KR830005105A - 사이클로헥센 유도체류 - Google Patents

사이클로헥센 유도체류 Download PDF

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Publication number
KR830005105A
KR830005105A KR1019810000259A KR810000259A KR830005105A KR 830005105 A KR830005105 A KR 830005105A KR 1019810000259 A KR1019810000259 A KR 1019810000259A KR 810000259 A KR810000259 A KR 810000259A KR 830005105 A KR830005105 A KR 830005105A
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KR
South Korea
Prior art keywords
group
formula
compound
lower alkyl
alkyl group
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KR1019810000259A
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English (en)
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KR850000626B1 (ko
Inventor
브루더러 한스
에드워드 피쉬리 알버트
피스터 루돌프
Original Assignee
쿠르트 네셀 보쉬, 한스 스튀클린
에프. 호프만-라 롯슈 앤드 캄파니 아크티엔 게젤샤프트
한스 스튀클린
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Application filed by 쿠르트 네셀 보쉬, 한스 스튀클린, 에프. 호프만-라 롯슈 앤드 캄파니 아크티엔 게젤샤프트, 한스 스튀클린 filed Critical 쿠르트 네셀 보쉬, 한스 스튀클린
Publication of KR830005105A publication Critical patent/KR830005105A/ko
Priority to KR1019840004584A priority Critical patent/KR850000627B1/ko
Application granted granted Critical
Publication of KR850000626B1 publication Critical patent/KR850000626B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

내용 없음

Description

사이클로헥센 유도체류
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (1)

  1. 다음 일반식(Ⅱ) 또는 (Ⅰa)의 화합물을 질소원자에서 적당히 치환시키거나 다음 일반식(Ⅲ) 또는 (Ⅳ)의 화합물을 환원시키거나 다음 일반식(Ⅴ)의 화합물을 다음 일반식(Ⅵ)의 아민과 반응시키거나 다음 일반식(Ⅶ)의 4급암모늄염기를 가열시키거나 적당한 상응하는 4급 암모늄염을 가열시키거나 염기로 처리하거나 다음 일반식(Ⅰb) 또는 (Ⅷ)로부터 R5로 표시되는 알킬기 또는 R6로 표시되는 보호기를 떼어내거나 다음 일반식(Ⅰc)의 화합물을 에테르화하거나 다음 일반식(Ⅸ)의 화합물을 환원조건하 일반식(Ⅵ)의 아민과 반응시키거나 일반식(Ⅰ)의 라세미 화합물을 광학적 활성 대장체로 분해시키거나 일반식(Ⅰ)의 화합물을 약학적으로 무독한 산부가염으로 전환시킴을 포함하는 다음 일반식(Ⅰ)의 화합물 및 그의 약학적으로 무독한 산부가염을 제조하는 방법.
    상기식에서
    R1은 하이드록시 또는 저급알콕시기를 나타내며
    n은 1 또는 2를 나타내고
    R2는 저급알킬기를 나타내며
    R3은 수소원자 또는 저급알킬, 저급알케닐 또는 저급 사이클로 알킬메틸기를 나타내며
    R11은 저급알콕시기를 나타내며
    R31는 수소원자 또는 저급알케닐 또는 저급 사이클로알킬메틸기를 나타내며
    R32는 저급알킬기를 나타내고
    R33는 수소원자 또는 저급알킬, 저급알케닐 또는 저급 사이클로 알킬메틸기를 나타내며
    R4는 포르밀, 저급알카노일 또는 저급알콕시카보닐기를 나타내거나
    R33이 저급알킬기를 나타내고 R4가 저급사이클로알킬카보닐기를 나타내며
    X는 이탈기를 나타내며
    R5는 저급알킬기를 나타내고
    R6는 보호기를 나타내며
    R34는 저급알킬, 저급알케닐 또는 저급사이클로알킬메틸기를 나타낸다.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019810000259A 1980-01-29 1981-01-28 시클로헥센 유도체의 제조방법 KR850000626B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019840004584A KR850000627B1 (ko) 1980-01-29 1984-08-01 시클로헥센 유도체의 제조방법

