IT1135001B - Cicloesen-derivati - Google Patents

Cicloesen-derivati

Info

Publication number
IT1135001B
IT1135001B IT19047/81A IT1904781A IT1135001B IT 1135001 B IT1135001 B IT 1135001B IT 19047/81 A IT19047/81 A IT 19047/81A IT 1904781 A IT1904781 A IT 1904781A IT 1135001 B IT1135001 B IT 1135001B
Authority
IT
Italy
Prior art keywords
cyclohexen
derivatives
Prior art date
Application number
IT19047/81A
Other languages
English (en)
Other versions
IT8119047A0 (it
Inventor
Hans Bruderer
Albert Eduard Fischli
Rudolf Pfister
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of IT8119047A0 publication Critical patent/IT8119047A0/it
Application granted granted Critical
Publication of IT1135001B publication Critical patent/IT1135001B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
IT19047/81A 1980-01-29 1981-01-08 Cicloesen-derivati IT1135001B (it)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH72480A CH644580A5 (de) 1980-01-29 1980-01-29 Cyclohexen-derivate.

Publications (2)

Publication Number Publication Date
IT8119047A0 IT8119047A0 (it) 1981-01-08
IT1135001B true IT1135001B (it) 1986-08-20

Family

ID=4193699

Family Applications (1)

Application Number Title Priority Date Filing Date
IT19047/81A IT1135001B (it) 1980-01-29 1981-01-08 Cicloesen-derivati

Country Status (32)

Country Link
US (2) US4336268A (it)
EP (1) EP0033156B1 (it)
JP (1) JPS56120650A (it)
KR (6) KR850000626B1 (it)
AR (1) AR227906A1 (it)
AT (2) ATE9895T1 (it)
AU (1) AU540697B2 (it)
BR (1) BR8100484A (it)
CA (1) CA1161064A (it)
CH (1) CH644580A5 (it)
CS (6) CS219941B2 (it)
DE (2) DE3102603A1 (it)
DK (1) DK15681A (it)
ES (6) ES498866A0 (it)
FI (1) FI801147A (it)
FR (1) FR2479815A1 (it)
GB (1) GB2068373B (it)
HU (1) HU182280B (it)
IE (1) IE50885B1 (it)
IL (1) IL61961A (it)
IT (1) IT1135001B (it)
LU (1) LU83096A1 (it)
MC (1) MC1365A1 (it)
NL (1) NL8100403A (it)
NO (1) NO149958C (it)
NZ (1) NZ196086A (it)
PH (1) PH16098A (it)
PT (1) PT72415B (it)
SE (1) SE8100403L (it)
YU (1) YU332180A (it)
ZA (1) ZA81459B (it)
ZW (1) ZW31480A1 (it)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6372919B1 (en) * 2001-01-11 2002-04-16 Dov Pharmaceutical, Inc. (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane, compositions thereof, and uses as an anti-depressant agent
US6569887B2 (en) * 2001-08-24 2003-05-27 Dov Pharmaceuticals Inc. (−)-1-(3,4-Dichlorophenyl)-3-azabicyclo[3.1.0]hexane, compositions thereof, and uses as a dopamine-reuptake
US20060173064A1 (en) * 2001-08-24 2006-08-03 Lippa Arnold S (-)-1-(3,4-Dichlorophenyl)-3-azabi cyclo[3.1.0]hexane, compositions thereof, and uses for treating alcohol-related disorders
US20080081834A1 (en) 2002-07-31 2008-04-03 Lippa Arnold S Methods and compositions employing bicifadine for treating disability or functional impairment associated with acute pain, chronic pain, or neuropathic disorders
US20070043100A1 (en) 2005-08-16 2007-02-22 Hagen Eric J Novel polymorphs of azabicyclohexane
US20060100263A1 (en) * 2004-11-05 2006-05-11 Anthony Basile Antipyretic compositions and methods
CA2659215C (en) 2005-07-27 2018-07-10 Dov Pharmaceutical, Inc. Novel 1-aryl-3-azabicyclo[3.1.0]hexanes: preparation and use to treat neuropsychiatric disorders
US20080045725A1 (en) * 2006-04-28 2008-02-21 Murry Jerry A Process For The Synthesis of (+) And (-)-1-(3,4-Dichlorophenyl)-3-Azabicyclo[3.1.0]Hexane
US20080269348A1 (en) * 2006-11-07 2008-10-30 Phil Skolnick Novel Arylbicyclo[3.1.0]Hexylamines And Methods And Compositions For Their Preparation And Use
US8138377B2 (en) * 2006-11-07 2012-03-20 Dov Pharmaceutical, Inc. Arylbicyclo[3.1.0]hexylamines and methods and compositions for their preparation and use
US20090069374A1 (en) * 2007-06-06 2009-03-12 Phil Skolnick Novel 1-Heteroaryl-3-Azabicyclo[3.1.0]Hexanes, Methods For Their Preparation And Their Use As Medicaments
US9133159B2 (en) 2007-06-06 2015-09-15 Neurovance, Inc. 1-heteroaryl-3-azabicyclo[3.1.0]hexanes, methods for their preparation and their use as medicaments

