KR830005105A - 사이클로헥센 유도체류 - Google Patents
사이클로헥센 유도체류 Download PDFInfo
- Publication number
- KR830005105A KR830005105A KR1019810000259A KR810000259A KR830005105A KR 830005105 A KR830005105 A KR 830005105A KR 1019810000259 A KR1019810000259 A KR 1019810000259A KR 810000259 A KR810000259 A KR 810000259A KR 830005105 A KR830005105 A KR 830005105A
- Authority
- KR
- South Korea
- Prior art keywords
- group
- formula
- compound
- lower alkyl
- alkyl group
- Prior art date
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
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- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pain & Pain Management (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (1)
- 다음 일반식(Ⅱ) 또는 (Ⅰa)의 화합물을 질소원자에서 적당히 치환시키거나 다음 일반식(Ⅲ) 또는 (Ⅳ)의 화합물을 환원시키거나 다음 일반식(Ⅴ)의 화합물을 다음 일반식(Ⅵ)의 아민과 반응시키거나 다음 일반식(Ⅶ)의 4급암모늄염기를 가열시키거나 적당한 상응하는 4급 암모늄염을 가열시키거나 염기로 처리하거나 다음 일반식(Ⅰb) 또는 (Ⅷ)로부터 R5로 표시되는 알킬기 또는 R6로 표시되는 보호기를 떼어내거나 다음 일반식(Ⅰc)의 화합물을 에테르화하거나 다음 일반식(Ⅸ)의 화합물을 환원조건하 일반식(Ⅵ)의 아민과 반응시키거나 일반식(Ⅰ)의 라세미 화합물을 광학적 활성 대장체로 분해시키거나 일반식(Ⅰ)의 화합물을 약학적으로 무독한 산부가염으로 전환시킴을 포함하는 다음 일반식(Ⅰ)의 화합물 및 그의 약학적으로 무독한 산부가염을 제조하는 방법.상기식에서R1은 하이드록시 또는 저급알콕시기를 나타내며n은 1 또는 2를 나타내고R2는 저급알킬기를 나타내며R3은 수소원자 또는 저급알킬, 저급알케닐 또는 저급 사이클로 알킬메틸기를 나타내며R11은 저급알콕시기를 나타내며R31는 수소원자 또는 저급알케닐 또는 저급 사이클로알킬메틸기를 나타내며R32는 저급알킬기를 나타내고R33는 수소원자 또는 저급알킬, 저급알케닐 또는 저급 사이클로 알킬메틸기를 나타내며R4는 포르밀, 저급알카노일 또는 저급알콕시카보닐기를 나타내거나R33이 저급알킬기를 나타내고 R4가 저급사이클로알킬카보닐기를 나타내며X는 이탈기를 나타내며R5는 저급알킬기를 나타내고R6는 보호기를 나타내며R34는 저급알킬, 저급알케닐 또는 저급사이클로알킬메틸기를 나타낸다.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1019840004584A KR850000627B1 (ko) | 1980-01-29 | 1984-08-01 | 시클로헥센 유도체의 제조방법 |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH72480A CH644580A5 (de) | 1980-01-29 | 1980-01-29 | Cyclohexen-derivate. |
CH724/80 | 1980-01-29 |
Related Child Applications (5)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019840004582A Division KR840001552B1 (ko) | 1980-01-29 | 1984-08-01 | 시클로헥센 유도체의 제조방법 |
KR1019840004584A Division KR850000627B1 (ko) | 1980-01-29 | 1984-08-01 | 시클로헥센 유도체의 제조방법 |
KR1019840004583A Division KR840001553B1 (ko) | 1980-01-29 | 1984-08-01 | 시클로헥센 유도체의 제조방법 |
KR1019840004581A Division KR840001551B1 (ko) | 1980-01-29 | 1984-08-01 | 시클로헥센 유도체의 제조방법 |
KR1019840004585A Division KR840001554B1 (ko) | 1980-01-29 | 1984-08-01 | 시클로 헥센 유도체의 제조방법 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR830005105A true KR830005105A (ko) | 1983-07-23 |
KR850000626B1 KR850000626B1 (ko) | 1985-05-06 |
Family
ID=4193699
Family Applications (6)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019810000259A KR850000626B1 (ko) | 1980-01-29 | 1981-01-28 | 시클로헥센 유도체의 제조방법 |
KR1019840004585A KR840001554B1 (ko) | 1980-01-29 | 1984-08-01 | 시클로 헥센 유도체의 제조방법 |
KR1019840004581A KR840001551B1 (ko) | 1980-01-29 | 1984-08-01 | 시클로헥센 유도체의 제조방법 |
KR1019840004582A KR840001552B1 (ko) | 1980-01-29 | 1984-08-01 | 시클로헥센 유도체의 제조방법 |
