839A (en) 1980-10-01
NZ195061A (en) 1984-04-27
IE801946L (en) 1981-03-26
FR2465710A1 (fr) 1981-03-27
ES503019A0 (es) 1982-05-01
NL8005346A (nl) 1981-03-30
EG15020A (en) 1985-03-31
YU245080A (en) 1983-09-30
CA1128512A (en) 1982-07-27
CS227012B2 (en) 1984-04-16
ES8204715A1 (es) 1982-05-01
ZA805476B (en) 1981-11-25
YU43305B (en) 1989-06-30
HU183215B (en) 1984-04-28
IL60999A0 (en) 1980-11-30
SE448626B (sv) 1987-03-09
GR70049B (cs) 1982-07-26
ATA474580A (de) 1983-08-15
MX7159E (es) 1987-12-02
FI72967B (fi) 1987-04-30
PL128998B1 (en) 1984-03-31
BR8006042A (pt) 1981-04-07
JPH0141616B2 (cs) 1989-09-06
AT374170B (de) 1984-03-26
NO802834L (no) 1981-03-27
JPS5657751A (en) 1981-05-20
KE3307A (en) 1983-08-19
IN156255B (cs) 1985-06-08
ES495329A0 (es) 1981-10-16
DE3035688C2 (cs) 1990-05-17
GB2059963B (en) 1983-04-20
YU43306B (en) 1989-06-30
IN156254B (cs) 1985-06-08
IT1133823B (it) 1986-07-24
PT71839B (en) 1981-06-25
IL60999A (en) 1984-05-31
SE8006668L (sv) 1981-03-27
DK154136B (da) 1988-10-17
GB2059963A (en) 1981-04-29
IE50268B1 (en) 1986-03-19
IT8024948A0 (it) 1980-09-26
NO152128B (no) 1985-04-29
DE3035688A1 (de) 1981-04-16

Similar Documents

Publication Publication Date Title
US7893279B2 (en) Cyclohexanecarboxylic acid compound
US4313949A (en) Method of producing an inhibitory effect on blood platelet aggregation
NO170883B (no) Fremgangsmaate for fremstilling av 2-amino-5-hydroksy-4-metylpyrimidin-derivater
JPH0729922B2 (ja) ２‐アルコキシ‐ｎ‐（１‐アザビシクロ［２，２，２オクト‐３‐イル）ベンズアミド類およびチオベンズアミド類
US5391552A (en) Diphenylpiperazine derivative and drug for circulatory organ containing the same
US4503073A (en) 2-Amino-3-(alkylthiobenzoyl)-phenylacetic acids
KR840000763B1 (ko) 2-아미노-3-벤조일-페닐아세트아미드의 제조방법
CA1156655A (en) 2-amino-3-[hydroxy(phenyl)methyl] phenylacetic acids, esters and amides
JPS6157306B2 (cs)
JPS5989671A (ja) ２，５−ピペラジンジオン誘導体
CA1173852A (en) 2-amino-3-(halobenzoyl)-methylphenylacetic acids, esters and salts thereof
US4333951A (en) 2-Amino-6-biphenylacetic acids
CA1132562A (en) Halogeno derivatives of isopropylamino pyrimidine, their preparation and therapeutic use
EP0089426B1 (en) 2-amino-6-biphenylacetic acids
HUT75341A (en) New salts of 2-[(2,6-dichloro-phenyl)-amino]-phenyl-acetoxy-acetic acid with organic bases, pharmaceutical compns. contg. them and process for preparing the said compds.
KR840000605B1 (ko) 2-아미노-3-(알킬티오벤조일)-페닐아세트산유도체의 제조방법
US3928341A (en) N-Aminoalkyl-4-anilino pyridines
CA1099642A (en) Compositions containing cis-2-benzoyl-3- hydroxycrotononitrile and method of use to treat inflammation and joint deterioration
DE2836613A1 (de) Alpha -aminophenylessigsaeurederivate
US4472424A (en) Esters of 2-thenoylmercaptopropionylglycine with substituted hydroxybenzenes, process for their preparation and pharmaceutical compositions containing same
SU751007A1 (ru) 2- @ N-[4-(3,3-Диметилтриазено)-бензолсульфонил]-амидо @ -4,6-диметилпиримидин, про вл ющий противовоспалительное действие
GB2100261A (en) Aminophenylalkylamine derivatives, a process for their preparation and their use as pharmaceuticals
WO1994014750A1 (en) Novel salicylic acid derivatives, their salts, pharmaceutical compositions containing them and process for preparing same
EP0270292A2 (en) Radiation sensitizers
JPH03163079A (ja) キサンチン誘導体、それらを有効成分とする気管支拡張剤及び脳機能改善剤

Legal Events

Date Code Title Description
PA0109 Patent application

St.27 status event code: A-0-1-A10-A12-nap-PA0109

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PG1605 Publication of application before grant of patent

St.27 status event code: A-2-2-Q10-Q13-nap-PG1605

PE0701 Decision of registration

St.27 status event code: A-1-2-D10-D22-exm-PE0701

PR0701 Registration of establishment

St.27 status event code: A-2-4-F10-F11-exm-PR0701

PR1002 Payment of registration fee

St.27 status event code: A-2-2-U10-U11-oth-PR1002

Fee payment year number: 1

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 4

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 5

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 6

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 7

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 8

PC1903 Unpaid annual fee

St.27 status event code: A-4-4-U10-U13-oth-PC1903

Not in force date: 19920609

Payment event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

PC1903 Unpaid annual fee

St.27 status event code: N-4-6-H10-H13-oth-PC1903

Ip right cessation event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

Not in force date: 19920609