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH72480A CH644580A5 (de) 1980-01-29 1980-01-29 Cyclohexen-derivate.
CH724/80 1980-01-29

Related Child Applications (5)

Application Number Title Priority Date Filing Date
KR1019840004582A Division KR840001552B1 (ko) 1980-01-29 1984-08-01 시클로헥센 유도체의 제조방법
KR1019840004584A Division KR850000627B1 (ko) 1980-01-29 1984-08-01 시클로헥센 유도체의 제조방법
KR1019840004581A Division KR840001551B1 (ko) 1980-01-29 1984-08-01 시클로헥센 유도체의 제조방법
KR1019840004585A Division KR840001554B1 (ko) 1980-01-29 1984-08-01 시클로 헥센 유도체의 제조방법
KR1019840004583A Division KR840001553B1 (ko) 1980-01-29 1984-08-01 시클로헥센 유도체의 제조방법

Publications (2)

Publication Number Publication Date
KR830005105A true KR830005105A (ko) 1983-07-23
KR850000626B1 KR850000626B1 (ko) 1985-05-06

Family

ID=4193699

Family Applications (6)

Application Number Title Priority Date Filing Date
KR1019810000259A KR850000626B1 (ko) 1980-01-29 1981-01-28 시클로헥센 유도체의 제조방법
KR1019840004585A KR840001554B1 (ko) 1980-01-29 1984-08-01 시클로 헥센 유도체의 제조방법
KR1019840004581A KR840001551B1 (ko) 1980-01-29 1984-08-01 시클로헥센 유도체의 제조방법
KR1019840004584A KR850000627B1 (ko) 1980-01-29 1984-08-01 시클로헥센 유도체의 제조방법
KR1019840004582A KR840001552B1 (ko) 1980-01-29 1984-08-01 시클로헥센 유도체의 제조방법
KR1019840004583A KR840001553B1 (ko) 1980-01-29 1984-08-01 시클로헥센 유도체의 제조방법

Family Applications After (5)

Application Number Title Priority Date Filing Date
KR1019840004585A KR840001554B1 (ko) 1980-01-29 1984-08-01 시클로 헥센 유도체의 제조방법
KR1019840004581A KR840001551B1 (ko) 1980-01-29 1984-08-01 시클로헥센 유도체의 제조방법
KR1019840004584A KR850000627B1 (ko) 1980-01-29 1984-08-01 시클로헥센 유도체의 제조방법
KR1019840004582A KR840001552B1 (ko) 1980-01-29 1984-08-01 시클로헥센 유도체의 제조방법
KR1019840004583A KR840001553B1 (ko) 1980-01-29 1984-08-01 시클로헥센 유도체의 제조방법

Country Status (32)

Country Link
US (2) US4336268A (ko)
EP (1) EP0033156B1 (ko)
JP (1) JPS56120650A (ko)
KR (6) KR850000626B1 (ko)
AR (1) AR227906A1 (ko)
AT (2) ATE9895T1 (ko)
AU (1) AU540697B2 (ko)
BR (1) BR8100484A (ko)
CA (1) CA1161064A (ko)
CH (1) CH644580A5 (ko)
CS (6) CS219941B2 (ko)
DE (2) DE3102603A1 (ko)
DK (1) DK15681A (ko)
ES (6) ES498866A0 (ko)
FI (1) FI801147A (ko)
FR (1) FR2479815A1 (ko)
GB (1) GB2068373B (ko)
HU (1) HU182280B (ko)
IE (1) IE50885B1 (ko)
IL (1) IL61961A (ko)
IT (1) IT1135001B (ko)
LU (1) LU83096A1 (ko)
MC (1) MC1365A1 (ko)
NL (1) NL8100403A (ko)
NO (1) NO149958C (ko)
NZ (1) NZ196086A (ko)
PH (1) PH16098A (ko)
PT (1) PT72415B (ko)
SE (1) SE8100403L (ko)
YU (1) YU332180A (ko)
ZA (1) ZA81459B (ko)
ZW (1) ZW31480A1 (ko)