KR1019840004583A KR840001553B1 (ko) | 1980-01-29 | 1984-08-01 | 시클로헥센 유도체의 제조방법 |
KR1019840004584A KR850000627B1 (ko) | 1980-01-29 | 1984-08-01 | 시클로헥센 유도체의 제조방법 |
Family Applications After (5)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019840004585A KR840001554B1 (ko) | 1980-01-29 | 1984-08-01 | 시클로 헥센 유도체의 제조방법 |
KR1019840004581A KR840001551B1 (ko) | 1980-01-29 | 1984-08-01 | 시클로헥센 유도체의 제조방법 |
KR1019840004582A KR840001552B1 (ko) | 1980-01-29 | 1984-08-01 | 시클로헥센 유도체의 제조방법 |
KR1019840004583A KR840001553B1 (ko) | 1980-01-29 | 1984-08-01 | 시클로헥센 유도체의 제조방법 |
KR1019840004584A KR850000627B1 (ko) | 1980-01-29 | 1984-08-01 | 시클로헥센 유도체의 제조방법 |
Country Status (32)
Country | Link |
---|---|
US (2) | US4336268A (ko) |
EP (1) | EP0033156B1 (ko) |
JP (1) | JPS56120650A (ko) |
KR (6) | KR850000626B1 (ko) |
AR (1) | AR227906A1 (ko) |
AT (2) | ATE9895T1 (ko) |
AU (1) | AU540697B2 (ko) |
BR (1) | BR8100484A (ko) |
CA (1) | CA1161064A (ko) |
CH (1) | CH644580A5 (ko) |
CS (6) | CS219940B2 (ko) |
DE (2) | DE3102603A1 (ko) |
DK (1) | DK15681A (ko) |
ES (6) | ES498866A0 (ko) |
FI (1) | FI801147A (ko) |
FR (1) | FR2479815A1 (ko) |
GB (1) | GB2068373B (ko) |
HU (1) | HU182280B (ko) |
IE (1) | IE50885B1 (ko) |
IL (1) | IL61961A (ko) |
IT (1) | IT1135001B (ko) |
LU (1) | LU83096A1 (ko) |
MC (1) | MC1365A1 (ko) |
NL (1) | NL8100403A (ko) |
NO (1) | NO149958C (ko) |
NZ (1) | NZ196086A (ko) |
PH (1) | PH16098A (ko) |
PT (1) | PT72415B (ko) |
SE (1) | SE8100403L (ko) |
YU (1) | YU332180A (ko) |
ZA (1) | ZA81459B (ko) |
ZW (1) | ZW31480A1 (ko) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6372919B1 (en) * | 2001-01-11 | 2002-04-16 | Dov Pharmaceutical, Inc. | (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane, compositions thereof, and uses as an anti-depressant agent |
US20060173064A1 (en) * | 2001-08-24 | 2006-08-03 | Lippa Arnold S | (-)-1-(3,4-Dichlorophenyl)-3-azabi cyclo[3.1.0]hexane, compositions thereof, and uses for treating alcohol-related disorders |
US6569887B2 (en) * | 2001-08-24 | 2003-05-27 | Dov Pharmaceuticals Inc. | (−)-1-(3,4-Dichlorophenyl)-3-azabicyclo[3.1.0]hexane, compositions thereof, and uses as a dopamine-reuptake |
US20080081834A1 (en) | 2002-07-31 | 2008-04-03 | Lippa Arnold S | Methods and compositions employing bicifadine for treating disability or functional impairment associated with acute pain, chronic pain, or neuropathic disorders |
US20070043100A1 (en) | 2005-08-16 | 2007-02-22 | Hagen Eric J | Novel polymorphs of azabicyclohexane |
US20060100263A1 (en) * | 2004-11-05 | 2006-05-11 | Anthony Basile | Antipyretic compositions and methods |
WO2007016155A2 (en) | 2005-07-27 | 2007-02-08 | Dov Pharmaceutical, Inc. | Novel 1-aryl-3-azabicyclo[3.1.0]hexanes: preparation and use to treat neuropsychiatric disorders |
US20080045725A1 (en) | 2006-04-28 | 2008-02-21 | Murry Jerry A | Process For The Synthesis of (+) And (-)-1-(3,4-Dichlorophenyl)-3-Azabicyclo[3.1.0]Hexane |
