ES8602027A1 - Un procedimiento para la preparacion de nuevos derivados de fosfolipidos - Google Patents
Un procedimiento para la preparacion de nuevos derivados de fosfolipidosInfo
- Publication number
- ES8602027A1 ES8602027A1 ES530669A ES530669A ES8602027A1 ES 8602027 A1 ES8602027 A1 ES 8602027A1 ES 530669 A ES530669 A ES 530669A ES 530669 A ES530669 A ES 530669A ES 8602027 A1 ES8602027 A1 ES 8602027A1
- Authority
- ES
- Spain
- Prior art keywords
- alkoxy
- opt
- substd
- oxy
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000003904 phospholipids Chemical class 0.000 title abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 9
- 229910019142 PO4 Inorganic materials 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 abstract 3
- 239000010452 phosphate Substances 0.000 abstract 3
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 125000002723 alicyclic group Chemical group 0.000 abstract 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 230000000259 anti-tumor effect Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 229960000367 inositol Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H9/00—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
- C07H9/02—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical the hetero ring containing only oxygen as ring hetero atoms
- C07H9/04—Cyclic acetals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
- C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/10—Phosphatides, e.g. lecithin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/117—Esters of phosphoric acids with cycloaliphatic alcohols
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof
- C07H11/04—Phosphates; Phosphites; Polyphosphates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/08—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to carbocyclic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA PREPARACION DE NUEVOS DERIVADOS DE FOSFOLIPIDOS. CONSISTE EN HACER REACCIONAR A UN COMPUESTO DE FORMULA (II) CON UN COMPUESTO DE FORMULA (III), EN DISOLVENTE APROTIDOS COMO BENCENO, TOLUENO, XILENO Y OTROS, EN PRESENCIA DE BASES INORGANICAS COMO NAOH, KOH Y OTROS O BASES ORGANICAS COMO TRIMETILAMINA, TRIETILAMINA, PIRIDINA Y OTRAS, PARA OBTENER UN COMPUESTO DE FORMULA (IJ) Y SUS SALES. SIENDO; R1, ALQUILO, ALCOXI Y OTROS; R2, H, ALXI U OTROS; R3A HIDROXI PROTEGIDO; R4A ALQUILO INFERIOR O UN GRUPO ACICLICO INFERIOR SUSTITUIDO, CON 2 O MAS GRUPOS HIDROXIDOS PROTEGIDOS Y POR OTROS; N 0 O 1 Y X HAL CUANDO Y ES HIDROXI Y X PLATA-OXI CUANDO Y ES HALOGENO. SE UTILIZAN PARA EL TRATAMIENTO DEL CANCER EN EL HOMBRE Y EN LOS ANIMALES.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB8222020 | 1982-07-30 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8602027A1 true ES8602027A1 (es) | 1985-05-01 |
ES530669A0 ES530669A0 (es) | 1985-05-01 |
Family
ID=10532013
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES524610A Expired ES8501410A1 (es) | 1982-07-30 | 1983-07-29 | Un procedimiento para la preparacion de nuevos derivados de fosfolipidos. |
ES530668A Granted ES530668A0 (es) | 1982-07-30 | 1984-03-15 | Un procedimiento para la preparacion de nuevos derivados de fosfolipidos |
ES530669A Granted ES530669A0 (es) | 1982-07-30 | 1984-03-15 | Un procedimiento para la preparacion de nuevos derivados de fosfolipidos |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES524610A Expired ES8501410A1 (es) | 1982-07-30 | 1983-07-29 | Un procedimiento para la preparacion de nuevos derivados de fosfolipidos. |
ES530668A Granted ES530668A0 (es) | 1982-07-30 | 1984-03-15 | Un procedimiento para la preparacion de nuevos derivados de fosfolipidos |