Families Citing this family (12)

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US6372919B1 (en) * 2001-01-11 2002-04-16 Dov Pharmaceutical, Inc. (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane, compositions thereof, and uses as an anti-depressant agent
US6569887B2 (en) * 2001-08-24 2003-05-27 Dov Pharmaceuticals Inc. (−)-1-(3,4-Dichlorophenyl)-3-azabicyclo[3.1.0]hexane, compositions thereof, and uses as a dopamine-reuptake
US20060173064A1 (en) * 2001-08-24 2006-08-03 Lippa Arnold S (-)-1-(3,4-Dichlorophenyl)-3-azabi cyclo[3.1.0]hexane, compositions thereof, and uses for treating alcohol-related disorders
US20080081834A1 (en) 2002-07-31 2008-04-03 Lippa Arnold S Methods and compositions employing bicifadine for treating disability or functional impairment associated with acute pain, chronic pain, or neuropathic disorders
US20070043100A1 (en) 2005-08-16 2007-02-22 Hagen Eric J Novel polymorphs of azabicyclohexane
US20060100263A1 (en) * 2004-11-05 2006-05-11 Anthony Basile Antipyretic compositions and methods
CA2659215C (en) 2005-07-27 2018-07-10 Dov Pharmaceutical, Inc. Novel 1-aryl-3-azabicyclo[3.1.0]hexanes: preparation and use to treat neuropsychiatric disorders
US20080045725A1 (en) * 2006-04-28 2008-02-21 Murry Jerry A Process For The Synthesis of (+) And (-)-1-(3,4-Dichlorophenyl)-3-Azabicyclo[3.1.0]Hexane
US20080269348A1 (en) * 2006-11-07 2008-10-30 Phil Skolnick Novel Arylbicyclo[3.1.0]Hexylamines And Methods And Compositions For Their Preparation And Use
US8138377B2 (en) * 2006-11-07 2012-03-20 Dov Pharmaceutical, Inc. Arylbicyclo[3.1.0]hexylamines and methods and compositions for their preparation and use
US20090069374A1 (en) * 2007-06-06 2009-03-12 Phil Skolnick Novel 1-Heteroaryl-3-Azabicyclo[3.1.0]Hexanes, Methods For Their Preparation And Their Use As Medicaments
US9133159B2 (en) 2007-06-06 2015-09-15 Neurovance, Inc. 1-heteroaryl-3-azabicyclo[3.1.0]hexanes, methods for their preparation and their use as medicaments

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CH249052A (de) * 1944-03-20 1947-05-31 Ag J R Geigy Verfahren zur Darstellung eines basischen Amids einer 1-Aryl-cycloalkyl-1-carbonsäure.
CH249047A (de) * 1944-03-20 1947-05-31 Ag J R Geigy Verfahren zur Darstellung eines basischen Esters einer 1-Aryl-cycloalkyl-1-carbonsäure.
US2647122A (en) * 1948-10-01 1953-07-28 Sterling Drug Inc Tertiary amines and process of preparing them
US3109845A (en) * 1960-02-04 1963-11-05 Thomae Gmbh Dr K 1-cyclohexyl, 1-cyclohexenyl, 1-furyl, and 1-thienyl, tertiary amino substituted methanes
DE1518545A1 (de) * 1965-04-01 1970-01-15 Boehringer Mannheim Gmbh Verfahren zur Herstellung neuer Phenylcyclohexylalkylamine und ihrer Salze
DE1518663A1 (de) * 1965-08-02 1969-12-18 Gruenenthal Chemie Basisch substituierte Cycloalken-derivate und Verfahren zu ihrer Herstellung
US3408396A (en) * 1965-10-22 1968-10-29 Colgate Palmolive Co alpha-cyclohexyl-3, 4-disubstituted-phenyl acetamides
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US3737451A (en) * 1970-09-23 1973-06-05 Sandoz Ag Cis-3,4-diaryl-cyclopentylidene-and 1-cyclopentene-1-acetic acids and derivatives
US4053637A (en) * 1971-06-11 1977-10-11 Astra Lakemedal Aktiebolag Compounds of diphenylcyclopentylamine type and methods for their uses
CA1130318A (en) * 1978-10-11 1982-08-24 Peter M. Muller Cyclohexadiene derivatives