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH249052A (de) * 1944-03-20 1947-05-31 Ag J R Geigy Verfahren zur Darstellung eines basischen Amids einer 1-Aryl-cycloalkyl-1-carbonsäure.
CH249047A (de) * 1944-03-20 1947-05-31 Ag J R Geigy Verfahren zur Darstellung eines basischen Esters einer 1-Aryl-cycloalkyl-1-carbonsäure.
US2647122A (en) * 1948-10-01 1953-07-28 Sterling Drug Inc Tertiary amines and process of preparing them
US3109845A (en) * 1960-02-04 1963-11-05 Thomae Gmbh Dr K 1-cyclohexyl, 1-cyclohexenyl, 1-furyl, and 1-thienyl, tertiary amino substituted methanes
DE1518545A1 (de) * 1965-04-01 1970-01-15 Boehringer Mannheim Gmbh Verfahren zur Herstellung neuer Phenylcyclohexylalkylamine und ihrer Salze
DE1518663A1 (de) * 1965-08-02 1969-12-18 Gruenenthal Chemie Basisch substituierte Cycloalken-derivate und Verfahren zu ihrer Herstellung
US3408396A (en) * 1965-10-22 1968-10-29 Colgate Palmolive Co alpha-cyclohexyl-3, 4-disubstituted-phenyl acetamides
US3485873A (en) * 1966-12-21 1969-12-23 Sterling Drug Inc N-benzyl-n-methyl-omega-phenyl-omega-cycloalkyl-lower-alkylamines
US3737451A (en) * 1970-09-23 1973-06-05 Sandoz Ag Cis-3,4-diaryl-cyclopentylidene-and 1-cyclopentene-1-acetic acids and derivatives
US4053637A (en) * 1971-06-11 1977-10-11 Astra Lakemedal Aktiebolag Compounds of diphenylcyclopentylamine type and methods for their uses
CA1130318A (en) * 1978-10-11 1982-08-24 Peter M. Muller Cyclohexadiene derivatives

Also Published As

Publication number Publication date
CS219942B2 (en) 1983-03-25
GB2068373A (en) 1981-08-12
IL61961A (en) 1984-05-31
US4448991A (en) 1984-05-15
SE8100403L (sv) 1981-07-30
ATE9895T1 (de) 1984-11-15
CH644580A5 (de) 1984-08-15
ES8301200A1 (es) 1982-12-01
FI801147A (fi) 1981-07-30
NL8100403A (nl) 1981-08-17
PT72415A (en) 1981-02-01
EP0033156A3 (en) 1982-03-17
EP0033156B1 (de) 1984-10-17
NO149958B (no) 1984-04-16
KR840001552B1 (ko) 1984-10-05
ES8301883A1 (es) 1982-12-16
DE3166656D1 (en) 1984-11-22
YU332180A (en) 1983-10-31
BR8100484A (pt) 1981-08-18
HU182280B (en) 1983-12-28
ES506688A0 (es) 1982-12-16
FR2479815B1 (it) 1984-02-17
CS219941B2 (en) 1983-03-25
KR850002003A (ko) 1985-04-10
ES506685A0 (es) 1982-12-16
JPS56120650A (en) 1981-09-22
CS220347B2 (en) 1983-03-25
NO149958C (no) 1984-07-25
IE50885B1 (en) 1986-08-06
KR830005105A (ko) 1983-07-23
MC1365A1 (fr) 1981-10-23
KR850000627B1 (ko) 1985-05-06
US4336268A (en) 1982-06-22
FR2479815A1 (fr) 1981-10-09
KR840001554B1 (ko) 1984-10-05
AT376654B (de) 1984-12-27
CA1161064A (en) 1984-01-24
ES8301884A1 (es) 1982-12-16
ATA35581A (de) 1984-05-15
ES506686A0 (es) 1982-12-16
KR840001551B1 (ko) 1984-10-05
IT8119047A0 (it) 1981-01-08
CS219940B2 (en) 1983-03-25
IL61961A0 (en) 1981-02-27
ZW31480A1 (en) 1981-09-02
DK15681A (da) 1981-07-30
LU83096A1 (de) 1982-09-10
PT72415B (en) 1982-07-26
AU540697B2 (en) 1984-11-29
ES498866A0 (es) 1982-12-01
ZA81459B (en) 1982-02-24
PH16098A (en) 1983-06-24
DE3102603A1 (de) 1981-12-10
ES8400079A1 (es) 1983-10-16
AR227906A1 (es) 1982-12-30
GB2068373B (en) 1983-11-30
ES506684A0 (es) 1983-10-16
ES506687A0 (es) 1982-12-16
CS219944B2 (en) 1983-03-25
KR850000626B1 (ko) 1985-05-06
KR840001553B1 (ko) 1984-10-05
CS219943B2 (en) 1983-03-25
ES8301878A1 (es) 1982-12-16
AU6671981A (en) 1981-08-06
IE810153L (en) 1981-07-29
EP0033156A2 (de) 1981-08-05
NZ196086A (en) 1984-08-24
NO810297L (no) 1981-07-30
ES8301885A1 (es) 1982-12-16

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