KR20220123023A - 시클릭 화합물 및 이의 사용 방법 - Google Patents

시클릭 화합물 및 이의 사용 방법 Download PDF

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Publication number
KR20220123023A
KR20220123023A KR1020227025562A KR20227025562A KR20220123023A KR 20220123023 A KR20220123023 A KR 20220123023A KR 1020227025562 A KR1020227025562 A KR 1020227025562A KR 20227025562 A KR20227025562 A KR 20227025562A KR 20220123023 A KR20220123023 A KR 20220123023A
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KR
South Korea
Prior art keywords
compound
cancer
malt1
related cancer
subject
Prior art date
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Pending
Application number
KR1020227025562A
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English (en)
Korean (ko)
Inventor
슐루 펭
모건 로렌츠
고란 크릴로프
앤드루 플라책
저 녜
리니 트르조스
마이클 트르조스
하이펑 탕
에이치. 레이철 라기아코스
Original Assignee
슈뢰딩거, 인크.
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Application filed by 슈뢰딩거, 인크. filed Critical 슈뢰딩거, 인크.
Publication of KR20220123023A publication Critical patent/KR20220123023A/ko
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pyrane Compounds (AREA)
  • Saccharide Compounds (AREA)
KR1020227025562A 2019-12-27 2020-12-24 시클릭 화합물 및 이의 사용 방법 Pending KR20220123023A (ko)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201962954262P 2019-12-27 2019-12-27
US62/954,262 2019-12-27
US202063040582P 2020-06-18 2020-06-18
US63/040,582 2020-06-18
US202063119521P 2020-11-30 2020-11-30
US63/119,521 2020-11-30
PCT/US2020/066999 WO2021134004A1 (en) 2019-12-27 2020-12-24 Cyclic compounds and methods of using same

Publications (1)

Publication Number Publication Date
KR20220123023A true KR20220123023A (ko) 2022-09-05

Family

ID=74206185

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020227025562A Pending KR20220123023A (ko) 2019-12-27 2020-12-24 시클릭 화합물 및 이의 사용 방법

Country Status (14)

Country Link
US (1) US20240018157A1 (enExample)
EP (1) EP4081526A1 (enExample)
JP (2) JP7723666B2 (enExample)
KR (1) KR20220123023A (enExample)
CN (1) CN114945571B (enExample)
AU (1) AU2020413333A1 (enExample)
BR (1) BR112022012684A2 (enExample)
CA (1) CA3161339A1 (enExample)
CL (1) CL2022001741A1 (enExample)
IL (1) IL294214B2 (enExample)
MX (1) MX2022007171A (enExample)
PH (1) PH12022551523A1 (enExample)
TW (1) TWI878423B (enExample)
WO (1) WO2021134004A1 (enExample)

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EP4444340A4 (en) * 2021-12-10 2025-12-24 Rarefied Biosciences Inc METHODS OF TREATING DISEASES USING MALT1 INHIBITORS
KR20240144146A (ko) 2022-02-02 2024-10-02 오노 야꾸힝 고교 가부시키가이샤 Malt1 저해약을 유효 성분으로서 포함하는 암 치료제
JP2025524002A (ja) * 2022-07-22 2025-07-25 シュレーディンガー， インコーポレイテッド 環式化合物及びそれを使用する方法
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WO2026003045A1 (en) * 2024-06-26 2026-01-02 Janssen Pharmaceutica Nv Synthesis of a malt1 inhibitor
WO2026050766A1 (en) * 2024-09-02 2026-03-05 Blueprint Medicines Corporation Intermediate salts for synthesis of a cdk2 inhibitor
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Also Published As

Publication number Publication date
CA3161339A1 (en) 2021-07-01
PH12022551523A1 (en) 2024-01-29
CN114945571B (zh) 2025-02-25
JP2023509886A (ja) 2023-03-10
BR112022012684A2 (pt) 2023-03-07
CL2022001741A1 (es) 2023-01-27
CN114945571A (zh) 2022-08-26
AU2020413333A1 (en) 2022-06-16
TW202136270A (zh) 2021-10-01
IL294214A (en) 2022-08-01
IL294214B2 (en) 2026-04-01
JP7723666B2 (ja) 2025-08-14
TWI878423B (zh) 2025-04-01
US20240018157A1 (en) 2024-01-18
WO2021134004A1 (en) 2021-07-01
EP4081526A1 (en) 2022-11-02
IL294214B1 (en) 2025-12-01
JP2024023699A (ja) 2024-02-21
MX2022007171A (es) 2022-08-22

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St.27 status event code: A-1-2-D10-D22-exm-PE0701