Also Published As

Publication number Publication date
CS219942B2 (en) 1983-03-25
GB2068373A (en) 1981-08-12
IL61961A (en) 1984-05-31
US4448991A (en) 1984-05-15
SE8100403L (sv) 1981-07-30
ATE9895T1 (de) 1984-11-15
CH644580A5 (de) 1984-08-15
ES8301200A1 (es) 1982-12-01
FI801147A (fi) 1981-07-30
NL8100403A (nl) 1981-08-17
PT72415A (en) 1981-02-01
EP0033156A3 (en) 1982-03-17
EP0033156B1 (de) 1984-10-17
NO149958B (no) 1984-04-16
KR840001552B1 (ko) 1984-10-05
ES8301883A1 (es) 1982-12-16
DE3166656D1 (en) 1984-11-22
YU332180A (en) 1983-10-31
BR8100484A (pt) 1981-08-18
HU182280B (en) 1983-12-28
ES506688A0 (es) 1982-12-16
FR2479815B1 (ko) 1984-02-17
CS219941B2 (en) 1983-03-25
KR850002003A (ko) 1985-04-10
ES506685A0 (es) 1982-12-16
JPS56120650A (en) 1981-09-22
CS220347B2 (en) 1983-03-25
NO149958C (no) 1984-07-25
IE50885B1 (en) 1986-08-06
IT1135001B (it) 1986-08-20
MC1365A1 (fr) 1981-10-23
KR850000627B1 (ko) 1985-05-06
US4336268A (en) 1982-06-22
FR2479815A1 (fr) 1981-10-09
KR840001554B1 (ko) 1984-10-05
AT376654B (de) 1984-12-27
CA1161064A (en) 1984-01-24
ES8301884A1 (es) 1982-12-16
ATA35581A (de) 1984-05-15
ES506686A0 (es) 1982-12-16
KR840001551B1 (ko) 1984-10-05
IT8119047A0 (it) 1981-01-08
CS219940B2 (en) 1983-03-25
IL61961A0 (en) 1981-02-27
ZW31480A1 (en) 1981-09-02
DK15681A (da) 1981-07-30
LU83096A1 (de) 1982-09-10
PT72415B (en) 1982-07-26
AU540697B2 (en) 1984-11-29
ES498866A0 (es) 1982-12-01
ZA81459B (en) 1982-02-24
PH16098A (en) 1983-06-24
DE3102603A1 (de) 1981-12-10
ES8400079A1 (es) 1983-10-16
AR227906A1 (es) 1982-12-30
GB2068373B (en) 1983-11-30
ES506684A0 (es) 1983-10-16
ES506687A0 (es) 1982-12-16
CS219944B2 (en) 1983-03-25
KR850000626B1 (ko) 1985-05-06
KR840001553B1 (ko) 1984-10-05
CS219943B2 (en) 1983-03-25
ES8301878A1 (es) 1982-12-16
AU6671981A (en) 1981-08-06
IE810153L (en) 1981-07-29
EP0033156A2 (de) 1981-08-05
NZ196086A (en) 1984-08-24
NO810297L (no) 1981-07-30
ES8301885A1 (es) 1982-12-16

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