US8138377B2 (en) * | 2006-11-07 | 2012-03-20 | Dov Pharmaceutical, Inc. | Arylbicyclo[3.1.0]hexylamines and methods and compositions for their preparation and use |
US20080269348A1 (en) * | 2006-11-07 | 2008-10-30 | Phil Skolnick | Novel Arylbicyclo[3.1.0]Hexylamines And Methods And Compositions For Their Preparation And Use |
WO2008153937A2 (en) * | 2007-06-06 | 2008-12-18 | Dov Pharmaceutical, Inc. | Novel 1- heteroaryl-3-azabicyclo[3.1.0]hexanes, methods for their preparation and their use as medicaments |
US9133159B2 (en) | 2007-06-06 | 2015-09-15 | Neurovance, Inc. | 1-heteroaryl-3-azabicyclo[3.1.0]hexanes, methods for their preparation and their use as medicaments |
US20140206740A1 (en) | 2011-07-30 | 2014-07-24 | Neurovance, Inc. | Use Of (1R,5S)-(+)-(Napthalen-2-yl)-3-Azabicyclo[3.1.0]Hexane In The Treatment Of Conditions Affected By Monoamine Neurotransmitters |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH249047A (de) * | 1944-03-20 | 1947-05-31 | Ag J R Geigy | Verfahren zur Darstellung eines basischen Esters einer 1-Aryl-cycloalkyl-1-carbonsäure. |
CH249052A (de) * | 1944-03-20 | 1947-05-31 | Ag J R Geigy | Verfahren zur Darstellung eines basischen Amids einer 1-Aryl-cycloalkyl-1-carbonsäure. |
US2647122A (en) * | 1948-10-01 | 1953-07-28 | Sterling Drug Inc | Tertiary amines and process of preparing them |
US3109845A (en) * | 1960-02-04 | 1963-11-05 | Thomae Gmbh Dr K | 1-cyclohexyl, 1-cyclohexenyl, 1-furyl, and 1-thienyl, tertiary amino substituted methanes |
DE1518545A1 (de) * | 1965-04-01 | 1970-01-15 | Boehringer Mannheim Gmbh | Verfahren zur Herstellung neuer Phenylcyclohexylalkylamine und ihrer Salze |
DE1518663A1 (de) * | 1965-08-02 | 1969-12-18 | Gruenenthal Chemie | Basisch substituierte Cycloalken-derivate und Verfahren zu ihrer Herstellung |
US3408396A (en) * | 1965-10-22 | 1968-10-29 | Colgate Palmolive Co | alpha-cyclohexyl-3, 4-disubstituted-phenyl acetamides |
US3485873A (en) * | 1966-12-21 | 1969-12-23 | Sterling Drug Inc | N-benzyl-n-methyl-omega-phenyl-omega-cycloalkyl-lower-alkylamines |
US3737451A (en) * | 1970-09-23 | 1973-06-05 | Sandoz Ag | Cis-3,4-diaryl-cyclopentylidene-and 1-cyclopentene-1-acetic acids and derivatives |
US4053637A (en) * | 1971-06-11 | 1977-10-11 | Astra Lakemedal Aktiebolag | Compounds of diphenylcyclopentylamine type and methods for their uses |
CA1130318A (en) * | 1978-10-11 | 1982-08-24 | Peter M. Muller | Cyclohexadiene derivatives |
-
1980
- 1980-01-29 CH CH72480A patent/CH644580A5/de not_active IP Right Cessation
- 1980-04-10 FI FI801147A patent/FI801147A/fi not_active Application Discontinuation
- 1980-12-11 CA CA000366550A patent/CA1161064A/en not_active Expired
- 1980-12-19 ZW ZW314/80A patent/ZW31480A1/xx unknown
- 1980-12-30 YU YU03321/80A patent/YU332180A/xx unknown
-
1981
- 1981-01-08 IT IT19047/81A patent/IT1135001B/it active