Country Status (6)
Country | Link |
---|---|
US (1) | US4585762A (es) |
EP (1) | EP0100499A3 (es) |
JP (1) | JPS5942394A (es) |
KR (1) | KR840005464A (es) |
DK (1) | DK347383A (es) |
ES (3) | ES8501410A1 (es) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3239817A1 (de) * | 1982-07-06 | 1984-01-12 | Max Planck Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen | Neue glycerinderivate zur synthese von phospholipiden |
JPS6122096A (ja) * | 1984-07-09 | 1986-01-30 | Kao Corp | 糖リン酸エステルおよびその製造方法 |
IT1244546B (it) * | 1991-02-01 | 1994-07-15 | Mediolanum Farmaceutici Spa | Analoghi del fosfatidilinositolo inibitori della fosfolipasi c fosfatidilinositolo-specifica |
JP2553171Y2 (ja) * | 1991-05-31 | 1997-11-05 | 東陶機器株式会社 | 便器装置 |
SE9102068L (sv) * | 1991-07-03 | 1993-01-04 | Perstorp Ab | Derivat av inositol, kompositioner innehaallande dessa samt anvaendning daerav |
IT1255476B (it) * | 1992-07-30 | 1995-11-02 | Glicerofosfoderivati farmacologicamente attivi | |
DE4234130A1 (de) * | 1992-10-09 | 1994-04-14 | Max Planck Gesellschaft | Phospholipase A¶2¶ inhibierende Phosphatidylcholinverbindungen |
US5354853A (en) * | 1993-03-12 | 1994-10-11 | Genzyme Corporation | Phospholipid-saccharide conjugates |
WO1995007089A1 (en) | 1993-09-09 | 1995-03-16 | Imutec Corporation | Immunomodulating compositions from bile |
US6551623B1 (en) | 1993-09-09 | 2003-04-22 | Lorus Therapeutics Inc. | Immunomodulating compositions from bile |
AU711294B2 (en) | 1995-03-16 | 1999-10-07 | Erin Mills Biotech Inc. | Immunomodulating compositions from bile for the treatment of immune system disorders |
US20040101569A1 (en) * | 1996-05-16 | 2004-05-27 | Lorus Therapeutics Inc. | Immunomodulating compositions from bile |
CA2427352C (en) * | 2000-11-07 | 2010-10-12 | I.R.B. Istituto Di Ricerche Biotecnologiche S.R.L. | Glycerophosphoinositol derivatives as modulators of cytosolic phospholipase |
EP1537129B1 (en) * | 2002-09-03 | 2013-11-06 | Georgetown University | Akt inhibitors, pharmaceutical compositions, and uses thereof |
US20110218176A1 (en) | 2006-11-01 | 2011-09-08 | Barbara Brooke Jennings-Spring | Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2287901A1 (fr) * | 1974-10-14 | 1976-05-14 | Pasteur Institut | Medicament immunostimulant contenant un derive d'ose ou de polyose phosphoryle |
DE2659048A1 (de) * | 1976-12-27 | 1978-07-06 | Nattermann A & Cie | Neue inositphosphatid-derivate und verfahren zur herstellung dieser verbindungen |
-
1983
- 1983-07-13 US US06/513,451 patent/US4585762A/en not_active Expired - Fee Related
- 1983-07-23 KR KR1019830003406A patent/KR840005464A/ko not_active Application Discontinuation
- 1983-07-23 EP EP83107236A patent/EP0100499A3/en not_active Withdrawn
- 1983-07-28 DK DK347383A patent/DK347383A/da not_active Application Discontinuation
- 1983-07-29 ES ES524610A patent/ES8501410A1/es not_active Expired
- 1983-07-29 JP JP58139709A patent/JPS5942394A/ja active Pending
-
1984
- 1984-03-15 ES ES530668A patent/ES530668A0/es active Granted
- 1984-03-15 ES ES530669A patent/ES530669A0/es active Granted
Also Published As
Publication number | Publication date |
---|---|
DK347383A (da) | 1984-01-31 |
DK347383D0 (da) | 1983-07-28 |
EP0100499A3 (en) | 1985-06-12 |
ES8604243A1 (es) | 1985-07-01 |
ES530668A0 (es) | 1985-07-01 |
EP0100499A2 (en) | 1984-02-15 |
US4585762A (en) | 1986-04-29 |
ES524610A0 (es) | 1984-12-01 |
KR840005464A (ko) | 1984-11-12 |
ES8501410A1 (es) | 1984-12-01 |
ES530669A0 (es) | 1985-05-01 |
JPS5942394A (ja) | 1984-03-08 |
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