KR840005464A - 포스포리피드 유도체의 제조방법 - Google Patents

포스포리피드 유도체의 제조방법 Download PDF

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KR840005464A
KR840005464A KR1019830003406A KR830003406A KR840005464A KR 840005464 A KR840005464 A KR 840005464A KR 1019830003406 A KR1019830003406 A KR 1019830003406A KR 830003406 A KR830003406 A KR 830003406A KR 840005464 A KR840005464 A KR 840005464A
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compound
formula
salt
alkoxy
group
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KR1019830003406A
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쓰도무 데라지 (외 4)
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후지사와 도모기찌로
후지사와 야꾸힝 고교 가부시끼 가이샤
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Publication of KR840005464A publication Critical patent/KR840005464A/ko

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    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H9/00—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
    • C07H9/02—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical the hetero ring containing only oxygen as ring hetero atoms
    • C07H9/04—Cyclic acetals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/10—Phosphatides, e.g. lecithin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/117—Esters of phosphoric acids with cycloaliphatic alcohols
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    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof
    • C07H11/04—Phosphates; Phosphites; Polyphosphates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/08—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to carbocyclic rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
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  • General Chemical & Material Sciences (AREA)
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  • Animal Behavior & Ethology (AREA)
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Abstract

내용 없음

Description

포스포리피드 유도체의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (10)

  1. 다음 구조식(Ⅱ)의 화합물 또는 그 염을 다음 구조식(Ⅲ)화합물 또는 그 염과 반응시켜서 다음 구조식(Ia)화합물 또는 그 염을 제조하거나 다음 구조식(Ⅳ)의 화합물을 다음 구조식(Ⅴ)의 화합물 또는 그 염과 반응시켜서 다음 구조식(Ib)의 화합물 또는 그 염을 제조하거나, 또는 다음 구조식(Ic)의 화합물 또는 그 염에서 보호기를 제거하여 다음 구조식(Id)의 화합물 또는 그 염을 제조함을 특징으로 하는 다음 구조식(I)의 화합물 또는 그 염을 제조하는 방법.
  2. (I)(Ⅱ)
  3. (Ⅲ)(Ia)
  4. (Ⅳ)(Ⅴ)
  5. (Ib)(Ic)
  6. (Id)
  7. 상기 식에서 R1은 알킬, 알콕시, 알킬티오 또는 알킬설포닐; R2는 수소, 하이드록시, 알콕시, 저급알카노일옥시 또는 저급알킬카바모일옥시; n은 0 또는 1 ;R3는 하이드록시 또는 보호된 하이드록시이며; R4는 저급알콕시; 2이상의 하이드록시 또는 보호된 하이드록시기로 치환된 저급알콕시 또는 저급 알리사이클릭옥시기; 저급알콕시 또는 2이상의 하이드록시기를 가지는 다른 알리사이클릭-옥시기로 치환된 저급알콕시 또는 저급알리사이클릭-옥시기, 알리사이클릭 링은 산소원자를 함유할 수 있다.
  8. R2 a는 수소, 알콕시, 저급알카노일옥시 또는 저급알킬카바모일옥시; R3 a는 보호된 하이드록시; X는 할로겐 또는 실버옥시; R4 a는 저급알킬; 또는 2이상의 보호된 하이드록시기로 치환되고, 저급알콕시, 또는 2이상의 보호된 하이드록시기를 가지는 다른 알리사이클릭-옥시기로 치환될 수도 있는 저급알리사이클릭기, 여기에서 알리사이클릭기는 하나의 산소원자를 함유할 수 있다.
  9. Y는 X가 할로겐인때 하이드록시기이거나, X가 실버옥시일때 할로겐이며; R3 b와 R4 b는 적어도 하나의 보호된 하이드록시기가 R3 b및 R4 b에 함유된 조건하에 각각 R3및 R4와 같으며; R3 c및 R4 c는 적어도 하나의 하이드록시기가 R3및 R4에 함유된 조건하에 R3및 R4와 같다.
  10. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019830003406A 1982-07-30 1983-07-23 포스포리피드 유도체의 제조방법 KR840005464A (ko)

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GB8222020 1982-07-30
GB8222020 1982-07-30

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US (1) US4585762A (ko)
EP (1) EP0100499A3 (ko)
JP (1) JPS5942394A (ko)
KR (1) KR840005464A (ko)
DK (1) DK347383A (ko)
ES (3) ES8501410A1 (ko)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3239817A1 (de) * 1982-07-06 1984-01-12 Max Planck Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen Neue glycerinderivate zur synthese von phospholipiden
JPS6122096A (ja) * 1984-07-09 1986-01-30 Kao Corp 糖リン酸エステルおよびその製造方法
IT1244546B (it) * 1991-02-01 1994-07-15 Mediolanum Farmaceutici Spa Analoghi del fosfatidilinositolo inibitori della fosfolipasi c fosfatidilinositolo-specifica
JP2553171Y2 (ja) * 1991-05-31 1997-11-05 東陶機器株式会社 便器装置
SE9102068L (sv) * 1991-07-03 1993-01-04 Perstorp Ab Derivat av inositol, kompositioner innehaallande dessa samt anvaendning daerav
IT1255476B (it) * 1992-07-30 1995-11-02 Glicerofosfoderivati farmacologicamente attivi
DE4234130A1 (de) * 1992-10-09 1994-04-14 Max Planck Gesellschaft Phospholipase A¶2¶ inhibierende Phosphatidylcholinverbindungen
US5354853A (en) * 1993-03-12 1994-10-11 Genzyme Corporation Phospholipid-saccharide conjugates
WO1995007089A1 (en) 1993-09-09 1995-03-16 Imutec Corporation Immunomodulating compositions from bile
US6551623B1 (en) 1993-09-09 2003-04-22 Lorus Therapeutics Inc. Immunomodulating compositions from bile
AU711294B2 (en) 1995-03-16 1999-10-07 Erin Mills Biotech Inc. Immunomodulating compositions from bile for the treatment of immune system disorders
US20040101569A1 (en) * 1996-05-16 2004-05-27 Lorus Therapeutics Inc. Immunomodulating compositions from bile
CA2427352C (en) * 2000-11-07 2010-10-12 I.R.B. Istituto Di Ricerche Biotecnologiche S.R.L. Glycerophosphoinositol derivatives as modulators of cytosolic phospholipase
EP1537129B1 (en) * 2002-09-03 2013-11-06 Georgetown University Akt inhibitors, pharmaceutical compositions, and uses thereof
US20110218176A1 (en) 2006-11-01 2011-09-08 Barbara Brooke Jennings-Spring Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development

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FR2287901A1 (fr) * 1974-10-14 1976-05-14 Pasteur Institut Medicament immunostimulant contenant un derive d'ose ou de polyose phosphoryle
DE2659048A1 (de) * 1976-12-27 1978-07-06 Nattermann A & Cie Neue inositphosphatid-derivate und verfahren zur herstellung dieser verbindungen

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DK347383A (da) 1984-01-31
DK347383D0 (da) 1983-07-28
EP0100499A3 (en) 1985-06-12
ES8604243A1 (es) 1985-07-01
ES530668A0 (es) 1985-07-01
EP0100499A2 (en) 1984-02-15
ES8602027A1 (es) 1985-05-01
US4585762A (en) 1986-04-29
ES524610A0 (es) 1984-12-01
ES8501410A1 (es) 1984-12-01
ES530669A0 (es) 1985-05-01
JPS5942394A (ja) 1984-03-08

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