- 1981-01-14 DK DK15681A patent/DK15681A/da not_active Application Discontinuation
- 1981-01-19 CS CS81362A patent/CS219940B2/cs unknown
- 1981-01-19 CS CS817016A patent/CS219942B2/cs unknown
- 1981-01-19 CS CS817017A patent/CS220347B2/cs unknown
- 1981-01-19 CS CS817018A patent/CS219943B2/cs unknown
- 1981-01-19 CS CS817015A patent/CS219941B2/cs unknown
- 1981-01-19 CS CS817019A patent/CS219944B2/cs unknown
- 1981-01-20 PH PH25103A patent/PH16098A/en unknown
- 1981-01-22 ZA ZA00810459A patent/ZA81459B/xx unknown
- 1981-01-22 NZ NZ196086A patent/NZ196086A/en unknown
- 1981-01-22 IL IL61961A patent/IL61961A/xx unknown
- 1981-01-23 SE SE8100403A patent/SE8100403L/xx not_active Application Discontinuation
- 1981-01-23 AR AR284052A patent/AR227906A1/es active
- 1981-01-26 MC MC811495A patent/MC1365A1/xx unknown
- 1981-01-27 DE DE19813102603 patent/DE3102603A1/de not_active Withdrawn
- 1981-01-27 EP EP81100576A patent/EP0033156B1/de not_active Expired
- 1981-01-27 LU LU83096A patent/LU83096A1/de unknown
- 1981-01-27 AT AT81100576T patent/ATE9895T1/de active
- 1981-01-27 FR FR8101480A patent/FR2479815A1/fr active Granted
- 1981-01-27 US US06/228,793 patent/US4336268A/en not_active Expired - Fee Related
- 1981-01-27 JP JP975781A patent/JPS56120650A/ja active Pending
- 1981-01-27 DE DE8181100576T patent/DE3166656D1/de not_active Expired
- 1981-01-28 BR BR8100484A patent/BR8100484A/pt unknown
- 1981-01-28 IE IE153/81A patent/IE50885B1/en unknown
- 1981-01-28 NO NO810297A patent/NO149958C/no unknown
- 1981-01-28 NL NL8100403A patent/NL8100403A/nl not_active Application Discontinuation
- 1981-01-28 HU HU81178A patent/HU182280B/hu unknown
- 1981-01-28 PT PT72415A patent/PT72415B/pt unknown
- 1981-01-28 GB GB8102555A patent/GB2068373B/en not_active Expired
- 1981-01-28 KR KR1019810000259A patent/KR850000626B1/ko active IP Right Grant
- 1981-01-28 AT AT0035581A patent/AT376654B/de not_active IP Right Cessation
- 1981-01-28 ES ES498866A patent/ES498866A0/es active Granted
- 1981-01-29 AU AU66719/81A patent/AU540697B2/en not_active Ceased
- 1981-10-29 ES ES506685A patent/ES506685A0/es active Granted
- 1981-10-29 ES ES506688A patent/ES506688A0/es active Granted
- 1981-10-29 ES ES506684A patent/ES8400079A1/es not_active Expired
- 1981-10-29 ES ES506687A patent/ES506687A0/es active Granted
- 1981-10-29 ES ES506686A patent/ES506686A0/es active Granted
-
1982
- 1982-03-24 US US06/361,290 patent/US4448991A/en not_active Expired - Fee Related
-
1984
- 1984-08-01 KR KR1019840004585A patent/KR840001554B1/ko active IP Right Grant
- 1984-08-01 KR KR1019840004581A patent/KR840001551B1/ko active IP Right Grant
- 1984-08-01 KR KR1019840004582A patent/KR840001552B1/ko active IP Right Grant
- 1984-08-01 KR KR1019840004583A patent/KR840001553B1/ko active IP Right Grant
- 1984-08-01 KR KR1019840004584A patent/KR850000627B1/ko active IP Right Grant
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